Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Irène Baccelli, Andreas Schneeweiss, Sabine Riethdorf, Albrecht Stenzinger, Anja Schillert, Vanessa Vogel, Corinna Klein, Massimo Saini, Tobias Bäuerle, Markus Wallwiener, Tim Holland-Letz, Thomas Höfner, Martin Sprick, Martina Scharpff, Frederik Marmé, Hans Peter Sinn, Klaus Pantel, Wilko Weichert, Andreas Trumpp

ABSTRACT

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is an indicator of poor prognosis in several carcinoma entities, the existence and phenotype of metastasis-initiating cells (MICs) among CTCs has not been experimentally demonstrated. Here we developed a xenograft assay and used it to show that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice. These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET. In a small cohort of patients with metastases, the number of EPCAM(+)CD44(+)CD47(+)MET(+) CTCs, but not of bulk EPCAM(+) CTCs, correlated with lower overall survival and increased number of metastasic sites. These data describe functional circulating MICs and associated markers, which may aid the design of better tools to diagnose and treat metastatic breast cancer. More... »

PAGES

539

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.2576

DOI

http://dx.doi.org/10.1038/nbt.2576

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051440749

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23609047


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Cells, Circulating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baccelli", 
        "givenName": "Ir\u00e8ne", 
        "id": "sg:person.01125564233.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125564233.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneeweiss", 
        "givenName": "Andreas", 
        "id": "sg:person.01321116407.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321116407.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Tumor Biology, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riethdorf", 
        "givenName": "Sabine", 
        "id": "sg:person.0737522203.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737522203.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stenzinger", 
        "givenName": "Albrecht", 
        "id": "sg:person.0642700650.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schillert", 
        "givenName": "Anja", 
        "id": "sg:person.01356241233.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356241233.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.", 
            "Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogel", 
        "givenName": "Vanessa", 
        "id": "sg:person.0632635133.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632635133.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Corinna", 
        "id": "sg:person.0700750333.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700750333.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg Institute for Stem Cell Technology and Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.482664.a", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saini", 
        "givenName": "Massimo", 
        "id": "sg:person.0747063533.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747063533.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Medical Physics in Radiology, DKFZ, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "B\u00e4uerle", 
        "givenName": "Tobias", 
        "id": "sg:person.01174610520.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174610520.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wallwiener", 
        "givenName": "Markus", 
        "id": "sg:person.0724672011.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724672011.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Biostatistics, DKFZ, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holland-Letz", 
        "givenName": "Tim", 
        "id": "sg:person.01342734010.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342734010.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f6fner", 
        "givenName": "Thomas", 
        "id": "sg:person.01102064441.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102064441.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sprick", 
        "givenName": "Martin", 
        "id": "sg:person.0664160435.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664160435.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scharpff", 
        "givenName": "Martina", 
        "id": "sg:person.01135011746.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135011746.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marm\u00e9", 
        "givenName": "Frederik", 
        "id": "sg:person.01342233540.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342233540.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sinn", 
        "givenName": "Hans Peter", 
        "id": "sg:person.01347112471.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347112471.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Tumor Biology, Universit\u00e4tsklinikum Hamburg-Eppendorf, Hamburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pantel", 
        "givenName": "Klaus", 
        "id": "sg:person.01112361603.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112361603.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weichert", 
        "givenName": "Wilko", 
        "id": "sg:person.0657434205.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.", 
            "Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.", 
            "German Cancer Consortium, Heidelberg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trumpp", 
        "givenName": "Andreas", 
        "id": "sg:person.01035704764.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035704764.63"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002235630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002993405", 
          "https://doi.org/10.1038/nrm3012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002993405", 
