Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

M Feng, W H Jackson, C K Goldman, C Rancourt, M Wang, S K Dusing, G Siegal, D T Curiel

ABSTRACT

Gene therapy to correct defective genes requires efficient gene delivery and long-term gene expression. The available vector systems have not allowed the simultaneous achievement of both goals. We have developed a chimeric viral vector system that incorporates favorable aspects of both adenoviral and retroviral vectors. Adenoviral vectors induce target cells to function as transient retroviral producer cells in vivo. The progeny retroviral vector particles are then able to stably transduce neighboring cells. In this system, the nonintegrative adenoviral vector is rendered functionally integrative via the intermediate generation of a retroviral producer cell. The chimeric vectors may allow realization of the requisite goals for specific gene-therapy applications. More... »

PAGES

866

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt0997-866

DOI

http://dx.doi.org/10.1038/nbt0997-866

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004249552

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9306401


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