Molecular identification of a renal urate–anion exchanger that regulates blood urate levels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-04-14

AUTHORS

Atsushi Enomoto, Hiroaki Kimura, Arthit Chairoungdua, Yasuhiro Shigeta, Promsuk Jutabha, Seok Ho Cha, Makoto Hosoyamada, Michio Takeda, Takashi Sekine, Takashi Igarashi, Hirotaka Matsuo, Yuichi Kikuchi, Takashi Oda, Kimiyoshi Ichida, Tatsuo Hosoya, Kaoru Shimokata, Toshimitsu Niwa, Yoshikatsu Kanai, Hitoshi Endou

ABSTRACT

Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes1,2,3, as demonstrated by its capacity of neuroprotection4,5. It is present at higher levels in human blood (200–500 µM) than in other mammals6, because humans have an effective renal urate reabsorption system, despite their evolutionary loss of hepatic uricase by mutational silencing6,7,8. The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences6,9,10. Here we identify the long-hypothesized9,10,11 urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Moreover, we provide evidence that patients with idiopathic renal hypouricaemia (lack of blood uric acid) have defects in SLC22A12. Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution. More... »

PAGES

447-452

Journal

TITLE

Nature

ISSUE

6887

VOLUME

417

Related Patents

  • 3,4-Di-Substituted Pyridine Compound, Methods Of Using And Compositions Comprising The Same
  • Composition For Regulating Urat1 Activity
  • 3,4-Di-Substituted Pyridine Compound, Methods Of Using And Compositions Comprising The Same
  • Urat1 Inhibitor
  • Compounds, Compositions And Methods Of Using Same For Modulating Uric Acid Levels
  • Compounds, Compositions And Methods Of Using Same For Modulating Uric Acid Levels
  • Molecule Associated With Onset Of Gout, And Method And Kit For Evaluating Diathesis Of Uric Acid-Related Diseases And Inflammation-Related Diseases, And Inspection Object And Drug
  • Difluoromethylene Compound
  • Compounds And Compositions And Methods Of Use
  • Compounds, Compositions And Methods Of Using Same For Modulating Uric Acid Levels
  • Methods Of Modulating Uric Acid Levels
  • Carboxy Substituted (Hetero) Aromatic Ring Derivatives And Preparation Method And Uses Thereof
  • Compounds, Compositions And Methods Of Using Same For Modulating Uric Acid Levels
  • Compounds And Compositions And Methods Of Use
  • Carboxylic Acid Urat1 Inhibitor Containing Diarylmethane Structure, Preparation Method And Use Thereof
  • Urate Transporter, As Well As Method And Kit For Evaluating Urate Transport-Related Disease Factor And Inflammation-Related Disease Factor, And Test Sample And Drug
  • Cycloalkyl Acid Derivative, Preparation Method Thereof, And Pharmaceutical Application Thereof
  • Difluoromethylene Compound
  • Compounds And Compositions And Methods Of Use
  • Compounds And Compositions And Methods Of Use
  • Compounds And Compositions And Methods Of Use
  • Compounds, Compositions And Methods Of Using Same For Modulating Uric Acid Levels
  • Heterocyclic Derivatives
  • Pyridine Derivative
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature742

