An anti-infective peptide that selectively modulates the innate immune response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04

AUTHORS

Monisha G Scott, Edie Dullaghan, Neeloffer Mookherjee, Natalie Glavas, Matthew Waldbrook, Annick Thompson, Aikun Wang, Ken Lee, Silvana Doria, Pam Hamill, Jie Jessie Yu, Yuexin Li, Oreola Donini, M Marta Guarna, B Brett Finlay, John R North, Robert E W Hancock

ABSTRACT

We show that an innate defense-regulator peptide (IDR-1) was protective in mouse models of infection with important Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Salmonella enterica serovar Typhimurium. When given from 48 h before to 6 h after infection, the peptide was effective by both local and systemic administration. Because protection by IDR-1 was prevented by in vivo depletion of monocytes and macrophages, but not neutrophils or B- and T-lymphocytes, we conclude that monocytes and macrophages are key effector cells. IDR-1 was not directly antimicrobial: gene and protein expression analysis in human and mouse monocytes and macrophages indicated that IDR-1, acting through mitogen-activated protein kinase and other signaling pathways, enhanced the levels of monocyte chemokines while reducing pro-inflammatory cytokine responses. To our knowledge, an innate defense regulator that counters infection by selective modulation of innate immunity without obvious toxicities has not been reported previously. More... »

PAGES

465-472

References to SciGraph publications

  • 2004-06. Can innate immunity be enhanced to treat microbial infections? in NATURE REVIEWS MICROBIOLOGY
  • 2005. Toll-Like Receptors: Linking Innate and Adaptive Immunity in MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION X
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1288

    DOI

    http://dx.doi.org/10.1038/nbt1288

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1029788541

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17384586


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Infective Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bacterial Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipopolysaccharides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Immunological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Scott", 
            "givenName": "Monisha G", 
            "id": "sg:person.01131476506.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131476506.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dullaghan", 
            "givenName": "Edie", 
            "id": "sg:person.0606411052.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606411052.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mookherjee", 
            "givenName": "Neeloffer", 
            "id": "sg:person.01241425222.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241425222.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Glavas", 
            "givenName": "Natalie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waldbrook", 
            "givenName": "Matthew", 
            "id": "sg:person.01156424207.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156424207.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thompson", 
            "givenName": "Annick", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Aikun", 
            "id": "sg:person.01252650510.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252650510.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Ken", 
            "id": "sg:person.01065060404.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065060404.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doria", 
            "givenName": "Silvana", 
            "id": "sg:person.01256006724.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256006724.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hamill", 
            "givenName": "Pam", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Jie Jessie", 
            "id": "sg:person.0771004427.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771004427.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Yuexin", 
            "id": "sg:person.01216026542.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216026542.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Donini", 
            "givenName": "Oreola", 
            "id": "sg:person.01153646136.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153646136.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guarna", 
            "givenName": "M Marta", 
            "id": "sg:person.0771064024.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771064024.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Michael Smith Laboratories, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finlay", 
            "givenName": "B Brett", 
            "id": "sg:person.012432200437.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012432200437.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inimex Pharmaceuticals (Canada)", 
              "id": "https://www.grid.ac/institutes/grid.292528.6", 
              "name": [
                "Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2."
              ], 
              "type": "Organization"
            }, 
            "familyName": "North", 
            "givenName": "John R", 
            "id": "sg:person.01037417536.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037417536.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of British Columbia", 
              "id": "https://www.grid.ac/institutes/grid.17091.3e", 
              "name": [
                "Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hancock", 
            "givenName": "Robert E W", 
            "id": "sg:person.01125176622.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125176622.90"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1080/00365540310015935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002439582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003315974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003315974"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.00-0459fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006951343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000083976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009475980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m102165200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009896978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-387-24180-9_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017918564", 
              "https://doi.org/10.1007/0-387-24180-9_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019440812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.49.5.1727-1732.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020625378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/rcmb.2005-0170oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025057121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m207448200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026065635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2005.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026360665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2006.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028251632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.9.e45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030834024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032248507", 
              "https://doi.org/10.1038/nrmicro908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032248507", 
              "https://doi.org/10.1038/nrmicro908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2005.05.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034750956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/420937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035647475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.22.13493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037600455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2005.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038598649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.47.8.2507-2512.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038717864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkh446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041187811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200104)31:4<1066::aid-immu1066>3.0.co;2-#", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042662737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0704380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044943319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.176.4.2455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045733464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.74.1.469-480.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053091660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074731729", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077193985", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.1.665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077258148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082499419", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-04", 
        "datePublishedReg": "2007-04-01", 
        "description": "We show that an innate defense-regulator peptide (IDR-1) was protective in mouse models of infection with important Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Salmonella enterica serovar Typhimurium. When given from 48 h before to 6 h after infection, the peptide was effective by both local and systemic administration. Because protection by IDR-1 was prevented by in vivo depletion of monocytes and macrophages, but not neutrophils or B- and T-lymphocytes, we conclude that monocytes and macrophages are key effector cells. IDR-1 was not directly antimicrobial: gene and protein expression analysis in human and mouse monocytes and macrophages indicated that IDR-1, acting through mitogen-activated protein kinase and other signaling pathways, enhanced the levels of monocyte chemokines while reducing pro-inflammatory cytokine responses. To our knowledge, an innate defense regulator that counters infection by selective modulation of innate immunity without obvious toxicities has not been reported previously.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nbt1288", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1115214", 
            "issn": [
              "1087-0156", 
              "1546-1696"
            ], 
            "name": "Nature Biotechnology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "name": "An anti-infective peptide that selectively modulates the innate immune response", 
        "pagination": "465-472", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "8de85aadeaf19cf984c2d56ece7f84b213186491cc72a4b92a9157105a79db9f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "17384586"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9604648"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nbt1288"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1029788541"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nbt1288", 
          "https://app.dimensions.ai/details/publication/pub.1029788541"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nbt1288"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt1288'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt1288'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt1288'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt1288'