          "https://doi.org/10.1038/nrm3012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.07.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006096408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2010.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006097930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906549106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006171690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906549106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006171690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201202014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008525908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009055747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.05.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010587660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1012539107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012852520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1228522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013110936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2012.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014539889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0530291100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018724794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019406366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdn786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019406366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-2042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020064288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020158834", 
          "https://doi.org/10.1038/nrc2622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020158834", 
          "https://doi.org/10.1038/nrc2622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021371367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201010021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022367381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr3099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022859552", 
          "https://doi.org/10.1186/bcr3099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023057659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006732107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023408641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006732107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023408641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1121629109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024026172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024802170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-04-1417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025843647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026279478", 
          "https://doi.org/10.1038/nature06385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026879393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026879393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028112819", 
          "https://doi.org/10.1038/nrc3171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0033788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032135069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032774444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.28.7045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033931920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2001-12-0207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035575608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1121623109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035761828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1121623109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035761828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036752523", 
          "https://doi.org/10.1038/nbt.2295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037538258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041233330", 
          "https://doi.org/10.1038/nature05236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041233330", 
          "https://doi.org/10.1038/nature05236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041233330", 
          "https://doi.org/10.1038/nature05236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042231533", 
          "https://doi.org/10.1038/nrclinonc.2009.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042231533", 
          "https://doi.org/10.1038/nrclinonc.2009.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043103741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046514044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048356671", 
          "https://doi.org/10.1038/nrc3205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.242602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048510702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048972336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048972336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049695125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049979157", 
          "https://doi.org/10.1038/nm886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049979157", 
          "https://doi.org/10.1038/nm886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050054921"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is an indicator of poor prognosis in several carcinoma entities, the existence and phenotype of metastasis-initiating cells (MICs) among CTCs has not been experimentally demonstrated. Here we developed a xenograft assay and used it to show that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice. These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET. In a small cohort of patients with metastases, the number of EPCAM(+)CD44(+)CD47(+)MET(+) CTCs, but not of bulk EPCAM(+) CTCs, correlated with lower overall survival and increased number of metastasic sites. These data describe functional circulating MICs and associated markers, which may aid the design of better tools to diagnose and treat metastatic breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nbt.2576", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3783348", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115214", 
        "issn": [
          "1087-0156", 
          "1546-1696"
        ], 
        "name": "Nature Biotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay", 
    "pagination": "539", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f50ad203504c7c1e2a7a975fd9fccdb7b0a14239e082fac8eee9f771bf28f41c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23609047"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9604648"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nbt.2576"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051440749"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nbt.2576", 
      "https://app.dimensions.ai/details/publication/pub.1051440749"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nbt.2576"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt.2576'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt.2576'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt.2576'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt.2576'


