DNA-guided genome editing using the Natronobacterium gregoryi Argonaute View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05-02

AUTHORS

Feng Gao, Xiao Z Shen, Feng Jiang, Yongqiang Wu, Chunyu Han

ABSTRACT

The RNA-guided endonuclease Cas9 has made genome editing a widely accessible technique. Similar to Cas9, endonucleases from the Argonaute protein family also use oligonucleotides as guides to degrade invasive genomes. Here we report that the Natronobacterium gregoryi Argonaute (NgAgo) is a DNA-guided endonuclease suitable for genome editing in human cells. NgAgo binds 5' phosphorylated single-stranded guide DNA (gDNA) of ∼24 nucleotides, efficiently creates site-specific DNA double-strand breaks when loaded with the gDNA. The NgAgo-gDNA system does not require a protospacer-adjacent motif (PAM), as does Cas9, and preliminary characterization suggests a low tolerance to guide-target mismatches and high efficiency in editing (G+C)-rich genomic targets. More... »

PAGES

768

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.3547

DOI

http://dx.doi.org/10.1038/nbt.3547

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047211077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27136078


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