Environment dominates over host genetics in shaping human gut microbiota View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02-28

AUTHORS

Daphna Rothschild, Omer Weissbrod, Elad Barkan, Alexander Kurilshikov, Tal Korem, David Zeevi, Paul I. Costea, Anastasia Godneva, Iris N. Kalka, Noam Bar, Smadar Shilo, Dar Lador, Arnau Vich Vila, Niv Zmora, Meirav Pevsner-Fischer, David Israeli, Noa Kosower, Gal Malka, Bat Chen Wolf, Tali Avnit-Sagi, Maya Lotan-Pompan, Adina Weinberger, Zamir Halpern, Shai Carmi, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Eran Elinav, Eran Segal

ABSTRACT

Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds. More... »

PAGES

210-215

References to SciGraph publications

  • 2011-05-30. Moving pictures of the human microbiome in GENOME BIOLOGY
  • 2009. The Elements of Statistical Learning, Data Mining, Inference, and Prediction in NONE
  • 2017-05-22. Reevaluation of SNP heritability in complex human traits in NATURE GENETICS
  • 2016-10-03. The effect of host genetics on the gut microbiome in NATURE GENETICS
  • 2014-11-12. Further Improvements to Linear Mixed Models for Genome-Wide Association Studies in SCIENTIFIC REPORTS
  • 2012-09-12. Diversity, stability and resilience of the human gut microbiota in NATURE
  • 2014-09-05. PathoScope 2.0: a complete computational framework for strain identification in environmental or clinical sequencing samples in MICROBIOME
  • 2013-08-28. Richness of human gut microbiome correlates with metabolic markers in NATURE
  • 2016-10-03. Association of host genome with intestinal microbial composition in a large healthy cohort in NATURE GENETICS
  • 2016-10-10. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota in NATURE GENETICS
  • 2015-09-30. A global reference for human genetic variation in NATURE
  • 2010-10-17. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 in NATURE GENETICS
  • 2010-06-09. The genome-wide structure of the Jewish people in NATURE
  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • 2010-04-11. QIIME allows analysis of high-throughput community sequencing data in NATURE METHODS
  • 2014-07-06. An integrated catalog of reference genes in the human gut microbiome in NATURE BIOTECHNOLOGY
  • 2012-06-10. Metagenomic microbial community profiling using unique clade-specific marker genes in NATURE METHODS
  • 2016-10-03. Reference-based phasing using the Haplotype Reference Consortium panel in NATURE GENETICS
  • 2014-01-29. Advantages and pitfalls in the application of mixed-model association methods in NATURE GENETICS
  • 2008-11-26. Lactose digestion and the evolutionary genetics of lactase persistence in HUMAN GENETICS
  • 2014-09-09. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins in NATURE COMMUNICATIONS
  • 2010-06-20. Common SNPs explain a large proportion of the heritability for human height in NATURE GENETICS
  • 2012-10-28. The GEM mapper: fast, accurate and versatile alignment by filtration in NATURE METHODS
  • 2012-05-30. Improved linear mixed models for genome-wide association studies in NATURE METHODS
  • 2008-03-04. Heritability in the genomics era — concepts and misconceptions in NATURE REVIEWS GENETICS
  • 2015-09-15. Host genetic variation impacts microbiome composition across human body sites in GENOME BIOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7695

