Processing of Protein Precursors by a Novel Family of Subtilisin-Related Mammalian Endoproteases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-02

AUTHORS

S P Smeekens

ABSTRACT

The recent identification of a novel family of mammalian endoproteases that carry out intracellular processing of protein precursors at dibasic sites has ended a search that began twenty-five years ago with the discovery of the first such precursor, proinsulin. The five proteases found thus far are all related to the yeast dibasic-specific endoprotease kex2, and include PC2, PC3/PC1, PC4, furin/PACE, and PACE4. All are Ca(2+)-dependent serine proteases with catalytic domains organized similarly to the bacterial subtilisins. The emerging characteristics of these endoproteases, including their tissue-specific expression, subcellular localization, and cleavage site selectivity, indicates that members of this family arose during evolution to process a diverse group of functionally distinct precursors in a highly specific, compartmentalized and regulated fashion. More... »

PAGES

182

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt0293-182

DOI

http://dx.doi.org/10.1038/nbt0293-182

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020789725

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7763370


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