Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-27

AUTHORS

Yuan Zong, Yanpeng Wang, Chao Li, Rui Zhang, Kunling Chen, Yidong Ran, Jin-Long Qiu, Daowen Wang, Caixia Gao

ABSTRACT

Targeted base editing in plants without the need for a foreign DNA donor or double-stranded DNA cleavage would accelerate genome modification and breeding in a wide array of crops. We used a CRISPR-Cas9 nickase-cytidine deaminase fusion to achieve targeted conversion of cytosine to thymine from position 3 to 9 within the protospacer in both protoplasts and regenerated rice, wheat and maize plants at frequencies of up to 43.48%. More... »

PAGES

438-440

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.3811

DOI

http://dx.doi.org/10.1038/nbt.3811

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084128647

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28244994


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