Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-19

AUTHORS

Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Ahmad Ahmado, Amanda Vernon, Julie T Daniels, Britta Nommiste, Shazeen M Hasan, Sakina B Gooljar, Amanda-Jayne F Carr, Anthony Vugler, Conor M Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G Robson, Graham E Holder, Mandeep S Sagoo, Peter T Loudon, Paul Whiting, Peter J Coffey

ABSTRACT

An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients.

PAGES

328-337

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.4114

DOI

http://dx.doi.org/10.1038/nbt.4114

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101559880

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29553577


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "author": [
      {
        "affiliation": {
          "alternateName": "Wellcome/EPSRC Centre for Interventional & Surgical Sciences (WEISS), Charles Bell House, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.497851.6", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
            "Wellcome/EPSRC Centre for Interventional & Surgical Sciences (WEISS), Charles Bell House, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "da Cruz", 
        "givenName": "Lyndon", 
        "id": "sg:person.0630215443.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630215443.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fynes", 
        "givenName": "Kate", 
        "id": "sg:person.01350031470.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350031470.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Georgiadis", 
        "givenName": "Odysseas", 
        "id": "sg:person.010142471713.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142471713.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cell and Gene Therapy Catapult, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.502751.4", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK", 
            "Cell and Gene Therapy Catapult, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerby", 
        "givenName": "Julie", 
        "id": "sg:person.0624552066.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624552066.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Yvonne H", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahmado", 
        "givenName": "Ahmad", 
        "id": "sg:person.016164070217.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164070217.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vernon", 
        "givenName": "Amanda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Daniels", 
        "givenName": "Julie T", 
        "id": "sg:person.016010741722.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016010741722.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nommiste", 
        "givenName": "Britta", 
        "id": "sg:person.0727241514.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727241514.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasan", 
        "givenName": "Shazeen M", 
        "id": "sg:person.01240650356.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240650356.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gooljar", 
        "givenName": "Sakina B", 
        "id": "sg:person.01332575620.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332575620.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carr", 
        "givenName": "Amanda-Jayne F", 
        "id": "sg:person.012464315752.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012464315752.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vugler", 
        "givenName": "Anthony", 
        "id": "sg:person.01163055604.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163055604.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramsden", 
        "givenName": "Conor M", 
        "id": "sg:person.0760711427.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760711427.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bictash", 
        "givenName": "Magda", 
        "id": "sg:person.01015034603.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015034603.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fenster", 
        "givenName": "Mike", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steer", 
        "givenName": "Juliette", 
        "id": "sg:person.015666217311.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666217311.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harbinson", 
