A small molecule–kinase interaction map for clinical kinase inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-02-13

AUTHORS

Miles A Fabian, William H Biggs, Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar, David J Lockhart

ABSTRACT

Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring binding of small molecules to the ATP site of kinases. We have profiled 20 kinase inhibitors, including 16 that are approved drugs or in clinical development, against a panel of 119 protein kinases. We find that specificity varies widely and is not strongly correlated with chemical structure or the identity of the intended target. Many novel interactions were identified, including tight binding of the p38 inhibitor BIRB-796 to an imatinib-resistant variant of the ABL kinase, and binding of imatinib to the SRC-family kinase LCK. We also show that mutations in the epidermal growth factor receptor (EGFR) found in gefitinib-responsive patients do not affect the binding affinity of gefitinib or erlotinib. Our results represent a systematic small molecule-protein interaction map for clinical compounds across a large number of related proteins. More... »

PAGES

329-336

Journal

TITLE

Nature Biotechnology

ISSUE

3

VOLUME

23

Related Patents

  • Azolyl Urea Compounds And Methods Of Use Thereof
  • Compounds And Methods For Inhibition Of Hedgehog Signaling And Phosphodiesterase
  • Nucleic Acids Encoding Class Ii Human Histone Deacetylases, And Uses Related Thereto
  • Class Ii Human Histone Deacetylases, And Uses Related Thereto
  • Heteroaryl Compounds And Uses Thereof
  • Histone Deacetylases, And Uses Related Thereto
  • Methods And Compositions Related To Wrapping Of Dehydrons
  • Erk Inhibitors And Uses Thereof
  • Flt3 Receptor Antagonists For The Treatment Or The Prevention Of Pain Disorders
  • Taf1 Inhibitors For The Therapy Of Cancer
  • Heterocyclic Compounds And Methods Of Use Thereof
  • Methods Of Treating A Disease Or Disorder Associated With Bruton's Tyrosine Kinase
  • Heteroaryl Compounds And Uses Thereof
  • Ω-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
  • Optically Active Pyrazolylaminoquinazoline, And Pharmaceutical Compositions And Methods Of Use Thereof
  • Ω-Carboxyl Aryl Substituted Diphenyl Ureas As P38 Kinase Inhibitors
  • Biologically Active Complex And Its Preparation
  • Aryl Ureas With Angiogenisis Inhibiting Activity
  • Heteroaryl Compounds And Uses Thereof
  • Histone Deacetylases, And Uses Related Thereto
  • 2,4-Disubstituted Pyrimidines As Kinase Inhibitors
  • Optically Active Pyrazolylaminoquinazoline, And Pharmaceutical Compositions And Methods Of Use Thereof
  • Treatment Of Protein Degradation Disorders
  • Protein Kinase Inhibitors (Variants), Use Thereof In Treating Oncological Diseases And A Pharmaceutical Composition Based Thereon
  • Piperazinylpyrimidine Analogues As Protein Kinase Inhibitors
  • Novel Gak Modulators
  • Complex And Production Process
  • 2,4-Disubstituted Pyrimidines Useful As Kinase Inhibitors
  • Mutant-Selective Egfr Inhibitors And Uses Thereof
  • Methods For Treating Or Preventing Fatty Liver Disease Using Ctrp3
  • Compositions And Methods Of Modulating Anti-Tumor Immunity
  • Amino-Substituted Isothiazoles
  • Aryl Ureas With Angiogenesis Inhibiting Activity
  • Erk Inhibitors And Uses Thereof
  • Treatment Of Chronic Inflammation With A 1,2,4-Triazolo [1,5a] Pyridine Derivative
  • Bone Marrow On X Chromosome Kinase (Bmx) Inhibitors And Uses Thereof
  • Histone Deacetylase Inhibitors
  • Dioxanes And Uses Thereof
  • Inhibitors Of Bruton's Tyrosine Kinase
  • Histone Deacetylases, And Uses Related Thereto
  • Proteome-Wide Quantification Of Small Molecule Binding To Cellular Target Proteins
  • Pyrazolo[3,4-D]Pyrimidine And Pyrrolo[2,3-D]Pyrimidine Compounds As Kinase Inhibitors
  • Optically Active Pyrazolylaminoquinazoline, And Pharmaceutical Compositions And Methods Of Use Thereof
  • Methods For The Treatment Of Solid Tumors
  • Pyrazolo[3,4-D]Pyrimidine And Pyrrolo[2,3-D]Pyrimidine Compounds As Kinase Inhibitors
  • Methods And Use Of Bifunctional Enzyme-Building Clamp-Shaped Molecules
  • Mutation Mimicking Compounds That Bind To The Kinase Domain Of Egfr
  • Pyrrolopyrimidine Compounds As Kinase Inhibitors
  • 6-[5-Amino-6-(2-Ethoxyethoxy)-Imidazo[4,5-B]Pyridin-3-Yl]-Nicotinonitrile Derivatives And Their Use As Irak Inhibitors
  • Heterocyclic Compounds And Methods Of Use Thereof
  • Compound Useful For The Treatment Of Degenerative And Inflammatory Diseases
  • Pyridinone Compound, Pharmaceutical Composition Containing The Same And Use
  • Histone Deacetylases, And Uses Related Thereto
  • Pyrrolopyrimidine Compounds As Kinase Inhibitors
  • Diaryl Ureas For Diseases Mediated By Pdgfr
  • Salts Of An Epidermal Growth Factor Receptor Kinase Inhibitor
  • Heteroaryl Compounds And Uses Thereof
  • Salts Of An Epidermal Growth Factor Receptor Kinase Inhibitor
  • Methods Of Treating A Bruton's Tyrosine Kinase Disease Or Disorder
  • Erk Inhibitors And Uses Thereof
  • Pyrazolo[3,4-D]Pyrimidine And Pyrazolo[2,3-D]Pyrimidine Compounds As Kinase Inhibitors
  • Thiazolyl-Containing Compounds For Treating Proliferative Diseases
  • 1-Pyrazolyl-3-((4-((2-Anilinopyrimidin-4-Yl) Oxy) Napththalen-1-Yl) Ureas As P38 Map Kinase Inhibitors
  • Histone Deacetylases, And Uses Related Thereto
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1068

