Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-27

AUTHORS

Benjamin P Kleinstiver, Shengdar Q Tsai, Michelle S Prew, Nhu T Nguyen, Moira M Welch, Jose M Lopez, Zachary R McCaw, Martin J Aryee, J Keith Joung

ABSTRACT

On-target activities and genome-wide specificities of Cpf1 nucleases in human cells.

PAGES

869-874

References to SciGraph publications

  • 2014-03-02. CRISPR-Cas systems for editing, regulating and targeting genomes in NATURE BIOTECHNOLOGY
  • 2015-11-17. The Cpf1 CRISPR-Cas protein expands genome-editing tools in GENOME BIOLOGY
  • 2015-10-19. DNA-binding-domain fusions enhance the targeting range and precision of Cas9 in NATURE METHODS
  • 2011-03-30. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III in NATURE
  • 2016-01-06. High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects in NATURE
  • 2015-01-19. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors in NATURE BIOTECHNOLOGY
  • 2012-04-08. FLASH assembly of TALENs for high-throughput genome editing in NATURE BIOTECHNOLOGY
  • 2015-11-24. Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications in GENOME BIOLOGY
  • 2014-12-16. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases in NATURE BIOTECHNOLOGY
  • 2016-05-06. Open-source guideseq software for analysis of GUIDE-seq data in NATURE BIOTECHNOLOGY
  • 2015-11-02. Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition in NATURE BIOTECHNOLOGY
  • 2015-09-28. An updated evolutionary classification of CRISPR–Cas systems in NATURE REVIEWS MICROBIOLOGY
  • 2014-04-25. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2014-12-15. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases in NATURE BIOTECHNOLOGY
  • 2014-01-26. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs in NATURE BIOTECHNOLOGY
  • 2016-02-01. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo in NATURE BIOTECHNOLOGY
  • 2015-06-22. Engineered CRISPR-Cas9 nucleases with altered PAM specificities in NATURE
  • 2015-02-09. Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells in NATURE METHODS
  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    8

    VOLUME

    34

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.3620

    DOI

    http://dx.doi.org/10.1038/nbt.3620

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037993467

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27347757


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