 

This table displays all metadata directly associated to this object as RDF triples.

416 TRIPLES      21 PREDICATES      88 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nbt.2576 schema:about N11a138985398447f8686c3e1d7ac1457
2 N11bf44db6b394a10b6651bd51e76115e
3 N11c4649b74ac46b3b1fb97d6adf17e06
4 N126307c756b841c3a0331f240cf24fc2
5 N1ed07b502a8d42b0a20027a0693b62e0
6 N4c95f1ab7b57473ba70734bf7d9d27c2
7 N59adf9d3364e4cd9ad1615ed13f62bfc
8 N7b1e20ef77fa465a8e7d6c0befc47c74
9 N7ce4d61806d946e8a34bb3703219a14b
10 N86ed65fddf41484cab57dffdef0c84c6
11 N8f3604c17a9d4f86bc921fd36b7ab0a8
12 Na8a6ac0523a44366a11b6a0dbf5bff78
13 Nb69a677a28904606b67855289362dc66
14 Nbb47b40e9d5e462280b5f4ff1073a381
15 Ne84d016e4cd84339a69e11115918793a
16 Ne99b82712ff249b3ad5440a314a115bd
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N9354c3d577024d86be16f57b597df40b
20 schema:citation sg:pub.10.1038/nature05236
21 sg:pub.10.1038/nature06385
22 sg:pub.10.1038/nbt.2295
23 sg:pub.10.1038/nm886
24 sg:pub.10.1038/nrc2622
25 sg:pub.10.1038/nrc3171
26 sg:pub.10.1038/nrc3205
27 sg:pub.10.1038/nrclinonc.2009.44
28 sg:pub.10.1038/nrm3012
29 sg:pub.10.1186/bcr3099
30 https://doi.org/10.1016/j.cell.2009.05.045
31 https://doi.org/10.1016/j.cell.2009.11.025
32 https://doi.org/10.1016/j.cell.2010.07.044
33 https://doi.org/10.1016/j.cell.2011.11.025
34 https://doi.org/10.1016/j.coi.2012.01.010
35 https://doi.org/10.1016/j.ejca.2010.02.024
36 https://doi.org/10.1016/j.semcancer.2010.12.003
37 https://doi.org/10.1056/nejmoa040766
38 https://doi.org/10.1056/nejmoa050434
39 https://doi.org/10.1073/pnas.0530291100
40 https://doi.org/10.1073/pnas.0906549106
41 https://doi.org/10.1073/pnas.1006732107
42 https://doi.org/10.1073/pnas.1012539107
43 https://doi.org/10.1073/pnas.1121623109
44 https://doi.org/10.1073/pnas.1121629109
45 https://doi.org/10.1083/jcb.201010021
46 https://doi.org/10.1083/jcb.201202014
47 https://doi.org/10.1093/annonc/mdn786
48 https://doi.org/10.1101/gad.242602
49 https://doi.org/10.1126/science.1228522
50 https://doi.org/10.1158/0008-5472.can-10-2238
51 https://doi.org/10.1158/1078-0432.ccr-05-1769
52 https://doi.org/10.1158/1078-0432.ccr-06-1695
53 https://doi.org/10.1158/1078-0432.ccr-08-0872
54 https://doi.org/10.1158/1078-0432.ccr-09-2042
55 https://doi.org/10.1158/1078-0432.ccr-10-0349
56 https://doi.org/10.1172/jci39104
57 https://doi.org/10.1172/jci43414
58 https://doi.org/10.1182/blood-2001-12-0207
59 https://doi.org/10.1182/blood-2005-04-1417
60 https://doi.org/10.1200/jco.2010.28.7045
61 https://doi.org/10.1371/journal.pone.0033788
62 https://doi.org/10.3322/caac.20107
63 schema:datePublished 2013-06
64 schema:datePublishedReg 2013-06-01
65 schema:description It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is an indicator of poor prognosis in several carcinoma entities, the existence and phenotype of metastasis-initiating cells (MICs) among CTCs has not been experimentally demonstrated. Here we developed a xenograft assay and used it to show that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice. These MIC-containing CTC populations expressed EPCAM, CD44, CD47 and MET. In a small cohort of patients with metastases, the number of EPCAM(+)CD44(+)CD47(+)MET(+) CTCs, but not of bulk EPCAM(+) CTCs, correlated with lower overall survival and increased number of metastasic sites. These data describe functional circulating MICs and associated markers, which may aid the design of better tools to diagnose and treat metastatic breast cancer.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree false
69 schema:isPartOf N7cc3f9fbc66b4bdba5f8a8ab001cb55f
70 Nb84152a6a8e1434f89997c0c39a4706c
71 sg:journal.1115214
72 schema:name Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
73 schema:pagination 539
74 schema:productId N319306c897904474bdbb1b3816a9f0e3
75 N320ffb09e00648dd831af8824e9dcce5
76 N9d531dc2d15248dc8796435cab7d9321
77 Na7c090dfe8474c27b116a891f9a8eaed
78 Nebcf1ded8b114831aa4f7984c0fc6e19
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051440749
80 https://doi.org/10.1038/nbt.2576
81 schema:sdDatePublished 2019-04-10T16:30
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N183a208dac6c4a3cbc84daa7b538822d
84 schema:url https://www.nature.com/articles/nbt.2576
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N00f4d499157d4d47b8c02cfb98f0b9af rdf:first sg:person.0724672011.05
89 rdf:rest N27dd57e5e6cc4c2db95812284f71151a
90 N11a138985398447f8686c3e1d7ac1457 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Middle Aged
92 rdf:type schema:DefinedTerm
93 N11bf44db6b394a10b6651bd51e76115e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cell Line, Tumor
95 rdf:type schema:DefinedTerm
96 N11c4649b74ac46b3b1fb97d6adf17e06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N126307c756b841c3a0331f240cf24fc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Gene Expression Regulation, Neoplastic
101 rdf:type schema:DefinedTerm
102 N183a208dac6c4a3cbc84daa7b538822d schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N1c525c977e2f42648ffacc7b66a19a4f rdf:first sg:person.0664160435.08
105 rdf:rest N2962bc5fdbd143fb99e960c5add7dcce
106 N1ed07b502a8d42b0a20027a0693b62e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Mice
108 rdf:type schema:DefinedTerm
109 N23d841dc316241b49c4c8059aa1ec71b rdf:first sg:person.01347112471.45
110 rdf:rest N47301266fa6743339a4f4f3119414bb2
