An encapsulation system for the immunoisolation of pancreatic islets View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

Taylor Wang, Igor Lacík, Marcela Brissová, Amrutur V. Anilkumar, Ales Prokop, David Hunkeler, Ray Green, Keivan Shahrokhi, Alvin C. Powers

ABSTRACT

Over a thousand combinations of polyanions and polycations were tested to search for new polymer candidates that would be suitable for encapsulation of living cells. The combination of sodium alginate, cellulose sulfate, poly (methylene-co-guanidine) hydrochloride, calcium chloride, and sodium chloride was most promising. In parallel, a novel multiloop chamber reactor was developed to control the time of complex formation and to negate gravitational effects such as pancreatic islet sedimentation and droplet deformation during the encapsulation process. Encapsulated rat islets demonstrated glucose-stimulated insulin secretion in vitro, and reversed diabetes in mice. This new capsule formulation and encapsulation system allows independent adjustments of capsule size, wall thickness, mechanical strength, and permeability, which may offer distinct advantages for immunoisolating cells. More... »

PAGES

358-362

References to SciGraph publications

Journal

TITLE

Nature Biotechnology

ISSUE

4

VOLUME

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt0497-358

DOI

http://dx.doi.org/10.1038/nbt0497-358

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002224648

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9094138


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