High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Elisa Närvä, Reija Autio, Nelly Rahkonen, Lingjia Kong, Neil Harrison, Danny Kitsberg, Lodovica Borghese, Joseph Itskovitz-Eldor, Omid Rasool, Petr Dvorak, Outi Hovatta, Timo Otonkoski, Timo Tuuri, Wei Cui, Oliver Brüstle, Duncan Baker, Edna Maltby, Harry D Moore, Nissim Benvenisty, Peter W Andrews, Olli Yli-Harja, Riitta Lahesmaa

ABSTRACT

Prolonged culture of human embryonic stem cells (hESCs) can lead to adaptation and the acquisition of chromosomal abnormalities, underscoring the need for rigorous genetic analysis of these cells. Here we report the highest-resolution study of hESCs to date using an Affymetrix SNP 6.0 array containing 906,600 probes for single nucleotide polymorphisms (SNPs) and 946,000 probes for copy number variations (CNVs). Analysis of 17 different hESC lines maintained in different laboratories identified 843 CNVs of 50 kb-3 Mb in size. We identified, on average, 24% of the loss of heterozygosity (LOH) sites and 66% of the CNVs changed in culture between early and late passages of the same lines. Thirty percent of the genes detected within CNV sites had altered expression compared to samples with normal copy number states, of which >44% were functionally linked to cancer. Furthermore, LOH of the q arm of chromosome 16, which has not been observed previously in hESCs, was detected. More... »

PAGES

371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nbt.1615

DOI

http://dx.doi.org/10.1038/nbt.1615

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005590339

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20351689


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Culture Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "N\u00e4rv\u00e4", 
        "givenName": "Elisa", 
        "id": "sg:person.0723315771.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723315771.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tampere University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.6986.1", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland.", 
            "Department of Signal Processing, Tampere University of Technology, Tampere, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Autio", 
        "givenName": "Reija", 
        "id": "sg:person.01166044075.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166044075.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rahkonen", 
        "givenName": "Nelly", 
        "id": "sg:person.0771431171.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771431171.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tampere University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.6986.1", 
          "name": [
            "Department of Signal Processing, Tampere University of Technology, Tampere, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kong", 
        "givenName": "Lingjia", 
        "id": "sg:person.01225200247.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225200247.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrison", 
        "givenName": "Neil", 
        "id": "sg:person.01077707542.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077707542.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Technologies Ltd., Jerusalem, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitsberg", 
        "givenName": "Danny", 
        "id": "sg:person.01035336461.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035336461.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bonn", 
          "id": "https://www.grid.ac/institutes/grid.10388.32", 
          "name": [
            "Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borghese", 
        "givenName": "Lodovica", 
        "id": "sg:person.01177576717.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177576717.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rambam Health Care Campus", 
          "id": "https://www.grid.ac/institutes/grid.413731.3", 
          "name": [
            "Faculty of Medicine, Technion-Israel Institute of Technology and Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itskovitz-Eldor", 
        "givenName": "Joseph", 
        "id": "sg:person.01152773474.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152773474.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rasool", 
        "givenName": "Omid", 
        "id": "sg:person.01124435000.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124435000.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.424967.a", 
          "name": [
            "Department of Biology, Faculty of Medicine, Masaryk University & Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Brno, Czech Republic."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dvorak", 
        "givenName": "Petr", 
        "id": "sg:person.0737662345.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737662345.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovatta", 
        "givenName": "Outi", 
        "id": "sg:person.0654573365.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573365.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.424592.c", 
          "name": [
            "Program of Molecular Neurology, Biomedicum Stem Cell Center, University of Helsinki, Helsinki, Finland.", 
            "Children's Hospital, University of Helsinki, Helsinki, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otonkoski", 