    VOLUME

    555

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature25973

    DOI

    http://dx.doi.org/10.1038/nature25973

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101264718

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29489753


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Environment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Family Characteristics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastrointestinal Microbiome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene-Environment Interaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glucose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Healthy Volunteers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heredity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Israel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Life Style", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Bacterial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Ribosomal, 16S", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Twin Studies as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Twins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rothschild", 
            "givenName": "Daphna", 
            "id": "sg:person.01260544744.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260544744.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weissbrod", 
            "givenName": "Omer", 
            "id": "sg:person.01077321124.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077321124.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barkan", 
            "givenName": "Elad", 
            "id": "sg:person.07512522524.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07512522524.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kurilshikov", 
            "givenName": "Alexander", 
            "id": "sg:person.0675230535.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675230535.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korem", 
            "givenName": "Tal", 
            "id": "sg:person.01365336450.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365336450.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zeevi", 
            "givenName": "David", 
            "id": "sg:person.01105326676.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105326676.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costea", 
            "givenName": "Paul I.", 
            "id": "sg:person.01237713336.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237713336.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Godneva", 
            "givenName": "Anastasia", 
            "id": "sg:person.015466326524.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015466326524.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalka", 
            "givenName": "Iris N.", 
            "id": "sg:person.07560635724.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07560635724.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bar", 
            "givenName": "Noam", 
            "id": "sg:person.014054051367.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014054051367.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shilo", 
            "givenName": "Smadar", 
            "id": "sg:person.0654564250.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654564250.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lador", 
            "givenName": "Dar", 
            "id": "sg:person.0740065313.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740065313.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
                "Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vila", 
            "givenName": "Arnau Vich", 
            "id": "sg:person.01360056023.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360056023.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel", 
              "id": "http://www.grid.ac/institutes/grid.413449.f", 
              "name": [
                "Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Internal Medicine Department, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel", 
                "Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zmora", 
            "givenName": "Niv", 
            "id": "sg:person.01140522550.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140522550.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pevsner-Fischer", 
            "givenName": "Meirav", 
            "id": "sg:person.01121370340.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121370340.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul Hospital, Jerusalem Center for Mental Health, 9106000, Jerusalem, Israel", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul Hospital, Jerusalem Center for Mental Health, 9106000, Jerusalem, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Israeli", 
            "givenName": "David", 
            "id": "sg:person.01206200474.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206200474.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kosower", 
            "givenName": "Noa", 
            "id": "sg:person.01353104113.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353104113.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malka", 
            "givenName": "Gal", 
            "id": "sg:person.01304770713.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304770713.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolf", 
            "givenName": "Bat Chen", 
            "id": "sg:person.012614653124.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012614653124.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Avnit-Sagi", 
            "givenName": "Tali", 
            "id": "sg:person.0704126313.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704126313.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lotan-Pompan", 
            "givenName": "Maya", 
            "id": "sg:person.0644041626.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644041626.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weinberger", 
            "givenName": "Adina", 
            "id": "sg:person.01210745226.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210745226.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Digestive Center, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel", 
              "id": "http://www.grid.ac/institutes/grid.413449.f", 
              "name": [
                "Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel", 
                "Digestive Center, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halpern", 
            "givenName": "Zamir", 
            "id": "sg:person.01112755255.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112755255.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel", 
              "id": "http://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carmi", 
            "givenName": "Shai", 
            "id": "sg:person.01350433472.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350433472.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
                "Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fu", 
            "givenName": "Jingyuan", 
            "id": "sg:person.01316140701.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, 0424, Oslo, Norway", 
              "id": "http://www.grid.ac/institutes/grid.5510.1", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
                "Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, 0424, Oslo, Norway"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wijmenga", 
            "givenName": "Cisca", 
            "id": "sg:person.01372510466.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4494.d", 
              "name": [
                "Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhernakova", 
            "givenName": "Alexandra", 
            "id": "sg:person.01133243663.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133243663.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elinav", 
            "givenName": "Eran", 
            "id": "sg:person.0671152474.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671152474.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel", 
                "Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Segal", 
            "givenName": "Eran", 
            "id": "sg:person.01257060426.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257060426.96"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/s13059-015-0759-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017080966", 
              "https://doi.org/10.1186/s13059-015-0759-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015057090", 
              "https://doi.org/10.1038/ng.608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018819579", 
              "https://doi.org/10.1038/ng.3663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002138629", 
              "https://doi.org/10.1038/ng.3693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045203738", 
              "https://doi.org/10.1038/nmeth.2037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-008-0593-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015747323", 
              "https://doi.org/10.1007/s00439-008-0593-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-84858-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032573094", 
              "https://doi.org/10.1007/978-0-387-84858-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016276818", 
              "https://doi.org/10.1038/ng.2876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003823032", 
              "https://doi.org/10.1038/nature12506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.f.303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009032055", 
              "https://doi.org/10.1038/nmeth.f.303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023718631", 
              "https://doi.org/10.1038/ng.694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006541515", 
              "https://doi.org/10.1038/nmeth.1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010611135", 
              "https://doi.org/10.1038/nmeth.2066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025012822", 
              "https://doi.org/10.1038/nmeth.2221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028385096", 
              "https://doi.org/10.1038/ng.3695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050790781", 
              "https://doi.org/10.1038/nature09103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep06874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046573928", 
              "https://doi.org/10.1038/srep06874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2049-2618-2-33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050409938", 
              "https://doi.org/10.1186/2049-2618-2-33"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034000276", 
              "https://doi.org/10.1038/ng.3679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046913669", 
              "https://doi.org/10.1038/nrg2322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000673871", 
              "https://doi.org/10.1038/ncomms5835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006520065", 
              "https://doi.org/10.1038/nbt.2942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007512293", 
              "https://doi.org/10.1038/nature11550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085463261", 
              "https://doi.org/10.1038/ng.3865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-5-r50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050643751", 
              "https://doi.org/10.1186/gb-2011-12-5-r50"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-02-28", 
        "datePublishedReg": "2018-02-28", 
        "description": "Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature25973", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3625736", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3938583", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6622959", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4138555", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3799964", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3636147", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7695", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "555"
          }
        ], 
        "keywords": [
          "host genetics", 
          "microbiome composition", 
          "gut microbiome composition", 
          "clinical outcomes", 
          "microbiome alterations", 
          "human gut microbiota", 
          "obesity measures", 
          "anthropometric measurements", 
          "human gut microbiome composition", 
          "healthy individuals", 
          "gut microbiota", 
          "gut microbiome", 
          "multiple factors", 
          "genetic background", 
          "microbiome", 
          "microbiome data", 
          "distinct ancestral origins", 
          "microbiome variability", 
          "individuals", 
          "diverse genetic backgrounds", 
          "genetic ancestry", 
          "drugs", 
          "diet", 
          "outcomes", 
          "microbiota", 
          "factors", 
          "unrelated individuals", 
          "alterations", 
          "relative contribution", 
          "glucose", 
          "genetics", 
          "minor role", 
          "data", 
          "genotypes", 
          "role", 
          "background", 
          "measures", 
          "contrast", 
          "host", 
          "ancestry", 
          "ancestral origin", 
          "variability", 
          "origin", 
          "households", 
          "results", 
          "significant similarity", 
          "measurements", 
          "composition", 
          "model", 
          "similarity", 
          "contribution", 
          "common environment", 
          "accuracy", 
          "environment", 
          "traits", 
          "human traits", 
          "environmental data", 
          "prediction accuracy"
        ], 
        "name": "Environment dominates over host genetics in shaping human gut microbiota", 
        "pagination": "210-215", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101264718"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature25973"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29489753"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature25973", 
          "https://app.dimensions.ai/details/publication/pub.1101264718"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_794.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature25973"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature25973'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature25973'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature25973'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature25973'