    DOI

    http://dx.doi.org/10.1038/nature742

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009325209

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12024214


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biological Transport", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cloning, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Kidney Tubules, Proximal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organic Anion Transporters", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organic Cation Transport Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Substrate Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Uric Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenopus", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
                "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Enomoto", 
            "givenName": "Atsushi", 
            "id": "sg:person.01316272167.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316272167.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
                "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kimura", 
            "givenName": "Hiroaki", 
            "id": "sg:person.01023272763.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023272763.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chairoungdua", 
            "givenName": "Arthit", 
            "id": "sg:person.01230554453.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230554453.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Chiba University School of Medicine, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
                "Department of Urology, Chiba University School of Medicine, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shigeta", 
            "givenName": "Yasuhiro", 
            "id": "sg:person.01233337251.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233337251.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jutabha", 
            "givenName": "Promsuk", 
            "id": "sg:person.01015711306.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015711306.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ho Cha", 
            "givenName": "Seok", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosoyamada", 
            "givenName": "Makoto", 
            "id": "sg:person.01325066437.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325066437.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takeda", 
            "givenName": "Michio", 
            "id": "sg:person.01044741064.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044741064.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sekine", 
            "givenName": "Takashi", 
            "id": "sg:person.01355313301.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355313301.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Igarashi", 
            "givenName": "Takashi", 
            "id": "sg:person.0751552316.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751552316.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "First Department of Physiology, National Defense Medical College, 359-8513, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
                "First Department of Physiology, National Defense Medical College, 359-8513, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuo", 
            "givenName": "Hirotaka", 
            "id": "sg:person.013767233432.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013767233432.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Department of Internal Medicine, National Defense Medical College, 359-8513, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Second Department of Internal Medicine, National Defense Medical College, 359-8513, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kikuchi", 
            "givenName": "Yuichi", 
            "id": "sg:person.0635341517.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635341517.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, JSDF Kumamoto Hospital, 862-0902, Kumamoto, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Medicine, JSDF Kumamoto Hospital, 862-0902, Kumamoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oda", 
            "givenName": "Takashi", 
            "id": "sg:person.0707161415.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707161415.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ichida", 
            "givenName": "Kimiyoshi", 
            "id": "sg:person.01205146172.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205146172.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411898.d", 
              "name": [
                "Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hosoya", 
            "givenName": "Tatsuo", 
            "id": "sg:person.01223740571.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223740571.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimokata", 
            "givenName": "Kaoru", 
            "id": "sg:person.01222406666.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222406666.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.27476.30", 
              "name": [
                "Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niwa", 
            "givenName": "Toshimitsu", 
            "id": "sg:person.0664541766.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664541766.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanai", 
            "givenName": "Yoshikatsu", 
            "id": "sg:person.015216275622.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015216275622.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Endou", 
            "givenName": "Hitoshi", 
            "id": "sg:person.01013536335.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013536335.60"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/372549a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037916082", 
              "https://doi.org/10.1038/372549a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00853226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005736262", 
              "https://doi.org/10.1007/bf00853226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854081", 
              "https://doi.org/10.1038/35057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00163854", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019386346", 
              "https://doi.org/10.1007/bf00163854"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-04-14", 
        "datePublishedReg": "2002-04-14", 
        "description": "Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes1,2,3, as demonstrated by its capacity of neuroprotection4,5. It is present at higher levels in human blood (200\u2013500\u2009\u00b5M) than in other mammals6, because humans have an effective renal urate reabsorption system, despite their evolutionary loss of hepatic uricase by mutational silencing6,7,8. The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences6,9,10. Here we identify the long-hypothesized9,10,11 urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate\u2013anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Moreover, we provide evidence that patients with idiopathic renal hypouricaemia (lack of blood uric acid) have defects in SLC22A12. Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature742", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6887", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "417"
          }
        ], 
        "keywords": [
          "urate-anion exchanger", 
          "blood urate levels", 
          "evolutionary loss", 
          "antiuricosuric agents", 
          "molecular basis", 
          "molecular identification", 
          "urate transport system", 
          "human evolution", 
          "hepatic uricase", 
          "numerous diseases", 
          "urate homeostasis", 
          "biological oxidants", 
          "human kidney", 
          "purine metabolism", 
          "urate transporters", 
          "transport system", 
          "urate handling", 
          "transporters", 
          "homeostasis", 
          "identification", 
          "reabsorption system", 
          "high levels", 
          "metabolism", 
          "SLC22A12", 
          "levels", 
          "human blood", 
          "evolution", 
          "humans", 
          "insights", 
          "renal hypouricaemia", 
          "URAT1", 
          "scavengers", 
          "uricase", 
          "defects", 
          "agents", 
          "kidney", 
          "concomitant", 
          "loss", 
          "urate levels", 
          "development", 
          "evidence", 
          "basis", 
          "oxidants", 
          "disease", 
          "products", 
          "capacity", 
          "system", 
          "best agent", 
          "lead", 
          "exchanger", 
          "nature", 
          "blood", 
          "handling", 
          "hypouricaemia", 
          "difficulties", 
          "hyperuricaemia", 
          "patients"
        ], 
        "name": "Molecular identification of a renal urate\u2013anion exchanger that regulates blood urate levels", 
        "pagination": "447-452", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1009325209"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature742"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12024214"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature742", 
          "https://app.dimensions.ai/details/publication/pub.1009325209"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T16:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_357.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature742"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature742'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature742'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature742'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature742'