     

    This table displays all metadata directly associated to this object as RDF triples.

    317 TRIPLES      21 PREDICATES      70 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nbt1288 schema:about N02ac170a56004af49094af4bfe776ee9
    2 N02bd1b3f9e6744c9912a3187fae70720
    3 N0aa3a76679de47beb1329034a2266481
    4 N30d859a674b14663af889456b8d8c902
    5 N48bc6c73dbd14adfb7754a7d4c92eba9
    6 N5bf8b83ea485497fbe1a0ab09ea984ee
    7 N6a1ad0d9e7714235b4a3f2a464cac8b8
    8 N75eae383aa8246cba7c50d0ac4864abc
    9 N7ed625e237ac4472ac00690fab1a84db
    10 N903f49dfa6a84096b4350e29cdae1154
    11 Nc3d3bef83771414d8ff3d5d0fab5d667
    12 Nf08017d2a2d2429090fa47dbc6d0cb93
    13 Nfe1b23d3f68743cb8a231ec7dc58a4ba
    14 anzsrc-for:11
    15 anzsrc-for:1107
    16 schema:author Na3ae69b6cd23417abf7ea119678ec4f8
    17 schema:citation sg:pub.10.1007/0-387-24180-9_2
    18 sg:pub.10.1038/nrmicro908
    19 https://app.dimensions.ai/details/publication/pub.1074731729
    20 https://app.dimensions.ai/details/publication/pub.1077193985
    21 https://app.dimensions.ai/details/publication/pub.1082499419
    22 https://doi.org/10.1002/1521-4141(200104)31:4<1066::aid-immu1066>3.0.co;2-#
    23 https://doi.org/10.1016/j.coi.2005.06.002
    24 https://doi.org/10.1016/j.coi.2005.11.012
    25 https://doi.org/10.1016/j.it.2005.06.004
    26 https://doi.org/10.1016/j.jaci.2005.05.036
    27 https://doi.org/10.1016/j.yexcr.2006.03.003
    28 https://doi.org/10.1074/jbc.273.22.13493
    29 https://doi.org/10.1074/jbc.m102165200
    30 https://doi.org/10.1074/jbc.m207448200
    31 https://doi.org/10.1080/00365540310015935
    32 https://doi.org/10.1086/420937
    33 https://doi.org/10.1093/nar/29.9.e45
    34 https://doi.org/10.1093/nar/gkh446
    35 https://doi.org/10.1096/fj.00-0459fje
    36 https://doi.org/10.1128/aac.47.8.2507-2512.2003
    37 https://doi.org/10.1128/aac.49.5.1727-1732.2005
    38 https://doi.org/10.1128/iai.74.1.469-480.2006
    39 https://doi.org/10.1159/000083976
    40 https://doi.org/10.1165/rcmb.2005-0170oc
    41 https://doi.org/10.1172/jci119475
    42 https://doi.org/10.1189/jlb.0704380
    43 https://doi.org/10.4049/jimmunol.176.4.2455
    44 https://doi.org/10.4049/jimmunol.177.1.665
    45 schema:datePublished 2007-04
    46 schema:datePublishedReg 2007-04-01
    47 schema:description We show that an innate defense-regulator peptide (IDR-1) was protective in mouse models of infection with important Gram-positive and Gram-negative pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and Salmonella enterica serovar Typhimurium. When given from 48 h before to 6 h after infection, the peptide was effective by both local and systemic administration. Because protection by IDR-1 was prevented by in vivo depletion of monocytes and macrophages, but not neutrophils or B- and T-lymphocytes, we conclude that monocytes and macrophages are key effector cells. IDR-1 was not directly antimicrobial: gene and protein expression analysis in human and mouse monocytes and macrophages indicated that IDR-1, acting through mitogen-activated protein kinase and other signaling pathways, enhanced the levels of monocyte chemokines while reducing pro-inflammatory cytokine responses. To our knowledge, an innate defense regulator that counters infection by selective modulation of innate immunity without obvious toxicities has not been reported previously.
    48 schema:genre research_article
    49 schema:inLanguage en
    50 schema:isAccessibleForFree false
    51 schema:isPartOf N701189229bcd49e7a2225ac16b62a5cd
    52 Nfc5d525dd2ac4714ba518c5fc50b4878
    53 sg:journal.1115214
    54 schema:name An anti-infective peptide that selectively modulates the innate immune response
    55 schema:pagination 465-472
    56 schema:productId N6328a43e1c6a4c4cbb1545cdd07e5a60
    57 N97545bae87dc4e5abbac497e14580f6f
    58 N9f2c55b88577437480f26ae7de2bac6a
    59 Na58ef8ecc37146179b29eb4ec35842bf
    60 Nbc72b475c7254ab4a47f9918a640b972
    61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029788541
    62 https://doi.org/10.1038/nbt1288
    63 schema:sdDatePublished 2019-04-11T00:04
    64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    65 schema:sdPublisher N2b417146ede942ffbd63ffee4eb313a6
    66 schema:url http://www.nature.com/articles/nbt1288
    67 sgo:license sg:explorer/license/
    68 sgo:sdDataset articles
    69 rdf:type schema:ScholarlyArticle
    70 N02ac170a56004af49094af4bfe776ee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    71 schema:name Bacterial Infections