111 N27dd57e5e6cc4c2db95812284f71151a rdf:first sg:person.01342734010.26
112 rdf:rest N8f80ec7ca8564442a74773f1e495612a
113 N2962bc5fdbd143fb99e960c5add7dcce rdf:first sg:person.01135011746.65
114 rdf:rest Ne263fa2c36b34eb493390e8854539809
115 N2c03173b6874458291da4e48b4bf630a rdf:first sg:person.0642700650.98
116 rdf:rest N4cef506355e349b09ffb75704f571b17
117 N319306c897904474bdbb1b3816a9f0e3 schema:name readcube_id
118 schema:value f50ad203504c7c1e2a7a975fd9fccdb7b0a14239e082fac8eee9f771bf28f41c
119 rdf:type schema:PropertyValue
120 N320ffb09e00648dd831af8824e9dcce5 schema:name dimensions_id
121 schema:value pub.1051440749
122 rdf:type schema:PropertyValue
123 N3b009fb76a2f4dcd9100df3dafa70756 rdf:first sg:person.0657434205.21
124 rdf:rest Nbee9572cdbe14da9a634bed83e9f9b33
125 N47301266fa6743339a4f4f3119414bb2 rdf:first sg:person.01112361603.18
126 rdf:rest N3b009fb76a2f4dcd9100df3dafa70756
127 N4c95f1ab7b57473ba70734bf7d9d27c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Prognosis
129 rdf:type schema:DefinedTerm
130 N4cef506355e349b09ffb75704f571b17 rdf:first sg:person.01356241233.12
131 rdf:rest Nb8563dea5df348818d136b44d334ea85
132 N59adf9d3364e4cd9ad1615ed13f62bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Biomarkers, Tumor
134 rdf:type schema:DefinedTerm
135 N7b1e20ef77fa465a8e7d6c0befc47c74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Female
137 rdf:type schema:DefinedTerm
138 N7cc3f9fbc66b4bdba5f8a8ab001cb55f schema:volumeNumber 31
139 rdf:type schema:PublicationVolume
140 N7ce4d61806d946e8a34bb3703219a14b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Breast Neoplasms
142 rdf:type schema:DefinedTerm
143 N86ed65fddf41484cab57dffdef0c84c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Neoplastic Cells, Circulating
145 rdf:type schema:DefinedTerm
146 N8c50fe29a5d2448b8a062d4fbfaa2604 rdf:first sg:person.01174610520.68
147 rdf:rest N00f4d499157d4d47b8c02cfb98f0b9af
148 N8f3604c17a9d4f86bc921fd36b7ab0a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Neoplasm Metastasis
150 rdf:type schema:DefinedTerm
151 N8f80ec7ca8564442a74773f1e495612a rdf:first sg:person.01102064441.73
152 rdf:rest N1c525c977e2f42648ffacc7b66a19a4f
153 N9354c3d577024d86be16f57b597df40b rdf:first sg:person.01125564233.21
154 rdf:rest Nd2e7802276ee466f83b560486f820a33
155 N9d531dc2d15248dc8796435cab7d9321 schema:name pubmed_id
156 schema:value 23609047
157 rdf:type schema:PropertyValue
158 Na7c090dfe8474c27b116a891f9a8eaed schema:name nlm_unique_id
159 schema:value 9604648
160 rdf:type schema:PropertyValue
161 Na8a6ac0523a44366a11b6a0dbf5bff78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Adult
163 rdf:type schema:DefinedTerm
164 Nb69a677a28904606b67855289362dc66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Xenograft Model Antitumor Assays
166 rdf:type schema:DefinedTerm
167 Nb84152a6a8e1434f89997c0c39a4706c schema:issueNumber 6
168 rdf:type schema:PublicationIssue
169 Nb8563dea5df348818d136b44d334ea85 rdf:first sg:person.0632635133.80
170 rdf:rest Nc1ed7d14a805403a82a8dcede25c3902
171 Nbb47b40e9d5e462280b5f4ff1073a381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aged
173 rdf:type schema:DefinedTerm
174 Nbee9572cdbe14da9a634bed83e9f9b33 rdf:first sg:person.01035704764.63
175 rdf:rest rdf:nil
176 Nc1ed7d14a805403a82a8dcede25c3902 rdf:first sg:person.0700750333.28
177 rdf:rest Nded92f1887e34f5aa9171a9178719fb0
178 Nc235aa3608cb4e24917ce47c99ad2ac3 rdf:first sg:person.0737522203.00
179 rdf:rest N2c03173b6874458291da4e48b4bf630a
180 Nd2e7802276ee466f83b560486f820a33 rdf:first sg:person.01321116407.53
181 rdf:rest Nc235aa3608cb4e24917ce47c99ad2ac3
182 Nded92f1887e34f5aa9171a9178719fb0 rdf:first sg:person.0747063533.76
183 rdf:rest N8c50fe29a5d2448b8a062d4fbfaa2604
184 Ne263fa2c36b34eb493390e8854539809 rdf:first sg:person.01342233540.95
185 rdf:rest N23d841dc316241b49c4c8059aa1ec71b
186 Ne84d016e4cd84339a69e11115918793a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Animals
188 rdf:type schema:DefinedTerm
189 Ne99b82712ff249b3ad5440a314a115bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Cell Count
191 rdf:type schema:DefinedTerm
192 Nebcf1ded8b114831aa4f7984c0fc6e19 schema:name doi
193 schema:value 10.1038/nbt.2576
194 rdf:type schema:PropertyValue
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
199 schema:name Oncology and Carcinogenesis
200 rdf:type schema:DefinedTerm
201 sg:grant.3783348 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.2576
202 rdf:type schema:MonetaryGrant
203 sg:journal.1115214 schema:issn 1087-0156
204 1546-1696
205 schema:name Nature Biotechnology
206 rdf:type schema:Periodical
207 sg:person.01035704764.63 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
208 schema:familyName Trumpp
209 schema:givenName Andreas
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035704764.63
211 rdf:type schema:Person
212 sg:person.01102064441.73 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
213 schema:familyName Höfner
214 schema:givenName Thomas
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102064441.73
216 rdf:type schema:Person
217 sg:person.01112361603.18 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
218 schema:familyName Pantel
219 schema:givenName Klaus
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112361603.18
221 rdf:type schema:Person
222 sg:person.01125564233.21 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