     

    This table displays all metadata directly associated to this object as RDF triples.

    359 TRIPLES      21 PREDICATES      105 URIs      93 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature742 schema:about N019cb26acc1740b7a4c91b38a6332324
    2 N168b8a0b5fba494f8773939df2923143
    3 N2def5471bd414e16a9bc38321513d8b2
    4 N4ee80ac265c8474bab25b73196de1fab
    5 N635f614c4f8b4fcbbf60286e8d4ed9a4
    6 N6d4bde8018624d00afd9135c9781b220
    7 N72ffe9313213456a802ff99ca2b26a1f
    8 N805254a6a0184012830a76f2e6013074
    9 N836a8bd43a414e44b1e4dfeca8e07e47
    10 N935d9b4ee469420a8cbc13183cd93622
    11 N9a7e23456dad4ece83e7ead8b3705e99
    12 N9b0ff47b96ca4d08b7c6bbd06a593baa
    13 Na5af459c807d4cc186d02d1df430a001
    14 Na9dd4084c92a4c708ce70276134ea659
    15 Nb31b3e398878470b84fc37ebc46531d8
    16 Nc5195800b33b4da7a195dc0030add0e1
    17 Ne7b4fc58f3094c4489ee3dc716ee37ca
    18 Nf98e7dbaa734417680fdbb4d5f1f00d8
    19 Nfabb8c6b887440278130b86f2bfd0a38
    20 anzsrc-for:06
    21 anzsrc-for:0604
    22 schema:author Nf7c32531834748089528171a59b2b033
    23 schema:citation sg:pub.10.1007/bf00163854
    24 sg:pub.10.1007/bf00853226
    25 sg:pub.10.1038/35057062
    26 sg:pub.10.1038/372549a0
    27 schema:datePublished 2002-04-14
    28 schema:datePublishedReg 2002-04-14
    29 schema:description Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes1,2,3, as demonstrated by its capacity of neuroprotection4,5. It is present at higher levels in human blood (200–500 µM) than in other mammals6, because humans have an effective renal urate reabsorption system, despite their evolutionary loss of hepatic uricase by mutational silencing6,7,8. The molecular basis for urate handling in the human kidney remains unclear because of difficulties in understanding diverse urate transport systems and species differences6,9,10. Here we identify the long-hypothesized9,10,11 urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricosuric agents (which affect excretion of uric acid). Moreover, we provide evidence that patients with idiopathic renal hypouricaemia (lack of blood uric acid) have defects in SLC22A12. Identification of URAT1 should provide insights into the nature of urate homeostasis, as well as lead to the development of better agents against hyperuricaemia, a disadvantage concomitant with human evolution.
    30 schema:genre article
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N5b0d4f1c08b2485384557bc26c4a44e1
    33 Nd34428f5aedd4a6a9e12340db7165f39
    34 sg:journal.1018957
    35 schema:keywords SLC22A12
    36 URAT1
    37 agents
    38 antiuricosuric agents
    39 basis
    40 best agent
    41 biological oxidants
    42 blood
    43 blood urate levels
    44 capacity
    45 concomitant
    46 defects
    47 development
    48 difficulties
    49 disease
    50 evidence
    51 evolution
    52 evolutionary loss
    53 exchanger
    54 handling
    55 hepatic uricase
    56 high levels
    57 homeostasis
    58 human blood
    59 human evolution
    60 human kidney
    61 humans
    62 hyperuricaemia
    63 hypouricaemia
    64 identification
    65 insights
    66 kidney
    67 lead
    68 levels
    69 loss
    70 metabolism
    71 molecular basis
    72 molecular identification
    73 nature
    74 numerous diseases
    75 oxidants
    76 patients
    77 products
    78 purine metabolism
    79 reabsorption system
    80 renal hypouricaemia
    81 scavengers
    82 system
    83 transport system
    84 transporters
    85 urate handling
    86 urate homeostasis
    87 urate levels
    88 urate transport system
    89 urate transporters
