The landscape of genomic alterations across childhood cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03

AUTHORS

Susanne N. Gröbner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A. Rudneva, Pascal D. Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, ICGC PedBrain-Seq Project, Peter Lichter, Ursula Weber, Roland Eils, Andrey Korshunov, Olaf Witt, Stefan Pfister, Guido Reifenberger, Jörg Felsberg, Christof von Kalle, Manfred Schmidt, Cynthia Bartholomä, Michael Taylor, David Jones, Natalie Jäger, Jan Korbel, Adrian Stütz, Tobias Rausch, Bernhard Radlwimmer, Marie-Laure Yaspo, Hans Lehrach, Hans-Jörg Warnatz, Pablo Landgraf, Benedikt Brors, Marc Zapatka, ICGC MMML-Seq Project, Susanne Wagner, Andrea Haake, Julia Richter, Gesine Richter, Chris Lawerenz, Jules Kerssemakers, Christina Jaeger-Schmidt, Ingrid Scholz, Anke K. Bergmann, Christoph Borst, Birgit Burkhardt, Alexander Claviez, Martin Dreyling, Sonja Eberth, Hermann Einsele, Norbert Frickhofen, Siegfried Haas, Martin-Leo Hansmann, Dennis Karsch, Michael Kneba, Jasmin Lisfeld, Luisa Mantovani-Löffler, Marius Rohde, German Ott, Christina Stadler, Peter Staib, Stephan Stilgenbauer, Lorenz Trümper, Thorsten Zenz, Dieter Kube, Ralf Küppers, Marc Weniger, Michael Hummel, Wolfram Klapper, Ulrike Kostezka, Dido Lenze, Peter Möller, Andreas Rosenwald, Monika Szczepanowski, Ole Ammerpohl, Sietse M. Aukema, Vera Binder, Jessica I. Hoell, Ellen Leich, Cristina López, Inga Nagel, Jordan Pischimariov, Philip Rosenstiel, Markus Schilhabel, Stefan Schreiber, Inga Vater, Rabea Wagener, Stephan H. Bernhart, Hans Binder, Gero Doose, Steve Hoffmann, Lydia Hopp, Helene Kretzmer, Markus Kreuz, David Langenberger, Markus Loeffler, Maciej Rosolowski, Matthias Schlesner, Peter F. Stadler, Stephanie Sungalee, Christian P. Kratz, Cornelis M. van Tilburg, Christof M. Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Frühwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Jan Koster, Adam C. Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J. Waanders, Danny A. Zwijnenburg, Pichai Raman, Ursula D. Weber, Paul A. Northcott, Kristian W. Pajtler, Marcel Kool, Rosario M. Piro, Jan O. Korbel, David T. W. Jones, Lukas Chavez, Stefan M. Pfister

ABSTRACT

Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials. More... »

PAGES

321

References to SciGraph publications

  • 2015-12. Clock-like mutational processes in human somatic cells in NATURE GENETICS
  • 2015-06. Mutant PRPS1: a new therapeutic target in relapsed acute lymphoblastic leukemia in NATURE MEDICINE
  • 2014-10. Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness in ONCOGENE
  • 2018-03. Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours in NATURE
  • 2013-02. Tumor Protein p53 (TP53) Testing and Li-Fraumeni Syndrome in MOLECULAR DIAGNOSIS & THERAPY
  • 2016-12. The genomic landscape of core-binding factor acute myeloid leukemias in NATURE GENETICS
  • 2013-06. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas in NATURE GENETICS
  • 2013-10. Mutational landscape and significance across 12 major cancer types in NATURE
  • 2011-04. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers in GENOME BIOLOGY
  • 2013-10. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance in NATURE GENETICS
  • 2014-05. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma in NATURE GENETICS
  • 2012-03. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas in NATURE GENETICS
  • 2012-10. Chromothripsis and cancer: causes and consequences of chromosome shattering in NATURE REVIEWS CANCER
  • 2015-06. Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL in NATURE MEDICINE
  • 2013-11. IntOGen-mutations identifies cancer drivers across tumor types in NATURE METHODS
  • 2014-07. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma in NATURE
  • 2012-08. Novel mutations target distinct subgroups of medulloblastoma in NATURE
  • 2014-02. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy in NATURE
  • 2012-12. Medulloblastomics: the end of the beginning in NATURE REVIEWS CANCER
  • 2015-12. Genomic landscape of paediatric adrenocortical tumours in NATURE COMMUNICATIONS
  • 2015-10. An integrated map of structural variation in 2,504 human genomes in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2014-12. Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2013-08. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma in NATURE GENETICS
  • 2012-08. Dissecting the genomic complexity underlying medulloblastoma in NATURE
  • 2014-12. The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes in NATURE COMMUNICATIONS
  • 2016-11. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma in NATURE MEDICINE
  • 2014-07. Assessing the clinical utility of cancer genomic and proteomic data across tumor types in NATURE BIOTECHNOLOGY
  • 2012-03. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity in NATURE
  • 2013-05-01. Integrated genomic characterization of endometrial carcinoma in NATURE
  • 2012-06. The Pediatric Cancer Genome Project in NATURE GENETICS
  • 2010-12. Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome in RADIATION ONCOLOGY
  • 2013-10. Emerging landscape of oncogenic signatures across human cancers in NATURE GENETICS
  • 2013-12. Comprehensive identification of mutational cancer driver genes across 12 tumor types in SCIENTIFIC REPORTS
  • 2015-12. TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors in NATURE GENETICS
  • 2013-03. The genomic landscape of hypodiploid acute lymphoblastic leukemia in NATURE GENETICS
  • 1992-09. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours in NATURE
  • 2015-07-08. Data analysis: Create a cloud commons in NATURE
  • 2015-12. Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency in NATURE COMMUNICATIONS
  • 2008-11. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-09. Challenging issues in pediatric oncology in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2016-12. Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2013-10. Pan-cancer patterns of somatic copy number alteration in NATURE GENETICS
  • 2017-07. The whole-genome landscape of medulloblastoma subtypes in NATURE
  • 2014-02. C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma in NATURE
  • 2015-06. TP53 germline mutation may affect response to anticancer treatments: analysis of an intensively treated Li–Fraumeni family in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-01. A novel retinoblastoma therapy from genomic and epigenetic analyses in NATURE
  • 2013-03. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL in NATURE MEDICINE
  • 2015-04. The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias in NATURE GENETICS
  • 2013-08. Signatures of mutational processes in human cancer in NATURE
  • Journal