        "givenName": "Timo", 
        "id": "sg:person.01345030511.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345030511.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Program of Molecular Neurology, Biomedicum Stem Cell Center, University of Helsinki, Helsinki, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuuri", 
        "givenName": "Timo", 
        "id": "sg:person.01133310662.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133310662.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "Wei", 
        "id": "sg:person.01276263641.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276263641.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bonn", 
          "id": "https://www.grid.ac/institutes/grid.10388.32", 
          "name": [
            "Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Br\u00fcstle", 
        "givenName": "Oliver", 
        "id": "sg:person.0646045405.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646045405.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sheffield Diagnostic Genetic Services, Sheffield Children's NHS Trust, Sheffield, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "Duncan", 
        "id": "sg:person.01031574342.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031574342.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sheffield Diagnostic Genetic Services, Sheffield Children's NHS Trust, Sheffield, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maltby", 
        "givenName": "Edna", 
        "id": "sg:person.0705070171.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705070171.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Centre for Stem Cell Biology and the Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moore", 
        "givenName": "Harry D", 
        "id": "sg:person.015067176272.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015067176272.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebrew University of Jerusalem", 
          "id": "https://www.grid.ac/institutes/grid.9619.7", 
          "name": [
            "Stem Cell Unit, Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem, Israel."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benvenisty", 
        "givenName": "Nissim", 
        "id": "sg:person.0577576321.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577576321.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Sheffield", 
          "id": "https://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andrews", 
        "givenName": "Peter W", 
        "id": "sg:person.01046557135.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046557135.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Systems Biology", 
          "id": "https://www.grid.ac/institutes/grid.64212.33", 
          "name": [
            "Department of Signal Processing, Tampere University of Technology, Tampere, Finland.", 
            "Institute for Systems Biology, Seattle, Washington, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yli-Harja", 
        "givenName": "Olli", 
        "id": "sg:person.01134121530.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134121530.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lahesmaa", 
        "givenName": "Riitta", 
        "id": "sg:person.0767010034.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767010034.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng1416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002767840", 
          "https://doi.org/10.1038/ng1416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002767840", 
          "https://doi.org/10.1038/ng1416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gah051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005912635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005956847", 
          "https://doi.org/10.1038/nbt922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005956847", 
          "https://doi.org/10.1038/nbt922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.5.2391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006173594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.copbio.2007.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007493316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10409230701507757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008952417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0510741103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010266995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/19.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011853799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011895681", 
          "https://doi.org/10.1038/nbt.1510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012224204", 
          "https://doi.org/10.1038/nbt1285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013244477", 
          "https://doi.org/10.1038/ng1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013244477", 
          "https://doi.org/10.1038/ng1631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddm105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015685229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018548414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jfranklin.2003.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019923358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkj147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021525828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-1016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022082542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022216096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022731034", 