     

    This table displays all metadata directly associated to this object as RDF triples.

    570 TRIPLES      21 PREDICATES      137 URIs      103 LITERALS      35 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature25973 schema:about N02ba8038e2d145d7a1f93e27b44e6f8c
    2 N090b5e6bbd30452fa5049721fedb83cd
    3 N16e74cbc4c38434abb15b343f002a8c9
    4 N1d131cb9fa0b47ff91d4b68451100436
    5 N20298f4281fe44f9aee71150209e67ea
    6 N22b45df9ede84790ba056f5c9c4d3a7e
    7 N23119731549c4e6a9a3ef75d97f7f520
    8 N2ee9ea85333e477c8b6b9f1424421104
    9 N3d5c0cca061f4f86be23f77edcda8673
    10 N3e8ead6677e64e408eeee77fea9cb87c
    11 N5a121299b1014334a7cce02bfc8c5ffe
    12 N63e758e99d114c0e8c98c078ba6513dd
    13 N6dea3f3ee43f481ebb7ab2dbbb80e958
    14 N70677054567c40aab5dad7bdbf0ebd02
    15 N757b6e5c35e74a37afb55944f83262c9
    16 N75887347c72d48b39a3ba0b40de6bc5d
    17 N7c87b23af91e41649dd1bc6c84c6179a
    18 N80cdbf04d24240889ad776067c40c3ff
    19 N822451a4f35e447aa233f39f16adb385
    20 N8f7785b2fa5d464ea4edcb5b8954ef70
    21 N8fab1b36ba6a4229bb447e09a76c4a2a
    22 N9111d32816254528b0ed23bcb7c1bfed
    23 N9f0fc45d7acb49afa572dba6e72c2068
    24 Nafab37f26d554ec3b93ed0f4ff9daf8b
    25 Ncdcee93141084f70b25edb87d57865ca
    26 Ne089d73180ac498587ab93bb15129587
    27 Ne41c702598b7423ba241ead11c360ff0
    28 Nfde706ceb7c04bd0b83fb3fbea5c4fb5
    29 anzsrc-for:06
    30 anzsrc-for:0604
    31 schema:author N5b53b217065247228b15468b6a6812e8
    32 schema:citation sg:pub.10.1007/978-0-387-84858-7
    33 sg:pub.10.1007/s00439-008-0593-6
    34 sg:pub.10.1038/nature09103
    35 sg:pub.10.1038/nature11550
    36 sg:pub.10.1038/nature12506
    37 sg:pub.10.1038/nature15393
    38 sg:pub.10.1038/nbt.2942
    39 sg:pub.10.1038/ncomms5835
    40 sg:pub.10.1038/ng.2876
    41 sg:pub.10.1038/ng.3663
    42 sg:pub.10.1038/ng.3679
    43 sg:pub.10.1038/ng.3693
    44 sg:pub.10.1038/ng.3695
    45 sg:pub.10.1038/ng.3865
    46 sg:pub.10.1038/ng.608
    47 sg:pub.10.1038/ng.694
    48 sg:pub.10.1038/nmeth.1923
    49 sg:pub.10.1038/nmeth.2037
    50 sg:pub.10.1038/nmeth.2066
    51 sg:pub.10.1038/nmeth.2221
    52 sg:pub.10.1038/nmeth.f.303
    53 sg:pub.10.1038/nrg2322
    54 sg:pub.10.1038/srep06874
    55 sg:pub.10.1186/2049-2618-2-33
    56 sg:pub.10.1186/gb-2011-12-5-r50
    57 sg:pub.10.1186/s13059-015-0759-1
    58 schema:datePublished 2018-02-28
    59 schema:datePublishedReg 2018-02-28
    60 schema:description Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.
    61 schema:genre article
    62 schema:isAccessibleForFree true
    63 schema:isPartOf N4c027a733b3a4e73bf23c344b549e269
    64 Nefc9ee0aba6940a9a9699850480ee45b
    65 sg:journal.1018957
    66 schema:keywords accuracy
    67 alterations
    68 ancestral origin
    69 ancestry
    70 anthropometric measurements
    71 background
    72 clinical outcomes
    73 common environment
    74 composition
    75 contrast
    76 contribution
    77 data
    78 diet
    79 distinct ancestral origins
    80 diverse genetic backgrounds
    81 drugs
    82 environment
    83 environmental data
    84 factors
    85 genetic ancestry
    86 genetic background
    87 genetics
    88 genotypes
    89 glucose
    90 gut microbiome
    91 gut microbiome composition
    92 gut microbiota
    93 healthy individuals
    94 host
    95 host genetics
    96 households
    97 human gut microbiome composition
    98 human gut microbiota
    99 human traits
    100 individuals
    101 measurements
    102 measures
    103 microbiome
    104 microbiome alterations
    105 microbiome composition
    106 microbiome data
    107 microbiome variability
    108 microbiota
    109 minor role
    110 model
    111 multiple factors
    112 obesity measures
    113 origin
    114 outcomes
    115 prediction accuracy
    116 relative contribution
    117 results
    118 role
    119 significant similarity
    120 similarity
    121 traits
    122 unrelated individuals
    123 variability
    124 schema:name Environment dominates over host genetics in shaping human gut microbiota
    125 schema:pagination 210-215
    126 schema:productId N2509e6a8147c4ceca59b4927d66b7ea2
    127 N980cbe03c49d424cb1a1cf2cc90cb180
    128 Nc2ac68d6c8514496bf89a9973b43fd01
    129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101264718
    130 https://doi.org/10.1038/nature25973
    131 schema:sdDatePublished 2022-10-01T06:45
    132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    133 schema:sdPublisher Nc0041b33151a42ee8591a30f1198ae9d
    134 schema:url https://doi.org/10.1038/nature25973
    135 sgo:license sg:explorer/license/
    136 sgo:sdDataset articles
    137 rdf:type schema:ScholarlyArticle
