Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05-24

AUTHORS

Aly A Khan, Doron Betel, Martin L Miller, Chris Sander, Christina S Leslie, Debora S Marks

ABSTRACT

Transfection of siRNAs and miRNAs into cells has been observed to generate unexpected effects in the form of gene upregulation. By statistically analyzing published transfection experiments, Khan et al. explain these effects with a model that the transfected RNAs compete with miRNAs naturally expressed by the cell.

PAGES

549-555

References to SciGraph publications

  • 2004-09-15. The functions of animal microRNAs in NATURE
  • 2008-07. Erratum: Wandering eye for RNAi in NATURE MEDICINE
  • 2008-06. Community corner in NATURE MEDICINE
  • 2008-07-30. The impact of microRNAs on protein output in NATURE
  • 2007-09-26. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway in NATURE
  • 2005-01-30. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs in NATURE
  • 2004-07. MicroRNAs: small RNAs with a big role in gene regulation in NATURE REVIEWS GENETICS
  • 2005-10-30. Silencing of microRNAs in vivo with ‘antagomirs’ in NATURE
  • 2006-05. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways in NATURE
  • 2007-06-06. A microRNA component of the p53 tumour suppressor network in NATURE
  • 2008-10-19. The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities in NATURE MEDICINE
  • 2008-07-25. Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model in CANCER GENE THERAPY
  • 2006-10-09. Implications of micro-RNA profiling for cancer diagnosis in ONCOGENE
  • 2008-03-26. LNA-mediated microRNA silencing in non-human primates in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2008-07-30. Widespread changes in protein synthesis induced by microRNAs in NATURE
  • 2008-10. The perfect storm of tiny RNAs in NATURE MEDICINE
  • 2008-02. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? in NATURE REVIEWS GENETICS
  • 2003-05-18. Expression profiling reveals off-target gene regulation by RNAi in NATURE BIOTECHNOLOGY
  • 2005-11-23. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection in NATURE
  • Journal

    TITLE

    Nature Biotechnology

    ISSUE

    6

    VOLUME

    27

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nbt.1543

    DOI

    http://dx.doi.org/10.1038/nbt.1543

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036769338

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19465925


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