Molecular Beacons: Probes that Fluoresce upon Hybridization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-03

AUTHORS

Sanjay Tyagi, Fred Russell Kramer

ABSTRACT

We have developed novel nucleic acid probes that recognize and report the presence of specific nucleic acids in homogeneous solutions. These probes undergo a spontaneous fIuorogenic conforma-tional change when they hybridize to their targets. Only perfectly complementary targets elicit this response, as hybridization does not occur when the target contains a mismatched nucleotide or a deletion. The probes are particularly suited for monitoring the synthesis of specific nucleic acids in real time. When used in nucleic acid amplification assays, gene detection is homogeneous and sensitive, and can be carried out in a sealed tube. When introduced into living cells, these probes should enable the origin, movement, and fate of specific mRNAs to be traced. More... »

PAGES

303-308

References to SciGraph publications

Journal

TITLE

Nature Biotechnology

ISSUE

3

VOLUME

14

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  • Lafora's Disease Gene
  • High Throughput Single Nucleotide Polymorphism Assay
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  • Staphylococcus Detection Assays
  • Fluorescence-Based Computation System
  • Methods, Apparatus, And Computer Programs For Verifying The Integrity Of A Probe
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  • Containing At Least One D-Amino Acid And Functional Linker Moiety That Confers Target Cell Specificity
  • Optical Lens System And Method For Microfluidic Devices
  • Highly Conserved Tuf Genes And Their Use To Generate Probes And Primers For Detection Of Coagulase-Negative Staphylococcus
  • Method To Detect Prostate Cancer In A Sample
  • Replication; Hybridization; Kits
  • To Carry Out Thermal Cycling And Monitoring Of Various Biological Reactions, Such As The Polymerase Chain Reaction
  • Immobilization; Chelation; Incubation; Hybridization; Chromatography; Mass Spectrometry; Proteomics; Kits
  • Kinase And Phosphatase Assays
  • Compositions, Methods And Kits For Detection Of An Antigen On A Cell And In A Biological Mixture
  • Prostate Cancer Prognostic Compositions And Kits
  • Self-Complementary Arm Segments And Flexible Linkages That Promote Intramolecular Or Intermolecular Interactions; Probe-Based Nucleic Acid Sequence Detection, Analysis And Quantitation
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  • Isoforms Of Human Pregnancy-Associated Protein-E
  • Sample Container Cap With Centrifugation Status Indicator Device
  • Detecting Target Nucleotide Sequences In Sample; Obtain Sample Of Nucleotide Sequences, Incubate With Enzymes And Primers, Amplify, Illuminate Sample, Detect Fluorescent Emission
  • Method For Enhancing The Association Rates Of Polynucleotides
  • Time-Resolved Nucleic Acid Hybridization Probes
  • Use Of Fluorescent Molecular Beacons In The Detection Of Methylated Nucleic Acids
  • Reaction Mixtures For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Spatial Sequestration Of Dynamic Nucleic Acid Circuits
  • Method And Apparatus For Generating Thermal Melting Curves In A Microfluidic Device
  • Methods Of Labeling Polynucleotides With Energy Transfer Dyes
  • Methods, Kits And Compositions Pertaining To Detection Complexes
  • Dna Sequencing And Amplification Systems Using Nanoscale Field Effect Sensor Arrays
  • Use Of An Extraction Control In A Method Of Extracting Nucleic Acids
  • Non-Fluorescent Carbocyanine Quencher, Molecular Biology, Immunology And Fluorescence-Based Assays
  • Microfluidic Nucleic Acid Analysis
  • Digital Amplification
  • Optimization Of Gene Expression Analysis Using Immobilized Capture Probes
  • Compositions Comprising A Linked Acceptor Moiety
  • Monitoring Preferential Reactions; Obtain Sample, Incubate With Label And Ions, Monitor And Compare Fluorescent Polarization With Conrol
  • Microparticles With Enhanced Covalent Binding Capacity And Their Uses
  • Light Emitting Probes
  • Method For Identifying Polymorphism Of Nucleic Acid Molecules
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Detecting And Quantitating Target Nucleic Acid Molecules In A Sample Via Nucleic Acid Amplification
