Plant cell cultures for the production of recombinant proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Stephan Hellwig, Jürgen Drossard, Richard M Twyman, Rainer Fischer

ABSTRACT

The use of whole plants for the synthesis of recombinant proteins has received a great deal of attention recently because of advantages in economy, scalability and safety compared with traditional microbial and mammalian production systems. However, production systems that use whole plants lack several of the intrinsic benefits of cultured cells, including the precise control over growth conditions, batch-to-batch product consistency, a high level of containment and the ability to produce recombinant proteins in compliance with good manufacturing practice. Plant cell cultures combine the merits of whole-plant systems with those of microbial and animal cell cultures, and already have an established track record for the production of valuable therapeutic secondary metabolites. Although no recombinant proteins have yet been produced commercially using plant cell cultures, there have been many proof-of-principle studies and several companies are investigating the commercial feasibility of such production systems. More... »

PAGES

1415-1422

References to SciGraph publications

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  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    11

    VOLUME

    22

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt1027

    DOI

    http://dx.doi.org/10.1038/nbt1027

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041248860

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15529167


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