    138 N02ba8038e2d145d7a1f93e27b44e6f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Young Adult
    140 rdf:type schema:DefinedTerm
    141 N090b5e6bbd30452fa5049721fedb83cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Gastrointestinal Microbiome
    143 rdf:type schema:DefinedTerm
    144 N0c3e1dd787104a8a8c85fb8d927ba415 rdf:first sg:person.01105326676.72
    145 rdf:rest Nb9ab09e80e7040cd9bcdd5da3c228428
    146 N16e74cbc4c38434abb15b343f002a8c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Israel
    148 rdf:type schema:DefinedTerm
    149 N189fa48a33df40aa8c07688ff7cca1d3 rdf:first sg:person.07512522524.88
    150 rdf:rest N2c772f06b4d047ac9b06a21727807ba3
    151 N1b6966b53f3c4d78a5ddb3762551a086 rdf:first sg:person.01353104113.86
    152 rdf:rest N5609ffb3874c484a88592198ba175450
    153 N1d131cb9fa0b47ff91d4b68451100436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Life Style
    155 rdf:type schema:DefinedTerm
    156 N1eaf9b48e9504712bf8888a646d835df rdf:first sg:person.0704126313.19
    157 rdf:rest N26cff0c1a7594c57be281dba0b4b02f7
    158 N20298f4281fe44f9aee71150209e67ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name RNA, Bacterial
    160 rdf:type schema:DefinedTerm
    161 N22b45df9ede84790ba056f5c9c4d3a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Heredity
    163 rdf:type schema:DefinedTerm
    164 N23119731549c4e6a9a3ef75d97f7f520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Phenotype
    166 rdf:type schema:DefinedTerm
    167 N2509e6a8147c4ceca59b4927d66b7ea2 schema:name doi
    168 schema:value 10.1038/nature25973
    169 rdf:type schema:PropertyValue
    170 N26cff0c1a7594c57be281dba0b4b02f7 rdf:first sg:person.0644041626.75
    171 rdf:rest N7505aad9dbcf49019f8843b3aa9db3c3
    172 N2a229eaf5806467eb7c0f1838d585465 rdf:first sg:person.01077321124.09
    173 rdf:rest N189fa48a33df40aa8c07688ff7cca1d3
    174 N2c772f06b4d047ac9b06a21727807ba3 rdf:first sg:person.0675230535.53
    175 rdf:rest N9a8e9c91b8184e18a57fd113460ac231
    176 N2ee9ea85333e477c8b6b9f1424421104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Aged
    178 rdf:type schema:DefinedTerm
    179 N330c089cc9ba422982f739884a3dbaa6 rdf:first sg:person.0671152474.44
    180 rdf:rest N362bfdaea93647eb9a273598209d8691
    181 N362bfdaea93647eb9a273598209d8691 rdf:first sg:person.01257060426.96
    182 rdf:rest rdf:nil
    183 N3c2263d5405145408d6e8b7d4619ae90 rdf:first sg:person.0740065313.26
    184 rdf:rest Na1b2619ba7124a0fb6ab2d842ed00fbb
    185 N3d5c0cca061f4f86be23f77edcda8673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Family Characteristics
    187 rdf:type schema:DefinedTerm
    188 N3e8ead6677e64e408eeee77fea9cb87c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Humans
    190 rdf:type schema:DefinedTerm
    191 N401ead943c344cc3b46684596efaddcc rdf:first sg:person.01140522550.20
    192 rdf:rest N60164332c9d742a6897c12c46ca641ee
    193 N4c027a733b3a4e73bf23c344b549e269 schema:volumeNumber 555
    194 rdf:type schema:PublicationVolume
    195 N4c53d75e36d846e5b741d6de9ad185cd rdf:first sg:person.0654564250.70
    196 rdf:rest N3c2263d5405145408d6e8b7d4619ae90
    197 N4f9707399b3a4faaaf545e5a1de5c8eb rdf:first sg:person.01316140701.98
    198 rdf:rest Ne1588cbb814c476c803fa5e0c6a31892
    199 N5609ffb3874c484a88592198ba175450 rdf:first sg:person.01304770713.77
    200 rdf:rest N970c9de7983a45af984af9cb0b1b0ad0
    201 N5a121299b1014334a7cce02bfc8c5ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Glucose
    203 rdf:type schema:DefinedTerm
    204 N5b53b217065247228b15468b6a6812e8 rdf:first sg:person.01260544744.60
    205 rdf:rest N2a229eaf5806467eb7c0f1838d585465
    206 N60164332c9d742a6897c12c46ca641ee rdf:first sg:person.01121370340.74
    207 rdf:rest Na6a8af126e1742e79f7d991c4b8d96bd
    208 N63e758e99d114c0e8c98c078ba6513dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Obesity
    210 rdf:type schema:DefinedTerm
    211 N6dea3f3ee43f481ebb7ab2dbbb80e958 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Middle Aged
    213 rdf:type schema:DefinedTerm
    214 N70677054567c40aab5dad7bdbf0ebd02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Adolescent
    216 rdf:type schema:DefinedTerm
    217 N73f4d0d3e72049e4a3c75860859d5e5c rdf:first sg:person.01112755255.45
    218 rdf:rest Ndfc4602769d14a0b8228443bbaa1bac0
    219 N7505aad9dbcf49019f8843b3aa9db3c3 rdf:first sg:person.01210745226.99
    220 rdf:rest N73f4d0d3e72049e4a3c75860859d5e5c
    221 N757b6e5c35e74a37afb55944f83262c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Twin Studies as Topic
    223 rdf:type schema:DefinedTerm
    224 N75887347c72d48b39a3ba0b40de6bc5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Adult
    226 rdf:type schema:DefinedTerm