    TITLE

    Nature

    ISSUE

    7696

    VOLUME

    555

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature25480

    DOI

    http://dx.doi.org/10.1038/nature25480

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101264345

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29489754


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromothripsis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diploidy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genomics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Germ-Line Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Protein p53", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gr\u00f6bner", 
            "givenName": "Susanne N.", 
            "id": "sg:person.012641745337.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012641745337.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Worst", 
            "givenName": "Barbara C.", 
            "id": "sg:person.0760172546.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760172546.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany", 
                "The Finsen Laboratory, Rigshospitalet, Biotech Research and Innovation Centre (BRIC), Copenhagen University, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weischenfeldt", 
            "givenName": "Joachim", 
            "id": "sg:person.01350775415.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350775415.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buchhalter", 
            "givenName": "Ivo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kleinheinz", 
            "givenName": "Kortine", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany", 
                "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rudneva", 
            "givenName": "Vasilisa A.", 
            "id": "sg:person.07621127033.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07621127033.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johann", 
            "givenName": "Pascal D.", 
            "id": "sg:person.0664637017.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664637017.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balasubramanian", 
            "givenName": "Gnana Prakash", 
            "id": "sg:person.07422430275.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07422430275.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Segura-Wang", 
            "givenName": "Maia", 
            "id": "sg:person.01074160217.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074160217.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brabetz", 
            "givenName": "Sebastian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bender", 
            "givenName": "Sebastian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hutter", 
            "givenName": "Barbara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sturm", 
            "givenName": "Dominik", 
            "id": "sg:person.01124352515.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124352515.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfaff", 
            "givenName": "Elke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany", 
                "Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant Center, 69120, Heidelberg, Germany", 
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany", 
                "Department of Pediatric Immunology, Hematology and Oncology, University Hospital, Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "H\u00fcbschmann", 
            "givenName": "Daniel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zipprich", 
            "givenName": "Gideon", 
            "id": "sg:person.01104716566.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104716566.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant Center, 69120, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heinold", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Data Management Group, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eils", 
            "givenName": "J\u00fcrgen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Data Management Group, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawerenz", 
            "givenName": "Christian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Erkek", 
            "givenName": "Serap", 
            "id": "sg:person.01360270130.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360270130.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lambo", 
            "givenName": "Sander", 
            "id": "sg:person.01236575653.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236575653.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waszak", 
            "givenName": "Sebastian", 
            "id": "sg:person.01273213270.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273213270.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Olgahospital", 
              "id": "https://www.grid.ac/institutes/grid.459687.1", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Klinikum Stuttgart - Olgahospital, Zentrum f\u00fcr Kinder-, Jugend- und Frauenmedizin, P\u00e4diatrie, Stuttgart, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blattmann", 
            "givenName": "Claudia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Clinical Immunology, University Children\u2019s Hospital, Heinrich Heine University, D\u00fcsseldorf, Germany", 
                "Hematology and Clinical Immunology, University Hospital, D\u00fcsseldorf, Germany", 
                "Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Borkhardt", 
            "givenName": "Arndt", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Clinical Immunology, University Children\u2019s Hospital, Heinrich Heine University, D\u00fcsseldorf, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuhlen", 
            "givenName": "Michaela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eggert", 
            "givenName": "Angelika", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.411088.4", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Institute for Experimental Cancer Research in Pediatrics, University Hospital Frankfurt, Frankfurt am Main, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulda", 
            "givenName": "Simone", 
            "id": "sg:person.01331656400.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331656400.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gessler", 
            "givenName": "Manfred", 
            "id": "sg:person.01306511165.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306511165.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of W\u00fcrzburg, W\u00fcrzburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wegert", 
            "givenName": "Jenny", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Surgery, Research Laboratories, Dr von Hauner Children\u2019s Hospital, Ludwig Maximilians University Munich, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kappler", 
            "givenName": "Roland", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Basel", 
              "id": "https://www.grid.ac/institutes/grid.6612.3", 
              "name": [
                "Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baumhoer", 
            "givenName": "Daniel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Children\u2019s Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burdach", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kirschner-Schwabe", 
            "givenName": "Renate", 
            "id": "sg:person.01042507125.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042507125.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Pediatric Hematology and Oncology, University Medical Center Aachen, Aachen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kontny", 
            "givenName": "Udo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kulozik", 
            "givenName": "Andreas E.", 
            "id": "sg:person.01022515007.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022515007.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Essen University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.410718.b", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Human Genetics, University Hospital Essen, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lohmann", 
            "givenName": "Dietmar", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Freiburg", 
              "id": "https://www.grid.ac/institutes/grid.7708.8", 
              "name": [
                "Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Medical Center Freiburg, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hettmer", 
            "givenName": "Simone", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eckert", 
            "givenName": "Cornelia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Olgahospital", 
              "id": "https://www.grid.ac/institutes/grid.459687.1", 
              "name": [
                "Klinikum Stuttgart - Olgahospital, Zentrum f\u00fcr Kinder-, Jugend- und Frauenmedizin, P\u00e4diatrie, Stuttgart, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bielack", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinikum Kassel", 
              "id": "https://www.grid.ac/institutes/grid.419824.2", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Children\u2019s Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany", 
                "Department of Pediatric Oncology, Klinikum Kassel, Kassel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nathrath", 
            "givenName": "Michaela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Freiburg", 
              "id": "https://www.grid.ac/institutes/grid.7708.8", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Medical Center Freiburg, Freiburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niemeyer", 
            "givenName": "Charlotte", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Children\u2019s Cancer Research Centre and Department of Pediatrics, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Richter", 
            "givenName": "G\u00fcnther H.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology/Hematology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schulte", 
            "givenName": "Johannes", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, University of Ulm & University Hospital of Ulm, Ulm, Germany", 
                "Institute of Human Genetics, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siebert", 
            "givenName": "Reiner", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Westermann", 
            "givenName": "Frank", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Princess M\u00e1xima Center", 
              "id": "https://www.grid.ac/institutes/grid.487647.e", 
              "name": [
                "Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Molenaar", 
            "givenName": "Jan J.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut Gustave Roussy", 
              "id": "https://www.grid.ac/institutes/grid.14925.3b", 
              "name": [
                "Innovative Therapies for Children with Cancer Consortium and Department of Clinical Research, Gustave Roussy, Universit\u00e9 Paris-Saclay, Villejuif, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vassal", 
            "givenName": "Gilles", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witt", 
            "givenName": "Hendrik", 
            "type": "Person"
          }, 
          {
            "familyName": "Project", 
            "givenName": "ICGC PedBrain-Seq", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lichter", 
            "givenName": "Peter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber", 
            "givenName": "Ursula", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University and BioQuant Center, 69120, Heidelberg, Germany", 
                "Department for Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eils", 
            "givenName": "Roland", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korshunov", 
            "givenName": "Andrey", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany", 
                "Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witt", 
            "givenName": "Olaf", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Neuropathology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reifenberger", 
            "givenName": "Guido", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Neuropathology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Felsberg", 
            "givenName": "J\u00f6rg", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Translational Oncology, German Cancer Research Center (DKFZ)/National Center for Tumor Diseases (NCT), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "von Kalle", 
            "givenName": "Christof", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "GeneWerk GmbH, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Manfred", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "GeneWerk GmbH, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartholom\u00e4", 
            "givenName": "Cynthia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital for Sick Children", 
              "id": "https://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taylor", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "J\u00e4ger", 
            "givenName": "Natalie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany", 
                "EMBL Heidelberg, Genome Biology, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korbel", 
            "givenName": "Jan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "St\u00fctz", 
            "givenName": "Adrian", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rausch", 
            "givenName": "Tobias", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radlwimmer", 
            "givenName": "Bernhard", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.419538.2", 
              "name": [
                "Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics (MPI-MG), Berlin, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yaspo", 
            "givenName": "Marie-Laure", 
            "id": "sg:person.01076766505.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076766505.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.419538.2", 
              "name": [
                "Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics (MPI-MG), Berlin, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lehrach", 
            "givenName": "Hans", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Molecular Genetics", 
              "id": "https://www.grid.ac/institutes/grid.419538.2", 
              "name": [
                "Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics (MPI-MG), Berlin, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warnatz", 
            "givenName": "Hans-J\u00f6rg", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00fcsseldorf University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.14778.3d", 
              "name": [
                "University Hospital Cologne, Klinik und Poliklinik f\u00fcr Kinder- und Jugendmedizin, Cologne, Germany", 
                "Hematology and Clinical Immunology, University Hospital, D\u00fcsseldorf, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Landgraf", 
            "givenName": "Pablo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Applied Bioinformatics (G200), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC PedBrain-Seq Project", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brors", 
            "givenName": "Benedikt", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Freie Universit\u00e4t Berlin", 
              "id": "https://www.grid.ac/institutes/grid.14095.39", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Institute of Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany", 
                "ICGC PedBrain-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zapatka", 
            "givenName": "Marc", 
            "type": "Person"
          }, 
          {
            "familyName": "Project", 
            "givenName": "ICGC MMML-Seq", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wagner", 
            "givenName": "Susanne", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haake", 
            "givenName": "Andrea", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "Hematopathology Section, Institute of Pathology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Richter", 
            "givenName": "Julia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Richter", 
            "givenName": "Gesine", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawerenz", 
            "givenName": "Chris", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kerssemakers", 
            "givenName": "Jules", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jaeger-Schmidt", 
            "givenName": "Christina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Scholz", 
            "givenName": "Ingrid", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bergmann", 