    72 rdf:type schema:DefinedTerm
    73 N02bd1b3f9e6744c9912a3187fae70720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Peptides
    75 rdf:type schema:DefinedTerm
    76 N087f326c3f0a45338eba33b5b7ae5d59 rdf:first sg:person.0771064024.45
    77 rdf:rest Nd274d8759f0c431cb005c63be0628ac5
    78 N0aa3a76679de47beb1329034a2266481 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Treatment Outcome
    80 rdf:type schema:DefinedTerm
    81 N1e1d6fdb27ae470891565ae41b12607d rdf:first N72cf6714a118427ea29bd1075a88ce11
    82 rdf:rest Ne35162ccc09a48738dfe072908994bde
    83 N2b417146ede942ffbd63ffee4eb313a6 schema:name Springer Nature - SN SciGraph project
    84 rdf:type schema:Organization
    85 N30d859a674b14663af889456b8d8c902 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Lipopolysaccharides
    87 rdf:type schema:DefinedTerm
    88 N3250c651ea574d01a7b98fa4bd79b68c rdf:first sg:person.01256006724.50
    89 rdf:rest N1e1d6fdb27ae470891565ae41b12607d
    90 N48bc6c73dbd14adfb7754a7d4c92eba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Animals
    92 rdf:type schema:DefinedTerm
    93 N5acc0c0bdb924d59b7fe2ba215a7f0d4 rdf:first sg:person.01065060404.45
    94 rdf:rest N3250c651ea574d01a7b98fa4bd79b68c
    95 N5bf8b83ea485497fbe1a0ab09ea984ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Immunity, Innate
    97 rdf:type schema:DefinedTerm
    98 N6328a43e1c6a4c4cbb1545cdd07e5a60 schema:name doi
    99 schema:value 10.1038/nbt1288
    100 rdf:type schema:PropertyValue
    101 N63941f287d2946d5aa2cafbf3e910ae1 rdf:first sg:person.01252650510.56
    102 rdf:rest N5acc0c0bdb924d59b7fe2ba215a7f0d4
    103 N6a1ad0d9e7714235b4a3f2a464cac8b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Inflammation
    105 rdf:type schema:DefinedTerm
    106 N701189229bcd49e7a2225ac16b62a5cd schema:volumeNumber 25
    107 rdf:type schema:PublicationVolume
    108 N72c7b17f96414059b70b22dc1c5fb1cc rdf:first sg:person.01216026542.33
    109 rdf:rest Na26697c2f3624d55a95926c3a12f7684
    110 N72cf6714a118427ea29bd1075a88ce11 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    111 schema:familyName Hamill
    112 schema:givenName Pam
    113 rdf:type schema:Person
    114 N75eae383aa8246cba7c50d0ac4864abc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Models, Immunological
    116 rdf:type schema:DefinedTerm
    117 N7d1ad9b1e8c1480f836ed95e2dcbcd27 rdf:first N8f8c5367635d4ab3b3608f3dfe300aaa
    118 rdf:rest N63941f287d2946d5aa2cafbf3e910ae1
    119 N7ed625e237ac4472ac00690fab1a84db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Anti-Infective Agents
    121 rdf:type schema:DefinedTerm
    122 N87fb8f144f4c4fb28aaa266abe85522b rdf:first sg:person.01156424207.56
    123 rdf:rest N7d1ad9b1e8c1480f836ed95e2dcbcd27
    124 N8f8c5367635d4ab3b3608f3dfe300aaa schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    125 schema:familyName Thompson
    126 schema:givenName Annick
    127 rdf:type schema:Person
    128 N903f49dfa6a84096b4350e29cdae1154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Mice
    130 rdf:type schema:DefinedTerm
    131 N97545bae87dc4e5abbac497e14580f6f schema:name readcube_id
    132 schema:value 8de85aadeaf19cf984c2d56ece7f84b213186491cc72a4b92a9157105a79db9f
    133 rdf:type schema:PropertyValue
    134 N9f2c55b88577437480f26ae7de2bac6a schema:name dimensions_id
    135 schema:value pub.1029788541
    136 rdf:type schema:PropertyValue
    137 Na26697c2f3624d55a95926c3a12f7684 rdf:first sg:person.01153646136.40
    138 rdf:rest N087f326c3f0a45338eba33b5b7ae5d59
    139 Na3ae69b6cd23417abf7ea119678ec4f8 rdf:first sg:person.01131476506.40
    140 rdf:rest Nff3bf7b5bc0c4646aecfe2fd6718980e
    141 Na58ef8ecc37146179b29eb4ec35842bf schema:name nlm_unique_id
    142 schema:value 9604648
    143 rdf:type schema:PropertyValue
    144 Nae2562a280de48dda304158b10bbbfd3 rdf:first sg:person.01241425222.44
    145 rdf:rest Nce4ccef1cc284bf98731ca87f6837662
    146 Nbc72b475c7254ab4a47f9918a640b972 schema:name pubmed_id
    147 schema:value 17384586
    148 rdf:type schema:PropertyValue
    149 Nc3d3bef83771414d8ff3d5d0fab5d667 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Gene Expression Regulation
    151 rdf:type schema:DefinedTerm
    152 Nc552cad09dd04493b913fc16badc0b37 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    153 schema:familyName Glavas
    154 schema:givenName Natalie
    155 rdf:type schema:Person
    156 Nce4ccef1cc284bf98731ca87f6837662 rdf:first Nc552cad09dd04493b913fc16badc0b37