    DOI

    http://dx.doi.org/10.1038/nbt1068

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036157274

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15711537


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Benzamides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Escherichia coli", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Escherichia coli Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imatinib Mesylate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microchemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pharmaceutical Preparations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Piperazines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Interaction Mapping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Kinase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyrimidines", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fabian", 
            "givenName": "Miles A", 
            "id": "sg:person.01167170702.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167170702.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Biggs", 
            "givenName": "William H", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Treiber", 
            "givenName": "Daniel K", 
            "id": "sg:person.01201602253.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201602253.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atteridge", 
            "givenName": "Corey E", 
            "id": "sg:person.01313474530.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313474530.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Dr., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.418185.1", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
                "Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Dr., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azimioara", 
            "givenName": "Mihai D", 
            "id": "sg:person.01144522524.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144522524.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Buck Institute, 8001 Redwood Blvd., 94945, Novato, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.272799.0", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
                "Buck Institute, 8001 Redwood Blvd., 94945, Novato, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benedetti", 
            "givenName": "Michael G", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "Todd A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ciceri", 
            "givenName": "Pietro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Edeen", 
            "givenName": "Philip T", 
            "id": "sg:person.01214736405.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214736405.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Floyd", 
            "givenName": "Mark", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ford", 
            "givenName": "Julia M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Galvin", 
            "givenName": "Margaret", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Seattle Biomedical Research Institute, 307 Westlake Ave. N., Ste. 500, 98109, Seattle, Washington, USA", 
              "id": "http://www.grid.ac/institutes/grid.53964.3d", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
                "Seattle Biomedical Research Institute, 307 Westlake Ave. N., Ste. 500, 98109, Seattle, Washington, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerlach", 
            "givenName": "Jay L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grotzfeld", 
            "givenName": "Robert M", 
            "id": "sg:person.0616424202.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616424202.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herrgard", 
            "givenName": "Sanna", 
            "id": "sg:person.01365451030.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365451030.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Insko", 
            "givenName": "Darren E", 
            "id": "sg:person.0625545775.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625545775.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Metabasis Therapeutics, 9390 Towne Centre Dr., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.418267.e", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
                "Metabasis Therapeutics, 9390 Towne Centre Dr., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Insko", 
            "givenName": "Michael A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lai", 
            "givenName": "Andiliy G", 
            "id": "sg:person.0732652602.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732652602.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00e9lias", 
            "givenName": "Jean-Michel", 
            "id": "sg:person.0575433216.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575433216.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mehta", 
            "givenName": "Shamal A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Milanov", 
            "givenName": "Zdravko V", 
            "id": "sg:person.01231443002.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231443002.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Velasco", 
            "givenName": "Anne Marie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wodicka", 
            "givenName": "Lisa M", 
            "id": "sg:person.01070257255.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070257255.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Hitesh K", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zarrinkar", 
            "givenName": "Patrick P", 