        "givenName": "Tricia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilbrey", 
        "givenName": "Anna", 
        "id": "sg:person.01237630270.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237630270.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tufail", 
        "givenName": "Adnan", 
        "id": "sg:person.0744062507.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744062507.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Gang", 
        "id": "sg:person.010173450124.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010173450124.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whitlock", 
        "givenName": "Mark", 
        "id": "sg:person.0717772741.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717772741.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robson", 
        "givenName": "Anthony G", 
        "id": "sg:person.01046761052.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046761052.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holder", 
        "givenName": "Graham E", 
        "id": "sg:person.01041031123.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041031123.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moorfields Eye Hospital NHS Foundation Trust, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436474.6", 
          "name": [
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Moorfields Eye Hospital NHS Foundation Trust, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sagoo", 
        "givenName": "Mandeep S", 
        "id": "sg:person.01175460321.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175460321.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer, Granta Park, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loudon", 
        "givenName": "Peter T", 
        "id": "sg:person.0750714660.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750714660.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UCL Institute of Neurology, Queen Square, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.436283.8", 
          "name": [
            "Pfizer, Granta Park, Cambridge, UK", 
            "UCL Institute of Neurology, Queen Square, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Whiting", 
        "givenName": "Paul", 
        "id": "sg:person.011076130257.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076130257.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center for Stem Cell Biology and Engineering, NRI, UC, Santa Barbara, California, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK", 
            "NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK", 
            "Center for Stem Cell Biology and Engineering, NRI, UC, Santa Barbara, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coffey", 
        "givenName": "Peter J", 
        "id": "sg:person.07450630137.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07450630137.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nbt1318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033397919", 
          "https://doi.org/10.1038/nbt1318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037543923", 
          "https://doi.org/10.1038/sj.clpt.6100321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00417-009-1201-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022137162", 
          "https://doi.org/10.1007/s00417-009-1201-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-71994-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019188449", 
          "https://doi.org/10.1007/978-3-540-71994-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-62703-080-9_20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012815559", 
          "https://doi.org/10.1007/978-1-62703-080-9_20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-00142-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084130279", 
          "https://doi.org/10.1038/s41598-017-00142-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03-19", 
    "datePublishedReg": "2018-03-19", 
    "description": "An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nbt.4114", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2755492", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115214", 
        "issn": [
          "1087-0156", 
          "1546-1696"