223 schema:familyName Baccelli
224 schema:givenName Irène
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125564233.21
226 rdf:type schema:Person
227 sg:person.01135011746.65 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
228 schema:familyName Scharpff
229 schema:givenName Martina
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135011746.65
231 rdf:type schema:Person
232 sg:person.01174610520.68 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
233 schema:familyName Bäuerle
234 schema:givenName Tobias
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174610520.68
236 rdf:type schema:Person
237 sg:person.01321116407.53 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
238 schema:familyName Schneeweiss
239 schema:givenName Andreas
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321116407.53
241 rdf:type schema:Person
242 sg:person.01342233540.95 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
243 schema:familyName Marmé
244 schema:givenName Frederik
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342233540.95
246 rdf:type schema:Person
247 sg:person.01342734010.26 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
248 schema:familyName Holland-Letz
249 schema:givenName Tim
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342734010.26
251 rdf:type schema:Person
252 sg:person.01347112471.45 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
253 schema:familyName Sinn
254 schema:givenName Hans Peter
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347112471.45
256 rdf:type schema:Person
257 sg:person.01356241233.12 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
258 schema:familyName Schillert
259 schema:givenName Anja
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356241233.12
261 rdf:type schema:Person
262 sg:person.0632635133.80 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
263 schema:familyName Vogel
264 schema:givenName Vanessa
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632635133.80
266 rdf:type schema:Person
267 sg:person.0642700650.98 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
268 schema:familyName Stenzinger
269 schema:givenName Albrecht
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98
271 rdf:type schema:Person
272 sg:person.0657434205.21 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
273 schema:familyName Weichert
274 schema:givenName Wilko
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21
276 rdf:type schema:Person
277 sg:person.0664160435.08 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
278 schema:familyName Sprick
279 schema:givenName Martin
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664160435.08
281 rdf:type schema:Person
282 sg:person.0700750333.28 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
283 schema:familyName Klein
284 schema:givenName Corinna
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700750333.28
286 rdf:type schema:Person
287 sg:person.0724672011.05 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
288 schema:familyName Wallwiener
289 schema:givenName Markus
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724672011.05
291 rdf:type schema:Person
292 sg:person.0737522203.00 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
293 schema:familyName Riethdorf
294 schema:givenName Sabine
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737522203.00
296 rdf:type schema:Person
297 sg:person.0747063533.76 schema:affiliation https://www.grid.ac/institutes/grid.482664.a
298 schema:familyName Saini
299 schema:givenName Massimo
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747063533.76
301 rdf:type schema:Person
302 sg:pub.10.1038/nature05236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041233330
303 https://doi.org/10.1038/nature05236
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/nature06385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026279478
306 https://doi.org/10.1038/nature06385
307 rdf:type schema:CreativeWork
308 sg:pub.10.1038/nbt.2295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036752523
309 https://doi.org/10.1038/nbt.2295
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/nm886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049979157
312 https://doi.org/10.1038/nm886
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/nrc2622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020158834
315 https://doi.org/10.1038/nrc2622
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/nrc3171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028112819
318 https://doi.org/10.1038/nrc3171
319 rdf:type schema:CreativeWork
320 sg:pub.10.1038/nrc3205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048356671
321 https://doi.org/10.1038/nrc3205
322 rdf:type schema:CreativeWork
323 sg:pub.10.1038/nrclinonc.2009.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042231533
324 https://doi.org/10.1038/nrclinonc.2009.44
325 rdf:type schema:CreativeWork
326 sg:pub.10.1038/nrm3012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002993405
327 https://doi.org/10.1038/nrm3012
328 rdf:type schema:CreativeWork
329 sg:pub.10.1186/bcr3099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022859552
330 https://doi.org/10.1186/bcr3099
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.cell.2009.05.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010587660
