Transposition Mediated Re–positioning and Subsequent Elimination of Marker Genes from Transgenic Tomato View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-11

AUTHORS

Andrew P. Goldsbrough, Cleofe N. Lastrella, John I. Yoder

ABSTRACT

We describe a new plant transformation vector system which utilizes the transposition functions of the maize Ac/Ds transposable element family to re-position transgenes in transgenic crop plants. The practical applications of the system are two-fold. It allows the production of plants which exhibit a range of different stabilizable transgene expression levels following a single primary transformation event, and it allows for the elimination of specific transgene sequences—such as a selectable marker gene—subsequent to the transformation event. We have demonstrated the system using the NptII selectable marker gene and a Ds element containing the GUS reporter gene. Progeny plants were recovered from primary transformants from which either the NptII gene or the Ds/GUS element have been eliminated. We also show that the expression level of the GUS gene within both individual and amplified Ds elements can vary as a function of their position in the genome following transposition. More... »

PAGES

1286

References to SciGraph publications

  • 1987-12. Assaying chimeric genes in plants: The GUS gene fusion system in PLANT MOLECULAR BIOLOGY REPORTER
  • 1986-06. Genetics of actin-related sequences in tomato in THEORETICAL AND APPLIED GENETICS
  • 1989-07. Genetic transactivation of Dissociation elements in transgenic tomato plants in MOLECULAR GENETICS AND GENOMICS
  • 1993-04. Transposition of the maize autonomous element Activator in transgenic Nicotiana plumbaginifolia plants in MOLECULAR GENETICS AND GENOMICS
  • 1988-08. Ac transposition in transgenic tomato plants in MOLECULAR GENETICS AND GENOMICS
  • 1992-02. Selectable Marker Genes: Safe For Plants? in BIO/TECHNOLOGY
  • 1990-06. Transcriptional regulation of a patatin-1 gene in potato in PLANT MOLECULAR BIOLOGY
  • 1992-11. Effective vectors for transformation, expression of heterologous genes, and assaying transposon excision in transgenic plants in TRANSGENIC RESEARCH
  • 1991-02. New patterns of gene activity in plants detected using an Agrobacterium vector in PLANT MOLECULAR BIOLOGY
  • 1987-11. Segregation of genes transferred to one plant cell from two separate Agrobacterium strains in PLANT MOLECULAR BIOLOGY
  • 1983-05. A binary plant vector strategy based on separation of vir- and T-region of the Agrobacterium tumefaciens Ti-plasmid in NATURE
  • 1992-07. Directed excision of a transgene from the plant genome in MOLECULAR GENETICS AND GENOMICS
  • 1989-11. A maize Ds transposable element containing a dihydrofolate reductase gene transposes in Nicotiana tabacum and Arabidopsis thaliana in MOLECULAR GENETICS AND GENOMICS
  • 1992-11. Biosafety of kanamycin-resistant transgenic plants in TRANSGENIC RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1193-1286

    DOI

    http://dx.doi.org/10.1038/nbt1193-1286

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035170318


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