            "givenName": "Anke K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neum\u00fcnster, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Borst", 
            "givenName": "Christoph", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Gie\u00dfen und Marburg", 
              "id": "https://www.grid.ac/institutes/grid.411067.5", 
              "name": [
                "Pediatric Hematology and Oncology, University Hospital M\u00fcnster, M\u00fcnster, Germany", 
                "University Hospital Muenster - Pediatric Hematology and Oncology, M\u00fcnster, Germany", 
                "University Hospital Giessen, Pediatric Hematology and Oncology, Giessen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burkhardt", 
            "givenName": "Birgit", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Claviez", 
            "givenName": "Alexander", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Klinikum der Universit\u00e4t M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.411095.8", 
              "name": [
                "Department of Medicine III - Campus Grosshadern, University Hospital Munich, Munich, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dreyling", 
            "givenName": "Martin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.7450.6", 
              "name": [
                "Department of Hematology and Oncology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eberth", 
            "givenName": "Sonja", 
            "id": "sg:person.01323403207.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323403207.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University Hospital W\u00fcrzburg, Department of Medicine and Poliklinik II, University of W\u00fcrzburg, W\u00fcrzburg", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Einsele", 
            "givenName": "Hermann", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Medicine III, Hematology and Oncology, Dr Horst-Schmidt-Kliniken of Wiesbaden, Wiesbaden, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Frickhofen", 
            "givenName": "Norbert", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neum\u00fcnster, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haas", 
            "givenName": "Siegfried", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Senckenberg Institute of Pathology, University of Frankfurt Medical School, Frankfurt am Main, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hansmann", 
            "givenName": "Martin-Leo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Internal Medicine II: Hematology and Oncology, University Medical Centre, Campus Kiel, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karsch", 
            "givenName": "Dennis", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Internal Medicine II: Hematology and Oncology, University Medical Centre, Campus Kiel, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kneba", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Gie\u00dfen und Marburg", 
              "id": "https://www.grid.ac/institutes/grid.411067.5", 
              "name": [
                "University Hospital Giessen, Pediatric Hematology and Oncology, Giessen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lisfeld", 
            "givenName": "Jasmin", 
            "id": "sg:person.01043665622.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043665622.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hospital of Internal Medicine II, Hematology and Oncology, St-Georg Hospital Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mantovani-L\u00f6ffler", 
            "givenName": "Luisa", 
            "id": "sg:person.01207525377.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207525377.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Gie\u00dfen und Marburg", 
              "id": "https://www.grid.ac/institutes/grid.411067.5", 
              "name": [
                "University Hospital Giessen, Pediatric Hematology and Oncology, Giessen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rohde", 
            "givenName": "Marius", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Robert Bosch Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416008.b", 
              "name": [
                "Department of Pathology, Robert-Bosch-Hospital, Stuttgart, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ott", 
            "givenName": "German", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.7450.6", 
              "name": [
                "Department of Hematology and Oncology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stadler", 
            "givenName": "Christina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sankt-Antonius-Hospital Eschweiler", 
              "id": "https://www.grid.ac/institutes/grid.459927.4", 
              "name": [
                "Clinic for Hematology and Oncology, St-Antonius-Hospital, Eschweiler, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Staib", 
            "givenName": "Peter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Ulm", 
              "id": "https://www.grid.ac/institutes/grid.410712.1", 
              "name": [
                "Department for Internal Medicine III, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stilgenbauer", 
            "givenName": "Stephan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.7450.6", 
              "name": [
                "Department of Hematology and Oncology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tr\u00fcmper", 
            "givenName": "Lorenz", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "National Centre for Tumor Disease, Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zenz", 
            "givenName": "Thorsten", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.7450.6", 
              "name": [
                "Department of Hematology and Oncology, Georg-August-University of G\u00f6ttingen, G\u00f6ttingen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kube", 
            "givenName": "Dieter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Duisburg-Essen, Medical School, Essen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "K\u00fcppers", 
            "givenName": "Ralf", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Duisburg-Essen, Medical School, Essen, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weniger", 
            "givenName": "Marc", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "Institute of Pathology, Charit\u00e9 \u2013 University Medicine Berlin, Berlin, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hummel", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Hematopathology Section, Institute of Pathology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klapper", 
            "givenName": "Wolfram", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Ulm", 
              "id": "https://www.grid.ac/institutes/grid.410712.1", 
              "name": [
                "Comprehensive Cancer Center Ulm (CCCU), University Hospital Ulm, Ulm, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kostezka", 
            "givenName": "Ulrike", 
            "id": "sg:person.013221515166.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013221515166.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "Institute of Pathology, Charit\u00e9 \u2013 University Medicine Berlin, Berlin, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lenze", 
            "givenName": "Dido", 
            "id": "sg:person.01256454306.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256454306.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Ulm", 
              "id": "https://www.grid.ac/institutes/grid.410712.1", 
              "name": [
                "Institute of Pathology, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00f6ller", 
            "givenName": "Peter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenwald", 
            "givenName": "Andreas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Hematopathology Section, Institute of Pathology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szczepanowski", 
            "givenName": "Monika", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ammerpohl", 
            "givenName": "Ole", 
            "id": "sg:person.0730602457.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730602457.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "Hematopathology Section, Institute of Pathology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aukema", 
            "givenName": "Sietse M.", 
            "id": "sg:person.0635065571.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635065571.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Binder", 
            "givenName": "Vera", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, D\u00fcsseldorf, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoell", 
            "givenName": "Jessica I.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leich", 
            "givenName": "Ellen", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00f3pez", 
            "givenName": "Cristina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagel", 
            "givenName": "Inga", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of W\u00fcrzburg", 
              "id": "https://www.grid.ac/institutes/grid.8379.5", 
              "name": [
                "Institute of Pathology, University of W\u00fcrzburg, W\u00fcrzburg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pischimariov", 
            "givenName": "Jordan", 
            "id": "sg:person.015460151766.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015460151766.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenstiel", 
            "givenName": "Philip", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schilhabel", 
            "givenName": "Markus", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Department of General Internal Medicine, University Kiel, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schreiber", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vater", 
            "givenName": "Inga", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Human Genetics, University of Ulm and University Hospital of Ulm, Ulm, Germany", 
                "Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wagener", 
            "givenName": "Rabea", 
            "id": "sg:person.01254175041.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254175041.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bernhart", 
            "givenName": "Stephan H.", 
            "id": "sg:person.0753447607.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753447607.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Binder", 
            "givenName": "Hans", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doose", 
            "givenName": "Gero", 
            "id": "sg:person.0650317071.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650317071.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hoffmann", 
            "givenName": "Steve", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hopp", 
            "givenName": "Lydia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kretzmer", 
            "givenName": "Helene", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kreuz", 
            "givenName": "Markus", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langenberger", 
            "givenName": "David", 
            "id": "sg:person.0667127770.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667127770.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loeffler", 
            "givenName": "Markus", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leipzig University", 
              "id": "https://www.grid.ac/institutes/grid.9647.c", 
              "name": [
                "Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosolowski", 
            "givenName": "Maciej", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Bioinformatics and Omics Data Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Bioinformatics and Omics Data Analytics (B240), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schlesner", 
            "givenName": "Matthias", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Mathematics in the Sciences", 
              "id": "https://www.grid.ac/institutes/grid.419532.8", 
              "name": [
                "Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany", 
                "Bioinformatics Group, Department of Computer, University of Leipzig, Leipzig, Germany", 
                "Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany", 
                "RNomics Group, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany", 
                "Santa Fe Institute, Santa Fe, New Mexico, USA", 
                "Max-Planck-Institute for Mathematics in Sciences, Leipzig, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stadler", 
            "givenName": "Peter F.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "EMBL Heidelberg, Genome Biology, Heidelberg, Germany", 
                "ICGC MMML-Seq Project"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sungalee", 
            "givenName": "Stephanie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hannover Medical School", 
              "id": "https://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kratz", 
            "givenName": "Christian P.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Center for Individualized Pediatric Oncology (ZIPO) and Brain Tumors, University Hospital and German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Tilburg", 
            "givenName": "Cornelis M.", 
            "id": "sg:person.01040301351.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040301351.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.411984.1", 
              "name": [
                "Division of Pediatric Hematology and Oncology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kramm", 
            "givenName": "Christof M.", 
            "id": "sg:person.01162773425.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162773425.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Essen University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.410718.b", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Pediatric Oncology & Hematology, Pediatrics III, University Hospital of Essen, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fleischhack", 
            "givenName": "Gudrun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Essen University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.410718.b", 
              "name": [
                "Pediatric Oncology & Hematology, Pediatrics III, University Hospital of Essen, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dirksen", 
            "givenName": "Uta", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Hamburg-Eppendorf", 
              "id": "https://www.grid.ac/institutes/grid.13648.38", 
              "name": [
                "Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rutkowski", 
            "givenName": "Stefan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Augsburg Hospital", 
              "id": "https://www.grid.ac/institutes/grid.419801.5", 
              "name": [
                "Swabian Children\u2019s Cancer Center, Children\u2019s Hospital, Klinikum Augsburg, Augsburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fr\u00fchwald", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Medical Center Hamburg-Eppendorf", 
              "id": "https://www.grid.ac/institutes/grid.13648.38", 
              "name": [
                "Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "von Hoff", 
            "givenName": "Katja", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Genomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolf", 
            "givenName": "Stephan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.411088.4", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Hospital for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klingebiel", 
            "givenName": "Thomas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Olgahospital", 
              "id": "https://www.grid.ac/institutes/grid.459687.1", 
              "name": [
                "Klinikum Stuttgart - Olgahospital, Zentrum f\u00fcr Kinder-, Jugend- und Frauenmedizin, P\u00e4diatrie, Stuttgart, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koscielniak", 
            "givenName": "Ewa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Academic Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koster", 
            "givenName": "Jan", 
            "id": "sg:person.013413514417.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013413514417.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Philadelphia", 
              "id": "https://www.grid.ac/institutes/grid.239552.a", 
              "name": [
                "Division of Neurosurgery, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Resnick", 