  • Uv Excitable Fluorescent Energy Transfer Dyes
  • Detection Of Target Nucleic Acid In Sample; Obtain Samples, Incubate With Probes, Detect Bound, Presence Of Bound Probe Indicate Presence Of Target Nucleotide Sequences
  • Uv Excitable Fluorescent Energy Transfer Dyes
  • Molecular Beacons
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Beta Cell Derived Dna As A Measure Of Beta Cell Loss In Diabetes
  • Magnetic Immuno Digital Pcr Assay
  • Hepatocyte Lineage Cells
  • Method For Detecting The Presence Of A Nucleic Acid In A Sample
  • Fluorescence Based Biosensor
  • Microfluidic Reaction Apparatus For High Throughput Screening
  • Pdx1 Expressing Endoderm
  • Bioelectronic Detectors Based On Oligonucleotides Including Synthetic And Naturally-Occurring Nucleotide Polymers Such As Aptamers, Dna, And Rna And Their Use To Detect Molecular Targets Via Target-Induced Strand Displacement.
  • Detection Of Target Nucleotide Sequences In Sample; Provide Probe, Incubate With Nucleotide Sequence Sample, Detect The Presence Or Absence Of The Target Nucleic Acid By Measuring A Change In Fluorescence
  • Using Primer Extension Chain Reaction And Single Detection Probes To Identify Preferential Nucleotide Sequences And Pathogens In Sample
  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
  • Il-2 Conjugates And Methods Of Use Thereof
  • Microfluidic Device And Method Of Using Same
  • Use Of Base-Modified Deoxynucleoside Triphosphates To Improve Nucleic Acid Detection
  • Protease Transducers And Sensors Based On Dna Loops
  • Methods And Kits For Treating Cardiovascular Disease
  • Imaging Individual Mrna Molecules Using Multiple Singly Labeled Probes
  • System And Method Of Using Multi-Chambered Receptacles
  • Molecular Torches
  • Nucleic Acid Enzyme Biosensors For Ions
  • Optical Lens System And Method For Microfluidic Devices
  • Primers And Probes For Detecting Human Papillomavirus And Human Beta Globin Sequences In Test Samples
  • Methods For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Isothermal Amplification Components And Processes
  • Pdx1 Expressing Endoderm
  • Protein Expression Profiling
  • Quantitating High Titer Samples By Digital Pcr
  • Enzymatic Nucleic Acid Synthesis: Compositions And Methods For Inhibiting Pyrophosphorolysis
  • Nested Pcr Employing Degradable Primers
  • Dark Quenchers, Probes And Other Conjugates Incorporating The Same, And Their Use
  • Direct Amplification And Detection Of Viral And Bacterial Pathogens
  • Methods For Making Anterior Foregut Endoderm
  • Enzymatic Nucleic Acid Synthesis: Compositions And Methods For Inhibiting Pyrophosphorolysis
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Method And System For Real Time Quantification And Monitoring Of Nucleic Acid Amplification Using Electroconductive Or Electrochemically Active Labels
  • Cytokine Conjugates For The Treatment Of Proliferative And Infectious Diseases
  • Primers And Probes For Detection And Discrimination Of Types And Subtypes Of Influenza Viruses
  • Using Shed Cellular Material As Evaluative Indicator Of Cell Proliferative Disorders
  • Robotic Arm
  • Isothermal Amplification Components And Processes
  • Detecting Nucleic Acids In Samples By Binding A Fluorescently Labeled Nucleic Acid Probe, Having A Hairpin Structure, To A Solid Phase; Solid Phase Quenches The Label If The Hairpin Structure Exists; Analyzing Nucleic Acid Sequences
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Β Cell Derived Dna As A Measure Of Β Cell Loss In Diabetes
  • Macrocyclic Hopo Chelators
  • Optical Lens System And Method For Microfluidic Devices
  • Probe And Method For Detection And Discrimination Of Types And Subtypes Of Influenza Viruses
  • Use Of Rna/Dna Chimeric Primers For Improved Nucleic Acid Amplification Reactions
  • Arrayed Biomolecules And Their Use In Sequencing
  • Self-Assembled Polynucleotide Structure
  • Cyanine Dyes
  • Nucleic Acid Sequences That Can Be Used As Primers And Probes In The Amplification And Detection Of Sars Coronavirus
  • Pcr Reaction Mixtures And Methods Of Using Same
  • Kit For Assessing Mitochondrial Toxicity
  • Detecting A Target Analyte By Altering The Redox Potential Of A Redox Effector In Solution; Eliminating The Need For Immobilizing The Analyte On A Support; Redox Report Laccase, Glucose Oxidase, Bilirubin Oxidase, Cholesterol Oxidase, Alcohol Dehydrogenase, Lactate Dehydrogenase, And D-Amino Acid Oxidase