    90 urate-anion exchanger
    91 uricase
    92 schema:name Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
    93 schema:pagination 447-452
    94 schema:productId N5b3f2a96e5134aab9843866b5b6b832f
    95 N8725af255e5e4af0ab67819847e09a26
    96 Nd1edf35bb78649feab7da2ccfee66b95
    97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009325209
    98 https://doi.org/10.1038/nature742
    99 schema:sdDatePublished 2022-08-04T16:54
    100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    101 schema:sdPublisher N1edc4d9b8ab143b48680d84a8212625e
    102 schema:url https://doi.org/10.1038/nature742
    103 sgo:license sg:explorer/license/
    104 sgo:sdDataset articles
    105 rdf:type schema:ScholarlyArticle
    106 N001c6873c9034f1fb077c64e9f255fcc rdf:first sg:person.0635341517.54
    107 rdf:rest Nbdff0d04676f40b1b0a6dd5f3c7a8d5a
    108 N019cb26acc1740b7a4c91b38a6332324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Immunohistochemistry
    110 rdf:type schema:DefinedTerm
    111 N0c21880fbeb54049ba2ddff03b9d2324 rdf:first sg:person.015216275622.87
    112 rdf:rest N18bba0381f2c422bb21649dc44d1e6b0
    113 N168b8a0b5fba494f8773939df2923143 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Humans
    115 rdf:type schema:DefinedTerm
    116 N183c74a565ac42e497e01615223af494 rdf:first sg:person.01205146172.74
    117 rdf:rest Nbc63c61530c447348e6b8d595b16b40a
    118 N18bba0381f2c422bb21649dc44d1e6b0 rdf:first sg:person.01013536335.60
    119 rdf:rest rdf:nil
    120 N1edc4d9b8ab143b48680d84a8212625e schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N2def5471bd414e16a9bc38321513d8b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Amino Acid Sequence
    124 rdf:type schema:DefinedTerm
    125 N3d058a9ca6d44f4bbc0a3e86e59f45e3 rdf:first sg:person.01222406666.04
    126 rdf:rest N545da0b7b22a4c9a9c64bc82493ad968
    127 N4ee80ac265c8474bab25b73196de1fab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Kidney Tubules, Proximal
    129 rdf:type schema:DefinedTerm
    130 N545da0b7b22a4c9a9c64bc82493ad968 rdf:first sg:person.0664541766.05
    131 rdf:rest N0c21880fbeb54049ba2ddff03b9d2324
    132 N5b0d4f1c08b2485384557bc26c4a44e1 schema:issueNumber 6887
    133 rdf:type schema:PublicationIssue
    134 N5b3f2a96e5134aab9843866b5b6b832f schema:name pubmed_id
    135 schema:value 12024214
    136 rdf:type schema:PropertyValue
    137 N5eb7fed393ad4d32b0342e51d58c0e6b rdf:first sg:person.01355313301.08
    138 rdf:rest N96a93a64aaf84d38a619a8e4f3d78664
    139 N635f614c4f8b4fcbbf60286e8d4ed9a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Substrate Specificity
    141 rdf:type schema:DefinedTerm
    142 N6d4bde8018624d00afd9135c9781b220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Mutation
    144 rdf:type schema:DefinedTerm
    145 N72ffe9313213456a802ff99ca2b26a1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Uric Acid
    147 rdf:type schema:DefinedTerm
    148 N805254a6a0184012830a76f2e6013074 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Carrier Proteins
    150 rdf:type schema:DefinedTerm
    151 N836a8bd43a414e44b1e4dfeca8e07e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Anions
    153 rdf:type schema:DefinedTerm
    154 N8725af255e5e4af0ab67819847e09a26 schema:name dimensions_id
    155 schema:value pub.1009325209
    156 rdf:type schema:PropertyValue
    157 N935d9b4ee469420a8cbc13183cd93622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Organic Cation Transport Proteins
    159 rdf:type schema:DefinedTerm
    160 N96a93a64aaf84d38a619a8e4f3d78664 rdf:first sg:person.0751552316.36
    161 rdf:rest Nfe394a7bed594f27ba601200df9babb1
