A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-06

AUTHORS

Sarah L. Crittenden, David S. Bernstein, Jennifer L. Bachorik, Beth E. Thompson, Maria Gallegos, Andrei G. Petcherski, Gary Moulder, Robert Barstead, Marvin Wickens, Judith Kimble

ABSTRACT

Germline stem cells are defined by their unique ability to generate more of themselves as well as differentiated gametes. The molecular mechanisms controlling the decision between self-renewal and differentiation are central unsolved problems in developmental biology with potentially broad medical implications. In Caenorhabditis elegans, germline stem cells are controlled by the somatic distal tip cell. FBF-1 and FBF-2, two nearly identical proteins, which together are called FBF ('fem-3 mRNA binding factor'), were originally discovered as regulators of germline sex determination. Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, germline proliferation is initially normal, but stem cells are not maintained. We suggest that FBF controls germline stem cells, at least in part, by repressing gld-1, which itself promotes commitment to the meiotic cell cycle. FBF belongs to the PUF family ('Pumilio and FBF') of RNA-binding proteins. Pumilio controls germline stem cells in Drosophila females, and, in lower eukaryotes, PUF proteins promote continued mitoses. We suggest that regulation by PUF proteins may be an ancient and widespread mechanism for control of stem cells. More... »

PAGES

660

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature754

DOI

http://dx.doi.org/10.1038/nature754

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004880751

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12050669


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3' Untranslated Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Lineage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disorders of Sex Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoretic Mobility Shift Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Helminth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helminth Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meiosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Two-Hybrid System Techniques", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "*Howard Hughes Medical Institute, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crittenden", 
        "givenName": "Sarah L.", 
        "id": "sg:person.01006030150.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006030150.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2020Department of Biochemistry, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernstein", 
        "givenName": "David S.", 
        "id": "sg:person.0602263077.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602263077.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2021Program in Cellular and Molecular Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachorik", 
        "givenName": "Jennifer L.", 
        "id": "sg:person.01255530722.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255530722.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2021Program in Cellular and Molecular Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Beth E.", 
        "id": "sg:person.01041372161.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041372161.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2021Program in Cellular and Molecular Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gallegos", 
        "givenName": "Maria", 
        "id": "sg:person.01054143350.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054143350.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2020Department of Biochemistry, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petcherski", 
        "givenName": "Andrei G.", 
        "id": "sg:person.01032740077.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032740077.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oklahoma Medical Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.274264.1", 
          "name": [
            "\u2016Program in Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moulder", 
        "givenName": "Gary", 
        "id": "sg:person.01371433663.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371433663.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oklahoma Medical Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.274264.1", 
          "name": [
            "\u2016Program in Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barstead", 
        "givenName": "Robert", 
        "id": "sg:person.01147166477.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147166477.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "\u2020Department of Biochemistry, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wickens", 
        "givenName": "Marvin", 
        "id": "sg:person.015335756757.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015335756757.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Wisconsin\u2013Madison", 
          "id": "https://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "*Howard Hughes Medical Institute, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA", 
            "\u2020Department of Biochemistry, University of Wisconsin\u2013Madison, Madison, Wisconsin 53706, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimble", 
        "givenName": "Judith", 
        "id": "sg:person.01022674570.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022674570.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80219-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003398351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-9525(01)02616-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012112269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.102.5.1778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015126580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.3.552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016656132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004120050256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019687555", 
          "https://doi.org/10.1007/s004120050256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80449-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021179298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1996.0293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027451104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.1.258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032967664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1046-2023(02)00015-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039621299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1046-2023(02)00015-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039621299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.915901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040029656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.16.8496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041863740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.12.1491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042261954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(81)90284-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042961133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81481-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049735011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051546774", 
          "https://doi.org/10.1038/37297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/37297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051546774", 
          "https://doi.org/10.1038/37297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90368-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054549984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.287.5457.1427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062568510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074478961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074960348", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082432708", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082476316", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082476317", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083108382", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083199533", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083245882", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-06", 
    "datePublishedReg": "2002-06-01", 
    "description": "Germline stem cells are defined by their unique ability to generate more of themselves as well as differentiated gametes. The molecular mechanisms controlling the decision between self-renewal and differentiation are central unsolved problems in developmental biology with potentially broad medical implications. In Caenorhabditis elegans, germline stem cells are controlled by the somatic distal tip cell. FBF-1 and FBF-2, two nearly identical proteins, which together are called FBF ('fem-3 mRNA binding factor'), were originally discovered as regulators of germline sex determination. Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, germline proliferation is initially normal, but stem cells are not maintained. We suggest that FBF controls germline stem cells, at least in part, by repressing gld-1, which itself promotes commitment to the meiotic cell cycle. FBF belongs to the PUF family ('Pumilio and FBF') of RNA-binding proteins. Pumilio controls germline stem cells in Drosophila females, and, in lower eukaryotes, PUF proteins promote continued mitoses. We suggest that regulation by PUF proteins may be an ancient and widespread mechanism for control of stem cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature754", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6889", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "417"
      }
    ], 
    "name": "A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans", 
    "pagination": "660", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1741d589492254b358da86aeb71cc2f09d84b2d267ee9409f33dc588d6c863ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12050669"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature754"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004880751"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature754", 
      "https://app.dimensions.ai/details/publication/pub.1004880751"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87079_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature754"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature754'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature754'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature754'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature754'