  • Benzopyrylium Compounds
  • Method And Kit For Establishing An In Vitro Prognosis On A Patient Exhibiting Sirs
  • Methods, Kits And Compositions Pertaining To Linear Beacons
  • Quantitating High Titer Samples By Digital Pcr
  • Multi-Aptamer-Based, Cell-Specific, One-Step Tumor Cell Detection Assays
  • High Specificity Primers, Amplification Methods And Kits
  • Methods, Compositions, And Kits For Detecting Allelic Variants
  • Method And Materials For The Cooperative Hybridization Of Oligonucleotides
  • Patch Production
  • Method For Determining An Allele Profile Of Nucleic Acid
  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
  • Using Primer Extension Chain Reaction And Single Detection Probes To Identify Preferential Nucleotide Sequences And Pathogens In Sample
  • Il-2 Conjugates And Methods Of Use Thereof
  • Use Of Base-Modified Deoxynucleoside Triphosphates To Improve Nucleic Acid Detection
  • Apparatus And Methods For Conducting Assays And High Throughput Screening
  • Pdx1 Expressing Endoderm
  • Digital Amplification
  • Regents Labeled With Energy Transfer Dyes
  • Bioelectronic Detectors Based On Oligonucleotides Including Synthetic And Naturally-Occurring Nucleotide Polymers Such As Aptamers, Dna, And Rna And Their Use To Detect Molecular Targets Via Target-Induced Strand Displacement.
  • Detection Of Target Nucleotide Sequences In Sample; Provide Probe, Incubate With Nucleotide Sequence Sample, Detect The Presence Or Absence Of The Target Nucleic Acid By Measuring A Change In Fluorescence
  • Compounds And Methods Of Use Thereof For Assaying Lysophospholipase D Activity
  • Using Lipid Phosphates Activity Profile As Diagnostic Tool For Detection And Treatment Of Cancer; Pregnancy Determination; Kits
  • Microfluidic Device And Method Of Using Same
  • Reaction Mixtures For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Method And Kit For The Detection Of Nucleic Acids
  • Self-Assembled Polynucleotide Structure
  • Use Of Rna/Dna Chimeric Primers For Improved Nucleic Acid Amplification Reactions
  • Arrayed Biomolecules And Their Use In Sequencing
  • Nucleic Acid Hairpin Probes And Uses Thereof
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Isothermal Amplification Components And Processes
  • Pdx1 Expressing Endoderm
  • High Specificity Primers, Amplification Methods And Kits
  • Methods, Compositions, And Kits For Detecting Allelic Variants
  • Self-Complementary Arm Segments And Flexible Linkages That Promote Intramolecular Or Intermolecular Interactions; Probe-Based Nucleic Acid Sequence Detection, Analysis And Quantitation
  • Prostate Cancer Prognostic Compositions And Kits
  • Detecting Nucleic Acids In Samples By Binding A Fluorescently Labeled Nucleic Acid Probe, Having A Hairpin Structure, To A Solid Phase; Solid Phase Quenches The Label If The Hairpin Structure Exists; Analyzing Nucleic Acid Sequences
  • Macrocyclic Hopo Chelators
  • Optical Lens System And Method For Microfluidic Devices
  • Kit For Assessing Mitochondrial Toxicity
  • Cyanine Dyes
  • Nucleic Acid Sequences That Can Be Used As Primers And Probes In The Amplification And Detection Of Sars Coronavirus
  • Donor Dye Coupled To Acceptor Dyes By Novel Linker With Amide, Carboxy Ester Or Carbon-Oxygen-Sulfur Moiety; For Efficient Transfer Of Energy; Used In Nucleotide Sequencing Methods
  • Protease Transducers And Sensors Based On Dna Loops
  • Methods And Kits For Treating Cardiovascular Disease
  • Detecting A Target Analyte By Altering The Redox Potential Of A Redox Effector In Solution; Eliminating The Need For Immobilizing The Analyte On A Support; Redox Report Laccase, Glucose Oxidase, Bilirubin Oxidase, Cholesterol Oxidase, Alcohol Dehydrogenase, Lactate Dehydrogenase, And D-Amino Acid Oxidase
  • Mri Contrast Agents And High-Throughput Screening By Mri
  • Container For Carrying Out And Monitoring Biological Processes
  • Definitive Endoderm
  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
  • Markers Of Definitive Endoderm
  • Detection Probes, Kits And Assays
  • Instruments And Methods For Mixing The Contents Of A Detection Chamber
  • Aptamer Based Colorimetric Sensor Systems
