Highly efficient RNA-guided base editing in mouse embryos View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-27

AUTHORS

Kyoungmi Kim, Seuk-Min Ryu, Sang-Tae Kim, Gayoung Baek, Daesik Kim, Kayeong Lim, Eugene Chung, Sunghyun Kim, Jin-Soo Kim

ABSTRACT

Base editors (BEs) composed of a cytidine deaminase fused to CRISPR-Cas9 convert cytidine to uridine, leading to single-base-pair substitutions in eukaryotic cells. We delivered BE mRNA or ribonucleoproteins targeting the Dmd or Tyr gene via electroporation or microinjection into mouse zygotes. F0 mice showed nonsense mutations with an efficiency of 44-57% and allelic frequencies of up to 100%, demonstrating an efficient method to generate mice with targeted point mutations. More... »

PAGES

435-437

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.3816

DOI

http://dx.doi.org/10.1038/nbt.3816

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084128652

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28244995


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