          "https://doi.org/10.1038/nrc1299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022731034", 
          "https://doi.org/10.1038/nrc1299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-006-1019-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023888345", 
          "https://doi.org/10.1007/s10577-006-1019-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10577-006-1019-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023888345", 
          "https://doi.org/10.1007/s10577-006-1019-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026201814", 
          "https://doi.org/10.1038/nbt.1509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.062527199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031273938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-10-054247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031752720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2005.apm_305.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033377720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2005.apm_305.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033377720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033454038", 
          "https://doi.org/10.1038/nrg1767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033454038", 
          "https://doi.org/10.1038/nrg1767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033654326", 
          "https://doi.org/10.1038/nature02168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033654326", 
          "https://doi.org/10.1038/nature02168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034459123", 
          "https://doi.org/10.1038/sj.onc.1209919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034459123", 
          "https://doi.org/10.1038/sj.onc.1209919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.22.8751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035339616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1098918", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037256982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039633163", 
          "https://doi.org/10.1038/nbt1383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gni179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040526112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044817080", 
          "https://doi.org/10.1038/sj.onc.1209690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044817080", 
          "https://doi.org/10.1038/sj.onc.1209690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046465156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-02-075069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047374661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gan025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047607038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052925490", 
          "https://doi.org/10.1038/nature05329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052925490", 
          "https://doi.org/10.1038/nature05329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052925490", 
          "https://doi.org/10.1038/nature05329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053612445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst20051526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2004.13.325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i43.6740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071363900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082764337", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-04", 
    "datePublishedReg": "2010-04-01", 
    "description": "Prolonged culture of human embryonic stem cells (hESCs) can lead to adaptation and the acquisition of chromosomal abnormalities, underscoring the need for rigorous genetic analysis of these cells. Here we report the highest-resolution study of hESCs to date using an Affymetrix SNP 6.0 array containing 906,600 probes for single nucleotide polymorphisms (SNPs) and 946,000 probes for copy number variations (CNVs). Analysis of 17 different hESC lines maintained in different laboratories identified 843 CNVs of 50 kb-3 Mb in size. We identified, on average, 24% of the loss of heterozygosity (LOH) sites and 66% of the CNVs changed in culture between early and late passages of the same lines. Thirty percent of the genes detected within CNV sites had altered expression compared to samples with normal copy number states, of which >44% were functionally linked to cancer. Furthermore, LOH of the q arm of chromosome 16, which has not been observed previously in hESCs, was detected.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nbt.1615", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2781764", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2779383", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4730771", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4249379", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115214", 
        "issn": [
          "1087-0156", 
