Dynamic single-cell imaging of direct reprogramming reveals an early specifying event View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05-02

AUTHORS

Zachary D Smith, Iftach Nachman, Aviv Regev, Alexander Meissner

ABSTRACT

Smith et al. use time-lapse imaging to study the conversion of mouse embryonic fibroblasts to induced pluripotent stem cells. By reconstructing movies of single cells over a two-week period, they identify an early phenotypic change characteristic of cells that are successfully reprogrammed.

PAGES

521-526

References to SciGraph publications

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  • 2009-08-09. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity in NATURE
  • 2009-08-09. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells in NATURE
  • 2009-08-02. Adult mice generated from induced pluripotent stem cells in NATURE
  • 2009-11-08. Direct cell reprogramming is a stochastic process amenable to acceleration in NATURE
  • 2009-08-09. The Ink4/Arf locus is a barrier for iPS cell reprogramming in NATURE
  • 2009-07-23. iPS cells produce viable mice through tetraploid complementation in NATURE
  • 2008-05-28. Dissecting direct reprogramming through integrative genomic analysis in NATURE
  • 2009-08-09. Suppression of induced pluripotent stem cell generation by the p53–p21 pathway in NATURE
  • 2008-02. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation in NATURE REVIEWS GENETICS
  • 2009-07. Elite and stochastic models for induced pluripotent stem cell generation in NATURE
  • 2007-06-06. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state in NATURE
  • 2008-07-01. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types in NATURE BIOTECHNOLOGY
  • 2009-01-11. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb in NATURE CELL BIOLOGY
  • 2009-08-09. Linking the p53 tumour suppressor pathway to somatic cell reprogramming in NATURE
  • 2007-11-30. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts in NATURE BIOTECHNOLOGY
  • 2007-06-06. Generation of germline-competent induced pluripotent stem cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.1632

    DOI

    http://dx.doi.org/10.1038/nbt.1632

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046760203

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20436460


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