            "givenName": "Adam C.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Jinghui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Yanling", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Computational Biology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Xin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Philadelphia", 
              "id": "https://www.grid.ac/institutes/grid.239552.a", 
              "name": [
                "Division of Oncology, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia, Philadelphia, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waanders", 
            "givenName": "Angela J.", 
            "id": "sg:person.014005602554.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014005602554.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Academic Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Department of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zwijnenburg", 
            "givenName": "Danny A.", 
            "id": "sg:person.01254025021.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254025021.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Children's Hospital of Philadelphia", 
              "id": "https://www.grid.ac/institutes/grid.239552.a", 
              "name": [
                "Division of Neurosurgery, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raman", 
            "givenName": "Pichai", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber", 
            "givenName": "Ursula D.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "St. Jude Children's Research Hospital", 
              "id": "https://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Developmental Neurobiology, St Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Northcott", 
            "givenName": "Paul A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pajtler", 
            "givenName": "Kristian W.", 
            "id": "sg:person.0647670107.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647670107.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kool", 
            "givenName": "Marcel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Charit\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.6363.0", 
              "name": [
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Institute of Computer Science, Freie Universit\u00e4t Berlin, Berlin, Germany", 
                "Institute of Medical Genetics and Human Genetics, Charit\u00e9 University Hospital, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piro", 
            "givenName": "Rosario M.", 
            "id": "sg:person.0714253406.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714253406.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "European Molecular Biology Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.4709.a", 
              "name": [
                "European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Korbel", 
            "givenName": "Jan O.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jones", 
            "givenName": "David T. W.", 
            "id": "sg:person.011536141544.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011536141544.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chavez", 
            "givenName": "Lukas", 
            "id": "sg:person.01250404162.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250404162.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Hopp-Children\u2019s Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany", 
                "Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany", 
                "Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Stefan M.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.18632/oncotarget.5685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000812736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btr329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000866662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2014.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001161958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001472300", 
              "https://doi.org/10.1038/ng.2938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001644479", 
              "https://doi.org/10.1038/nature12634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002905656", 
              "https://doi.org/10.1038/ncomms9940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2012.228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003051075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1508054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004852583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004871541", 
              "https://doi.org/10.1038/nature13108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004984574", 
              "https://doi.org/10.1038/nature12113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra023001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005718906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.1.308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005817660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006449583", 
              "https://doi.org/10.1038/ng.2735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006780793", 
              "https://doi.org/10.1038/nature10733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006983905", 
              "https://doi.org/10.1038/ncomms7302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nou327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007343491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcb.10411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007476137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep02650", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008012273", 
              "https://doi.org/10.1038/srep02650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008014790", 
              "https://doi.org/10.1038/nm.3078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359162a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008302153", 
              "https://doi.org/10.1038/359162a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2013.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008446619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2016.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008502755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2012.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008799776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009937083", 
              "https://doi.org/10.1038/ng.2682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0900571106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010385254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011007538", 
              "https://doi.org/10.1038/ng.3441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012216516", 
              "https://doi.org/10.1038/nrc3410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2015.129692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013492937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/kxh008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014431182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014600483", 
              "https://doi.org/10.1038/nature13379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015539365", 
              "https://doi.org/10.1038/onc.2013.427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2013.427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015539365", 
              "https://doi.org/10.1038/onc.2013.427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08159.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016060661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2010.08159.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016060661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0071711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017490348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018906597", 
              "https://doi.org/10.1038/ncomms4630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020792304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2611", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020945251", 
              "https://doi.org/10.1038/ng.2611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812064", 
              "https://doi.org/10.1038/nature15393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2011.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022584996", 
              "https://doi.org/10.1038/nrclinonc.2011.95"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40291-013-0020-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022921391", 
              "https://doi.org/10.1007/s40291-013-0020-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023005667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2051-5960-2-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023092170", 
              "https://doi.org/10.1186/2051-5960-2-10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026374177", 
              "https://doi.org/10.1038/nrc3352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-04-531871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026486489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.10.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028906009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030165831", 
              "https://doi.org/10.1038/nsmb.1499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.02.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030611397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031274231", 
              "https://doi.org/10.1038/nature15394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2015.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031483094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-015-3424-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032437477", 
              "https://doi.org/10.1007/s10549-015-3424-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.21332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032745321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bts378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032917074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1748-717x-5-104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032940348", 
              "https://doi.org/10.1186/1748-717x-5-104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033127948", 
              "https://doi.org/10.1038/nm.3840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034126900", 
              "https://doi.org/10.1038/nm.4204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2015.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034457047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cjp2.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035095296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036060000", 
              "https://doi.org/10.1038/nature11003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/523149a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036345766", 
              "https://doi.org/10.1038/523149a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2011-12-4-r41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036416165", 
              "https://doi.org/10.1186/gb-2011-12-4-r41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jhep.2014.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036901383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2004.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037193790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038149511", 
              "https://doi.org/10.1038/nmeth.2642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/msb.20156505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039080860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039302414", 
              "https://doi.org/10.1038/nature11284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240428", 
              "https://doi.org/10.1038/nature11213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2004.04948.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040992335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041260635", 
              "https://doi.org/10.1038/ng.3709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3324/haematol.2014.104992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041546740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2016.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042025420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2760", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042520483", 
              "https://doi.org/10.1038/ng.2760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043446290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1209318109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044177480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.134635.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044550376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.66.6552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044899496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046256121", 
              "https://doi.org/10.1038/ng.2532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047195002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047500017", 
              "https://doi.org/10.1038/nm.3876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048296872", 
              "https://doi.org/10.1038/ng.1102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048699191", 
              "https://doi.org/10.1038/ng.3230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048811261", 
              "https://doi.org/10.1038/ng.2762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2016.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049228857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050302969", 
              "https://doi.org/10.1038/nbt.2940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjmed.2012.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050751430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050781394", 
              "https://doi.org/10.1038/nature13109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050797629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.03.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051674590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-016-0456-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052602162", 
              "https://doi.org/10.1186/s13046-016-0456-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13046-016-0456-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052602162", 
              "https://doi.org/10.1186/s13046-016-0456-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052693550", 
              "https://doi.org/10.1038/ng.3438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053062388", 
              "https://doi.org/10.1038/ng.2287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-14-2744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063224819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18637/jss.v030.i03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068672445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074219023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090777008", 
              "https://doi.org/10.1038/nature22973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090777008", 
              "https://doi.org/10.1038/nature22973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.09.048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092293111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101264519", 
              "https://doi.org/10.1038/nature25795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature25795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101264519", 
              "https://doi.org/10.1038/nature25795"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03", 
        "datePublishedReg": "2018-03-01", 
        "description": "Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature25480", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3795437", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7696", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "555"
          }
        ], 
        "name": "The landscape of genomic alterations across childhood cancers", 
        "pagination": "321", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ae636187540c4acf147e78912ff09ac1f175e4fa3cbd6412ef2fbe855dd99cb6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29489754"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature25480"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1101264345"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature25480", 
          "https://app.dimensions.ai/details/publication/pub.1101264345"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87106_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature25480"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature25480'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature25480'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature25480'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature25480'


