Molecular Beacons: Probes that Fluoresce upon Hybridization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-03

AUTHORS

Sanjay Tyagi, Fred Russell Kramer

ABSTRACT

We have developed novel nucleic acid probes that recognize and report the presence of specific nucleic acids in homogeneous solutions. These probes undergo a spontaneous fIuorogenic conforma-tional change when they hybridize to their targets. Only perfectly complementary targets elicit this response, as hybridization does not occur when the target contains a mismatched nucleotide or a deletion. The probes are particularly suited for monitoring the synthesis of specific nucleic acids in real time. When used in nucleic acid amplification assays, gene detection is homogeneous and sensitive, and can be carried out in a sealed tube. When introduced into living cells, these probes should enable the origin, movement, and fate of specific mRNAs to be traced. More... »

PAGES

303-308

References to SciGraph publications

Journal

TITLE

Nature Biotechnology

ISSUE

3

VOLUME

14

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  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
  • Methods And Devices Related To Toehold-Based Strand Displacement With Loop-Mediated Isothermal Amplification
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  • Oligonucleotide Encoded Chemical Libraries
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  • Inversion Probes
  • Apparatus And Methods For Conducting Assays And High Throughput Screening
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  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
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  • Method And System For Real Time Quantification And Monitoring Of Nucleic Acid Amplification Using Electroconductive Or Electrochemically Active Labels
  • Uv Excitable Fluorescent Energy Transfer Dyes
  • Method For Enhancing The Association Rates Of Polynucleotides
  • Primers And Probes For Detection And Discrimination Of Types And Subtypes Of Influenza Viruses
  • Use Of Base-Modified Deoxynucleoside Triphosphates To Improve Nucleic Acid Detection
  • Pdx1 Expressing Endoderm
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Prostate Cancer Prognostic Compositions And Kits
  • To Carry Out Thermal Cycling And Monitoring Of Various Biological Reactions, Such As The Polymerase Chain Reaction
  • Using Lipid Phosphates Activity Profile As Diagnostic Tool For Detection And Treatment Of Cancer; Pregnancy Determination; Kits
  • Benzopyrylium Compounds
  • Quantitating High Titer Samples By Digital Pcr
  • Light Emitting Probes
  • Primers And Probes For Detecting Human Papillomavirus And Human Beta Globin Sequences In Test Samples
  • Isothermal Amplification Components And Processes
  • Staphylococcus Detection Assays
  • Kits For Detecting Group B Streptococci
  • Contacting With Nucleophilic Compound
  • Arid1a And Ppp2r1a Mutations In Cancer
  • Patch Production
  • Using Primer Extension Chain Reaction And Single Detection Probes To Identify Preferential Nucleotide Sequences And Pathogens In Sample
  • Apparatus And Methods For Conducting Assays And High Throughput Screening
  • Inversion Probes
  • Pcr Reaction Mixtures And Methods Of Using Same
  • Methods, Apparatus, And Computer Programs For Verifying The Integrity Of A Probe
  • Nucleic Acid Sequences That Can Be Used As Primers And Probes In The Amplification And Detection Of Sars Coronavirus
  • Optimization Of Gene Expression Analysis Using Immobilized Capture Probes
  • Container For Carrying Out And Monitoring Biological Processes
  • Fluorescence-Based Computation System
  • Methods, Compositions, And Kits For Detecting Allelic Variants
  • Beta 2 Adrenergic Polymorphism Detection
  • Imaging Individual Mrna Molecules Using Multiple Singly Labeled Probes
  • Using A Template-Deficient Oligonucleotide That Cannot Serve As A Template For Nucleic Acid Synthesis Over Part Of Its Length As A Primer And Using A Polymerase
  • Coating Method
  • Self-Complementary Arm Segments And Flexible Linkages That Promote Intramolecular Or Intermolecular Interactions; Probe-Based Nucleic Acid Sequence Detection, Analysis And Quantitation
  • System And Method Of Using Multi-Chambered Receptacles
  • Spatial Sequestration Of Dynamic Nucleic Acid Circuits
  • Magnetic Immuno Digital Pcr Assay
  • Sample Container Cap With Centrifugation Status Indicator Device
  • Detecting Nucleic Acids In Samples By Binding A Fluorescently Labeled Nucleic Acid Probe, Having A Hairpin Structure, To A Solid Phase; Solid Phase Quenches The Label If The Hairpin Structure Exists; Analyzing Nucleic Acid Sequences
  • Optical Lens System And Method For Microfluidic Devices