        ], 
        "name": "Nature Biotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "keywords": [
      "phase 1 clinical study", 
      "age-related macular degeneration", 
      "retinal pigment epithelium", 
      "clinical studies", 
      "macular degeneration", 
      "pigment epithelium", 
      "stem cells", 
      "patients", 
      "human embryonic stem cells", 
      "degeneration", 
      "epithelium", 
      "embryonic stem cells", 
      "eyes", 
      "cells", 
      "study", 
      "patches", 
      "engineered patch", 
      "embryonic stem cell\u2013derived retinal pigment epithelium patch", 
      "stem cell\u2013derived retinal pigment epithelium patch", 
      "cell\u2013derived retinal pigment epithelium patch", 
      "retinal pigment epithelium patch", 
      "pigment epithelium patch", 
      "epithelium patch"
    ], 
    "name": "Phase 1 clinical study of an embryonic stem cell\u2013derived retinal pigment epithelium patch in age-related macular degeneration", 
    "pagination": "328-337", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101559880"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nbt.4114"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29553577"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nbt.4114", 
      "https://app.dimensions.ai/details/publication/pub.1101559880"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_772.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nbt.4114"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt.4114'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt.4114'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt.4114'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt.4114'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      53 URIs      41 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nbt.4114 schema:author Na99609d280b34780be6ce89e3cdaad8b
2 schema:citation sg:pub.10.1007/978-1-62703-080-9_20
3 sg:pub.10.1007/978-3-540-71994-6
4 sg:pub.10.1007/s00417-009-1201-8
5 sg:pub.10.1038/nbt1318
6 sg:pub.10.1038/s41598-017-00142-7
7 sg:pub.10.1038/sj.clpt.6100321
8 schema:datePublished 2018-03-19
9 schema:datePublishedReg 2018-03-19
10 schema:description An engineered patch of retinal pigment epithelium generated from human embryonic stem cells is transplanted into the eyes of two patients.
11 schema:genre article
12 schema:inLanguage en
13 schema:isAccessibleForFree true
14 schema:isPartOf Nb02d56313b6b4150bbf66ef7edabe54d
15 Nb20ebc4c9a7f471286cd4398c62ab78a
16 sg:journal.1115214
17 schema:keywords age-related macular degeneration
18 cells
19 cell–derived retinal pigment epithelium patch
20 clinical studies
21 degeneration
22 embryonic stem cells
23 embryonic stem cell–derived retinal pigment epithelium patch
24 engineered patch
25 epithelium
26 epithelium patch
27 eyes
28 human embryonic stem cells
29 macular degeneration
30 patches
31 patients
32 phase 1 clinical study
33 pigment epithelium
34 pigment epithelium patch
35 retinal pigment epithelium
36 retinal pigment epithelium patch
37 stem cells
38 stem cell–derived retinal pigment epithelium patch
39 study
40 schema:name Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration
41 schema:pagination 328-337
42 schema:productId N5fef72bc9c794286a90f20a8707b5a2e
43 N725e061be2cb4176aad8b5582744e718
44 N81aefa480ae340daa934fb02b0a65000
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101559880
46 https://doi.org/10.1038/nbt.4114
47 schema:sdDatePublished 2022-01-01T18:48
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N7366bd95f73946048305093349971de1
50 schema:url https://doi.org/10.1038/nbt.4114
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N17ea2e5044c84455b632b9d25c47972f schema:affiliation grid-institutes:grid.83440.3b
55 schema:familyName Vernon
56 schema:givenName Amanda
57 rdf:type schema:Person
58 N18d39fa113124a81a71521d8929e6b0b rdf:first N6773bacbd3cc43f08c740376bf9e3c9f
59 rdf:rest Nbdbd6b053cb64fa292c1603c7ce74158
60 N1ebc189790d640989dae2231bde37937 rdf:first sg:person.01237630270.07
61 rdf:rest Nb016bdae032d4b98ae6c70ba6393b6c4
62 N2a244ce05a5446f6ad10918fc62f1bb9 rdf:first sg:person.01332575620.36
63 rdf:rest N67e616661f604e499aa74886130a4c41
64 N2c2571a920fa407dbdcfa3300b408a81 schema:affiliation grid-institutes:grid.418566.8
65 schema:familyName Fenster
66 schema:givenName Mike
67 rdf:type schema:Person