    162 N9a7e23456dad4ece83e7ead8b3705e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Animals
    164 rdf:type schema:DefinedTerm
    165 N9b0ff47b96ca4d08b7c6bbd06a593baa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Molecular Sequence Data
    167 rdf:type schema:DefinedTerm
    168 Na59b884b02d74f2084c2b16fd23afb46 rdf:first sg:person.01044741064.17
    169 rdf:rest N5eb7fed393ad4d32b0342e51d58c0e6b
    170 Na5af459c807d4cc186d02d1df430a001 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Cloning, Molecular
    172 rdf:type schema:DefinedTerm
    173 Na9dd4084c92a4c708ce70276134ea659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Oocytes
    175 rdf:type schema:DefinedTerm
    176 Nb31b3e398878470b84fc37ebc46531d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Xenopus
    178 rdf:type schema:DefinedTerm
    179 Nbc63c61530c447348e6b8d595b16b40a rdf:first sg:person.01223740571.61
    180 rdf:rest N3d058a9ca6d44f4bbc0a3e86e59f45e3
    181 Nbdff0d04676f40b1b0a6dd5f3c7a8d5a rdf:first sg:person.0707161415.44
    182 rdf:rest N183c74a565ac42e497e01615223af494
    183 Nc5195800b33b4da7a195dc0030add0e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Biological Transport
    185 rdf:type schema:DefinedTerm
    186 Ncf0298923f5a4273b4dc19fef77cc6c3 rdf:first sg:person.01015711306.65
    187 rdf:rest Ndb7201d4fe8a405aa8f5e3d108bb4e1d
    188 Nd1edf35bb78649feab7da2ccfee66b95 schema:name doi
    189 schema:value 10.1038/nature742
    190 rdf:type schema:PropertyValue
    191 Nd34428f5aedd4a6a9e12340db7165f39 schema:volumeNumber 417
    192 rdf:type schema:PublicationVolume
    193 Nd654eb403ac04c78b32e28548a1c64f8 rdf:first sg:person.01233337251.47
    194 rdf:rest Ncf0298923f5a4273b4dc19fef77cc6c3
    195 Ndb7201d4fe8a405aa8f5e3d108bb4e1d rdf:first Nfb78b8ee54ca4b0484035cdf4d22f616
    196 rdf:rest Ne958022c05cb4f8ab483588ffd4f50b7
    197 Ne620d3e43cf5452596a8284d53a35a83 rdf:first sg:person.01230554453.09
    198 rdf:rest Nd654eb403ac04c78b32e28548a1c64f8
    199 Ne7b4fc58f3094c4489ee3dc716ee37ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Organic Anion Transporters
    201 rdf:type schema:DefinedTerm
    202 Ne958022c05cb4f8ab483588ffd4f50b7 rdf:first sg:person.01325066437.28
    203 rdf:rest Na59b884b02d74f2084c2b16fd23afb46
    204 Nf5542bffa291479aa5974a0b49dd5355 rdf:first sg:person.01023272763.45
    205 rdf:rest Ne620d3e43cf5452596a8284d53a35a83
    206 Nf7c32531834748089528171a59b2b033 rdf:first sg:person.01316272167.03
    207 rdf:rest Nf5542bffa291479aa5974a0b49dd5355
    208 Nf98e7dbaa734417680fdbb4d5f1f00d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name RNA, Messenger
    210 rdf:type schema:DefinedTerm
    211 Nfabb8c6b887440278130b86f2bfd0a38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Kidney
    213 rdf:type schema:DefinedTerm
    214 Nfb78b8ee54ca4b0484035cdf4d22f616 schema:affiliation grid-institutes:grid.411205.3
    215 schema:familyName Ho Cha
    216 schema:givenName Seok
    217 rdf:type schema:Person
    218 Nfe394a7bed594f27ba601200df9babb1 rdf:first sg:person.013767233432.29
    219 rdf:rest N001c6873c9034f1fb077c64e9f255fcc
    220 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    221 schema:name Biological Sciences
    222 rdf:type schema:DefinedTerm
    223 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Genetics
    225 rdf:type schema:DefinedTerm
    226 sg:journal.1018957 schema:issn 0028-0836
    227 1476-4687
    228 schema:name Nature
    229 schema:publisher Springer Nature
    230 rdf:type schema:Periodical
    231 sg:person.01013536335.60 schema:affiliation grid-institutes:grid.411205.3
