Variation in the safety of induced pluripotent stem cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08

AUTHORS

Kyoko Miura, Yohei Okada, Takashi Aoi, Aki Okada, Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Michiyo Koyanagi, Koji Tanabe, Mari Ohnuki, Daisuke Ogawa, Eiji Ikeda, Hideyuki Okano, Shinya Yamanaka

ABSTRACT

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells. More... »

PAGES

743-745

Journal

TITLE

Nature Biotechnology

ISSUE

8

VOLUME

27

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.1554

    DOI

    http://dx.doi.org/10.1038/nbt.1554

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026579194

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19590502


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