68 N32be3cce64174880bdf35f5b3254ec0c rdf:first sg:person.0760711427.06
69 rdf:rest N6fab67ee10574789bc50a7cc81b7447a
70 N3d2e5b6d2315490cbefe94371d93340b rdf:first N3ea04c44d4ad4838b9071e6c84c74a9a
71 rdf:rest N1ebc189790d640989dae2231bde37937
72 N3ea04c44d4ad4838b9071e6c84c74a9a schema:affiliation grid-institutes:grid.418566.8
73 schema:familyName Harbinson
74 schema:givenName Tricia
75 rdf:type schema:Person
76 N4814089b60e14843a3256f30d9f2b032 rdf:first sg:person.011076130257.92
77 rdf:rest N58df17ba7cb1428598c2fb9ec81b7d30
78 N58df17ba7cb1428598c2fb9ec81b7d30 rdf:first sg:person.07450630137.43
79 rdf:rest rdf:nil
80 N5a7ad3ba820f45d5a6d8029906005df8 rdf:first sg:person.015666217311.02
81 rdf:rest N3d2e5b6d2315490cbefe94371d93340b
82 N5fef72bc9c794286a90f20a8707b5a2e schema:name dimensions_id
83 schema:value pub.1101559880
84 rdf:type schema:PropertyValue
85 N669b7273bde94014bf03f3f9a6d7456a rdf:first sg:person.016010741722.38
86 rdf:rest Nfdc43aaad60243efaf8822617851b13f
87 N6773bacbd3cc43f08c740376bf9e3c9f schema:affiliation grid-institutes:grid.436474.6
88 schema:familyName Luo
89 schema:givenName Yvonne H
90 rdf:type schema:Person
91 N67e616661f604e499aa74886130a4c41 rdf:first sg:person.012464315752.27
92 rdf:rest Ne0c848862300420393645f26074f197d
93 N67eabc0d588f428d8bdc7096a21edb76 rdf:first N17ea2e5044c84455b632b9d25c47972f
94 rdf:rest N669b7273bde94014bf03f3f9a6d7456a
95 N6945ed655d81407ba36ad1febc99e1b4 rdf:first sg:person.010173450124.24
96 rdf:rest Nc58f6e6f09f5477dbfa2d4eaa74fe4ff
97 N6fab67ee10574789bc50a7cc81b7447a rdf:first sg:person.01015034603.79
98 rdf:rest Ndeed01518eb1433e82391cb3fe55166f
99 N725e061be2cb4176aad8b5582744e718 schema:name doi
100 schema:value 10.1038/nbt.4114
101 rdf:type schema:PropertyValue
102 N728c39523e864e94a3087ee56554bf78 rdf:first sg:person.01350031470.68
103 rdf:rest Naef5c2d1d3544b32b0f0d80ee1c08a0a
104 N7366bd95f73946048305093349971de1 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N81aefa480ae340daa934fb02b0a65000 schema:name pubmed_id
107 schema:value 29553577
108 rdf:type schema:PropertyValue
109 N948123e37d11400c9ac654b700d983f7 rdf:first sg:person.01240650356.13
110 rdf:rest N2a244ce05a5446f6ad10918fc62f1bb9
111 N9918e5c5e3034733b6ca1822f6660fd1 rdf:first sg:person.01175460321.40
112 rdf:rest Nea6721c512bf4771bbb664b627757945
113 Na99609d280b34780be6ce89e3cdaad8b rdf:first sg:person.0630215443.42
114 rdf:rest N728c39523e864e94a3087ee56554bf78
115 Naef5c2d1d3544b32b0f0d80ee1c08a0a rdf:first sg:person.010142471713.43
116 rdf:rest Ne36a69eff83546318751b1c3bec2e5d1
117 Nb016bdae032d4b98ae6c70ba6393b6c4 rdf:first sg:person.0744062507.00
118 rdf:rest N6945ed655d81407ba36ad1febc99e1b4
119 Nb02d56313b6b4150bbf66ef7edabe54d schema:volumeNumber 36
120 rdf:type schema:PublicationVolume
121 Nb20ebc4c9a7f471286cd4398c62ab78a schema:issueNumber 4
122 rdf:type schema:PublicationIssue
123 Nbdbd6b053cb64fa292c1603c7ce74158 rdf:first sg:person.016164070217.29
124 rdf:rest N67eabc0d588f428d8bdc7096a21edb76
125 Nc58f6e6f09f5477dbfa2d4eaa74fe4ff rdf:first sg:person.0717772741.14
126 rdf:rest Nfeeaab1554d844b0aa2f3692828333e0
127 Ndeed01518eb1433e82391cb3fe55166f rdf:first N2c2571a920fa407dbdcfa3300b408a81
128 rdf:rest N5a7ad3ba820f45d5a6d8029906005df8
129 Ne0c848862300420393645f26074f197d rdf:first sg:person.01163055604.81
130 rdf:rest N32be3cce64174880bdf35f5b3254ec0c
131 Ne36a69eff83546318751b1c3bec2e5d1 rdf:first sg:person.0624552066.67
132 rdf:rest N18d39fa113124a81a71521d8929e6b0b
133 Nea6721c512bf4771bbb664b627757945 rdf:first sg:person.0750714660.64
134 rdf:rest N4814089b60e14843a3256f30d9f2b032
135 Nf0af05d640174879b8a9a920fa9b9e8b rdf:first sg:person.01041031123.29
136 rdf:rest N9918e5c5e3034733b6ca1822f6660fd1
137 Nfdc43aaad60243efaf8822617851b13f rdf:first sg:person.0727241514.52
138 rdf:rest N948123e37d11400c9ac654b700d983f7
139 Nfeeaab1554d844b0aa2f3692828333e0 rdf:first sg:person.01046761052.49
140 rdf:rest Nf0af05d640174879b8a9a920fa9b9e8b
141 sg:grant.2755492 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.4114
142 rdf:type schema:MonetaryGrant
143 sg:journal.1115214 schema:issn 1087-0156
144 1546-1696
145 schema:name Nature Biotechnology
146 schema:publisher Springer Nature
147 rdf:type schema:Periodical
148 sg:person.010142471713.43 schema:affiliation grid-institutes:grid.436474.6
149 schema:familyName Georgiadis
150 schema:givenName Odysseas
