Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-06

AUTHORS

Michael Agadjanyan, Ping Luo, M.A. Julie Westerink, Lisa A. Carey, Wendy Hutchins, Zenon Steplewski, David B. Weiner, Thomas Kieber-Emmons

ABSTRACT

Cancer-related, mucin-type carbohydrate epitopes, principally mannose and sialo-syl residues, are expressed on the envelope protein gp160 of the human immunodeficiency virus (HIV). Anticarbohydrate antibodies directed toward these and other carbohydrate epitopes are known to neutralize HIV-1 infection by cell-free virus. Carbohydrates, however, being T cell–independent antigens, typically elicit diminished immune responses. To overcome this potential draw back, we have examined the ability of peptides that mimic such epitopes to elicit immune responses that cross-react with carbohydrate structures. We report that mouse polyclonal antisera generated against peptides that mimic mucin-related carbohydrate epitopes have anti–HIV-1 activity. Generation of antibodies was not Ir-gene restricted, as at least two different strains of mice, Balb/c (H-2d) and C57BI/6 (H-2b), responded equally to the peptides. The antipeptide sera displayed neutralizing activity against HIV-I/MN and HIV-I/3B viral strains. This neutralization was as good as human anti-HIV sera. These results indicate that peptide mimics of carbohydrates provide a novel strategy for the further development of reagents that elicit immune responses to carbohydrate epitopes associated with many infectious organisms and tumor cells. More... »

PAGES

547-551

Journal

TITLE

Nature Biotechnology

ISSUE

6

VOLUME

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt0697-547

DOI

http://dx.doi.org/10.1038/nbt0697-547

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012907035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9181577


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