    227 N75ff0cb253df468c810c7e2e37138990 rdf:first sg:person.01133243663.61
    228 rdf:rest N330c089cc9ba422982f739884a3dbaa6
    229 N7c87b23af91e41649dd1bc6c84c6179a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Cohort Studies
    231 rdf:type schema:DefinedTerm
    232 N80cdbf04d24240889ad776067c40c3ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    233 schema:name Environment
    234 rdf:type schema:DefinedTerm
    235 N822451a4f35e447aa233f39f16adb385 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Twins
    237 rdf:type schema:DefinedTerm
    238 N8f7785b2fa5d464ea4edcb5b8954ef70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Diet
    240 rdf:type schema:DefinedTerm
    241 N8fab1b36ba6a4229bb447e09a76c4a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Reproducibility of Results
    243 rdf:type schema:DefinedTerm
    244 N9111d32816254528b0ed23bcb7c1bfed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Polymorphism, Single Nucleotide
    246 rdf:type schema:DefinedTerm
    247 N970c9de7983a45af984af9cb0b1b0ad0 rdf:first sg:person.012614653124.36
    248 rdf:rest N1eaf9b48e9504712bf8888a646d835df
    249 N980cbe03c49d424cb1a1cf2cc90cb180 schema:name dimensions_id
    250 schema:value pub.1101264718
    251 rdf:type schema:PropertyValue
    252 N9a8e9c91b8184e18a57fd113460ac231 rdf:first sg:person.01365336450.29
    253 rdf:rest N0c3e1dd787104a8a8c85fb8d927ba415
    254 N9f0fc45d7acb49afa572dba6e72c2068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Aged, 80 and over
    256 rdf:type schema:DefinedTerm
    257 Na1b2619ba7124a0fb6ab2d842ed00fbb rdf:first sg:person.01360056023.68
    258 rdf:rest N401ead943c344cc3b46684596efaddcc
    259 Na6a8af126e1742e79f7d991c4b8d96bd rdf:first sg:person.01206200474.69
    260 rdf:rest N1b6966b53f3c4d78a5ddb3762551a086
    261 Nafab37f26d554ec3b93ed0f4ff9daf8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Female
    263 rdf:type schema:DefinedTerm
    264 Nb9ab09e80e7040cd9bcdd5da3c228428 rdf:first sg:person.01237713336.87
    265 rdf:rest Nfa905a15ffb145f58c8f2d4bcccfeb38
    266 Nc0041b33151a42ee8591a30f1198ae9d schema:name Springer Nature - SN SciGraph project
    267 rdf:type schema:Organization
    268 Nc2ac68d6c8514496bf89a9973b43fd01 schema:name pubmed_id
    269 schema:value 29489753
    270 rdf:type schema:PropertyValue
    271 Nc38d625ed9e14e6484d58ebc88527b03 rdf:first sg:person.07560635724.49
    272 rdf:rest Nd12d215120e34ed98691135df3a10766
    273 Ncdcee93141084f70b25edb87d57865ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    274 schema:name RNA, Ribosomal, 16S
    275 rdf:type schema:DefinedTerm
    276 Nd12d215120e34ed98691135df3a10766 rdf:first sg:person.014054051367.57
    277 rdf:rest N4c53d75e36d846e5b741d6de9ad185cd
    278 Ndfc4602769d14a0b8228443bbaa1bac0 rdf:first sg:person.01350433472.32
    279 rdf:rest N4f9707399b3a4faaaf545e5a1de5c8eb
    280 Ne089d73180ac498587ab93bb15129587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Male
    282 rdf:type schema:DefinedTerm
    283 Ne1588cbb814c476c803fa5e0c6a31892 rdf:first sg:person.01372510466.28
    284 rdf:rest N75ff0cb253df468c810c7e2e37138990
    285 Ne41c702598b7423ba241ead11c360ff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name Healthy Volunteers
    287 rdf:type schema:DefinedTerm
    288 Nefc9ee0aba6940a9a9699850480ee45b schema:issueNumber 7695
    289 rdf:type schema:PublicationIssue
    290 Nfa905a15ffb145f58c8f2d4bcccfeb38 rdf:first sg:person.015466326524.08
    291 rdf:rest Nc38d625ed9e14e6484d58ebc88527b03
    292 Nfde706ceb7c04bd0b83fb3fbea5c4fb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    293 schema:name Gene-Environment Interaction
    294 rdf:type schema:DefinedTerm
    295 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    296 schema:name Biological Sciences
    297 rdf:type schema:DefinedTerm
    298 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    299 schema:name Genetics
    300 rdf:type schema:DefinedTerm
    301 sg:grant.3625736 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    302 rdf:type schema:MonetaryGrant
    303 sg:grant.3636147 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    304 rdf:type schema:MonetaryGrant
    305 sg:grant.3799964 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    306 rdf:type schema:MonetaryGrant
    307 sg:grant.3938583 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    308 rdf:type schema:MonetaryGrant
    309 sg:grant.4138555 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    310 rdf:type schema:MonetaryGrant
    311 sg:grant.6622959 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25973
    312 rdf:type schema:MonetaryGrant
    313 sg:journal.1018957 schema:issn 0028-0836