            "id": "sg:person.01030450261.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030450261.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lockhart", 
            "givenName": "David J", 
            "id": "sg:person.01222024017.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222024017.15"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/372739a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047199166", 
              "https://doi.org/10.1038/372739a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0596-561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051513257", 
              "https://doi.org/10.1038/nm0596-561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033195003", 
              "https://doi.org/10.1038/nsb949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011169875", 
              "https://doi.org/10.1038/nrd773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb0497-311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010651654", 
              "https://doi.org/10.1038/nsb0497-311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041708615", 
              "https://doi.org/10.1038/nrd1066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047088421", 
              "https://doi.org/10.1038/79534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052740573", 
              "https://doi.org/10.1038/nrd1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsb770", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030730287", 
              "https://doi.org/10.1038/nsb770"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-02-13", 
        "datePublishedReg": "2005-02-13", 
        "description": "Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring binding of small molecules to the ATP site of kinases. We have profiled 20 kinase inhibitors, including 16 that are approved drugs or in clinical development, against a panel of 119 protein kinases. We find that specificity varies widely and is not strongly correlated with chemical structure or the identity of the intended target. Many novel interactions were identified, including tight binding of the p38 inhibitor BIRB-796 to an imatinib-resistant variant of the ABL kinase, and binding of imatinib to the SRC-family kinase LCK. We also show that mutations in the epidermal growth factor receptor (EGFR) found in gefitinib-responsive patients do not affect the binding affinity of gefitinib or erlotinib. Our results represent a systematic small molecule-protein interaction map for clinical compounds across a large number of related proteins.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nbt1068", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1115214", 
            "issn": [
              "1087-0156", 
              "1546-1696"
            ], 
            "name": "Nature Biotechnology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "keywords": [
          "epidermal growth factor receptor", 
          "interaction map", 
          "Src family kinase Lck", 
          "kinase inhibitors", 
          "clinical kinase inhibitors", 
          "kinase Lck", 
          "protein kinase", 
          "growth factor receptor", 
          "related proteins", 
          "novel interaction", 
          "inhibitor specificity", 
          "Abl kinase", 
          "ATP site", 
          "kinase", 
          "BIRB 796", 
          "factor receptor", 
          "small molecules", 
          "tight binding", 
          "binding", 
          "inhibitors", 
          "clinical compounds", 
          "imatinib-resistant variants", 
          "Lck", 
          "protein", 
          "mutations", 
          "specificity", 
          "great promise", 
          "large number", 
          "intended target", 
          "receptors", 
          "therapeutics", 
          "variants", 
          "affinity", 
          "target", 
          "sites", 
          "molecules", 
          "new class", 
          "chemical structure", 
          "gefitinib", 
          "interaction", 
          "identity", 
          "clinical development", 
          "maps", 
          "erlotinib", 
          "development", 
          "compounds", 
          "structure", 
          "number", 
          "panel", 
          "class", 
          "promise", 
          "imatinib", 
          "results", 
          "drugs", 
          "efficient way", 
          "way", 
          "patients", 
          "kinase inhibitor specificity", 
          "p38 inhibitor BIRB-796", 
          "inhibitor BIRB-796", 
          "gefitinib-responsive patients", 
          "affinity of gefitinib", 
          "systematic small molecule-protein interaction map", 
          "small molecule-protein interaction map", 
          "molecule-protein interaction map", 
          "small molecule\u2013kinase interaction map", 
          "molecule\u2013kinase interaction map"
        ], 
        "name": "A small molecule\u2013kinase interaction map for clinical kinase inhibitors", 
        "pagination": "329-336", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036157274"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nbt1068"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15711537"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nbt1068", 
          "https://app.dimensions.ai/details/publication/pub.1036157274"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_406.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nbt1068"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt1068'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt1068'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt1068'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt1068'


     

    This table displays all metadata directly associated to this object as RDF triples.

