CRISPR-Cas systems for editing, regulating and targeting genomes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

Jeffry D Sander, J Keith Joung

ABSTRACT

Targeted genome editing using engineered nucleases has rapidly gone from being a niche technology to a mainstream method used by many biological researchers. This widespread adoption has been largely fueled by the emergence of the clustered, regularly interspaced, short palindromic repeat (CRISPR) technology, an important new approach for generating RNA-guided nucleases, such as Cas9, with customizable specificities. Genome editing mediated by these nucleases has been used to rapidly, easily and efficiently modify endogenous genes in a wide variety of biomedically important cell types and in organisms that have traditionally been challenging to manipulate genetically. Furthermore, a modified version of the CRISPR-Cas9 system has been developed to recruit heterologous domains that can regulate endogenous gene expression or label specific genomic loci in living cells. Although the genome-wide specificities of CRISPR-Cas9 systems remain to be fully defined, the power of these systems to perform targeted, highly efficient alterations of genome sequence and gene expression will undoubtedly transform biological research and spur the development of novel molecular therapeutics for human disease. More... »

PAGES

347-355

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  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    4

    VOLUME

    32

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.2842

    DOI

    http://dx.doi.org/10.1038/nbt.2842

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038520013

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24584096


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