    314 1476-4687
    315 schema:name Nature
    316 schema:publisher Springer Nature
    317 rdf:type schema:Periodical
    318 sg:person.01077321124.09 schema:affiliation grid-institutes:grid.13992.30
    319 schema:familyName Weissbrod
    320 schema:givenName Omer
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077321124.09
    322 rdf:type schema:Person
    323 sg:person.01105326676.72 schema:affiliation grid-institutes:grid.13992.30
    324 schema:familyName Zeevi
    325 schema:givenName David
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105326676.72
    327 rdf:type schema:Person
    328 sg:person.01112755255.45 schema:affiliation grid-institutes:grid.413449.f
    329 schema:familyName Halpern
    330 schema:givenName Zamir
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112755255.45
    332 rdf:type schema:Person
    333 sg:person.01121370340.74 schema:affiliation grid-institutes:grid.13992.30
    334 schema:familyName Pevsner-Fischer
    335 schema:givenName Meirav
    336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121370340.74
    337 rdf:type schema:Person
    338 sg:person.01133243663.61 schema:affiliation grid-institutes:grid.4494.d
    339 schema:familyName Zhernakova
    340 schema:givenName Alexandra
    341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133243663.61
    342 rdf:type schema:Person
    343 sg:person.01140522550.20 schema:affiliation grid-institutes:grid.413449.f
    344 schema:familyName Zmora
    345 schema:givenName Niv
    346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140522550.20
    347 rdf:type schema:Person
    348 sg:person.01206200474.69 schema:affiliation grid-institutes:None
    349 schema:familyName Israeli
    350 schema:givenName David
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206200474.69
    352 rdf:type schema:Person
    353 sg:person.01210745226.99 schema:affiliation grid-institutes:grid.13992.30
    354 schema:familyName Weinberger
    355 schema:givenName Adina
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210745226.99
    357 rdf:type schema:Person
    358 sg:person.01237713336.87 schema:affiliation grid-institutes:grid.13992.30
    359 schema:familyName Costea
    360 schema:givenName Paul I.
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237713336.87
    362 rdf:type schema:Person
    363 sg:person.01257060426.96 schema:affiliation grid-institutes:grid.13992.30
    364 schema:familyName Segal
    365 schema:givenName Eran
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257060426.96
    367 rdf:type schema:Person
    368 sg:person.01260544744.60 schema:affiliation grid-institutes:grid.13992.30
    369 schema:familyName Rothschild
    370 schema:givenName Daphna
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260544744.60
    372 rdf:type schema:Person
    373 sg:person.012614653124.36 schema:affiliation grid-institutes:grid.13992.30
    374 schema:familyName Wolf
    375 schema:givenName Bat Chen
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012614653124.36
    377 rdf:type schema:Person
    378 sg:person.01304770713.77 schema:affiliation grid-institutes:grid.13992.30
    379 schema:familyName Malka
    380 schema:givenName Gal
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304770713.77
    382 rdf:type schema:Person
    383 sg:person.01316140701.98 schema:affiliation grid-institutes:grid.4494.d
    384 schema:familyName Fu
    385 schema:givenName Jingyuan
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98
    387 rdf:type schema:Person
    388 sg:person.01350433472.32 schema:affiliation grid-institutes:grid.9619.7
    389 schema:familyName Carmi
    390 schema:givenName Shai
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350433472.32
    392 rdf:type schema:Person
    393 sg:person.01353104113.86 schema:affiliation grid-institutes:grid.13992.30
    394 schema:familyName Kosower
    395 schema:givenName Noa
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353104113.86
    397 rdf:type schema:Person
    398 sg:person.01360056023.68 schema:affiliation grid-institutes:grid.4494.d
    399 schema:familyName Vila
    400 schema:givenName Arnau Vich
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360056023.68
    402 rdf:type schema:Person
    403 sg:person.01365336450.29 schema:affiliation grid-institutes:grid.13992.30
    404 schema:familyName Korem
    405 schema:givenName Tal
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365336450.29
    407 rdf:type schema:Person
    408 sg:person.01372510466.28 schema:affiliation grid-institutes:grid.5510.1
    409 schema:familyName Wijmenga
    410 schema:givenName Cisca
    411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28
    412 rdf:type schema:Person
