Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Ramu A Subbramanian, Chikaya Moriya, Kristi L Martin, Fred W Peyerl, Atsuhiko Hasegawa, Akira Naoi, Heng Chhay, Patrick Autissier, Darci A Gorgone, Michelle A Lifton, Kristine Kuus-Reichel, Jörn E Schmitz, Norman L Letvin, Marcelo J Kuroda

ABSTRACT

In this study we extend tetramerization technology to T-cell receptors (TCRs). We identified TCR alpha beta pairs in the absence of accessory molecules, ensuring isolation of high-affinity TCRs that maintain stable binding characteristics after tetramerization. Subtle changes in cognate peptide levels bound to the class I molecule were accurately reflected by parallel changes in the mean fluorescence intensity of cells that bound TCR tetramers, allowing us to accurately assess the binding affinity of a panel of peptides to major histocompatibility complex (MHC) class I. Using a TCR tetramer specific for the Mamu-A(*)01 allele, we identified animals expressing this restricting class I allele from a large cohort of outbred rhesus macaques. TCR tetramers should facilitate analysis of the MHC-peptide interface and, more generally, the design of immunotherapeutics and vaccines. More... »

PAGES

1429-1434

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt1024

DOI

http://dx.doi.org/10.1038/nbt1024

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035444319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15502816


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt1024'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt1024'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt1024'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt1024'


 

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