 

This table displays all metadata directly associated to this object as RDF triples.

306 TRIPLES      21 PREDICATES      79 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature754 schema:about N06cdeb21a9b145f8ab372a0fed72fbbd
2 N125b249b54704674915f760c6315d092
3 N16d07f7efd874f9195c4d49015d6a3e2
4 N1c64ae904c4740959d03b0afd5a20f84
5 N220d3a5e84d44799be4c194ac347c658
6 N3088b16247e3405088f5bec1e28a102f
7 N3532e8c6f86049e4a8515d52f04028d3
8 N3646fbd20c1d4a3cbce8266c73b87fae
9 N42e4ea7ac3e34a909d7eb72a05587a2e
10 N44e4197ac8d1465db74cbe77b5ed8206
11 N4deb4d7e5d8842019dbdc8d982d5e22d
12 N5f9e301494be4f30b3c1a7ca0298f892
13 N7d9fd1cc852f4d7d8ba350dbd681de62
14 N87b334a92e2a4bfd9804518337380ae2
15 N8f4932ec30c143caa8f74676400a3817
16 Na04cf7cc784848f8bf32862a9a2c3ce9
17 Nac032df9303e450e9994aaebf42797b4
18 Nc8abf967922645759090758d5bfede36
19 Ncdd1fd3789a04408a2eddeda6fab05aa
20 Nd30d43ab1c3d4f40acda88fa033af1be
21 Nd61a7be57b1048b0867be5089e52ff3b
22 Nd71c0f10ef71481cb36971d1fad1365c
23 Ne15f3a88d5114f56b44847a4d33d3f9a
24 Ne831a359e5094be1aa075d28be44db25
25 Nfef1c5919d8e4c13a67889b20814aa22
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author Ncb551cf9c62d4d7c958bc79f8a4a17a9
29 schema:citation sg:pub.10.1007/s004120050256
30 sg:pub.10.1038/37297
31 https://app.dimensions.ai/details/publication/pub.1074478961
32 https://app.dimensions.ai/details/publication/pub.1074960348
33 https://app.dimensions.ai/details/publication/pub.1082432708
34 https://app.dimensions.ai/details/publication/pub.1082476316
35 https://app.dimensions.ai/details/publication/pub.1082476317
36 https://app.dimensions.ai/details/publication/pub.1083108382
37 https://app.dimensions.ai/details/publication/pub.1083199533
38 https://app.dimensions.ai/details/publication/pub.1083245882
39 https://doi.org/10.1006/dbio.1996.0293
40 https://doi.org/10.1016/0012-1606(81)90284-0
41 https://doi.org/10.1016/0092-8674(91)90368-9
42 https://doi.org/10.1016/s0092-8674(00)80219-6
43 https://doi.org/10.1016/s0092-8674(00)81481-6
44 https://doi.org/10.1016/s0168-9525(01)02616-6
45 https://doi.org/10.1016/s0960-9822(99)80449-7
46 https://doi.org/10.1016/s1046-2023(02)00015-4
47 https://doi.org/10.1073/pnas.93.16.8496
48 https://doi.org/10.1083/jcb.102.5.1778
49 https://doi.org/10.1093/emboj/18.1.258
50 https://doi.org/10.1093/emboj/20.3.552
51 https://doi.org/10.1101/gad.9.12.1491
52 https://doi.org/10.1101/gad.915901
53 https://doi.org/10.1126/science.287.5457.1427
54 schema:datePublished 2002-06
55 schema:datePublishedReg 2002-06-01
56 schema:description Germline stem cells are defined by their unique ability to generate more of themselves as well as differentiated gametes. The molecular mechanisms controlling the decision between self-renewal and differentiation are central unsolved problems in developmental biology with potentially broad medical implications. In Caenorhabditis elegans, germline stem cells are controlled by the somatic distal tip cell. FBF-1 and FBF-2, two nearly identical proteins, which together are called FBF ('fem-3 mRNA binding factor'), were originally discovered as regulators of germline sex determination. Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, germline proliferation is initially normal, but stem cells are not maintained. We suggest that FBF controls germline stem cells, at least in part, by repressing gld-1, which itself promotes commitment to the meiotic cell cycle. FBF belongs to the PUF family ('Pumilio and FBF') of RNA-binding proteins. Pumilio controls germline stem cells in Drosophila females, and, in lower eukaryotes, PUF proteins promote continued mitoses. We suggest that regulation by PUF proteins may be an ancient and widespread mechanism for control of stem cells.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N6257a2f36f44431bb54ff78b29263067
61 Ne5c9ed932cc947aeac581b120fbcd513
62 sg:journal.1018957
63 schema:name A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans
64 schema:pagination 660
65 schema:productId N15ff001e4fe64000af91fd9ca34511dd