  • Multiplex Quantification Of Nucleic Acids In Diseased Cells
  • Oligonucleotide Probes Bearing Quenchable Fluorescent Labels, And Methods Of Use Thereof
  • Used For Genetic Replication/Polymerase Chain Reaction (Pcr); Solid Phase Synthesis
  • Diagnosis And Treatment Of Alzheimer's Disease
  • Contact Of Sample With Buffer, (Contact And Incubation Of Mixture With A Weakly Basic Polymer, And Release Of The Dna Bound To Polymer In By Contact With Alkali, Method Eliminates The Need For Extraction With Alcohol Or Other Solvent And Toxic Materials
  • For Replication/Sequencing; Gene Expression Inhibition
  • Molecular Modification Assays
  • Detection Method Using Dissociated Rolling Circle Amplification
  • Primers And Methods For Nucleic Acid Amplification
  • Method For Simultaneously Performing Multiple Amplification Reactions
  • Nucleic Acid Amplification
  • Method For Discriminating Single Nucleotide Polymorphisms
  • Nucleic Acid Probe Is Attached With Fluorescent Dyes At Two Different Sites, Being Separated From One Another By About 3 To About 60 Nucleotides; Detection Of A Target Nucleic Acid Sequence To Clinical Diagnostics; Synthetic Simplicity, Spectral Versatility And Superior Fluorescent Signal
  • Turn Over Probes And Use Thereof For Nucleic Acid Detection
  • Method For Generating Proximity Probes
  • System And Method For Carrying Out And Monitoring Biological Processes
  • Detection Of Small Nucleic Acids
  • Kits For Using E6 Viral Transcript Expression As Diagnostic Indicator In Detection And Classification Of Cervical Cancers
  • Method And Apparatus For Generating Thermal Melting Curves In A Microfluidic Device
  • Methods For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Methods Of Analyzing Polynucleotides Employing Energy Transfer Dyes
  • Method For Performing An Assay With A Nucleic Acid Present In A Specimen
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  • Ultra High-Throughput Opti-Nanopore Dna Readout Platform
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  • Method Of Making A Microbead Array With Attached Biomolecules
  • Patch Production
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  • Detection Nucleic Acid Sequences
  • Microfabricated Structure Having Parallel And Orthogonal Flow Channels Controlled By Row And Column Multiplexors
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  • Expansion Of Definitive Endoderm Cells
  • Multiplexed Analysis Of Polymorphic Loci By Concurrent Interrogation And Enzyme-Mediated Detection
  • Templated Nanoconjugates
  • Methine-Substituted Cyanine Dye Compounds
  • Highly Conserved Genes And Their Use To Generate Probes And Primers For Detection Of Microorganisms
  • Recovering Long-Range Linkage Information From Preserved Samples
  • Delivery Device
  • Particles For Detecting Intracellular Targets
  • Reagentless, Reusable, Bioelectronic Detectors
  • Haemoplasma Detection Method
  • Novel Labelled Oligonucleotide
  • Zymogenic Nucleic Acid Molecules
  • Compositions Of Toehold Primer Duplexes And Methods Of Use
  • Detecting Binding Positions On Preferential Particles; Obtain Microspheres, Incubate With Reaction Mixtures, Detect Bound Particles, Record Positions
  • Reliable Fluorescence Correction Method For Two-Color Measurement Fluorescence System
  • High Specificity Primers, Amplification Methods And Kits
  • Oligonucleotide Conjugates
  • For Replication/Sequencing; Gene Expression Inhibition
  • Aptamer- And Nucleic Acid Enzyme-Based Systems For Simultaneous Detection Of Multiple Analytes
  • Methods And Probes For Detecting A Vancomycin Resistance Gene
  • Membrane-Permeant Peptide Complexes For Medical Imaging, Diagnostics, And Pharmaceutical Therapy
  • Methods Of Using Fet Labeled Oligonucleotides That Include A 3′-5′ Exonuclease Resistant Quencher Domain And Compositions For Practicing The Same
  • Apparatus And Methods For Conducting Assays And High Throughput Screening
  • Charge Switch Nucleotides
  • Monitoring Enzymatic Activity; Incubate Substrate And Binding Particles, Incubate Substrate And Enzyme, Detect And Evaluate Enzymatic Response; Detecting Molecular Modifications Such As Phosphate Modifications; Detecting Nucleotide Cyclization Or Decyclization In A Sample