    413 sg:person.014054051367.57 schema:affiliation grid-institutes:grid.13992.30
    414 schema:familyName Bar
    415 schema:givenName Noam
    416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014054051367.57
    417 rdf:type schema:Person
    418 sg:person.015466326524.08 schema:affiliation grid-institutes:grid.13992.30
    419 schema:familyName Godneva
    420 schema:givenName Anastasia
    421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015466326524.08
    422 rdf:type schema:Person
    423 sg:person.0644041626.75 schema:affiliation grid-institutes:grid.13992.30
    424 schema:familyName Lotan-Pompan
    425 schema:givenName Maya
    426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644041626.75
    427 rdf:type schema:Person
    428 sg:person.0654564250.70 schema:affiliation grid-institutes:grid.13992.30
    429 schema:familyName Shilo
    430 schema:givenName Smadar
    431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654564250.70
    432 rdf:type schema:Person
    433 sg:person.0671152474.44 schema:affiliation grid-institutes:grid.13992.30
    434 schema:familyName Elinav
    435 schema:givenName Eran
    436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671152474.44
    437 rdf:type schema:Person
    438 sg:person.0675230535.53 schema:affiliation grid-institutes:grid.4494.d
    439 schema:familyName Kurilshikov
    440 schema:givenName Alexander
    441 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675230535.53
    442 rdf:type schema:Person
    443 sg:person.0704126313.19 schema:affiliation grid-institutes:grid.13992.30
    444 schema:familyName Avnit-Sagi
    445 schema:givenName Tali
    446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704126313.19
    447 rdf:type schema:Person
    448 sg:person.0740065313.26 schema:affiliation grid-institutes:grid.13992.30
    449 schema:familyName Lador
    450 schema:givenName Dar
    451 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740065313.26
    452 rdf:type schema:Person
    453 sg:person.07512522524.88 schema:affiliation grid-institutes:grid.13992.30
    454 schema:familyName Barkan
    455 schema:givenName Elad
    456 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07512522524.88
    457 rdf:type schema:Person
    458 sg:person.07560635724.49 schema:affiliation grid-institutes:grid.13992.30
    459 schema:familyName Kalka
    460 schema:givenName Iris N.
    461 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07560635724.49
    462 rdf:type schema:Person
    463 sg:pub.10.1007/978-0-387-84858-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032573094
    464 https://doi.org/10.1007/978-0-387-84858-7
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1007/s00439-008-0593-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015747323
    467 https://doi.org/10.1007/s00439-008-0593-6
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/nature09103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050790781
    470 https://doi.org/10.1038/nature09103
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1038/nature11550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007512293
    473 https://doi.org/10.1038/nature11550
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1038/nature12506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003823032
    476 https://doi.org/10.1038/nature12506
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1038/nature15393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812064
    479 https://doi.org/10.1038/nature15393
    480 rdf:type schema:CreativeWork
    481 sg:pub.10.1038/nbt.2942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006520065
    482 https://doi.org/10.1038/nbt.2942
    483 rdf:type schema:CreativeWork
    484 sg:pub.10.1038/ncomms5835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000673871
    485 https://doi.org/10.1038/ncomms5835
    486 rdf:type schema:CreativeWork
    487 sg:pub.10.1038/ng.2876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016276818
    488 https://doi.org/10.1038/ng.2876
    489 rdf:type schema:CreativeWork
    490 sg:pub.10.1038/ng.3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018819579
    491 https://doi.org/10.1038/ng.3663
    492 rdf:type schema:CreativeWork
    493 sg:pub.10.1038/ng.3679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034000276
    494 https://doi.org/10.1038/ng.3679
    495 rdf:type schema:CreativeWork
    496 sg:pub.10.1038/ng.3693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002138629
    497 https://doi.org/10.1038/ng.3693
    498 rdf:type schema:CreativeWork
    499 sg:pub.10.1038/ng.3695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028385096
    500 https://doi.org/10.1038/ng.3695