66 N2d0d7db4d9084f25937aeda432a3d1e2
67 N556750513a41406da6bc9e037bd890b6
68 N7bad2216e653405d84d90a0ba2127e4d
69 Nf49f204a477e45bba1bb68354ff0351c
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880751
71 https://doi.org/10.1038/nature754
72 schema:sdDatePublished 2019-04-11T12:21
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N581417cdb1aa487588d25a62ea4665ae
75 schema:url https://www.nature.com/articles/nature754
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N06cdeb21a9b145f8ab372a0fed72fbbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Germ Cells
81 rdf:type schema:DefinedTerm
82 N0ef57304c9e34727857f3cb3396802f8 rdf:first sg:person.015335756757.32
83 rdf:rest N12750017d02a4456a7cff79fd8d38d00
84 N125b249b54704674915f760c6315d092 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Electrophoretic Mobility Shift Assay
86 rdf:type schema:DefinedTerm
87 N12750017d02a4456a7cff79fd8d38d00 rdf:first sg:person.01022674570.06
88 rdf:rest rdf:nil
89 N15ff001e4fe64000af91fd9ca34511dd schema:name pubmed_id
90 schema:value 12050669
91 rdf:type schema:PropertyValue
92 N16d07f7efd874f9195c4d49015d6a3e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Repressor Proteins
94 rdf:type schema:DefinedTerm
95 N1c64ae904c4740959d03b0afd5a20f84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name RNA-Binding Proteins
97 rdf:type schema:DefinedTerm
98 N220d3a5e84d44799be4c194ac347c658 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Cell Lineage
100 rdf:type schema:DefinedTerm
101 N2d0d7db4d9084f25937aeda432a3d1e2 schema:name nlm_unique_id
102 schema:value 0410462
103 rdf:type schema:PropertyValue
104 N2e6a9af70b0e454ea1411dd6a077247b rdf:first sg:person.01041372161.21
105 rdf:rest Nefa1e58e937445dfb826974860a30b61
106 N3088b16247e3405088f5bec1e28a102f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 N3532e8c6f86049e4a8515d52f04028d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Conserved Sequence
111 rdf:type schema:DefinedTerm
112 N3646fbd20c1d4a3cbce8266c73b87fae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Disorders of Sex Development
114 rdf:type schema:DefinedTerm
115 N42e4ea7ac3e34a909d7eb72a05587a2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Genes, Helminth
117 rdf:type schema:DefinedTerm
118 N44e4197ac8d1465db74cbe77b5ed8206 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mutation
120 rdf:type schema:DefinedTerm
121 N4deb4d7e5d8842019dbdc8d982d5e22d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name 3' Untranslated Regions
123 rdf:type schema:DefinedTerm
124 N556750513a41406da6bc9e037bd890b6 schema:name dimensions_id
125 schema:value pub.1004880751
126 rdf:type schema:PropertyValue
127 N581417cdb1aa487588d25a62ea4665ae schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N5f9e301494be4f30b3c1a7ca0298f892 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Protein Binding
131 rdf:type schema:DefinedTerm
132 N60e2227d4919409aa1a0750202dec73f rdf:first sg:person.0602263077.94
133 rdf:rest N6879d36c97ae42a18070d5cea44e0338
134 N6257a2f36f44431bb54ff78b29263067 schema:issueNumber 6889
135 rdf:type schema:PublicationIssue
136 N6879d36c97ae42a18070d5cea44e0338 rdf:first sg:person.01255530722.89
137 rdf:rest N2e6a9af70b0e454ea1411dd6a077247b
138 N7bad2216e653405d84d90a0ba2127e4d schema:name doi
139 schema:value 10.1038/nature754
140 rdf:type schema:PropertyValue
141 N7c015116c91c483188c0e2b87dd8057e rdf:first sg:person.01147166477.18
142 rdf:rest N0ef57304c9e34727857f3cb3396802f8
143 N7d9fd1cc852f4d7d8ba350dbd681de62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Response Elements
145 rdf:type schema:DefinedTerm
146 N87b334a92e2a4bfd9804518337380ae2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cell Division
148 rdf:type schema:DefinedTerm
149 N8f4932ec30c143caa8f74676400a3817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Stem Cells
151 rdf:type schema:DefinedTerm
152 Na04cf7cc784848f8bf32862a9a2c3ce9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Base Sequence
154 rdf:type schema:DefinedTerm
