Discovery and characterization of chromatin states for systematic annotation of the human genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07-25

AUTHORS

Jason Ernst, Manolis Kellis

ABSTRACT

Which of the possible combinations of epigenetic marks have biological significance is a major question in epigenetics. Analyzing data from human T-cells, Ernst and Kellis discover 51 distinct, recurring combinations of histone modifications that can be correlated with the functional annotations of the underlying DNA sequences.

PAGES

817-825

References to SciGraph publications

  • 2009-08-16. Chromatin organization marks exon-intron structure in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-08-16. Nucleosome positioning as a determinant of exon recognition in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1998. A View of the Em Algorithm that Justifies Incremental, Sparse, and other Variants in LEARNING IN GRAPHICAL MODELS
  • 2007-10. A second generation human haplotype map of over 3.1 million SNPs in NATURE
  • 2008-05-07. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions in NATURE
  • 2006-04-28. Genome-wide analysis of mammalian promoter architecture and evolution in NATURE GENETICS
  • 2006-04-05. STEM: a tool for the analysis of short time series gene expression data in BMC BIOINFORMATICS
  • 2008-12-18. Prediction of regulatory elements in mammalian genomes using chromatin signatures in BMC BIOINFORMATICS
  • 2000-01. The language of covalent histone modifications in NATURE
  • 2008-06-15. Combinatorial patterns of histone acetylations and methylations in the human genome in NATURE GENETICS
  • 2007-02-04. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome in NATURE GENETICS
  • 2009-02-01. Differential chromatin marking of introns and expressed exons by H3K36me3 in NATURE GENETICS
  • 2009-02-08. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction in NATURE GENETICS
  • 2009-03-18. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2009-02-01. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals in NATURE
  • 2009. Spatial Clustering of Multivariate Genomic and Epigenomic Information in RESEARCH IN COMPUTATIONAL MOLECULAR BIOLOGY
  • 2009-06-17. Unlocking the secrets of the genome in NATURE
  • 2007-06. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project in NATURE
  • 2008-11-13. Identifying Positioned Nucleosomes with Epigenetic Marks in Human from ChIP-Seq in BMC GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.1662

    DOI

    http://dx.doi.org/10.1038/nbt.1662

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050061238

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20657582


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