    157 rdf:rest N87fb8f144f4c4fb28aaa266abe85522b
    158 Nd1a7ab9f810342ada238eea655c4c3a7 rdf:first sg:person.01037417536.68
    159 rdf:rest Nfe20f7cad2ee45dbab955ecfdab2cacf
    160 Nd274d8759f0c431cb005c63be0628ac5 rdf:first sg:person.012432200437.02
    161 rdf:rest Nd1a7ab9f810342ada238eea655c4c3a7
    162 Ne35162ccc09a48738dfe072908994bde rdf:first sg:person.0771004427.16
    163 rdf:rest N72c7b17f96414059b70b22dc1c5fb1cc
    164 Nf08017d2a2d2429090fa47dbc6d0cb93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Disease Models, Animal
    166 rdf:type schema:DefinedTerm
    167 Nfc5d525dd2ac4714ba518c5fc50b4878 schema:issueNumber 4
    168 rdf:type schema:PublicationIssue
    169 Nfe1b23d3f68743cb8a231ec7dc58a4ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 Nfe20f7cad2ee45dbab955ecfdab2cacf rdf:first sg:person.01125176622.90
    173 rdf:rest rdf:nil
    174 Nff3bf7b5bc0c4646aecfe2fd6718980e rdf:first sg:person.0606411052.26
    175 rdf:rest Nae2562a280de48dda304158b10bbbfd3
    176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Medical and Health Sciences
    178 rdf:type schema:DefinedTerm
    179 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Immunology
    181 rdf:type schema:DefinedTerm
    182 sg:journal.1115214 schema:issn 1087-0156
    183 1546-1696
    184 schema:name Nature Biotechnology
    185 rdf:type schema:Periodical
    186 sg:person.01037417536.68 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    187 schema:familyName North
    188 schema:givenName John R
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037417536.68
    190 rdf:type schema:Person
    191 sg:person.01065060404.45 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    192 schema:familyName Lee
    193 schema:givenName Ken
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065060404.45
    195 rdf:type schema:Person
    196 sg:person.01125176622.90 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    197 schema:familyName Hancock
    198 schema:givenName Robert E W
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125176622.90
    200 rdf:type schema:Person
    201 sg:person.01131476506.40 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    202 schema:familyName Scott
    203 schema:givenName Monisha G
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131476506.40
    205 rdf:type schema:Person
    206 sg:person.01153646136.40 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    207 schema:familyName Donini
    208 schema:givenName Oreola
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153646136.40
    210 rdf:type schema:Person
    211 sg:person.01156424207.56 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    212 schema:familyName Waldbrook
    213 schema:givenName Matthew
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156424207.56
    215 rdf:type schema:Person
    216 sg:person.01216026542.33 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    217 schema:familyName Li
    218 schema:givenName Yuexin
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216026542.33
    220 rdf:type schema:Person
    221 sg:person.01241425222.44 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    222 schema:familyName Mookherjee
    223 schema:givenName Neeloffer
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241425222.44
    225 rdf:type schema:Person
    226 sg:person.012432200437.02 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    227 schema:familyName Finlay
    228 schema:givenName B Brett
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012432200437.02
    230 rdf:type schema:Person
    231 sg:person.01252650510.56 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    232 schema:familyName Wang
    233 schema:givenName Aikun
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252650510.56
    235 rdf:type schema:Person
    236 sg:person.01256006724.50 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    237 schema:familyName Doria
    238 schema:givenName Silvana
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256006724.50
    240 rdf:type schema:Person
    241 sg:person.0606411052.26 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    242 schema:familyName Dullaghan
    243 schema:givenName Edie
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606411052.26
    245 rdf:type schema:Person
    246 sg:person.0771004427.16 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
    247 schema:familyName Yu
    248 schema:givenName Jie Jessie
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771004427.16