    501 rdf:type schema:CreativeWork
    502 sg:pub.10.1038/ng.3865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085463261
    503 https://doi.org/10.1038/ng.3865
    504 rdf:type schema:CreativeWork
    505 sg:pub.10.1038/ng.608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015057090
    506 https://doi.org/10.1038/ng.608
    507 rdf:type schema:CreativeWork
    508 sg:pub.10.1038/ng.694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023718631
    509 https://doi.org/10.1038/ng.694
    510 rdf:type schema:CreativeWork
    511 sg:pub.10.1038/nmeth.1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006541515
    512 https://doi.org/10.1038/nmeth.1923
    513 rdf:type schema:CreativeWork
    514 sg:pub.10.1038/nmeth.2037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045203738
    515 https://doi.org/10.1038/nmeth.2037
    516 rdf:type schema:CreativeWork
    517 sg:pub.10.1038/nmeth.2066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010611135
    518 https://doi.org/10.1038/nmeth.2066
    519 rdf:type schema:CreativeWork
    520 sg:pub.10.1038/nmeth.2221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025012822
    521 https://doi.org/10.1038/nmeth.2221
    522 rdf:type schema:CreativeWork
    523 sg:pub.10.1038/nmeth.f.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009032055
    524 https://doi.org/10.1038/nmeth.f.303
    525 rdf:type schema:CreativeWork
    526 sg:pub.10.1038/nrg2322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046913669
    527 https://doi.org/10.1038/nrg2322
    528 rdf:type schema:CreativeWork
    529 sg:pub.10.1038/srep06874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046573928
    530 https://doi.org/10.1038/srep06874
    531 rdf:type schema:CreativeWork
    532 sg:pub.10.1186/2049-2618-2-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050409938
    533 https://doi.org/10.1186/2049-2618-2-33
    534 rdf:type schema:CreativeWork
    535 sg:pub.10.1186/gb-2011-12-5-r50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050643751
    536 https://doi.org/10.1186/gb-2011-12-5-r50
    537 rdf:type schema:CreativeWork
    538 sg:pub.10.1186/s13059-015-0759-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017080966
    539 https://doi.org/10.1186/s13059-015-0759-1
    540 rdf:type schema:CreativeWork
    541 grid-institutes:None schema:alternateName Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul Hospital, Jerusalem Center for Mental Health, 9106000, Jerusalem, Israel
    542 schema:name Day Care Unit and the Laboratory of Imaging and Brain Stimulation, Kfar Shaul Hospital, Jerusalem Center for Mental Health, 9106000, Jerusalem, Israel
    543 rdf:type schema:Organization
    544 grid-institutes:grid.13992.30 schema:alternateName Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel
    545 Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel
    546 schema:name Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 7610001, Rehovot, Israel
    547 Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel
    548 Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel
    549 rdf:type schema:Organization
    550 grid-institutes:grid.413449.f schema:alternateName Digestive Center, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel
    551 Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel
    552 schema:name Digestive Center, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel
    553 Immunology Department, Weizmann Institute of Science, 7610001, Rehovot, Israel
    554 Internal Medicine Department, Tel Aviv Sourasky Medical Center, 6423906, Tel Aviv, Israel
    555 Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel
    556 rdf:type schema:Organization
    557 grid-institutes:grid.4494.d schema:alternateName Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    558 Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    559 Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    560 schema:name Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    561 Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    562 Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    563 rdf:type schema:Organization
    564 grid-institutes:grid.5510.1 schema:alternateName Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, 0424, Oslo, Norway
    565 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands
    566 Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, 0424, Oslo, Norway
    567 rdf:type schema:Organization
    568 grid-institutes:grid.9619.7 schema:alternateName Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel
    569 schema:name Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel
    570 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...