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.cell.2009.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050054921
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.cell.2010.07.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006096408
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.cell.2011.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032774444
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/j.coi.2012.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014539889
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.ejca.2010.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024802170
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/j.semcancer.2010.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006097930
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1056/nejmoa040766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037538258
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1056/nejmoa050434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048972336
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1073/pnas.0530291100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018724794
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1073/pnas.0906549106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006171690
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1073/pnas.1006732107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023408641
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1073/pnas.1012539107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012852520
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1073/pnas.1121623109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035761828
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1073/pnas.1121629109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024026172
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1083/jcb.201010021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022367381
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1083/jcb.201202014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008525908
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1093/annonc/mdn786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019406366
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1101/gad.242602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048510702
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.1228522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013110936
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1158/0008-5472.can-10-2238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023057659
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1158/1078-0432.ccr-05-1769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046514044
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1158/1078-0432.ccr-06-1695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043103741
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1158/1078-0432.ccr-08-0872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021371367
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1158/1078-0432.ccr-09-2042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020064288
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1158/1078-0432.ccr-10-0349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002235630
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1172/jci39104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026879393
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1172/jci43414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049695125
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1182/blood-2001-12-0207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035575608
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1182/blood-2005-04-1417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025843647
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1200/jco.2010.28.7045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033931920
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1371/journal.pone.0033788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032135069
395 rdf:type schema:CreativeWork
396 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
397 rdf:type schema:CreativeWork
398 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
399 schema:name Department of Tumor Biology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
400 rdf:type schema:Organization
401 https://www.grid.ac/institutes/grid.482664.a schema:alternateName Heidelberg Institute for Stem Cell Technology and Experimental Medicine
402 schema:name Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
403 rdf:type schema:Organization
404 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
405 schema:name Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
406 Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
407 Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
408 National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
411 schema:name Department of Biostatistics, DKFZ, Heidelberg, Germany.
412 Department of Medical Physics in Radiology, DKFZ, Heidelberg, Germany.
413 Divison of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
414 German Cancer Consortium, Heidelberg, Germany.
415 Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH, Heidelberg, Germany.
416 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...