Ontology type: schema:ScholarlyArticle Open Access: True
2009-09
AUTHORSMeng Li, Wei-dong Chen, Nickolas Papadopoulos, Steven N Goodman, Niels Christian Bjerregaard, Søren Laurberg, Bernard Levin, Hartmut Juhl, Nadir Arber, Helen Moinova, Kris Durkee, Kerstin Schmidt, Yiping He, Frank Diehl, Victor E Velculescu, Shibin Zhou, Luis A Diaz, Kenneth W Kinzler, Sanford D Markowitz, Bert Vogelstein
ABSTRACTAnalysis of abnormally methylated genes is increasingly important in basic research and in the development of cancer biomarkers. We have developed methyl-BEAMing technology to enable absolute quantification of the number of methylated molecules in a sample. Individual DNA fragments are amplified and analyzed either by flow cytometry or next-generation sequencing. We demonstrate enumeration of as few as one methylated molecule in approximately 5,000 unmethylated molecules in DNA from plasma or fecal samples. Using methylated vimentin as a biomarker in plasma samples, methyl-BEAMing detected 59% of cancer cases. In early-stage colorectal cancers, this sensitivity was four times more than that obtained by assaying serum-carcinoembryonic antigen (CEA). With stool samples, methyl-BEAMing detected 41% of cancers and 45% of advanced adenomas. In addition to diagnostic and prognostic applications, this digital quantification of rare methylation events should be applicable to preclinical assessment of new epigenetic biomarkers and quantitative analyses in epigenetic research. More... »
PAGES858-863
http://scigraph.springernature.com/pub.10.1038/nbt.1559
DOIhttp://dx.doi.org/10.1038/nbt.1559
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1003456878
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19684580
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Methylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Feces",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sensitivity and Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vimentin",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Meng",
"id": "sg:person.01045227550.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045227550.35"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Medicine and Ireland Cancer Center, Case Western Reserve University and Case Medical Center of University Hospitals of Cleveland and Howard Hughes Medical Institute, Cleveland, Ohio, USA."
],
"type": "Organization"
},
"familyName": "Chen",
"givenName": "Wei-dong",
"id": "sg:person.014466504320.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014466504320.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Papadopoulos",
"givenName": "Nickolas",
"id": "sg:person.013623242142.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013623242142.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Biostatistics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Goodman",
"givenName": "Steven N",
"id": "sg:person.013730377746.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013730377746.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University Hospital",
"id": "https://www.grid.ac/institutes/grid.154185.c",
"name": [
"Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark."
],
"type": "Organization"
},
"familyName": "Bjerregaard",
"givenName": "Niels Christian",
"id": "sg:person.013160753267.56",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013160753267.56"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Aarhus University Hospital",
"id": "https://www.grid.ac/institutes/grid.154185.c",
"name": [
"Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark."
],
"type": "Organization"
},
"familyName": "Laurberg",
"givenName": "S\u00f8ren",
"id": "sg:person.01127302037.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127302037.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"U.T.M.D. Anderson Cancer Center, Houston, Texas, USA."
],
"type": "Organization"
},
"familyName": "Levin",
"givenName": "Bernard",
"id": "sg:person.01056221576.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056221576.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Israelitisches Krankenhaus",
"id": "https://www.grid.ac/institutes/grid.414844.9",
"name": [
"Indivumed, Center for Cancer Research at Israelitic Hospital, Hamburg, Germany."
],
"type": "Organization"
},
"familyName": "Juhl",
"givenName": "Hartmut",
"id": "sg:person.0605614271.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605614271.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tel Aviv University",
"id": "https://www.grid.ac/institutes/grid.12136.37",
"name": [
"Tel Aviv University, Tel Aviv Medical Center and Sackler School of Medicine and Integrated Cancer Prevention Center, Tel Aviv, Israel."
],
"type": "Organization"
},
"familyName": "Arber",
"givenName": "Nadir",
"id": "sg:person.01203466672.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203466672.61"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Medicine and Ireland Cancer Center, Case Western Reserve University and Case Medical Center of University Hospitals of Cleveland and Howard Hughes Medical Institute, Cleveland, Ohio, USA."
],
"type": "Organization"
},
"familyName": "Moinova",
"givenName": "Helen",
"id": "sg:person.01267662055.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267662055.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Exact Sciences (United States)",
"id": "https://www.grid.ac/institutes/grid.428370.a",
"name": [
"Exact Sciences Corp., Marlborough, Massachusetts, USA."
