Ontology type: schema:ScholarlyArticle
2006-12
AUTHORSChetan Bettegowda, Xin Huang, Jimmy Lin, Ian Cheong, Manu Kohli, Stephen A Szabo, Xiaosong Zhang, Luis A Diaz, Victor E Velculescu, Giovanni Parmigiani, Kenneth W Kinzler, Bert Vogelstein, Shibin Zhou
ABSTRACTBacteriolytic anti-cancer therapies employ attenuated bacterial strains that selectively proliferate within tumors. Clostridium novyi-NT spores represent one of the most promising of these agents, as they generate potent anti-tumor effects in experimental animals. We have determined the 2.55-Mb genomic sequence of C. novyi-NT, identifying a new type of transposition and 139 genes that do not have homologs in other bacteria. The genomic sequence was used to facilitate the detection of transcripts expressed at various stages of the life cycle of this bacterium in vitro as well as in infections of tumors in vivo. Through this analysis, we found that C. novyi-NT spores contained mRNA and that the spore transcripts were distinct from those in vegetative forms of the bacterium. More... »
PAGES1573-1580
http://scigraph.springernature.com/pub.10.1038/nbt1256
DOIhttp://dx.doi.org/10.1038/nbt1256
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17115055
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt1256'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt1256'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt1256'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt1256'
This table displays all metadata directly associated to this object as RDF triples.
370 TRIPLES
21 PREDICATES
95 URIs
35 LITERALS
23 BLANK NODES