Transgene Inactivation: Plants Fight Back! View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09-01

AUTHORS

Jean Finnegan, David McElroy

ABSTRACT

Desirable new phenotypes created by the introduction of foreign DNA into plants are frequently unstable following propagation, leading to a loss of the newly acquired traits. This genetic instability is due not to deletion or mutation of the introduced DNA but rather to the inactivation of the transgene. In this review, we discuss the mechanisms that might be responsible for transgene inactivation and examine means of stabilizing gene expression in transgenic plants. More... »

PAGES

883-888

References to SciGraph publications

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  • 1991-01. High-level expression of a tobacco chitinase gene in Nicotiana sylvestris. Susceptibility of transgenic plants to Cercospora nicotianae infection in PLANT MOLECULAR BIOLOGY
  • 1992-02. Endogenous and environmental factors influence 35S promoter methylation of a maize A1 gene construct in transgenic petunia and its colour phenotype in MOLECULAR GENETICS AND GENOMICS
  • 1973-12. A comparison of the instabilities at the Nivea and Pallida loci in Antirrhinum majus in HEREDITY
  • 1994-03. Transformation Systems for Generating Marker–Free Transgenic Plants in NATURE BIOTECHNOLOGY
  • 1993-09. Epigenetic repeat-induced gene silencing (RIGS) inArabidopsis in PLANT MOLECULAR BIOLOGY
  • 1993-10. Down-regulation of two non-homologous endogenous tomato genes with a single chimaeric sense gene construct in PLANT MOLECULAR BIOLOGY
  • 1986-07. Clones from a shooty tobacco crown gall tumor II: irregular T-DNA structures and organization, T-DNA methylation and conditional expression of opine genes in PLANT MOLECULAR BIOLOGY
  • 1991-05. Differential inactivation and methylation of a transgene in plants by two suppressor loci containing homologous sequences in PLANT MOLECULAR BIOLOGY
  • 1990-12. Expression of a truncated tomato polygalacturonase gene inhibits expression of the endogenous gene in transgenic plants in MOLECULAR GENETICS AND GENOMICS
  • 1994-07. Epigenetic variants of a transgenic petunia line show hypermethylation in transgene DNA: an indication for specific recognition of foreign DNA in transgenic plants in MOLECULAR GENETICS AND GENOMICS
  • 1990-12. The effect of T-DNA copy number, position and methylation on reporter gene expression in tobacco transformants in PLANT MOLECULAR BIOLOGY
  • 1990-07. Epigenetic changes in the expression of the maize A1 gene inPetunia hybrida: Role of numbers of integrated gene copies and state of methylation in MOLECULAR GENETICS AND GENOMICS
  • 1992-11. Regulated inactivation of homologous gene expression in transgenic Nicotiana sylvestris plants containing a defense-related tobacco chitinase gene in MOLECULAR GENETICS AND GENOMICS
  • 1993-01. Transgene copy number can be positively or negatively associated with transgene expression in PLANT MOLECULAR BIOLOGY
  • 1992-05. Petunia plants escape from negative selection against a transgene by silencing the foreign DNA via methylation in MOLECULAR GENETICS AND GENOMICS
  • 1989-09. A nuclear DNA attachment element mediates elevated and position-independent gene activity in NATURE
  • 1984-11. Changes in T-DNA methylation and expression are associated with phenotypic variation and plant regeneration in a crown gall tumor line in MOLECULAR GENETICS AND GENOMICS
  • 1993-01. A variety of epistatic interactions can occur between partially homologous transgene loci brought together by sexual crossing in MOLECULAR GENETICS AND GENOMICS
  • 1989-04. Rapid induction of genomic demethylation and T-DNA gene expression in plant cells by 5-azacytosine derivatives in PLANT MOLECULAR BIOLOGY
  • 1991-08. Reversible inactivation of a transgene in Arabidopsis thaliana in MOLECULAR GENETICS AND GENOMICS
  • 1987-12. A new petunia flower colour generated by transformation of a mutant with a maize gene in NATURE
  • 1989-09. Genetic manipulation of floral pigmentation genes in PLANT MOLECULAR BIOLOGY
  • 1993-07. Identification and genetic analysis of normal and mutant phytoene synthase genes of tomato by sequencing, complementation and co-suppression in PLANT MOLECULAR BIOLOGY
  • 1985-05. Organ-specific expression of three leaf/stem specific cDNAs from potato is regulated by light and correlated with chloroplast development in MOLECULAR GENETICS AND GENOMICS
  • 1988-05. Analysis of the T-DNA structure in a large number of transgenic petunias generated by Agrobacterium-mediated transformation in PLANT MOLECULAR BIOLOGY
  • 1988-05. Expression and inheritance of kanamycin resistance in a large number of transgenic petunias generated by Agrobacterium-mediated transformation in PLANT MOLECULAR BIOLOGY
  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    9

    VOLUME

    12

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt0994-883

    DOI

    http://dx.doi.org/10.1038/nbt0994-883

    DIMENSIONS

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