  • Microparticles With Enhanced Covalent Binding Capacity And Their Uses
  • Method To Detect Prostate Cancer In A Sample
  • Macrocyclic Hopo Chelators
  • Cytokine Conjugates For The Treatment Of Proliferative And Infectious Diseases
  • Multifunctional Magnetic Nanoparticle Probes For Intracellular Molecular Imaging And Monitoring
  • Primers And Probes For Detecting Human Papillomavirus And Human Beta Globin Sequences In Test Samples
  • Quantitating High Titer Samples By Digital Pcr
  • Complexing; Quantitative Analysis
  • Bioelectronic Detectors Based On Oligonucleotides Including Synthetic And Naturally-Occurring Nucleotide Polymers Such As Aptamers, Dna, And Rna And Their Use To Detect Molecular Targets Via Target-Induced Strand Displacement.
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Kinase And Phosphatase Assays
  • Method And Kit For The Detection Of Nucleic Acids
  • Microfluidic Device And Method Of Using Same
  • Protease Transducers And Sensors Based On Dna Loops
  • Methods Of Labeling Polynucleotides With Energy Transfer Dyes
  • Kit For Assessing Mitochondrial Toxicity
  • Nucleotide Sequences For Use In The Diagnosis And Treatment Of Cardiomyopathies, Vision And Ear Defects
  • Enzymatic Nucleic Acid Synthesis: Compositions And Methods For Inhibiting Pyrophosphorolysis
  • Methods And Compositions To Detect Nucleic Acids In A Biological Sample
  • High Specificity Primers, Amplification Methods And Kits
  • Method For Nucleic Acid Amplification That Results In Low Amplification Bias
  • Methods And Materials Using Signaling Probes
  • Isoforms Of Human Pregnancy-Associated Protein-E
  • Uv Excitable Fluorescent Energy Transfer Dyes
  • Dark Quenchers, Probes And Other Conjugates Incorporating The Same, And Their Use
  • Include An Array Of Reaction Chambers Formed By Intersecting Vertical And Horizontal Flow Channels, With The Ability To Regulate Temperature At The Reaction Chambers; Methods Of Using The Same In Various Types Of Thermal Cycling Reactions
  • Using Shed Cellular Material As Evaluative Indicator Of Cell Proliferative Disorders
  • Optical Lens System And Method For Microfluidic Devices
  • Compositions, Methods And Kits For Detection Of An Antigen On A Cell And In A Biological Mixture
  • Methods For Making Anterior Foregut Endoderm
  • Pdx1 Expressing Endoderm
  • Robotic Arm
  • Il-2 Conjugates And Methods Of Use Thereof
  • Use Of Fluorescent Molecular Beacons In The Detection Of Methylated Nucleic Acids
  • Detection Of Target Nucleotide Sequences In Sample; Provide Probe, Incubate With Nucleotide Sequence Sample, Detect The Presence Or Absence Of The Target Nucleic Acid By Measuring A Change In Fluorescence
  • Methods For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Β Cell Derived Dna As A Measure Of Β Cell Loss In Diabetes
  • Markers For Breast Cancer
  • Sieving Of Nucleic Acid Samples
  • Method For The Detection And Identification Of Methicillin-Resistant Staphylococcus Aureus
  • Mri Contrast Agents And High-Throughput Screening By Mri
  • Enzymatic Nucleic Acid Synthesis: Compositions And Methods For Inhibiting Pyrophosphorolysis
  • Reaction Mixtures For Quantitative Amplification And Detection Over A Wide Dynamic Range
  • Methods, Kits And Compositions Pertaining To Detection Complexes
  • Replication; Hybridization; Kits
  • Methods Of Using Fet Labeled Oligonucleotides That Include A 3′-5′ Exonuclease Resistant Quencher Domain And Compositions For Practicing The Same
  • Protein Expression Profiling
  • Labeling Dye For Detecting Biomolecule, Labeling Kit, And Method For Detecting Biomolecule
  • Method For Identifying Polymorphism Of Nucleic Acid Molecules
  • Method For Detecting The Presence Of A Nucleic Acid In A Sample
  • Method And Materials For The Cooperative Hybridization Of Oligonucleotides
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Beta Cell Derived Dna As A Measure Of Beta Cell Loss In Diabetes
  • Method For Enhancing The Association Rates Of Polynucleotides
  • Compounds And Methods Of Use Thereof For Assaying Lysophospholipase D Activity
  • Nucleic Acid Hairpin Probes And Uses Thereof
  • Primers And Probes For Detecting Human Papillomavirus And Human Beta Globin Sequences In Test Samples
  • Prostate Cancer Prognostic Compositions And Kits
  • Arid1a And Ppp2r1a Mutations In Cancer
  • Contacting With Nucleophilic Compound
  • To Carry Out Thermal Cycling And Monitoring Of Various Biological Reactions, Such As The Polymerase Chain Reaction
  • Light Emitting Probes
  • Using Lipid Phosphates Activity Profile As Diagnostic Tool For Detection And Treatment Of Cancer; Pregnancy Determination; Kits