    392 TRIPLES      22 PREDICATES      114 URIs      97 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nbt1068 schema:about N0883cef5b582439aa9801974b3ca1528
    2 N0a050a63cfdb4e839e0d1125524f6fac
    3 N1714628aac4b473f86598946786798e3
    4 N2ec9ddbde6c147c4b6f8ca35fd0be837
    5 N2f90a51f67284f81a62e8a2a99006b40
    6 N397f663fd85a4911be7d4652eb501747
    7 N5c482821fffc461b814df6e7931310e1
    8 N6c5f50ea1cb54337a4b847b2dc6231f1
    9 N734a6dacd89c45719051d1d62b3526c8
    10 N7c9f62e724ce420887766e3a4eafeea3
    11 N8cb8dcdbc781491299b95c366561b633
    12 Nef1c5da5dc054059a2a8017972491046
    13 anzsrc-for:06
    14 anzsrc-for:0601
    15 schema:author N0a04e81bab474ea7a8928b57c643312c
    16 schema:citation sg:pub.10.1038/372739a0
    17 sg:pub.10.1038/79534
    18 sg:pub.10.1038/nm0596-561
    19 sg:pub.10.1038/nrd1066
    20 sg:pub.10.1038/nrd1177
    21 sg:pub.10.1038/nrd773
    22 sg:pub.10.1038/nsb0497-311
    23 sg:pub.10.1038/nsb770
    24 sg:pub.10.1038/nsb949
    25 schema:datePublished 2005-02-13
    26 schema:datePublishedReg 2005-02-13
    27 schema:description Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an efficient way to determine kinase inhibitor specificity by measuring binding of small molecules to the ATP site of kinases. We have profiled 20 kinase inhibitors, including 16 that are approved drugs or in clinical development, against a panel of 119 protein kinases. We find that specificity varies widely and is not strongly correlated with chemical structure or the identity of the intended target. Many novel interactions were identified, including tight binding of the p38 inhibitor BIRB-796 to an imatinib-resistant variant of the ABL kinase, and binding of imatinib to the SRC-family kinase LCK. We also show that mutations in the epidermal growth factor receptor (EGFR) found in gefitinib-responsive patients do not affect the binding affinity of gefitinib or erlotinib. Our results represent a systematic small molecule-protein interaction map for clinical compounds across a large number of related proteins.
    28 schema:genre article
    29 schema:inLanguage en
    30 schema:isAccessibleForFree false
    31 schema:isPartOf N0a13f81c3feb406dafd6b1971257195e
    32 N0f2703c42700457dbcc6d3c66d3dc4d7
    33 sg:journal.1115214
    34 schema:keywords ATP site
    35 Abl kinase
    36 BIRB 796
    37 Lck
    38 Src family kinase Lck
    39 affinity
    40 affinity of gefitinib
    41 binding
    42 chemical structure
    43 class
    44 clinical compounds
    45 clinical development
    46 clinical kinase inhibitors
    47 compounds
    48 development
    49 drugs
    50 efficient way
    51 epidermal growth factor receptor
    52 erlotinib
    53 factor receptor
    54 gefitinib
    55 gefitinib-responsive patients
    56 great promise
    57 growth factor receptor
    58 identity
    59 imatinib
    60 imatinib-resistant variants
    61 inhibitor BIRB-796
    62 inhibitor specificity
    63 inhibitors
    64 intended target
    65 interaction
    66 interaction map
    67 kinase
    68 kinase Lck
    69 kinase inhibitor specificity
    70 kinase inhibitors
    71 large number
    72 maps
    73 molecule-protein interaction map
    74 molecules
    75 molecule–kinase interaction map
    76 mutations
    77 new class
    78 novel interaction
    79 number
    80 p38 inhibitor BIRB-796
    81 panel
    82 patients
    83 promise
    84 protein
    85 protein kinase
    86 receptors
    87 related proteins
    88 results
    89 sites
    90 small molecule-protein interaction map
    91 small molecules
    92 small molecule–kinase interaction map
    93 specificity
    94 structure
    95 systematic small molecule-protein interaction map
    96 target
    97 therapeutics
    98 tight binding
    99 variants
    100 way
    101 schema:name A small molecule–kinase interaction map for clinical kinase inhibitors