     

    This table displays all metadata directly associated to this object as RDF triples.

    1763 TRIPLES      21 PREDICATES      144 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature25480 schema:about N2b53636c621e45c38962457cbb94e323
    2 N2d1a7c2689654b5b835396baa66f78af
    3 N3368a189fe56424fade2775d20d16dea
    4 N532201fa69c3468c9faefa2fa5830c93
    5 N555e2bfe7e014265b491c69a0b37d1e1
    6 N76ae8d350b4e4bf481f288cfae6c11e1
    7 N79fdfbb1353e46a688a0bf9890a367ab
    8 N94177d054fc9421e8ec4d20293cc8bad
    9 Na0ee9e25155c452a9adeb43d321c8612
    10 Na8a93177d4f74d9d999183e95a7e0923
    11 Nab95c9fcf4b940b49cd00b24093d76de
    12 Nadc027a183d4494197ef2ee1101baebb
    13 Nb19330e758cd444e9d816d0098b659d4
    14 Nb2a32f10f1494662811935089134164e
    15 Nbec8546ad5994159ad6408a285035df6
    16 Nc503cff29cdb46c1b61f2d4a023d7c33
    17 Ne67ffde936184a37a25887b99648e6d0
    18 Nf3dc2e49cede4460b578174b2c497fa1
    19 anzsrc-for:11
    20 anzsrc-for:1112
    21 schema:author N74889b24205a4206b3bcc1500c330966
    22 schema:citation sg:pub.10.1007/s10549-015-3424-1
    23 sg:pub.10.1007/s40291-013-0020-0
    24 sg:pub.10.1038/359162a0
    25 sg:pub.10.1038/523149a
    26 sg:pub.10.1038/nature10733
    27 sg:pub.10.1038/nature11003
    28 sg:pub.10.1038/nature11213
    29 sg:pub.10.1038/nature11284
    30 sg:pub.10.1038/nature12113
    31 sg:pub.10.1038/nature12477
    32 sg:pub.10.1038/nature12634
    33 sg:pub.10.1038/nature13108
    34 sg:pub.10.1038/nature13109
    35 sg:pub.10.1038/nature13379
    36 sg:pub.10.1038/nature15393
    37 sg:pub.10.1038/nature15394
    38 sg:pub.10.1038/nature22973
    39 sg:pub.10.1038/nature25795
    40 sg:pub.10.1038/nbt.2940
    41 sg:pub.10.1038/ncomms4630
    42 sg:pub.10.1038/ncomms7302
    43 sg:pub.10.1038/ncomms9940
    44 sg:pub.10.1038/ng.1102
    45 sg:pub.10.1038/ng.2287
    46 sg:pub.10.1038/ng.2532
    47 sg:pub.10.1038/ng.2611
    48 sg:pub.10.1038/ng.2682
    49 sg:pub.10.1038/ng.2735
    50 sg:pub.10.1038/ng.2760
    51 sg:pub.10.1038/ng.2762
    52 sg:pub.10.1038/ng.2938
    53 sg:pub.10.1038/ng.3230
    54 sg:pub.10.1038/ng.3438
    55 sg:pub.10.1038/ng.3441
    56 sg:pub.10.1038/ng.3709
    57 sg:pub.10.1038/nm.3078
    58 sg:pub.10.1038/nm.3840
    59 sg:pub.10.1038/nm.3876
    60 sg:pub.10.1038/nm.4204
    61 sg:pub.10.1038/nmeth.2642
    62 sg:pub.10.1038/nrc1299
    63 sg:pub.10.1038/nrc3352
    64 sg:pub.10.1038/nrc3410
    65 sg:pub.10.1038/nrclinonc.2011.95
    66 sg:pub.10.1038/nsmb.1499
    67 sg:pub.10.1038/onc.2013.427
    68 sg:pub.10.1038/srep02650
    69 sg:pub.10.1186/1748-717x-5-104
    70 sg:pub.10.1186/2051-5960-2-10
    71 sg:pub.10.1186/gb-2011-12-4-r41
    72 sg:pub.10.1186/s13046-016-0456-2
    73 https://doi.org/10.1001/jama.2012.228
    74 https://doi.org/10.1002/cjp2.27
    75 https://doi.org/10.1002/jcb.10411
    76 https://doi.org/10.1002/path.4880
    77 https://doi.org/10.1016/j.amjmed.2012.01.013
    78 https://doi.org/10.1016/j.ccell.2015.01.002
    79 https://doi.org/10.1016/j.ccell.2015.04.002
    80 https://doi.org/10.1016/j.ccell.2016.02.001
    81 https://doi.org/10.1016/j.ccr.2012.10.007
    82 https://doi.org/10.1016/j.ccr.2013.11.002
    83 https://doi.org/10.1016/j.ccr.2014.02.004
    84 https://doi.org/10.1016/j.cell.2011.12.013
    85 https://doi.org/10.1016/j.cell.2013.02.023
    86 https://doi.org/10.1016/j.cell.2017.09.048
    87 https://doi.org/10.1016/j.celrep.2012.12.008
    88 https://doi.org/10.1016/j.celrep.2013.07.003
    89 https://doi.org/10.1016/j.celrep.2014.03.003
    90 https://doi.org/10.1016/j.ejca.2016.04.001
    91 https://doi.org/10.1016/j.ejca.2016.06.009
    92 https://doi.org/10.1016/j.jhep.2014.08.009
    93 https://doi.org/10.1016/j.molcel.2004.06.020
    94 https://doi.org/10.1016/j.molcel.2012.03.030
    95 https://doi.org/10.1056/nejmoa1508054
    96 https://doi.org/10.1056/nejmra023001
    97 https://doi.org/10.1073/pnas.0900571106
    98 https://doi.org/10.1073/pnas.1209318109
    99 https://doi.org/10.1093/bioinformatics/btr329
    100 https://doi.org/10.1093/bioinformatics/bts378
    101 https://doi.org/10.1093/biostatistics/kxh008
    102 https://doi.org/10.1093/nar/29.1.308
    103 https://doi.org/10.1093/nar/gkq603
    104 https://doi.org/10.1093/neuonc/nou327
    105 https://doi.org/10.1101/gr.134635.111
    106 https://doi.org/10.1111/j.1365-2141.2004.04948.x
    107 https://doi.org/10.1111/j.1365-2141.2010.08159.x
    108 https://doi.org/10.1158/1078-0432.ccr-14-2744
    109 https://doi.org/10.1182/blood-2014-04-531871
    110 https://doi.org/10.1200/jco.2016.66.6552
    111 https://doi.org/10.1371/journal.pgen.1000529
    112 https://doi.org/10.1371/journal.pone.0071711
    113 https://doi.org/10.15252/msb.20156505
    114 https://doi.org/10.18632/oncotarget.5685
    115 https://doi.org/10.18637/jss.v030.i03
    116 https://doi.org/10.3322/caac.21332
    117 https://doi.org/10.3324/haematol.2014.104992
    118 https://doi.org/10.3324/haematol.2015.129692
    119 schema:datePublished 2018-03
    120 schema:datePublishedReg 2018-03-01
    121 schema:description Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
    122 schema:genre research_article
    123 schema:inLanguage en
    124 schema:isAccessibleForFree true
    125 schema:isPartOf N1e0f981f4fac4c5b9f707a57b72a7c9b
    126 N3794c1cb2e0d40cbbd5ba9287eb3b22e
    127 sg:journal.1018957
    128 schema:name The landscape of genomic alterations across childhood cancers
    129 schema:pagination 321
    130 schema:productId N02e00873febd410ca3fc04b19b6413db
    131 N3a5b21baaee34b9c86a61acbb5316db0
    132 N743d0f82a5c34f56b4db26fa498fe457
    133 Nb3e4f4af886e4b6a8ced110ef02f0d34
    134 Nb4a94c30c0534fe988a25b36a747f33a
    135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101264345
