In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Marcin Kortylewski, Piotr Swiderski, Andreas Herrmann, Lin Wang, Claudia Kowolik, Maciej Kujawski, Heehyoung Lee, Anna Scuto, Yong Liu, Chunmei Yang, Jiehui Deng, Harris S. Soifer, Andrew Raubitschek, Stephen Forman, John J. Rossi, Drew M. Pardoll, Richard Jove, Hua Yu

ABSTRACT

Efficient delivery of small interfering (si)RNA to specific cell populations in vivo remains a formidable challenge to its successful therapeutic application. We show that siRNA synthetically linked to a CpG oligonucleotide agonist of toll-like receptor (TLR)9 targets and silences genes in TLR9(+) myeloid cells and B cells, both of which are key components of the tumor microenvironment. When a CpG-conjugated siRNA that targets the immune suppressor gene Stat3 is injected in mice either locally at the tumor site or intravenously, it enters tumor-associated dendritic cells, macrophages and B cells. Silencing of Stat3 leads to activation of tumor-associated immune cells and ultimately to potent antitumor immune responses. Our findings demonstrate the potential of TLR agonist-siRNA conjugates for targeted gene silencing coupled with TLR stimulation and immune activation in the tumor microenvironment. More... »

PAGES

925-932

References to SciGraph publications

  • 2007-07. Transvascular delivery of small interfering RNA to the central nervous system in NATURE
  • 2007-01. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment in NATURE REVIEWS IMMUNOLOGY
  • 2004-10. Toll-like receptor control of the adaptive immune responses in NATURE IMMUNOLOGY
  • 2005-06. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors in NATURE BIOTECHNOLOGY
  • 2001-04. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity in NATURE
  • 2004-04. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis in ONCOGENE
  • 2005-04. Immunosuppressive networks in the tumour environment and their therapeutic relevance in NATURE REVIEWS CANCER
  • 2006-05. RNAi-mediated gene silencing in non-human primates in NATURE
  • 1995-04. CpG motifs in bacterial DNA trigger direct B-cell activation in NATURE
  • 2008-01. Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies in ONCOGENE
  • 2004-02. TLR9 signals after translocating from the ER to CpG DNA in the lysosome in NATURE IMMUNOLOGY
  • 2002-10. Transcription factors as targets for cancer therapy in NATURE REVIEWS CANCER
  • 2005-02. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy in NATURE BIOTECHNOLOGY
  • 2005-12. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity in NATURE MEDICINE
  • 2000-12. A Toll-like receptor recognizes bacterial DNA in NATURE
  • 2004-01. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells in NATURE MEDICINE
  • 2004-02. The STATs of cancer — new molecular targets come of age in NATURE REVIEWS CANCER
  • 2008-01. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer in ONCOGENE
  • 2005-09. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque in NATURE MEDICINE
  • 2005-08. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing in NATURE
  • 2007-12. Adaptive immunity maintains occult cancer in an equilibrium state in NATURE
  • 2006-08. Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras in NATURE BIOTECHNOLOGY
  • 2008-11. 5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma in NATURE MEDICINE
  • 2007-05. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.1564

    DOI

    http://dx.doi.org/10.1038/nbt.1564

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024403859

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19749770


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