          "1546-1696"
        ], 
        "name": "Nature Biotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity", 
    "pagination": "371", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1aa2776df524e02fc51b9797029c86ad8c9d1bf6d2d9294d3f3a035e3123e726"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20351689"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9604648"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nbt.1615"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005590339"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nbt.1615", 
      "https://app.dimensions.ai/details/publication/pub.1005590339"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nbt.1615"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt.1615'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt.1615'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt.1615'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt.1615'


 

This table displays all metadata directly associated to this object as RDF triples.

439 TRIPLES      21 PREDICATES      79 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nbt.1615 schema:about N3d7cc39eaae84fdfadaa42b2eef4807c
2 N523b8e9346e94dc4ace02a1d39d9664b
3 N601be0110e1947d4b5b039d2014e15e0
4 N64513613e52f4fecabe856fc5783400f
5 N6ca4b45886014641bd27fda88644b247
6 N6e33b993df52409f9eec16d557e6bba7
7 N8820f4908d47403c976bf9a0e351d596
8 N9207e8c066e34d1d82212ebf9a685c5d
9 Nd326bc888b7e49f6b60315f128f00b25
10 Nd6e2c3d6e606486ea89788d3cd1c58c0
11 anzsrc-for:06
12 anzsrc-for:0604
13 schema:author N36a13e47765540a68a3d137425eeaee6
14 schema:citation sg:pub.10.1007/s10577-006-1019-8
15 sg:pub.10.1038/nature02168
16 sg:pub.10.1038/nature05329
17 sg:pub.10.1038/nbt.1509
18 sg:pub.10.1038/nbt.1510
19 sg:pub.10.1038/nbt1285
20 sg:pub.10.1038/nbt1383
21 sg:pub.10.1038/nbt922
22 sg:pub.10.1038/ng1416
23 sg:pub.10.1038/ng1631
24 sg:pub.10.1038/nrc1299
25 sg:pub.10.1038/nrg1767
26 sg:pub.10.1038/sj.onc.1209690
27 sg:pub.10.1038/sj.onc.1209919
28 https://app.dimensions.ai/details/publication/pub.1082764337
29 https://doi.org/10.1002/gcc.20070
30 https://doi.org/10.1016/j.copbio.2007.11.004
31 https://doi.org/10.1016/j.jfranklin.2003.12.005
32 https://doi.org/10.1042/bst20051526
33 https://doi.org/10.1073/pnas.0510741103
34 https://doi.org/10.1073/pnas.062527199
35 https://doi.org/10.1073/pnas.87.22.8751
36 https://doi.org/10.1080/10409230701507757
37 https://doi.org/10.1089/scd.2004.13.325
38 https://doi.org/10.1093/bioinformatics/19.2.185
39 https://doi.org/10.1093/hmg/ddi345
40 https://doi.org/10.1093/hmg/ddm105
41 https://doi.org/10.1093/molehr/gah051
42 https://doi.org/10.1093/molehr/gan025
43 https://doi.org/10.1093/nar/gkj147
44 https://doi.org/10.1093/nar/gkl996
45 https://doi.org/10.1093/nar/gni179
46 https://doi.org/10.1111/j.1600-0463.2005.apm_305.x
47 https://doi.org/10.1126/science.1098918
48 https://doi.org/10.1128/mcb.12.5.2391
49 https://doi.org/10.1182/blood-2006-10-054247
50 https://doi.org/10.1182/blood-2007-02-075069
51 https://doi.org/10.1634/stemcells.2007-0993
52 https://doi.org/10.1634/stemcells.2007-1016
53 https://doi.org/10.3748/wjg.v11.i43.6740
54 schema:datePublished 2010-04
55 schema:datePublishedReg 2010-04-01
56 schema:description Prolonged culture of human embryonic stem cells (hESCs) can lead to adaptation and the acquisition of chromosomal abnormalities, underscoring the need for rigorous genetic analysis of these cells. Here we report the highest-resolution study of hESCs to date using an Affymetrix SNP 6.0 array containing 906,600 probes for single nucleotide polymorphisms (SNPs) and 946,000 probes for copy number variations (CNVs). Analysis of 17 different hESC lines maintained in different laboratories identified 843 CNVs of 50 kb-3 Mb in size. We identified, on average, 24% of the loss of heterozygosity (LOH) sites and 66% of the CNVs changed in culture between early and late passages of the same lines. Thirty percent of the genes detected within CNV sites had altered expression compared to samples with normal copy number states, of which >44% were functionally linked to cancer. Furthermore, LOH of the q arm of chromosome 16, which has not been observed previously in hESCs, was detected.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N41d9c4c493994fcc822b24d06059ff10
61 Nb7d18956480a44f09f4865bcf45c1875
62 sg:journal.1115214
63 schema:name High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity
64 schema:pagination 371
65 schema:productId N263888537ccf4f87b08eea0cda06158b
66 N400eb9f195a0488b9bb9bcbda6746065
67 N51a13f48775549bb8f76623ac7b7a3ef
68 N76858b18ca8a4f628099289b44e57a6b
69 Nd65fe7d43af94e9398569e1686d4b1a1
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005590339
71 https://doi.org/10.1038/nbt.1615
72 schema:sdDatePublished 2019-04-10T22:20
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nc66b6bc47ae24397b77128e9d185c8b5
75 schema:url https://www.nature.com/articles/nbt.1615
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N02d348dd56d14568b1c94ffe2b36d079 schema:name Stem Cell Technologies Ltd., Jerusalem, Israel.
80 rdf:type schema:Organization
81 N045a040dfa1a4fdda141c947bd93a23f rdf:first sg:person.0577576321.96
82 rdf:rest N4de8ce48c06440e59f2eeb05e0112cc0
83 N0d81ed6ab6f0432d9b65f6571df68002 schema:name Sheffield Diagnostic Genetic Services, Sheffield Children's NHS Trust, Sheffield, UK.