  • Detecting A Target Analyte By Altering The Redox Potential Of A Redox Effector In Solution; Eliminating The Need For Immobilizing The Analyte On A Support; Redox Report Laccase, Glucose Oxidase, Bilirubin Oxidase, Cholesterol Oxidase, Alcohol Dehydrogenase, Lactate Dehydrogenase, And D-Amino Acid Oxidase
  • Method And System For Real Time Quantification And Monitoring Of Nucleic Acid Amplification Using Electroconductive Or Electrochemically Active Labels
  • Microfluidic Reaction Apparatus For High Throughput Screening
  • Isothermal Amplification Components And Processes
  • Patch Production
  • Benzopyrylium Compounds
  • Quantitating High Titer Samples By Digital Pcr
  • Kits For Detecting Group B Streptococci
  • Protein Expression Profiling
  • Nucleic Acid Functionalized Nanoparticles For Therapeutic Applications
  • Compositions Comprising A Linked Acceptor Moiety
  • Staphylococcus Detection Assays
  • Pdx1 Expressing Endoderm
  • Devices And Methods For Detecting Nucleic Acid Analytes In Samples
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Hepatocyte Lineage Cells
  • Fluorescence Based Biosensor
  • Peptides And Antiviral Drug
  • Self-Assembled Polynucleotide Structure
  • Cyanine Dyes
  • Beta 2 Adrenergic Polymorphism Detection
  • Imaging Individual Mrna Molecules Using Multiple Singly Labeled Probes
  • Using A Template-Deficient Oligonucleotide That Cannot Serve As A Template For Nucleic Acid Synthesis Over Part Of Its Length As A Primer And Using A Polymerase
  • Coating Method
  • Self-Complementary Arm Segments And Flexible Linkages That Promote Intramolecular Or Intermolecular Interactions; Probe-Based Nucleic Acid Sequence Detection, Analysis And Quantitation
  • Microfluidic Nucleic Acid Analysis
  • Pcr Reaction Mixtures And Methods Of Using Same
  • Methods, Apparatus, And Computer Programs For Verifying The Integrity Of A Probe
  • Optimization Of Gene Expression Analysis Using Immobilized Capture Probes
  • Container For Carrying Out And Monitoring Biological Processes
  • Nucleic Acid Sequences That Can Be Used As Primers And Probes In The Amplification And Detection Of Sars Coronavirus
  • Monitoring Preferential Reactions; Obtain Sample, Incubate With Label And Ions, Monitor And Compare Fluorescent Polarization With Conrol
  • Spatial Sequestration Of Dynamic Nucleic Acid Circuits
  • Signal Amplification With Lollipop Probes
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  • Reagentless, Reusable, Bioelectronic Detectors
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  • Detection Of Small Nucleic Acids
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  • Nucleic Acid Amplification Using Microfluidic Devices
  • Hybridization Chain Reaction Amplification For In Situ Imaging
  • Methods Of Analyzing Polynucleotides Employing Energy Transfer Dyes
  • Particles For Detecting Intracellular Targets
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  • Methods Of Using Fet Labeled Oligonucleotides That Include A 3′-5′ Exonuclease Resistant Quencher Domain And Compositions For Practicing The Same
  • Quality Control Of Substrate Coatings
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Beta Cell Derived Dna As A Measure Of Beta Cell Loss In Diabetes
  • Method For Performing An Assay With A Nucleic Acid Present In A Specimen
  • High Specificity Primers, Amplification Methods And Kits
  • Compositions Of Toehold Primer Duplexes And Methods Of Use
  • Centrifuge System And Workflow
  • Detection Of Target Nucleic Acid Variants
  • Multiplexed Analysis Of Polymorphic Loci By Concurrent Interrogation And Enzyme-Mediated Detection
  • Dark Quenchers For Donor-Acceptor Energy Transfer
  • Method For Determining The Presence Or Absence Of Methylation In A Sample
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  • Patch Production
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  • Device And Method For Coating Surfaces
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  • Contact Of Sample With Buffer, (Contact And Incubation Of Mixture With A Weakly Basic Polymer, And Release Of The Dna Bound To Polymer In By Contact With Alkali, Method Eliminates The Need For Extraction With Alcohol Or Other Solvent And Toxic Materials
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  • Creation Of Functionalized Microparticle Libraries By Oligonucleotide Ligation Or Elongation
  • Polyvalent Rna-Nanoparticle Compositions
  • Recovering Long-Range Linkage Information From Preserved Samples
  • Reliable Fluorescence Correction Method For Two-Color Measurement Fluorescence System
  • Method Of Delivering Material Or Stimulus To A Biological Subject
