Post-translational modifications in the context of therapeutic proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

Gary Walsh, Roy Jefferis

ABSTRACT

The majority of protein-based biopharmaceuticals approved or in clinical trials bear some form of post-translational modification (PTM), which can profoundly affect protein properties relevant to their therapeutic application. Whereas glycosylation represents the most common modification, additional PTMs, including carboxylation, hydroxylation, sulfation and amidation, are characteristic of some products. The relationship between structure and function is understood for many PTMs but remains incomplete for others, particularly in the case of complex PTMs, such as glycosylation. A better understanding of such structural-functional relationships will facilitate the development of second-generation products displaying a PTM profile engineered to optimize therapeutic usefulness. More... »

PAGES

1241-1252

References to SciGraph publications

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  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    10

    VOLUME

    24

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1252

    DOI

    http://dx.doi.org/10.1038/nbt1252

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033656955

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17033665


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