84 rdf:type schema:Organization
85 N0f9e71c1b6574cd4a587e845bf3b06bb rdf:first sg:person.0767010034.41
86 rdf:rest rdf:nil
87 N14b54da7a9f945b28b129afced313c9a rdf:first sg:person.0646045405.15
88 rdf:rest Ncb8fcb3ebfa74d66a33938bc12eb1937
89 N2165b1c5bfb74fde8fbae6315971992c rdf:first sg:person.01276263641.91
90 rdf:rest N14b54da7a9f945b28b129afced313c9a
91 N22e0fa4a2fd543ddbd95d8498f59b58e rdf:first sg:person.01345030511.27
92 rdf:rest Nba70089ee8844432b572de5bdd6dec6d
93 N263888537ccf4f87b08eea0cda06158b schema:name readcube_id
94 schema:value 1aa2776df524e02fc51b9797029c86ad8c9d1bf6d2d9294d3f3a035e3123e726
95 rdf:type schema:PropertyValue
96 N310f68ee46304815b67f0e9d0372cba5 rdf:first sg:person.0737662345.94
97 rdf:rest Nd1dbbf7b534544f9b5fd4dd0fbc99e15
98 N31a653b475f64bf6b07adadb0cd6fc3e rdf:first sg:person.01225200247.47
99 rdf:rest Neafeb15cdc6b4923a6ac4331b16bc08d
100 N36a13e47765540a68a3d137425eeaee6 rdf:first sg:person.0723315771.33
101 rdf:rest N82297e453e17407d9362b2eb51609bbc
102 N3d7cc39eaae84fdfadaa42b2eef4807c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Base Sequence
104 rdf:type schema:DefinedTerm
105 N400eb9f195a0488b9bb9bcbda6746065 schema:name pubmed_id
106 schema:value 20351689
107 rdf:type schema:PropertyValue
108 N41d9c4c493994fcc822b24d06059ff10 schema:issueNumber 4
109 rdf:type schema:PublicationIssue
110 N41dbaf774707449f8eeb49a3c87d0ed7 rdf:first sg:person.01124435000.05
111 rdf:rest N310f68ee46304815b67f0e9d0372cba5
112 N44e662b1f9e94ca982a12ae58503e7fe rdf:first sg:person.015067176272.09
113 rdf:rest N045a040dfa1a4fdda141c947bd93a23f
114 N48f6dd4f8b654e749b2adfeeb8c80e41 rdf:first sg:person.01035336461.49
115 rdf:rest N9fe02e09adf44c72b8e53231a2b7a81b
116 N4d25320db57f4fd387a43a49b841de75 rdf:first sg:person.0771431171.72
117 rdf:rest N31a653b475f64bf6b07adadb0cd6fc3e
118 N4de8ce48c06440e59f2eeb05e0112cc0 rdf:first sg:person.01046557135.44
119 rdf:rest N4ef43c1a8d2943d393db210729ab56b4
120 N4ef43c1a8d2943d393db210729ab56b4 rdf:first sg:person.01134121530.92
121 rdf:rest N0f9e71c1b6574cd4a587e845bf3b06bb
122 N51a13f48775549bb8f76623ac7b7a3ef schema:name dimensions_id
123 schema:value pub.1005590339
124 rdf:type schema:PropertyValue
125 N523b8e9346e94dc4ace02a1d39d9664b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Molecular Sequence Data
127 rdf:type schema:DefinedTerm
128 N601be0110e1947d4b5b039d2014e15e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Culture Techniques
130 rdf:type schema:DefinedTerm
131 N64513613e52f4fecabe856fc5783400f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name DNA Mutational Analysis
133 rdf:type schema:DefinedTerm
134 N67d60293250f43d88e761d98d2114f88 schema:name Sheffield Diagnostic Genetic Services, Sheffield Children's NHS Trust, Sheffield, UK.