],
"type": "Organization"
},
"familyName": "Durkee",
"givenName": "Kris",
"id": "sg:person.013403552077.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013403552077.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Schmidt",
"givenName": "Kerstin",
"id": "sg:person.0747353005.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747353005.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "He",
"givenName": "Yiping",
"id": "sg:person.011732046677.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011732046677.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Diehl",
"givenName": "Frank",
"id": "sg:person.01300510513.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300510513.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Velculescu",
"givenName": "Victor E",
"id": "sg:person.010354303077.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354303077.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Zhou",
"givenName": "Shibin",
"id": "sg:person.016643122307.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016643122307.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Diaz",
"givenName": "Luis A",
"id": "sg:person.0644256174.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644256174.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Kinzler",
"givenName": "Kenneth W",
"id": "sg:person.0620642630.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Medicine and Ireland Cancer Center, Case Western Reserve University and Case Medical Center of University Hospitals of Cleveland and Howard Hughes Medical Institute, Cleveland, Ohio, USA."
],
"type": "Organization"
},
"familyName": "Markowitz",
"givenName": "Sanford D",
"id": "sg:person.015750001717.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015750001717.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Vogelstein",
"givenName": "Bert",
"id": "sg:person.011173760757.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.mrrev.2008.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001447331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1098-3597(02)90001-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002012690"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji204",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002388135"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004186565",
"https://doi.org/10.1038/nrc1045"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004186565",
"https://doi.org/10.1038/nrc1045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbcan.2006.10.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007837955"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009116910",
"https://doi.org/10.1038/nrc1279"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009116910",
"https://doi.org/10.1038/nrc1279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2007.01.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009285166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/28.8.e32",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014093221"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.96.16.9236",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020473434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/25.21.4422",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020518862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/29.13.e65",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022346000"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-0605",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023944589"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth898",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028618204",
"https://doi.org/10.1038/nmeth898"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth898",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028618204",
"https://doi.org/10.1038/nmeth898"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0507904102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030122941"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.18.9821",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030175469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1055-9965.epi-07-0518",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034140991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1039/b813595a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034533752"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2008.06.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034564602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2008.06.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034564602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/25.12.2532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036662191"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.088831.108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039572863"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/25.12.2529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041758865"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/j.gastro.2008.05.039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042252259"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1133470100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045398840"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc755",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049934401",
"https://doi.org/10.1038/nrc755"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc755",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049934401",
"https://doi.org/10.1038/nrc755"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm.1789",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051933380",
"https://doi.org/10.1038/nm.1789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2144/000112702",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069095720"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-137-5_part_1-200209030-00012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073705722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-150-3-200902030-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073710569"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074512813",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074782138",
"type": "CreativeWork"
}
],
"datePublished": "2009-09",
"datePublishedReg": "2009-09-01",
"description": "Analysis of abnormally methylated genes is increasingly important in basic research and in the development of cancer biomarkers. We have developed methyl-BEAMing technology to enable absolute quantification of the number of methylated molecules in a sample. Individual DNA fragments are amplified and analyzed either by flow cytometry or next-generation sequencing. We demonstrate enumeration of as few as one methylated molecule in approximately 5,000 unmethylated molecules in DNA from plasma or fecal samples. Using methylated vimentin as a biomarker in plasma samples, methyl-BEAMing detected 59% of cancer cases. In early-stage colorectal cancers, this sensitivity was four times more than that obtained by assaying serum-carcinoembryonic antigen (CEA). With stool samples, methyl-BEAMing detected 41% of cancers and 45% of advanced adenomas. In addition to diagnostic and prognostic applications, this digital quantification of rare methylation events should be applicable to preclinical assessment of new epigenetic biomarkers and quantitative analyses in epigenetic research.",
"genre": "research_article",
"id": "sg:pub.10.1038/nbt.1559",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2440141",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2478653",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2469185",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2634325",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1115214",
"issn": [
"1087-0156",
"1546-1696"
],
"name": "Nature Biotechnology",
"type": "Periodical"
},
{
"issueNumber": "9",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "27"
}
],
"name": "Sensitive digital quantification of DNA methylation in clinical samples",
"pagination": "858-863",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"107787a719c464cd6b0d38063ae4f690abc097e6645970aeb3c4941935e531c4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19684580"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9604648"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nbt.1559"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1003456878"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nbt.1559",
"https://app.dimensions.ai/details/publication/pub.1003456878"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000345_0000000345/records_64119_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/nbt/journal/v27/n9/full/nbt.1559.html"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nbt.1559'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nbt.1559'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nbt.1559'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nbt.1559'
This table displays all metadata directly associated to this object as RDF triples.
361 TRIPLES
21 PREDICATES
68 URIs
30 LITERALS
18 BLANK NODES