    136 https://doi.org/10.1038/nature25480
    137 schema:sdDatePublished 2019-04-11T12:25
    138 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    139 schema:sdPublisher N6ba3b80ce9f34200889b73155f0fa5a7
    140 schema:url https://www.nature.com/articles/nature25480
    141 sgo:license sg:explorer/license/
    142 sgo:sdDataset articles
    143 rdf:type schema:ScholarlyArticle
    144 N02e00873febd410ca3fc04b19b6413db schema:name pubmed_id
    145 schema:value 29489754
    146 rdf:type schema:PropertyValue
    147 N03744a69883949569412895c8674e80d schema:affiliation https://www.grid.ac/institutes/grid.9647.c
    148 schema:familyName Kreuz
    149 schema:givenName Markus
    150 rdf:type schema:Person
    151 N065a77bf83ae49539fba1619a3545cc8 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
    152 schema:familyName Kratz
    153 schema:givenName Christian P.
    154 rdf:type schema:Person
    155 N07acba0dc9c540f5a114582745097713 rdf:first Ne5786f71bf354d82b22b83458a811078
    156 rdf:rest Nf186fe1d797346bc9050284ca92d6f0e
    157 N081e05f427774c12ac44f8c452fa50f3 rdf:first N77daf6b92cef4a71bfc8fba4dd2246d9
    158 rdf:rest Nfd13d46ad0a0475ea26eedd9ea2dd704
    159 N0a1e65df8bfa408e8ed8ff1a39f4fb9c rdf:first Nb857b1802c3444a8b9deb2c6dadb6d09
    160 rdf:rest Nd8d48f9be57642c4ba1f239e944c2704
    161 N0a3b3a08d03841108de5b7b57e022899 rdf:first sg:person.0753447607.17
    162 rdf:rest N3d0858eda86e41c2ba3e85a1c672ca7f
    163 N0b94993403ca4272b779b3a08d79341c schema:affiliation N2ee3db8ef6ab4389b12bfe5e07b4ce55
    164 schema:familyName Weniger
    165 schema:givenName Marc
    166 rdf:type schema:Person
    167 N0be5c5b879e74e468d3b3a4c1bbbdc38 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    168 schema:familyName Jones
    169 schema:givenName David
    170 rdf:type schema:Person
    171 N0c960603ee2840edb4afdf9321d72fea schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    172 schema:familyName Richter
    173 schema:givenName Gesine
    174 rdf:type schema:Person
    175 N0d468d68cf4e4b5883eed4d09e118b51 rdf:first Nba45180799934af8994587f3ea290056
    176 rdf:rest Nf06dfd57c4514e0691d5140d427c55fa
    177 N10772ea11955483e9e09ff9d1cfac316 schema:affiliation https://www.grid.ac/institutes/grid.410718.b
    178 schema:familyName Fleischhack
    179 schema:givenName Gudrun
    180 rdf:type schema:Person
    181 N1085f5ecf08f4120b422836155ab22d3 schema:name ICGC MMML-Seq Project
    182 National Centre for Tumor Disease, Heidelberg, Germany
    183 rdf:type schema:Organization
    184 N10ac9adc02f24d49816c7c79433cf3b8 rdf:first N0c960603ee2840edb4afdf9321d72fea
    185 rdf:rest Nf95696d4f5aa42b981ca503dce25ed07
    186 N10bbd83d6bb648ebbda2cbf5fc651ff8 rdf:first Nfcfda55a7f5f4e6c9c443b39dd1235e0
    187 rdf:rest N16ada2d0a2b84c9b918e69c068a65b13
    188 N10cb41bad73c41b98837b8f88c43d52e schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    189 schema:familyName Korbel
    190 schema:givenName Jan
    191 rdf:type schema:Person
    192 N10d5ea00b673495987ac7949f013ca8e rdf:first N2f082f37cd7c4f129b665135da9f9ed5
    193 rdf:rest N5ab5153b217f466ba4121de95acebb72
    194 N1187f20b2d6e482f8b0280cf40f0857d rdf:first sg:person.01207525377.10
    195 rdf:rest N6651dd26acda4f7189a20079e7e8495a
    196 N12636f1865784c2ea12af8109f90305e rdf:first N03744a69883949569412895c8674e80d
    197 rdf:rest Ncb55e7493bd147c79b190c40a7cd2387
    198 N129ac3c7fb0745a397bb140413aed249 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    199 schema:familyName Burdach
    200 schema:givenName Stefan
    201 rdf:type schema:Person
    202 N137700500c6a4e89ad3c142a545b21a9 rdf:first Nd14c105d0e654c8f9db7ccbacf906077
    203 rdf:rest Nb2434a2a7ca443678c192b8f5e71c348
    204 N1421e428712140b7809195f42f799247 rdf:first N512e5841a246467cabfadc4ba965e851
    205 rdf:rest N5e3278fc82664a088295d93807a1ba4a
    206 N1570ba9c0ebc4b40ae33f215ebfe71d8 schema:familyName Project
    207 schema:givenName ICGC PedBrain-Seq
    208 rdf:type schema:Person
    209 N158fed8d4d6d4055bb9f7fb3ea257374 rdf:first sg:person.014005602554.26
    210 rdf:rest Nbdf6197244c7498c8d243beaaca1e507
    211 N16ada2d0a2b84c9b918e69c068a65b13 rdf:first N8a182da25d014a61a94f6b4455e6ac6f
    212 rdf:rest N95f1bfc5f7e14cae97aca663ee0733eb
    213 N172795eace054e1aa875b71218d101c5 rdf:first Nf0614f980f2a46f19c083134d224afba
    214 rdf:rest N324fd9aa87414ed396f43556714ed0b4
    215 N1744a36aa6484e97b5d5249457a111a4 schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    216 schema:familyName Northcott
    217 schema:givenName Paul A.
    218 rdf:type schema:Person
    219 N1759b951d29e49448e89455e8cde8328 rdf:first sg:person.01040301351.76
    220 rdf:rest N2ba182594c844b9f95b6e24f7843faeb
    221 N17bbd2c0aa3c4d6885187bdb809f9595 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
    222 schema:familyName Zapatka
    223 schema:givenName Marc
    224 rdf:type schema:Person
    225 N182d0aa360e647f8a53cec3f3ebc9dfb schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    226 schema:familyName Scholz
    227 schema:givenName Ingrid
    228 rdf:type schema:Person
    229 N19fda505d02542238fb82da1f12fc34c schema:affiliation https://www.grid.ac/institutes/grid.6612.3
    230 schema:familyName Baumhoer
    231 schema:givenName Daniel
    232 rdf:type schema:Person
    233 N1a4afd3dd82e431c890a8854fa43590a rdf:first sg:person.07621127033.67
    234 rdf:rest N37a140a3342140ebac9fb9baf095e0ae
    235 N1d414a82c12d4692a02ba68c37d343e3 rdf:first Nb495ee7b07a3413795ab8a4d0799686f
    236 rdf:rest Nd021f89690884bb5a41f7f3b4053c2c2
    237 N1dd972115f6a45dfa8a32b95017dbf98 rdf:first Ncafe697f179847bba371ed8afc7a5713
    238 rdf:rest N1421e428712140b7809195f42f799247