135 rdf:type schema:Organization
136 N6ca4b45886014641bd27fda88644b247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genetic Variation
138 rdf:type schema:DefinedTerm
139 N6e33b993df52409f9eec16d557e6bba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 N743877e3b14e4f56a0a17affc29fa5e6 rdf:first sg:person.01152773474.98
143 rdf:rest N41dbaf774707449f8eeb49a3c87d0ed7
144 N76858b18ca8a4f628099289b44e57a6b schema:name doi
145 schema:value 10.1038/nbt.1615
146 rdf:type schema:PropertyValue
147 N82297e453e17407d9362b2eb51609bbc rdf:first sg:person.01166044075.38
148 rdf:rest N4d25320db57f4fd387a43a49b841de75
149 N8820f4908d47403c976bf9a0e351d596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name DNA Copy Number Variations
151 rdf:type schema:DefinedTerm
152 N9207e8c066e34d1d82212ebf9a685c5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name DNA
154 rdf:type schema:DefinedTerm
155 N9fe02e09adf44c72b8e53231a2b7a81b rdf:first sg:person.01177576717.71
156 rdf:rest N743877e3b14e4f56a0a17affc29fa5e6
157 Nb48268a8f2c24defa4aeb0af1fbfac55 schema:name Department CLINTEC, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
158 rdf:type schema:Organization
159 Nb7d18956480a44f09f4865bcf45c1875 schema:volumeNumber 28
160 rdf:type schema:PublicationVolume
161 Nba70089ee8844432b572de5bdd6dec6d rdf:first sg:person.01133310662.88
162 rdf:rest N2165b1c5bfb74fde8fbae6315971992c
163 Nc66b6bc47ae24397b77128e9d185c8b5 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Ncb8fcb3ebfa74d66a33938bc12eb1937 rdf:first sg:person.01031574342.33
166 rdf:rest Nf8be397095b344efbcbe0b7577ef0314
167 Nd1dbbf7b534544f9b5fd4dd0fbc99e15 rdf:first sg:person.0654573365.68
168 rdf:rest N22e0fa4a2fd543ddbd95d8498f59b58e
169 Nd326bc888b7e49f6b60315f128f00b25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Embryonic Stem Cells
171 rdf:type schema:DefinedTerm
172 Nd65fe7d43af94e9398569e1686d4b1a1 schema:name nlm_unique_id
173 schema:value 9604648
174 rdf:type schema:PropertyValue
175 Nd6e2c3d6e606486ea89788d3cd1c58c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Sequence Analysis, DNA
177 rdf:type schema:DefinedTerm
178 Neafeb15cdc6b4923a6ac4331b16bc08d rdf:first sg:person.01077707542.81
179 rdf:rest N48f6dd4f8b654e749b2adfeeb8c80e41
180 Nf8be397095b344efbcbe0b7577ef0314 rdf:first sg:person.0705070171.99
181 rdf:rest N44e662b1f9e94ca982a12ae58503e7fe
182 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
183 schema:name Biological Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
186 schema:name Genetics
187 rdf:type schema:DefinedTerm
188 sg:grant.2779383 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.1615
189 rdf:type schema:MonetaryGrant
190 sg:grant.2781764 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.1615
191 rdf:type schema:MonetaryGrant
192 sg:grant.4249379 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.1615
193 rdf:type schema:MonetaryGrant
194 sg:grant.4730771 http://pending.schema.org/fundedItem sg:pub.10.1038/nbt.1615
195 rdf:type schema:MonetaryGrant
196 sg:journal.1115214 schema:issn 1087-0156
197 1546-1696
198 schema:name Nature Biotechnology
199 rdf:type schema:Periodical
200 sg:person.01031574342.33 schema:affiliation N0d81ed6ab6f0432d9b65f6571df68002
201 schema:familyName Baker
202 schema:givenName Duncan
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031574342.33
204 rdf:type schema:Person
205 sg:person.01035336461.49 schema:affiliation N02d348dd56d14568b1c94ffe2b36d079
206 schema:familyName Kitsberg
207 schema:givenName Danny
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035336461.49
209 rdf:type schema:Person
210 sg:person.01046557135.44 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
211 schema:familyName Andrews
212 schema:givenName Peter W
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046557135.44
214 rdf:type schema:Person
215 sg:person.01077707542.81 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
216 schema:familyName Harrison
217 schema:givenName Neil
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077707542.81
219 rdf:type schema:Person
220 sg:person.01124435000.05 schema:affiliation https://www.grid.ac/institutes/grid.452861.c
221 schema:familyName Rasool
222 schema:givenName Omid
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124435000.05
224 rdf:type schema:Person
225 sg:person.01133310662.88 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
226 schema:familyName Tuuri
227 schema:givenName Timo
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133310662.88
229 rdf:type schema:Person
230 sg:person.01134121530.92 schema:affiliation https://www.grid.ac/institutes/grid.64212.33
231 schema:familyName Yli-Harja
232 schema:givenName Olli
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134121530.92
234 rdf:type schema:Person
235 sg:person.01152773474.98 schema:affiliation https://www.grid.ac/institutes/grid.413731.3
236 schema:familyName Itskovitz-Eldor
237 schema:givenName Joseph
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152773474.98
239 rdf:type schema:Person
240 sg:person.01166044075.38 schema:affiliation https://www.grid.ac/institutes/grid.6986.1
241 schema:familyName Autio
242 schema:givenName Reija
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166044075.38
244 rdf:type schema:Person
245 sg:person.01177576717.71 schema:affiliation https://www.grid.ac/institutes/grid.10388.32
246 schema:familyName Borghese
247 schema:givenName Lodovica
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177576717.71
249 rdf:type schema:Person
