Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

Romain Zufferey, Dea Nagy, Ron J. Mandel, Luigi Naldini, Didier Trono

ABSTRACT

Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy. More... »

PAGES

871-875

Journal

TITLE

Nature Biotechnology

ISSUE

9

VOLUME

15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt0997-871

    DOI

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9306402


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    26 schema:description Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy.
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