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010142471713.43
152 rdf:type schema:Person
153 sg:person.01015034603.79 schema:affiliation grid-institutes:grid.418566.8
154 schema:familyName Bictash
155 schema:givenName Magda
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015034603.79
157 rdf:type schema:Person
158 sg:person.010173450124.24 schema:affiliation grid-institutes:grid.418566.8
159 schema:familyName Feng
160 schema:givenName Gang
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010173450124.24
162 rdf:type schema:Person
163 sg:person.01041031123.29 schema:affiliation grid-institutes:grid.436474.6
164 schema:familyName Holder
165 schema:givenName Graham E
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041031123.29
167 rdf:type schema:Person
168 sg:person.01046761052.49 schema:affiliation grid-institutes:grid.436474.6
169 schema:familyName Robson
170 schema:givenName Anthony G
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046761052.49
172 rdf:type schema:Person
173 sg:person.011076130257.92 schema:affiliation grid-institutes:grid.436283.8
174 schema:familyName Whiting
175 schema:givenName Paul
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076130257.92
177 rdf:type schema:Person
178 sg:person.01163055604.81 schema:affiliation grid-institutes:grid.83440.3b
179 schema:familyName Vugler
180 schema:givenName Anthony
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163055604.81
182 rdf:type schema:Person
183 sg:person.01175460321.40 schema:affiliation grid-institutes:grid.436474.6
184 schema:familyName Sagoo
185 schema:givenName Mandeep S
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175460321.40
187 rdf:type schema:Person
188 sg:person.01237630270.07 schema:affiliation grid-institutes:grid.418566.8
189 schema:familyName Wilbrey
190 schema:givenName Anna
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237630270.07
192 rdf:type schema:Person
193 sg:person.01240650356.13 schema:affiliation grid-institutes:grid.83440.3b
194 schema:familyName Hasan
195 schema:givenName Shazeen M
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240650356.13
197 rdf:type schema:Person
198 sg:person.012464315752.27 schema:affiliation grid-institutes:grid.83440.3b
199 schema:familyName Carr
200 schema:givenName Amanda-Jayne F
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012464315752.27
202 rdf:type schema:Person
203 sg:person.01332575620.36 schema:affiliation grid-institutes:grid.83440.3b
204 schema:familyName Gooljar
205 schema:givenName Sakina B
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332575620.36
207 rdf:type schema:Person
208 sg:person.01350031470.68 schema:affiliation grid-institutes:grid.83440.3b
209 schema:familyName Fynes
210 schema:givenName Kate
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350031470.68
212 rdf:type schema:Person
213 sg:person.015666217311.02 schema:affiliation grid-institutes:grid.418566.8
214 schema:familyName Steer
215 schema:givenName Juliette
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015666217311.02
217 rdf:type schema:Person
218 sg:person.016010741722.38 schema:affiliation grid-institutes:grid.83440.3b
219 schema:familyName Daniels
220 schema:givenName Julie T
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016010741722.38
222 rdf:type schema:Person
223 sg:person.016164070217.29 schema:affiliation grid-institutes:grid.83440.3b
224 schema:familyName Ahmado
225 schema:givenName Ahmad
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016164070217.29
227 rdf:type schema:Person
228 sg:person.0624552066.67 schema:affiliation grid-institutes:grid.502751.4
229 schema:familyName Kerby
230 schema:givenName Julie
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624552066.67
232 rdf:type schema:Person
233 sg:person.0630215443.42 schema:affiliation grid-institutes:grid.497851.6
234 schema:familyName da Cruz
235 schema:givenName Lyndon
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630215443.42
237 rdf:type schema:Person
238 sg:person.0717772741.14 schema:affiliation grid-institutes:grid.418566.8
239 schema:familyName Whitlock
240 schema:givenName Mark
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717772741.14
242 rdf:type schema:Person
243 sg:person.0727241514.52 schema:affiliation grid-institutes:grid.83440.3b
244 schema:familyName Nommiste
245 schema:givenName Britta