    250 rdf:type schema:Person
    251 sg:person.0771064024.45 schema:affiliation https://www.grid.ac/institutes/grid.292528.6
    252 schema:familyName Guarna
    253 schema:givenName M Marta
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771064024.45
    255 rdf:type schema:Person
    256 sg:pub.10.1007/0-387-24180-9_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017918564
    257 https://doi.org/10.1007/0-387-24180-9_2
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nrmicro908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032248507
    260 https://doi.org/10.1038/nrmicro908
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1074731729 schema:CreativeWork
    263 https://app.dimensions.ai/details/publication/pub.1077193985 schema:CreativeWork
    264 https://app.dimensions.ai/details/publication/pub.1082499419 schema:CreativeWork
    265 https://doi.org/10.1002/1521-4141(200104)31:4<1066::aid-immu1066>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1042662737
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.coi.2005.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003315974
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.coi.2005.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026360665
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.it.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038598649
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.jaci.2005.05.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034750956
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.yexcr.2006.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028251632
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1074/jbc.273.22.13493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037600455
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1074/jbc.m102165200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009896978
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1074/jbc.m207448200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026065635
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1080/00365540310015935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002439582
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1086/420937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035647475
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1093/nar/29.9.e45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030834024
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1093/nar/gkh446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041187811
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1096/fj.00-0459fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1006951343
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1128/aac.47.8.2507-2512.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038717864
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1128/aac.49.5.1727-1732.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020625378
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1128/iai.74.1.469-480.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053091660
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1159/000083976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009475980
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1165/rcmb.2005-0170oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1025057121
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1172/jci119475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019440812
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1189/jlb.0704380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044943319
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.4049/jimmunol.176.4.2455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045733464
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.4049/jimmunol.177.1.665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077258148
    310 rdf:type schema:CreativeWork
    311 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
    312 schema:name Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4
    313 Michael Smith Laboratories, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4.
    314 rdf:type schema:Organization
    315 https://www.grid.ac/institutes/grid.292528.6 schema:alternateName Inimex Pharmaceuticals (Canada)
    316 schema:name Inimex Pharmaceuticals Inc., 3650 Wesbrook Mall, Vancouver, British Columbia, Canada V6S 2L2.
    317 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...