An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-05

AUTHORS

Maureen Chase, Richard Y. Chung, E. Antonio Chiocca

ABSTRACT

Herpes simplex viruses type 1 (HSV-1) with an inactivated viral ribonucleotide reductase (Hsrr, ICP6) were designed to target tumor cells with upregulated mammalian ribonucleotide reductase (mRR), an enzyme whose expression is regulated by the p16/pRB tumor suppressor pathway. A recombinant HSV-1 was generated by knock-out of Hsrr and insertion of the rat CYP2B1 transgene responsible for the bioactivation of the prodrugs, cyclophosphamide and ifosfamide. The mutant virus replicated selectively in rat and human tumor cells that express mRR. Addition of cyclophosphamide potentiated oncolytic effects against cultured tumor cells and subcutaneous tumor xenografts established in athymic mice. More... »

PAGES

444

Journal

TITLE

Nature Biotechnology

ISSUE

5

VOLUME

16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt0598-444

DOI

http://dx.doi.org/10.1038/nbt0598-444

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018581344

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9592392


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