Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Kitai Kim, Rui Zhao, Akiko Doi, Kitwa Ng, Juli Unternaehrer, Patrick Cahan, Huo Hongguang, Yuin-Han Loh, Martin J Aryee, M William Lensch, Hu Li, James J Collins, Andrew P Feinberg, George Q Daley

ABSTRACT

We compared bona fide human induced pluripotent stem cells (iPSCs) derived from umbilical cord blood (CB) cells and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSCs and K-iPSCs were distinct in genome-wide DNA methylation profiles and differentiation potential. Extended passage of some iPSC clones in culture did not improve their epigenetic resemblance to embryonic stem cells, implying that some human iPSCs retain a residual 'epigenetic memory' of their tissue of origin. More... »

PAGES

1117

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.2052

DOI

http://dx.doi.org/10.1038/nbt.2052

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044135666

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22119740


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