155 Nac032df9303e450e9994aaebf42797b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Helminth Proteins
157 rdf:type schema:DefinedTerm
158 Nc8abf967922645759090758d5bfede36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Caenorhabditis elegans Proteins
160 rdf:type schema:DefinedTerm
161 Ncb551cf9c62d4d7c958bc79f8a4a17a9 rdf:first sg:person.01006030150.50
162 rdf:rest N60e2227d4919409aa1a0750202dec73f
163 Ncdd1fd3789a04408a2eddeda6fab05aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Two-Hybrid System Techniques
165 rdf:type schema:DefinedTerm
166 Nd30d43ab1c3d4f40acda88fa033af1be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Meiosis
168 rdf:type schema:DefinedTerm
169 Nd61a7be57b1048b0867be5089e52ff3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Female
171 rdf:type schema:DefinedTerm
172 Nd71c0f10ef71481cb36971d1fad1365c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Caenorhabditis elegans
174 rdf:type schema:DefinedTerm
175 Ndf60bee501104312b257862476d0c5a5 rdf:first sg:person.01371433663.73
176 rdf:rest N7c015116c91c483188c0e2b87dd8057e
177 Ne15f3a88d5114f56b44847a4d33d3f9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Male
179 rdf:type schema:DefinedTerm
180 Ne5c9ed932cc947aeac581b120fbcd513 schema:volumeNumber 417
181 rdf:type schema:PublicationVolume
182 Ne831a359e5094be1aa075d28be44db25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Gene Expression Regulation
184 rdf:type schema:DefinedTerm
185 Nee706e4281e7437eb20df91697d0cfd4 rdf:first sg:person.01032740077.03
186 rdf:rest Ndf60bee501104312b257862476d0c5a5
187 Nefa1e58e937445dfb826974860a30b61 rdf:first sg:person.01054143350.24
188 rdf:rest Nee706e4281e7437eb20df91697d0cfd4
189 Nf49f204a477e45bba1bb68354ff0351c schema:name readcube_id
190 schema:value 1741d589492254b358da86aeb71cc2f09d84b2d267ee9409f33dc588d6c863ed
191 rdf:type schema:PropertyValue
192 Nfef1c5919d8e4c13a67889b20814aa22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Cell Differentiation
194 rdf:type schema:DefinedTerm
195 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
196 schema:name Biological Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
199 schema:name Biochemistry and Cell Biology
200 rdf:type schema:DefinedTerm
201 sg:journal.1018957 schema:issn 0090-0028
202 1476-4687
203 schema:name Nature
204 rdf:type schema:Periodical
205 sg:person.01006030150.50 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
206 schema:familyName Crittenden
207 schema:givenName Sarah L.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006030150.50
209 rdf:type schema:Person
210 sg:person.01022674570.06 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
211 schema:familyName Kimble
212 schema:givenName Judith
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022674570.06
214 rdf:type schema:Person
215 sg:person.01032740077.03 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
216 schema:familyName Petcherski
217 schema:givenName Andrei G.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032740077.03
219 rdf:type schema:Person
220 sg:person.01041372161.21 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
221 schema:familyName Thompson
222 schema:givenName Beth E.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041372161.21
224 rdf:type schema:Person
225 sg:person.01054143350.24 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
226 schema:familyName Gallegos
227 schema:givenName Maria
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054143350.24
229 rdf:type schema:Person
230 sg:person.01147166477.18 schema:affiliation https://www.grid.ac/institutes/grid.274264.1
231 schema:familyName Barstead
232 schema:givenName Robert
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147166477.18
234 rdf:type schema:Person
235 sg:person.01255530722.89 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
236 schema:familyName Bachorik
237 schema:givenName Jennifer L.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255530722.89
239 rdf:type schema:Person
240 sg:person.01371433663.73 schema:affiliation https://www.grid.ac/institutes/grid.274264.1
