Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-16

AUTHORS

Michael Kosicki, Kärt Tomberg, Allan Bradley

ABSTRACT

Cas9-induced double stranded breaks can cause large deletions near the target site and more complex genomic rearrangements in mouse and human stem cells.

PAGES

765-771

References to SciGraph publications

  • 2015-09-01. Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells in NATURE BIOTECHNOLOGY
  • 2016-04-20. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage in NATURE
  • 2017-05-31. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome in NATURE COMMUNICATIONS
  • 2017-04-03. Refining strategies to translate genome editing to the clinic in NATURE MEDICINE
  • 2014-04-25. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification in NATURE BIOTECHNOLOGY
  • 2016-01-06. High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects in NATURE
  • 2013-06-23. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells in NATURE BIOTECHNOLOGY
  • 2015-05-30. Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression in GENOME BIOLOGY
  • 2014-12-16. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases in NATURE BIOTECHNOLOGY
  • 2009-06-14. Agouti C57BL/6N embryonic stem cells for mouse genetic resources in NATURE METHODS
  • 2015-08-31. CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo in NATURE METHODS
  • 2017-10-09. Revealing hidden complexities of genomic rearrangements generated with Cas9 in SCIENTIFIC REPORTS
  • 2013-07-21. DNA targeting specificity of RNA-guided Cas9 nucleases in NATURE BIOTECHNOLOGY
  • 2013-12-23. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library in NATURE BIOTECHNOLOGY
  • 2014-04-25. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2014-12-15. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases in NATURE BIOTECHNOLOGY
  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    8

    VOLUME

    36

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.4192

    DOI

    http://dx.doi.org/10.1038/nbt.4192

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105601158

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30010673


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