    102 schema:pagination 329-336
    103 schema:productId N2308f0a4dec5497587a4014df72b99be
    104 N32682ae74155427a9f00384257b6c4e6
    105 N40e78daf0f044f3d8c1e1d997e230dd9
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036157274
    107 https://doi.org/10.1038/nbt1068
    108 schema:sdDatePublished 2022-01-01T18:14
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher Na01c895869614fc99346ac49e52f8376
    111 schema:url https://doi.org/10.1038/nbt1068
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N04ccec2c8fac43fabdef4985119df35c schema:affiliation grid-institutes:grid.418267.e
    116 schema:familyName Insko
    117 schema:givenName Michael A
    118 rdf:type schema:Person
    119 N0883cef5b582439aa9801974b3ca1528 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Piperazines
    121 rdf:type schema:DefinedTerm
    122 N0a04e81bab474ea7a8928b57c643312c rdf:first sg:person.01167170702.25
    123 rdf:rest Nd1311ec927044a5696c74d6cb3771552
    124 N0a050a63cfdb4e839e0d1125524f6fac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Imatinib Mesylate
    126 rdf:type schema:DefinedTerm
    127 N0a13f81c3feb406dafd6b1971257195e schema:issueNumber 3
    128 rdf:type schema:PublicationIssue
    129 N0f2703c42700457dbcc6d3c66d3dc4d7 schema:volumeNumber 23
    130 rdf:type schema:PublicationVolume
    131 N13ae4522155c4bb887464e5a32a3cb28 schema:affiliation grid-institutes:None
    132 schema:familyName Velasco
    133 schema:givenName Anne Marie
    134 rdf:type schema:Person
    135 N1714628aac4b473f86598946786798e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Drug Design
    137 rdf:type schema:DefinedTerm
    138 N18be7ab838b740acaaf65ef8248cf64b schema:affiliation grid-institutes:None
    139 schema:familyName Ciceri
    140 schema:givenName Pietro
    141 rdf:type schema:Person
    142 N2308f0a4dec5497587a4014df72b99be schema:name doi
    143 schema:value 10.1038/nbt1068
    144 rdf:type schema:PropertyValue
    145 N26050192bd0b473b9623516be513a013 rdf:first sg:person.01201602253.10
    146 rdf:rest Ncf7619428b0b435a921b141965807b6e
    147 N2ec9ddbde6c147c4b6f8ca35fd0be837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Escherichia coli Proteins
    149 rdf:type schema:DefinedTerm
    150 N2f90a51f67284f81a62e8a2a99006b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Microchemistry
    152 rdf:type schema:DefinedTerm
    153 N32682ae74155427a9f00384257b6c4e6 schema:name dimensions_id
    154 schema:value pub.1036157274
    155 rdf:type schema:PropertyValue
    156 N37b44dbc21a14b60ac7ee88deb9074e1 schema:affiliation grid-institutes:grid.53964.3d
    157 schema:familyName Gerlach
    158 schema:givenName Jay L
    159 rdf:type schema:Person
    160 N397f663fd85a4911be7d4652eb501747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Protein Interaction Mapping
    162 rdf:type schema:DefinedTerm
    163 N3aeaec6f83014a0695f7bddc2b6adb2b rdf:first N18be7ab838b740acaaf65ef8248cf64b
    164 rdf:rest N7d1b6ffcfe9548d4bcd0cd08425c31d5
    165 N3df50e3beeb241e4b6c2c9911391a7f1 schema:affiliation grid-institutes:None
    166 schema:familyName Mehta
    167 schema:givenName Shamal A
    168 rdf:type schema:Person
    169 N40cd297f2e0c415e8e00eede533f1437 rdf:first Nd4df5bad42b54fe39b4c1286314896e8
    170 rdf:rest Na0dee4d853a94f97a552fa23ab223a98
    171 N40e78daf0f044f3d8c1e1d997e230dd9 schema:name pubmed_id
    172 schema:value 15711537
    173 rdf:type schema:PropertyValue
    174 N4348bdc235ae48138bc6da6d87618779 rdf:first sg:person.0625545775.89
    175 rdf:rest Naa1d1badb2084356a7aa46803e08c7b9
    176 N451066a86777417e82e01886f683b3cc rdf:first sg:person.01070257255.95
    177 rdf:rest N9a5e6024bdc247768836db78858eb0ab
    178 N4dcbeb65d5404136806fd4ffd37a6d63 rdf:first sg:person.01144522524.03
    179 rdf:rest N40cd297f2e0c415e8e00eede533f1437