241 schema:familyName Moulder
242 schema:givenName Gary
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371433663.73
244 rdf:type schema:Person
245 sg:person.015335756757.32 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
246 schema:familyName Wickens
247 schema:givenName Marvin
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015335756757.32
249 rdf:type schema:Person
250 sg:person.0602263077.94 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
251 schema:familyName Bernstein
252 schema:givenName David S.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602263077.94
254 rdf:type schema:Person
255 sg:pub.10.1007/s004120050256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019687555
256 https://doi.org/10.1007/s004120050256
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/37297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051546774
259 https://doi.org/10.1038/37297
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1074478961 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1074960348 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1082432708 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1082476316 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1082476317 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083108382 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1083199533 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1083245882 schema:CreativeWork
269 https://doi.org/10.1006/dbio.1996.0293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027451104
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0012-1606(81)90284-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042961133
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0092-8674(91)90368-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054549984
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0092-8674(00)80219-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003398351
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0092-8674(00)81481-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049735011
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0168-9525(01)02616-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012112269
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0960-9822(99)80449-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021179298
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s1046-2023(02)00015-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039621299
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.93.16.8496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041863740
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1083/jcb.102.5.1778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015126580
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1093/emboj/18.1.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032967664
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1093/emboj/20.3.552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016656132
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1101/gad.9.12.1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042261954
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1101/gad.915901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040029656
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1126/science.287.5457.1427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062568510
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
300 schema:name *Howard Hughes Medical Institute, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA
301 †Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA
302 ‡Program in Cellular and Molecular Biology, University of Wisconsin–Madison, Madison, Wisconsin 53706, USA
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.274264.1 schema:alternateName Oklahoma Medical Research Foundation
305 schema:name ‖Program in Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
306 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...