    232 schema:familyName Endou
    233 schema:givenName Hitoshi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013536335.60
    235 rdf:type schema:Person
    236 sg:person.01015711306.65 schema:affiliation grid-institutes:grid.411205.3
    237 schema:familyName Jutabha
    238 schema:givenName Promsuk
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015711306.65
    240 rdf:type schema:Person
    241 sg:person.01023272763.45 schema:affiliation grid-institutes:grid.411898.d
    242 schema:familyName Kimura
    243 schema:givenName Hiroaki
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023272763.45
    245 rdf:type schema:Person
    246 sg:person.01044741064.17 schema:affiliation grid-institutes:grid.411205.3
    247 schema:familyName Takeda
    248 schema:givenName Michio
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044741064.17
    250 rdf:type schema:Person
    251 sg:person.01205146172.74 schema:affiliation grid-institutes:grid.411898.d
    252 schema:familyName Ichida
    253 schema:givenName Kimiyoshi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205146172.74
    255 rdf:type schema:Person
    256 sg:person.01222406666.04 schema:affiliation grid-institutes:grid.27476.30
    257 schema:familyName Shimokata
    258 schema:givenName Kaoru
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222406666.04
    260 rdf:type schema:Person
    261 sg:person.01223740571.61 schema:affiliation grid-institutes:grid.411898.d
    262 schema:familyName Hosoya
    263 schema:givenName Tatsuo
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223740571.61
    265 rdf:type schema:Person
    266 sg:person.01230554453.09 schema:affiliation grid-institutes:grid.411205.3
    267 schema:familyName Chairoungdua
    268 schema:givenName Arthit
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230554453.09
    270 rdf:type schema:Person
    271 sg:person.01233337251.47 schema:affiliation grid-institutes:grid.136304.3
    272 schema:familyName Shigeta
    273 schema:givenName Yasuhiro
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233337251.47
    275 rdf:type schema:Person
    276 sg:person.01316272167.03 schema:affiliation grid-institutes:grid.27476.30
    277 schema:familyName Enomoto
    278 schema:givenName Atsushi
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316272167.03
    280 rdf:type schema:Person
    281 sg:person.01325066437.28 schema:affiliation grid-institutes:grid.411205.3
    282 schema:familyName Hosoyamada
    283 schema:givenName Makoto
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325066437.28
    285 rdf:type schema:Person
    286 sg:person.01355313301.08 schema:affiliation grid-institutes:grid.26999.3d
    287 schema:familyName Sekine
    288 schema:givenName Takashi
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355313301.08
    290 rdf:type schema:Person
    291 sg:person.013767233432.29 schema:affiliation grid-institutes:grid.416614.0
    292 schema:familyName Matsuo
    293 schema:givenName Hirotaka
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013767233432.29
    295 rdf:type schema:Person
    296 sg:person.015216275622.87 schema:affiliation grid-institutes:grid.411205.3
    297 schema:familyName Kanai
    298 schema:givenName Yoshikatsu
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015216275622.87
    300 rdf:type schema:Person
    301 sg:person.0635341517.54 schema:affiliation grid-institutes:grid.416614.0
    302 schema:familyName Kikuchi
    303 schema:givenName Yuichi
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635341517.54
    305 rdf:type schema:Person