250 sg:person.01225200247.47 schema:affiliation https://www.grid.ac/institutes/grid.6986.1
251 schema:familyName Kong
252 schema:givenName Lingjia
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225200247.47
254 rdf:type schema:Person
255 sg:person.01276263641.91 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
256 schema:familyName Cui
257 schema:givenName Wei
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276263641.91
259 rdf:type schema:Person
260 sg:person.01345030511.27 schema:affiliation https://www.grid.ac/institutes/grid.424592.c
261 schema:familyName Otonkoski
262 schema:givenName Timo
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345030511.27
264 rdf:type schema:Person
265 sg:person.015067176272.09 schema:affiliation https://www.grid.ac/institutes/grid.11835.3e
266 schema:familyName Moore
267 schema:givenName Harry D
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015067176272.09
269 rdf:type schema:Person
270 sg:person.0577576321.96 schema:affiliation https://www.grid.ac/institutes/grid.9619.7
271 schema:familyName Benvenisty
272 schema:givenName Nissim
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577576321.96
274 rdf:type schema:Person
275 sg:person.0646045405.15 schema:affiliation https://www.grid.ac/institutes/grid.10388.32
276 schema:familyName Brüstle
277 schema:givenName Oliver
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646045405.15
279 rdf:type schema:Person
280 sg:person.0654573365.68 schema:affiliation Nb48268a8f2c24defa4aeb0af1fbfac55
281 schema:familyName Hovatta
282 schema:givenName Outi
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654573365.68
284 rdf:type schema:Person
285 sg:person.0705070171.99 schema:affiliation N67d60293250f43d88e761d98d2114f88
286 schema:familyName Maltby
287 schema:givenName Edna
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705070171.99
289 rdf:type schema:Person
290 sg:person.0723315771.33 schema:affiliation https://www.grid.ac/institutes/grid.452861.c
291 schema:familyName Närvä
292 schema:givenName Elisa
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723315771.33
294 rdf:type schema:Person
295 sg:person.0737662345.94 schema:affiliation https://www.grid.ac/institutes/grid.424967.a
296 schema:familyName Dvorak
297 schema:givenName Petr
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737662345.94
299 rdf:type schema:Person
300 sg:person.0767010034.41 schema:affiliation https://www.grid.ac/institutes/grid.452861.c
301 schema:familyName Lahesmaa
302 schema:givenName Riitta
303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767010034.41
304 rdf:type schema:Person
305 sg:person.0771431171.72 schema:affiliation https://www.grid.ac/institutes/grid.452861.c
306 schema:familyName Rahkonen
307 schema:givenName Nelly
308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771431171.72
309 rdf:type schema:Person
310 sg:pub.10.1007/s10577-006-1019-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023888345
311 https://doi.org/10.1007/s10577-006-1019-8
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nature02168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033654326
314 https://doi.org/10.1038/nature02168
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nature05329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052925490
317 https://doi.org/10.1038/nature05329
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nbt.1509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026201814
320 https://doi.org/10.1038/nbt.1509
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nbt.1510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011895681
323 https://doi.org/10.1038/nbt.1510
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/nbt1285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012224204
326 https://doi.org/10.1038/nbt1285
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nbt1383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039633163
329 https://doi.org/10.1038/nbt1383
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nbt922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005956847
332 https://doi.org/10.1038/nbt922
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/ng1416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002767840
335 https://doi.org/10.1038/ng1416
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/ng1631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013244477
338 https://doi.org/10.1038/ng1631
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nrc1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731034
341 https://doi.org/10.1038/nrc1299
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nrg1767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033454038
344 https://doi.org/10.1038/nrg1767
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/sj.onc.1209690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044817080
347 https://doi.org/10.1038/sj.onc.1209690
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/sj.onc.1209919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034459123
350 https://doi.org/10.1038/sj.onc.1209919
351 rdf:type schema:CreativeWork
352 https://app.dimensions.ai/details/publication/pub.1082764337 schema:CreativeWork
353 https://doi.org/10.1002/gcc.20070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046465156
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.copbio.2007.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007493316
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.jfranklin.2003.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019923358
