Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

Murali Ramachandra, Amena Rahman, Aihua Zou, Mei Vaillancourt, John A. Howe, Douglas Antelman, Barry Sugarman, G. William Demers, Heidrun Engler, Duane Johnson, Paul Shabram

ABSTRACT

Replicating adenoviruses may prove to be effective anticancer agents if they can be engineered to selectively destroy tumor cells. We have constructed a virus (01/PEME) containing a novel regulatory circuit in which p53-dependent expression of an antagonist of the E2F transcription factor inhibits viral replication in normal cells. In tumor cells, however, the combination of p53 pathway defects and deregulated E2F allows replication of 01/PEME at near wild-type levels. The re-engineered virus also showed significantly enhanced efficacy compared with extensively studied E1b-deleted viruses such as dl1520 in human xenograft tumor models. More... »

PAGES

1035-1041

References to SciGraph publications

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  • 1998-06-18. Cell death and cancer: replacement of apoptotic genes and inactivation of death suppressor genes in therapy in GENE THERAPY
  • 2000-08. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer in NATURE MEDICINE
  • 2001-12. Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle α-actin promoter suppresses smooth muscle cell proliferation and neointima formation in GENE THERAPY
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  • 2000-01-20. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1101-1035

    DOI

    http://dx.doi.org/10.1038/nbt1101-1035

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031703717

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11689848


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