  • Nonlinear Optical Detection Of Molecules Comprising An Unnatural Amino Acid Possessing A Hyperpolarizability
  • Exposing To Molecular Beacon Comprised Of Nucleotides Complementary To Rna Of Interest; Isolating Cells That Fluoresce Upon Hybridization
  • Aptamer Based Colorimetric Sensor Systems
  • Assays For Short Sequence Variants
  • Markers Of Definitive Endoderm
  • Methods And Probes For Detecting A Vancomycin Resistance Gene
  • Molecular Modification Assays
  • Energy Transfer Dyes With Enhanced Fluorescence
  • Amphiphilic Substances And Functionalized Lipid Vesicles Including The Same
  • Homogeneous Nucleotide Amplification And Assay
  • Reagentless, Reusable, Bioelectronic Detectors
  • System And Method Including Multiple Processing Lanes Executing Processing Protocols
  • For Replication/Sequencing; Gene Expression Inhibition
  • Expansion Of Definitive Endoderm Cells
  • Detection Probes, Kits And Assays
  • Delivery Device
  • Method For Activating A Nucleic Acid For A Polymerase Reaction
  • Charge Switch Nucleotides
  • Method For Amplification-Free Nucleic Acid Detection On Optofluidic Chips
  • Method To Detect Prostate Cancer In A Sample
  • Methine-Substituted Cyanine Dye Compounds
  • Zymogenic Nucleic Acid Molecules
  • Methods Of Analyzing Polynucleotides Employing Energy Transfer Dyes
  • Triggered Rnai
  • Thermal Reaction Device And Method For Using The Same
  • Methods, Kits And Reaction Mixtures For Analyzing Single-Stranded Nucleic Acid Sequences
  • Nucleic Acid Probe Is Attached With Fluorescent Dyes At Two Different Sites, Being Separated From One Another By About 3 To About 60 Nucleotides; Detection Of A Target Nucleic Acid Sequence To Clinical Diagnostics; Synthetic Simplicity, Spectral Versatility And Superior Fluorescent Signal
  • Using Internal Control Polynucleotide And Primers, Target Polynucleotides And Primers, Non-Extendable Oligonucleotide Complementary To The Internal Control Primers, Polymerase With Exonuclease Activity, Self-Quenching Fluorescent Probes
  • Turn Over Probes And Use Thereof For Nucleic Acid Detection
  • Hybridizing Nucleic Acid Sequence With Fluorescently Labeled Oligonucleotide Primer In Presence Of Deoxynucleoside Triphosphates, Dideoxynucleoside Triphosphate And Dna Polymerase, Fluorescently Measuring Mixture Formed To Sequence
  • Markers Of Definitive Endoderm
  • Reliable Fluorescence Correction Method For Two-Color Measurement Fluorescence System
  • On Sample Nucleic Acid, Synthesizing Oligonucleotide Incorporating Two Fluorescent Dyes Each Covalently Linked To Separate Nucleotides; Detecting Fluorescence Energy Transfer From One To Another As Indicator Of Target Site
  • Chromosome Conformation Capture In Partitions
  • Templated Nanoconjugates
  • Method For Generating Proximity Probes
  • Method For Determining The Presence Or Absence Of Methylation In A Sample
  • Instruments And Methods For Mixing The Contents Of A Detection Chamber
  • Highly Conserved Genes And Their Use To Generate Probes And Primers For Detection Of Microorganisms
  • Hybridization Probe Of Single-Stranded Sequence Complementary To Target, Flanked By Oligonucleotide Arms With Interacting Labels Capable Of Forming Stem Duplex; Hybridization With Target Alters Level Of Signal At Least Ten Percent
  • Patch Production
  • Microfabricated Structure Having Parallel And Orthogonal Flow Channels Controlled By Row And Column Multiplexors
  • Detecting Binding Positions On Preferential Particles; Obtain Microspheres, Incubate With Reaction Mixtures, Detect Bound Particles, Record Positions
  • Primer Middle Sequence Interference Pcr Technology
  • Method For Discriminating Single Nucleotide Polymorphisms
  • Nucleic Acid Amplification Using Microfluidic Devices
  • Fractional Initiator Hybridization Chain Reaction
  • Hybridization Chain Reaction Amplification For In Situ Imaging
  • Compositions Of Toehold Primer Duplexes And Methods Of Use
  • Method For Performing An Assay With A Nucleic Acid Present In A Specimen
  • High Specificity Primers, Amplification Methods And Kits
  • Quality Control Of Substrate Coatings
  • Method For Using Probe Based Pcr Detection To Measure The Levels Of Circulating Demethylated Beta Cell Derived Dna As A Measure Of Beta Cell Loss In Diabetes
  • Centrifuge System And Workflow
  • Detection Of Target Nucleic Acid Variants
  • Multiplexed Analysis Of Polymorphic Loci By Concurrent Interrogation And Enzyme-Mediated Detection
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt0396-303

    DOI

    http://dx.doi.org/10.1038/nbt0396-303

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007118508

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9630890


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