    180 N4e773666643b4b329e4b0ac1f03d19ac rdf:first N3df50e3beeb241e4b6c2c9911391a7f1
    181 rdf:rest Nbdf31f7e10104effa9a16d09b8e129f0
    182 N5c482821fffc461b814df6e7931310e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Pyrimidines
    184 rdf:type schema:DefinedTerm
    185 N6afc5ce2220746ef83b01bf60e480966 schema:affiliation grid-institutes:None
    186 schema:familyName Biggs
    187 schema:givenName William H
    188 rdf:type schema:Person
    189 N6c5f50ea1cb54337a4b847b2dc6231f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Benzamides
    191 rdf:type schema:DefinedTerm
    192 N6d00eeb2da1a40dab4007cc44572e7f1 schema:affiliation grid-institutes:None
    193 schema:familyName Galvin
    194 schema:givenName Margaret
    195 rdf:type schema:Person
    196 N734a6dacd89c45719051d1d62b3526c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Escherichia coli
    198 rdf:type schema:DefinedTerm
    199 N7551ecde98734275825ab7561de6561f rdf:first sg:person.01030450261.60
    200 rdf:rest Nc1f1e3d5ac0b488091ff8837bf9fb309
    201 N755c8190dbcb47a693c6b9440c4d631e rdf:first sg:person.0575433216.07
    202 rdf:rest N4e773666643b4b329e4b0ac1f03d19ac
    203 N76896aec34c74c0383c7ffcf70d50f90 schema:affiliation grid-institutes:None
    204 schema:familyName Patel
    205 schema:givenName Hitesh K
    206 rdf:type schema:Person
    207 N783b0496d3434afaa8ab6c77b62275d6 rdf:first Nefb11d553e184664893bf7d2e2ae6780
    208 rdf:rest N7ae26b7a712a4b328d52407e574d90e9
    209 N799ff37d3dc64fff8321da14881c52ba schema:affiliation grid-institutes:None
    210 schema:familyName Carter
    211 schema:givenName Todd A
    212 rdf:type schema:Person
    213 N7ae26b7a712a4b328d52407e574d90e9 rdf:first N6d00eeb2da1a40dab4007cc44572e7f1
    214 rdf:rest Ndec0c7255c7442f4929cec2e90482f3e
    215 N7c9f62e724ce420887766e3a4eafeea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Protein Binding
    217 rdf:type schema:DefinedTerm
    218 N7d1b6ffcfe9548d4bcd0cd08425c31d5 rdf:first sg:person.01214736405.22
    219 rdf:rest Ne453736b13724b5680e5b376849af943
    220 N868e784f385546608d141416762d4d42 rdf:first sg:person.01365451030.14
    221 rdf:rest N4348bdc235ae48138bc6da6d87618779
    222 N8cb8dcdbc781491299b95c366561b633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Protein Kinase Inhibitors
    224 rdf:type schema:DefinedTerm
    225 N9a5e6024bdc247768836db78858eb0ab rdf:first N76896aec34c74c0383c7ffcf70d50f90
    226 rdf:rest N7551ecde98734275825ab7561de6561f
    227 N9b1334e131e8422d8f29a7ca6c4469d6 rdf:first sg:person.0616424202.06
    228 rdf:rest N868e784f385546608d141416762d4d42
    229 Na01c895869614fc99346ac49e52f8376 schema:name Springer Nature - SN SciGraph project
    230 rdf:type schema:Organization
    231 Na0dee4d853a94f97a552fa23ab223a98 rdf:first N799ff37d3dc64fff8321da14881c52ba
    232 rdf:rest N3aeaec6f83014a0695f7bddc2b6adb2b
    233 Naa1d1badb2084356a7aa46803e08c7b9 rdf:first N04ccec2c8fac43fabdef4985119df35c
    234 rdf:rest Nb0dd832e8f344a26836304d690706d05
    235 Nb0dd832e8f344a26836304d690706d05 rdf:first sg:person.0732652602.63
    236 rdf:rest N755c8190dbcb47a693c6b9440c4d631e
    237 Nbdf31f7e10104effa9a16d09b8e129f0 rdf:first sg:person.01231443002.69
    238 rdf:rest Nd1ed7c9ff61647f08c51de65dafebf94
    239 Nc1f1e3d5ac0b488091ff8837bf9fb309 rdf:first sg:person.01222024017.15
    240 rdf:rest rdf:nil
    241 Ncf7619428b0b435a921b141965807b6e rdf:first sg:person.01313474530.02
    242 rdf:rest N4dcbeb65d5404136806fd4ffd37a6d63
    243 Nd1311ec927044a5696c74d6cb3771552 rdf:first N6afc5ce2220746ef83b01bf60e480966
    244 rdf:rest N26050192bd0b473b9623516be513a013
    245 Nd1ed7c9ff61647f08c51de65dafebf94 rdf:first N13ae4522155c4bb887464e5a32a3cb28
    246 rdf:rest N451066a86777417e82e01886f683b3cc
    247 Nd4df5bad42b54fe39b4c1286314896e8 schema:affiliation grid-institutes:grid.272799.0
    248 schema:familyName Benedetti