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727241514.52
247 rdf:type schema:Person
248 sg:person.0744062507.00 schema:affiliation grid-institutes:grid.436474.6
249 schema:familyName Tufail
250 schema:givenName Adnan
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744062507.00
252 rdf:type schema:Person
253 sg:person.07450630137.43 schema:affiliation grid-institutes:None
254 schema:familyName Coffey
255 schema:givenName Peter J
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07450630137.43
257 rdf:type schema:Person
258 sg:person.0750714660.64 schema:affiliation grid-institutes:grid.418566.8
259 schema:familyName Loudon
260 schema:givenName Peter T
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750714660.64
262 rdf:type schema:Person
263 sg:person.0760711427.06 schema:affiliation grid-institutes:grid.436474.6
264 schema:familyName Ramsden
265 schema:givenName Conor M
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760711427.06
267 rdf:type schema:Person
268 sg:pub.10.1007/978-1-62703-080-9_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012815559
269 https://doi.org/10.1007/978-1-62703-080-9_20
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/978-3-540-71994-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019188449
272 https://doi.org/10.1007/978-3-540-71994-6
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s00417-009-1201-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022137162
275 https://doi.org/10.1007/s00417-009-1201-8
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nbt1318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033397919
278 https://doi.org/10.1038/nbt1318
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/s41598-017-00142-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084130279
281 https://doi.org/10.1038/s41598-017-00142-7
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/sj.clpt.6100321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543923
284 https://doi.org/10.1038/sj.clpt.6100321
285 rdf:type schema:CreativeWork
286 grid-institutes:None schema:alternateName Center for Stem Cell Biology and Engineering, NRI, UC, Santa Barbara, California, USA
287 schema:name Center for Stem Cell Biology and Engineering, NRI, UC, Santa Barbara, California, USA
288 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK
289 The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK
290 rdf:type schema:Organization
291 grid-institutes:grid.418566.8 schema:alternateName Pfizer, Granta Park, Cambridge, UK
292 schema:name Pfizer, Granta Park, Cambridge, UK
293 rdf:type schema:Organization
294 grid-institutes:grid.436283.8 schema:alternateName UCL Institute of Neurology, Queen Square, London, UK
295 schema:name Pfizer, Granta Park, Cambridge, UK
296 UCL Institute of Neurology, Queen Square, London, UK
297 rdf:type schema:Organization
298 grid-institutes:grid.436474.6 schema:alternateName Moorfields Eye Hospital NHS Foundation Trust, London, UK
299 schema:name Moorfields Eye Hospital NHS Foundation Trust, London, UK
300 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK
301 The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK
302 rdf:type schema:Organization
303 grid-institutes:grid.497851.6 schema:alternateName Wellcome/EPSRC Centre for Interventional & Surgical Sciences (WEISS), Charles Bell House, London, UK
304 schema:name Moorfields Eye Hospital NHS Foundation Trust, London, UK
305 NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, UCL Institute of Ophthalmology, London, UK
306 The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK
307 Wellcome/EPSRC Centre for Interventional & Surgical Sciences (WEISS), Charles Bell House, London, UK
308 rdf:type schema:Organization
309 grid-institutes:grid.502751.4 schema:alternateName Cell and Gene Therapy Catapult, London, UK
310 schema:name Cell and Gene Therapy Catapult, London, UK
311 Pfizer, Granta Park, Cambridge, UK
312 rdf:type schema:Organization
313 grid-institutes:grid.83440.3b schema:alternateName Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK
314 The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK
315 schema:name Cells for Sight, Transplantation & Research Program, UCL Institute of Ophthalmology, London, UK
316 The London Project to Cure Blindness, ORBIT, Institute of Ophthalmology, University College London (UCL), London, UK
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...