    306 sg:person.0664541766.05 schema:affiliation grid-institutes:grid.27476.30
    307 schema:familyName Niwa
    308 schema:givenName Toshimitsu
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664541766.05
    310 rdf:type schema:Person
    311 sg:person.0707161415.44 schema:affiliation grid-institutes:None
    312 schema:familyName Oda
    313 schema:givenName Takashi
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707161415.44
    315 rdf:type schema:Person
    316 sg:person.0751552316.36 schema:affiliation grid-institutes:grid.26999.3d
    317 schema:familyName Igarashi
    318 schema:givenName Takashi
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751552316.36
    320 rdf:type schema:Person
    321 sg:pub.10.1007/bf00163854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019386346
    322 https://doi.org/10.1007/bf00163854
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/bf00853226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005736262
    325 https://doi.org/10.1007/bf00853226
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
    328 https://doi.org/10.1038/35057062
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/372549a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037916082
    331 https://doi.org/10.1038/372549a0
    332 rdf:type schema:CreativeWork
    333 grid-institutes:None schema:alternateName Department of Medicine, JSDF Kumamoto Hospital, 862-0902, Kumamoto, Japan
    334 schema:name Department of Medicine, JSDF Kumamoto Hospital, 862-0902, Kumamoto, Japan
    335 rdf:type schema:Organization
    336 grid-institutes:grid.136304.3 schema:alternateName Department of Urology, Chiba University School of Medicine, 260-8670, Chiba, Japan
    337 schema:name Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    338 Department of Urology, Chiba University School of Medicine, 260-8670, Chiba, Japan
    339 rdf:type schema:Organization
    340 grid-institutes:grid.26999.3d schema:alternateName Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan
    341 schema:name Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 113-8655, Tokyo, Japan
    342 rdf:type schema:Organization
    343 grid-institutes:grid.27476.30 schema:alternateName Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan
    344 schema:name Department of Clinical Preventive Medicine, Nagoya University School of Medicine, 466-8560, Nagoya, Japan
    345 Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    346 rdf:type schema:Organization
    347 grid-institutes:grid.411205.3 schema:alternateName Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    348 schema:name Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    349 rdf:type schema:Organization
    350 grid-institutes:grid.411898.d schema:alternateName Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan
    351 schema:name Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    352 Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 105-8461, Tokyo, Japan
    353 rdf:type schema:Organization
    354 grid-institutes:grid.416614.0 schema:alternateName First Department of Physiology, National Defense Medical College, 359-8513, Saitama, Japan
    355 Second Department of Internal Medicine, National Defense Medical College, 359-8513, Saitama, Japan
    356 schema:name Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 181-8611, Tokyo, Japan
    357 First Department of Physiology, National Defense Medical College, 359-8513, Saitama, Japan
    358 Second Department of Internal Medicine, National Defense Medical College, 359-8513, Saitama, Japan
    359 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...