    249 schema:givenName Michael G
    250 rdf:type schema:Person
    251 Ndec0c7255c7442f4929cec2e90482f3e rdf:first N37b44dbc21a14b60ac7ee88deb9074e1
    252 rdf:rest N9b1334e131e8422d8f29a7ca6c4469d6
    253 Ne453736b13724b5680e5b376849af943 rdf:first Ne5cdb148b9cb4efb931eb7274401128c
    254 rdf:rest N783b0496d3434afaa8ab6c77b62275d6
    255 Ne5cdb148b9cb4efb931eb7274401128c schema:affiliation grid-institutes:None
    256 schema:familyName Floyd
    257 schema:givenName Mark
    258 rdf:type schema:Person
    259 Nef1c5da5dc054059a2a8017972491046 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Pharmaceutical Preparations
    261 rdf:type schema:DefinedTerm
    262 Nefb11d553e184664893bf7d2e2ae6780 schema:affiliation grid-institutes:None
    263 schema:familyName Ford
    264 schema:givenName Julia M
    265 rdf:type schema:Person
    266 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    267 schema:name Biological Sciences
    268 rdf:type schema:DefinedTerm
    269 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    270 schema:name Biochemistry and Cell Biology
    271 rdf:type schema:DefinedTerm
    272 sg:journal.1115214 schema:issn 1087-0156
    273 1546-1696
    274 schema:name Nature Biotechnology
    275 schema:publisher Springer Nature
    276 rdf:type schema:Periodical
    277 sg:person.01030450261.60 schema:affiliation grid-institutes:None
    278 schema:familyName Zarrinkar
    279 schema:givenName Patrick P
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030450261.60
    281 rdf:type schema:Person
    282 sg:person.01070257255.95 schema:affiliation grid-institutes:None
    283 schema:familyName Wodicka
    284 schema:givenName Lisa M
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070257255.95
    286 rdf:type schema:Person
    287 sg:person.01144522524.03 schema:affiliation grid-institutes:grid.418185.1
    288 schema:familyName Azimioara
    289 schema:givenName Mihai D
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144522524.03
    291 rdf:type schema:Person
    292 sg:person.01167170702.25 schema:affiliation grid-institutes:None
    293 schema:familyName Fabian
    294 schema:givenName Miles A
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167170702.25
    296 rdf:type schema:Person
    297 sg:person.01201602253.10 schema:affiliation grid-institutes:None
    298 schema:familyName Treiber
    299 schema:givenName Daniel K
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201602253.10
    301 rdf:type schema:Person
    302 sg:person.01214736405.22 schema:affiliation grid-institutes:None
    303 schema:familyName Edeen
    304 schema:givenName Philip T
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214736405.22
    306 rdf:type schema:Person
    307 sg:person.01222024017.15 schema:affiliation grid-institutes:None
    308 schema:familyName Lockhart
    309 schema:givenName David J
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222024017.15
    311 rdf:type schema:Person
    312 sg:person.01231443002.69 schema:affiliation grid-institutes:None
    313 schema:familyName Milanov
    314 schema:givenName Zdravko V
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231443002.69
    316 rdf:type schema:Person
    317 sg:person.01313474530.02 schema:affiliation grid-institutes:None
    318 schema:familyName Atteridge
    319 schema:givenName Corey E
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313474530.02
    321 rdf:type schema:Person
    322 sg:person.01365451030.14 schema:affiliation grid-institutes:None
    323 schema:familyName Herrgard
    324 schema:givenName Sanna
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365451030.14
    326 rdf:type schema:Person
    327 sg:person.0575433216.07 schema:affiliation grid-institutes:None
    328 schema:familyName Lélias
    329 schema:givenName Jean-Michel