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1042/bst20051526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717487
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1073/pnas.0510741103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010266995
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1073/pnas.062527199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031273938
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1073/pnas.87.22.8751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035339616
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1080/10409230701507757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008952417
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1089/scd.2004.13.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309395
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1093/bioinformatics/19.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853799
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1093/hmg/ddi345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053612445
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/hmg/ddm105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015685229
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/molehr/gah051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005912635
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/molehr/gan025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047607038
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/nar/gkj147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021525828
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/nar/gkl996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018548414
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/nar/gni179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040526112
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1111/j.1600-0463.2005.apm_305.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033377720
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1126/science.1098918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037256982
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1128/mcb.12.5.2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006173594
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1182/blood-2006-10-054247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031752720
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1182/blood-2007-02-075069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047374661
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1634/stemcells.2007-0993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022216096
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1634/stemcells.2007-1016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022082542
400 rdf:type schema:CreativeWork
401 https://doi.org/10.3748/wjg.v11.i43.6740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071363900
402 rdf:type schema:CreativeWork
403 https://www.grid.ac/institutes/grid.10388.32 schema:alternateName University of Bonn
404 schema:name Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany.
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.11835.3e schema:alternateName University of Sheffield
407 schema:name Centre for Stem Cell Biology and the Department of Biomedical Science, University of Sheffield, Sheffield, UK.
408 Centre for Stem Cell Biology and the Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK.
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.413731.3 schema:alternateName Rambam Health Care Campus
411 schema:name Faculty of Medicine, Technion-Israel Institute of Technology and Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.424592.c schema:alternateName Helsinki Children's Hospital
414 schema:name Children's Hospital, University of Helsinki, Helsinki, Finland.
415 Program of Molecular Neurology, Biomedicum Stem Cell Center, University of Helsinki, Helsinki, Finland.
416 rdf:type schema:Organization
417 https://www.grid.ac/institutes/grid.424967.a schema:alternateName Institute of Experimental Medicine
418 schema:name Department of Biology, Faculty of Medicine, Masaryk University & Department of Molecular Embryology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.452861.c schema:alternateName Turku Centre for Biotechnology
421 schema:name Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.64212.33 schema:alternateName Institute for Systems Biology
424 schema:name Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
425 Institute for Systems Biology, Seattle, Washington, USA.
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.6986.1 schema:alternateName Tampere University of Technology
428 schema:name Department of Signal Processing, Tampere University of Technology, Tampere, Finland.
429 Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
430 rdf:type schema:Organization
431 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
432 schema:name Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, UK.
433 rdf:type schema:Organization
434 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
435 schema:name Program of Molecular Neurology, Biomedicum Stem Cell Center, University of Helsinki, Helsinki, Finland.
436 rdf:type schema:Organization
437 https://www.grid.ac/institutes/grid.9619.7 schema:alternateName Hebrew University of Jerusalem
438 schema:name Stem Cell Unit, Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
439 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...