  • Nonlinear Optical Detection Of Molecules Comprising An Unnatural Amino Acid Possessing A Hyperpolarizability
  • Creation Of Functionalized Microparticle Libraries By Oligonucleotide Ligation Or Elongation
  • Pca3, Pca3 Genes, And Methods Of Use
  • Quality Control Of Substrate Coatings
  • Microfabricated Structure Having Parallel And Orthogonal Flow Channels Controlled By Row And Column Multiplexors
  • Pkr Activation Via Hybridization Chain Reaction
  • Expansion Of Definitive Endoderm Cells
  • Through Bond Energy Transfer In Fluorescent Dyes For Labelling Biological Molecules
  • Digital Amplification
  • Method For Determining The Presence Or Absence Of Methylation In A Sample
  • Optimization Of Gene Expression Analysis Using Immobilized Capture Probes
  • System And Method Of Using Multi-Chambered Receptacles
  • Attaching Dyes To Probe, Hybridizing To Dna Sequence, Recording Value Of Emissions, Heating, Monitoring Temperature At Which Emissions Are Reduced, And Determining Observed Melting Point; Reduced Melting Point Indicates Mutation
  • Method For Performing An Assay With A Nucleic Acid Present In A Specimen
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Paroxysmal Extreme Pain Disorder Treatment
  • Method Of Delivering Material Or Stimulus To A Biological Subject
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Method For Discriminating Single Nucleotide Polymorphisms
  • Methods For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Peptide Nucleic Acids (Pna); Self-Complementary Arm Segments And Flexible Linkages Which Promote Intra- Or Inter-Molecular Interactions; Use To Detect, Or Quantitate Target Sequence In A Sample; Fluorescence Resonance Energy Transfer
  • Detection Nucleic Acid Sequences
  • Methods, Kits And Reaction Mixtures For Analyzing Single-Stranded Nucleic Acid Sequences
  • Primer Middle Sequence Interference Pcr Technology
  • Definitive Endoderm
  • Hybridization Probe Of Single-Stranded Sequence Complementary To Target, Flanked By Oligonucleotide Arms With Interacting Labels Capable Of Forming Stem Duplex; Hybridization With Target Alters Level Of Signal At Least Ten Percent
  • Detection Method Using Dissociated Rolling Circle Amplification
  • Markers Of Definitive Endoderm
  • Bifunctional Contrast Agents That Are Operable For Both Magnetic Resonance Imaging Optical Imaging
  • Methods And Compositions For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • On Sample Nucleic Acid, Synthesizing Oligonucleotide Incorporating Two Fluorescent Dyes Each Covalently Linked To Separate Nucleotides; Detecting Fluorescence Energy Transfer From One To Another As Indicator Of Target Site
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  • Used For Genetic Replication/Polymerase Chain Reaction (Pcr); Solid Phase Synthesis
  • Diagnosis And Treatment Of Alzheimer's Disease
  • Primers And Methods For Nucleic Acid Amplification
  • Method For Simultaneously Performing Multiple Amplification Reactions
  • Exposing To Molecular Beacon Comprised Of Nucleotides Complementary To Rna Of Interest; Isolating Cells That Fluoresce Upon Hybridization
  • Method Of Making A Microbead Array With Attached Biomolecules
  • Patch Production
  • Method For Generating Proximity Probes
  • System And Method For Carrying Out And Monitoring Biological Processes
  • Detection Of Small Nucleic Acids
  • Triggered Rnai
  • Method For Activating A Nucleic Acid For A Polymerase Reaction
  • Contact Of Sample With Buffer, (Contact And Incubation Of Mixture With A Weakly Basic Polymer, And Release Of The Dna Bound To Polymer In By Contact With Alkali, Method Eliminates The Need For Extraction With Alcohol Or Other Solvent And Toxic Materials
  • Ultra High-Throughput Opti-Nanopore Dna Readout Platform
  • Using Internal Control Polynucleotide And Primers, Target Polynucleotides And Primers, Non-Extendable Oligonucleotide Complementary To The Internal Control Primers, Polymerase With Exonuclease Activity, Self-Quenching Fluorescent Probes
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt0396-303

    DOI

    http://dx.doi.org/10.1038/nbt0396-303

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007118508

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9630890


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