    239 N1e0f981f4fac4c5b9f707a57b72a7c9b schema:issueNumber 7696
    240 rdf:type schema:PublicationIssue
    241 N1e77eefd100c4d0f882c1b89681ab027 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    242 schema:familyName Brors
    243 schema:givenName Benedikt
    244 rdf:type schema:Person
    245 N1ecd429cc22a4ea08c64c31780418f7b rdf:first Na41bfd6bfae4490a882b0f5e0232841b
    246 rdf:rest N3c8258123cce4c1ca5b5b547156e1da8
    247 N1ef045631d744cf38f38acdd422d632f schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    248 schema:familyName Jäger
    249 schema:givenName Natalie
    250 rdf:type schema:Person
    251 N2317f469dff54156b1f8599fd9ccba5b rdf:first N9496624f00f247b8b53a4ba92fc35551
    252 rdf:rest N584fb53af5d1497fa7752efc2374b6f9
    253 N24892c702366425e9e49bc128fdc5e0f rdf:first N7d40b85b847c4e71968c44dedb093a75
    254 rdf:rest N49a8832827c0436fb757bb471d51b9b9
    255 N263380fc1a9c4ec7a4e47bae45a266c5 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    256 schema:familyName von Kalle
    257 schema:givenName Christof
    258 rdf:type schema:Person
    259 N2747f710e59041da8eecfdde1f36a370 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    260 schema:familyName Korbel
    261 schema:givenName Jan O.
    262 rdf:type schema:Person
    263 N2774f8d42de0459eb354732607b3985d schema:affiliation https://www.grid.ac/institutes/grid.410718.b
    264 schema:familyName Lohmann
    265 schema:givenName Dietmar
    266 rdf:type schema:Person
    267 N281e0fe6566742b29116cf74d1ada02d schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    268 schema:familyName Rosenwald
    269 schema:givenName Andreas
    270 rdf:type schema:Person
    271 N29bb7731b0ca4cba99045e119c3c3e41 rdf:first sg:person.01022515007.00
    272 rdf:rest N82b0ac12cca54704beaca150509de55e
    273 N29f14aff2ddd4956be5bcd7e0847cd96 schema:familyName Project
    274 schema:givenName ICGC MMML-Seq
    275 rdf:type schema:Person
    276 N2a1b39bd9ebe4fefbd5060ee7946155b schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    277 schema:familyName Brabetz
    278 schema:givenName Sebastian
    279 rdf:type schema:Person
    280 N2b53636c621e45c38962457cbb94e323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Child
    282 rdf:type schema:DefinedTerm
    283 N2ba182594c844b9f95b6e24f7843faeb rdf:first sg:person.01162773425.66
    284 rdf:rest N8048ea08da88431b986d97a61c69417e
    285 N2cfd31e0e42343b4adb03c827e0840d6 rdf:first N29f14aff2ddd4956be5bcd7e0847cd96
    286 rdf:rest N7e40b2dca7ac45199cfe2a15378d0aa9
    287 N2d1a7c2689654b5b835396baa66f78af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name Mutation
    289 rdf:type schema:DefinedTerm
    290 N2e1b7b78363f47399aa5c6307878d46c rdf:first Nc163b8da14eb4081b289357505058cf8
    291 rdf:rest N07acba0dc9c540f5a114582745097713
    292 N2ee3db8ef6ab4389b12bfe5e07b4ce55 schema:name ICGC MMML-Seq Project
    293 Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Duisburg-Essen, Medical School, Essen, Germany
    294 rdf:type schema:Organization
    295 N2f082f37cd7c4f129b665135da9f9ed5 schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    296 schema:familyName Stütz
    297 schema:givenName Adrian
    298 rdf:type schema:Person
    299 N31849b264e124730ab179714ae92ac0f schema:affiliation https://www.grid.ac/institutes/grid.9647.c
    300 schema:familyName Loeffler
    301 schema:givenName Markus
    302 rdf:type schema:Person
    303 N324fd9aa87414ed396f43556714ed0b4 rdf:first Nb8a51893ae1e4c5fbf93e672ac166c6c
    304 rdf:rest N0a1e65df8bfa408e8ed8ff1a39f4fb9c
    305 N3368a189fe56424fade2775d20d16dea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    306 schema:name Chromothripsis
    307 rdf:type schema:DefinedTerm
    308 N354de258dc6d4772acdded8a6075689c schema:affiliation https://www.grid.ac/institutes/grid.6363.0
    309 schema:familyName Eckert
    310 schema:givenName Cornelia
    311 rdf:type schema:Person
    312 N35fa61c1ae45476b93929c396c0e4dd3 rdf:first N5eb561e2a17b403099ade99d798cd700
    313 rdf:rest N9f25490a85e443f9bd121680d1c67b66
    314 N3752374982c941c9a8e2eca76570e274 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    315 schema:familyName Schlesner
    316 schema:givenName Matthias
    317 rdf:type schema:Person
    318 N3794c1cb2e0d40cbbd5ba9287eb3b22e schema:volumeNumber 555
    319 rdf:type schema:PublicationVolume
    320 N37a140a3342140ebac9fb9baf095e0ae rdf:first sg:person.0664637017.63
    321 rdf:rest N4b865630d263435bbf1d690bf53ffddd
    322 N37d94ff11a5f46a9a7441c9123d3d9be rdf:first sg:person.01076766505.13
    323 rdf:rest Nbb4cb1a900b54a9498444832d34847af
    324 N38f3ebe40bc3439fb5717a44f7680bca rdf:first sg:person.0760172546.56
    325 rdf:rest Ncfe300d1503245b4bbd7888833c82bc3
    326 N3a5b21baaee34b9c86a61acbb5316db0 schema:name nlm_unique_id
    327 schema:value 0410462
    328 rdf:type schema:PropertyValue
    329 N3c4a6cc3bcdb450fa54fbce8c620f2ce schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    330 schema:familyName Liu
    331 schema:givenName Yanling
    332 rdf:type schema:Person
    333 N3c8258123cce4c1ca5b5b547156e1da8 rdf:first sg:person.013221515166.56
    334 rdf:rest N88ecb83b6d964e48b15488499824d18b
    335 N3c993c8137ee4ed1a5c800dafb9985ec schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    336 schema:familyName Claviez
    337 schema:givenName Alexander
    338 rdf:type schema:Person
    339 N3cc01abb35b94934b446a247aeb0c1de rdf:first N1ef045631d744cf38f38acdd422d632f
    340 rdf:rest N5939ee4456394727b914705f73548686
    341 N3d0858eda86e41c2ba3e85a1c672ca7f rdf:first Nc49729b4be3e4aeb9996a71dc8bd058d
    342 rdf:rest Na6d54e27c94b44cab67040a60bed3caf
    343 N3f5202e17fe740cfad4d7303f4867f45 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    344 schema:familyName Pfister
