AIDS virus env Protein Expressed from a Recombinant Vaccinia Virus View Full Text


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Article Info

DATE

1986-09

AUTHORS

M. P. Kieny, G. Rautmann, D. Schmitt, K. Dott, S. Wain-Hobson, M. Alizon, M. Girard, S. Chamaret, A. Laurent, L. Montagnier, J-P. Lecocq

ABSTRACT

Lymphadenopathy–associated virus is the causative agent of AIDS, the acquired immunodeficiency syndrome. A retrovirus of the lentivirus group, LAV carries a single major target antigen at its surface: the env protein. We have introduced the env coding sequence into a vaccinia virus vector. The live recombinant virus, VVTGeLAV, determines the production of env protein in infected mammalian cells. The recombinant protein reacts with sera from AIDS patients and appears to be processed and glycosylated in a manner identical to authentic env of LAV retrovirus. Inoculation of mice with VVTGeLAV elicits high titres of antisera recognizing vaccinia determinants but only low titres of antibody recognizing env proteins of LAV. Cells infected with the recombinant virus rapidly liberate a processed form of the env protein into the culture medium. This shedding of surface antigen from AIDS virus may play a role in the pathophysiology of the disease. More... »

PAGES

790

Journal

TITLE

Nature Biotechnology

ISSUE

9

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt0986-790

    DOI

    http://dx.doi.org/10.1038/nbt0986-790

    DIMENSIONS

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