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575433216.07
    331 rdf:type schema:Person
    332 sg:person.0616424202.06 schema:affiliation grid-institutes:None
    333 schema:familyName Grotzfeld
    334 schema:givenName Robert M
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616424202.06
    336 rdf:type schema:Person
    337 sg:person.0625545775.89 schema:affiliation grid-institutes:None
    338 schema:familyName Insko
    339 schema:givenName Darren E
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625545775.89
    341 rdf:type schema:Person
    342 sg:person.0732652602.63 schema:affiliation grid-institutes:None
    343 schema:familyName Lai
    344 schema:givenName Andiliy G
    345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732652602.63
    346 rdf:type schema:Person
    347 sg:pub.10.1038/372739a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047199166
    348 https://doi.org/10.1038/372739a0
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/79534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047088421
    351 https://doi.org/10.1038/79534
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nm0596-561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051513257
    354 https://doi.org/10.1038/nm0596-561
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nrd1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041708615
    357 https://doi.org/10.1038/nrd1066
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nrd1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052740573
    360 https://doi.org/10.1038/nrd1177
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrd773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011169875
    363 https://doi.org/10.1038/nrd773
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nsb0497-311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010651654
    366 https://doi.org/10.1038/nsb0497-311
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nsb770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030730287
    369 https://doi.org/10.1038/nsb770
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/nsb949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033195003
    372 https://doi.org/10.1038/nsb949
    373 rdf:type schema:CreativeWork
    374 grid-institutes:None schema:alternateName Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    375 schema:name Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    376 rdf:type schema:Organization
    377 grid-institutes:grid.272799.0 schema:alternateName Buck Institute, 8001 Redwood Blvd., 94945, Novato, California, USA
    378 schema:name Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    379 Buck Institute, 8001 Redwood Blvd., 94945, Novato, California, USA
    380 rdf:type schema:Organization
    381 grid-institutes:grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Dr., 92121, San Diego, California, USA
    382 schema:name Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    383 Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Dr., 92121, San Diego, California, USA
    384 rdf:type schema:Organization
    385 grid-institutes:grid.418267.e schema:alternateName Metabasis Therapeutics, 9390 Towne Centre Dr., 92121, San Diego, California, USA
    386 schema:name Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    387 Metabasis Therapeutics, 9390 Towne Centre Dr., 92121, San Diego, California, USA
    388 rdf:type schema:Organization
    389 grid-institutes:grid.53964.3d schema:alternateName Seattle Biomedical Research Institute, 307 Westlake Ave. N., Ste. 500, 98109, Seattle, Washington, USA
    390 schema:name Ambit Biosciences, 4215 Sorrento Valley Blvd., 92121, San Diego, California, USA
    391 Seattle Biomedical Research Institute, 307 Westlake Ave. N., Ste. 500, 98109, Seattle, Washington, USA
    392 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...