    345 schema:givenName Stefan
    346 rdf:type schema:Person
    347 N40f0b869d8f042a9b3fd43e9d71f9143 rdf:first N8f5fd25bd29c485c92301b8543d97fe6
    348 rdf:rest N9c5fb72a0c154cd4a6e5abcb0ed1db1f
    349 N431caa83390a4e65ab9eb5ac839645bb rdf:first sg:person.0730602457.24
    350 rdf:rest Ncdc58b1d18d74c22a7283ee2f7f911d6
    351 N43757306199d40aa9e3e8ed9b7edf9a6 rdf:first N2a1b39bd9ebe4fefbd5060ee7946155b
    352 rdf:rest N6587fd767806458588c109ebfd639508
    353 N43a993ce8463448f88b706f9af21d175 rdf:first N571f43ba68034832ae47dddb84a78a00
    354 rdf:rest Ne68c42298e814e018cef629a00d262c3
    355 N43bd79bdc48a478daed969d9710cd0d4 rdf:first sg:person.01273213270.17
    356 rdf:rest N1dd972115f6a45dfa8a32b95017dbf98
    357 N4440021031a840f7b44e9019b99a9ef8 rdf:first N49bd68cffd8746ceb08fb82692eabc04
    358 rdf:rest N1d414a82c12d4692a02ba68c37d343e3
    359 N44482cc9d35d407a8b0784a2fe45241c schema:affiliation https://www.grid.ac/institutes/grid.240871.8
    360 schema:familyName Zhang
    361 schema:givenName Jinghui
    362 rdf:type schema:Person
    363 N464365017cad48f2a5863e964e27fa3b rdf:first Nfe9a9b743ed74c51916c6d636e4c94c7
    364 rdf:rest N95a9c5857fa440d4a2aa4a792f7aaf4d
    365 N4681753345d74de4bf124ddb4a7a3793 rdf:first Nae948456381047de80df86e5338a6b6c
    366 rdf:rest Nbedee74d2d2647ebae4fbd686d680fce
    367 N47161ac58daf4387833a3102ec01a430 rdf:first sg:person.01360270130.89
    368 rdf:rest N5e7e74d55f364f4e809820ac5777a2e3
    369 N47a01d51d26f4d66a4ee0ac71c3b3f6d schema:affiliation https://www.grid.ac/institutes/grid.411067.5
    370 schema:familyName Rohde
    371 schema:givenName Marius
    372 rdf:type schema:Person
    373 N48589e05161a465e986524dfd92caaea rdf:first N90f1b9ca860c4e6bbc227f5bd810d6b7
    374 rdf:rest Nd3fa4bbfea0a44a59c88fec7f72931bb
    375 N48658aeb03a94be5951328e947a8924b rdf:first N7d42d1579db940968fec5d145c4bf2c3
    376 rdf:rest Ndaf1457c5a374625a8c6470c1688eca1
    377 N499318193b7d4d42b15197b1fd310bc3 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    378 schema:familyName Wagner
    379 schema:givenName Susanne
    380 rdf:type schema:Person
    381 N49a8832827c0436fb757bb471d51b9b9 rdf:first N6d7e6a4b0c1e4f529eb779b380f80b85
    382 rdf:rest N47161ac58daf4387833a3102ec01a430
    383 N49bd68cffd8746ceb08fb82692eabc04 schema:affiliation https://www.grid.ac/institutes/grid.411088.4
    384 schema:familyName Klingebiel
    385 schema:givenName Thomas
    386 rdf:type schema:Person
    387 N4b865630d263435bbf1d690bf53ffddd rdf:first sg:person.07422430275.81
    388 rdf:rest N9c1d89270db1486d936754d75ec941e2
    389 N4b9fe81cc1014e44a929112a6e4d517c schema:affiliation https://www.grid.ac/institutes/grid.9647.c
    390 schema:familyName Kretzmer
    391 schema:givenName Helene
    392 rdf:type schema:Person
    393 N4e9be97f402e4bd9a78b2ef1d940f089 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    394 schema:familyName Kontny
    395 schema:givenName Udo
    396 rdf:type schema:Person
    397 N4ec6655a9e474d20952fcbdc5e1a61dc rdf:first sg:person.011536141544.42
    398 rdf:rest N86bca0a35e97457da4fad9a5c861e752
    399 N4fa8f2ebfa0d4f12ac344e1e84d89d9a rdf:first sg:person.0647670107.02
    400 rdf:rest N7a895d9688f947f4b9a7ecc8c9b3d6f1
    401 N511776c5510043f0b00e555780bf4a1a rdf:first N7aedead4b32b4dd188b7205955a65e3c
    402 rdf:rest N73f3fe9d962643a69010d9e01300675e
    403 N512e5841a246467cabfadc4ba965e851 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    404 schema:familyName Borkhardt
    405 schema:givenName Arndt
    406 rdf:type schema:Person
    407 N532201fa69c3468c9faefa2fa5830c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    408 schema:name Adolescent
    409 rdf:type schema:DefinedTerm
    410 N54cb1bd798cc4be79f53fa0851d917e3 schema:affiliation https://www.grid.ac/institutes/grid.14778.3d
    411 schema:familyName Landgraf
    412 schema:givenName Pablo
    413 rdf:type schema:Person
    414 N555e2bfe7e014265b491c69a0b37d1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    415 schema:name Genomics
    416 rdf:type schema:DefinedTerm
    417 N55d82c475e614365b70cb529d539d33f schema:name Department of Medicine III, Hematology and Oncology, Dr Horst-Schmidt-Kliniken of Wiesbaden, Wiesbaden, Germany
    418 ICGC MMML-Seq Project
    419 rdf:type schema:Organization
    420 N56f65d3d695b48368e7c08b9ecc0d592 rdf:first Nbe071083b3654288afaa45b686b952d0
    421 rdf:rest N431caa83390a4e65ab9eb5ac839645bb
    422 N571f43ba68034832ae47dddb84a78a00 schema:affiliation https://www.grid.ac/institutes/grid.410718.b
    423 schema:familyName Dirksen
    424 schema:givenName Uta
    425 rdf:type schema:Person
    426 N581c0d86a0aa4f9e920a3a268cb8dc3a schema:affiliation Ndf4cfd4b859b454c956e72048cfad6cf
    427 schema:familyName Kneba
    428 schema:givenName Michael
    429 rdf:type schema:Person
    430 N581d42db33a4450180459af92384ef64 schema:affiliation https://www.grid.ac/institutes/grid.410712.1
    431 schema:familyName Möller
    432 schema:givenName Peter
    433 rdf:type schema:Person
    434 N582eead6d24d4e2ca0920c2015e69ae5 rdf:first N1744a36aa6484e97b5d5249457a111a4
    435 rdf:rest N4fa8f2ebfa0d4f12ac344e1e84d89d9a
    436 N584fb53af5d1497fa7752efc2374b6f9 rdf:first N6ebabfaa84ce4c86b5e53fbf74b40e24
    437 rdf:rest Nbe51d438e4ac42139a096f4990d74f7d
    438 N5939ee4456394727b914705f73548686 rdf:first N10cb41bad73c41b98837b8f88c43d52e
    439 rdf:rest N10d5ea00b673495987ac7949f013ca8e
    440 N5aa89ec07cdb40b19f797eea270c313c schema:affiliation https://www.grid.ac/institutes/grid.6363.0
    441 schema:familyName Schulte
    442 schema:givenName Johannes
    443 rdf:type schema:Person
    444 N5ab5153b217f466ba4121de95acebb72 rdf:first N943062a2c345498a8aa021d2dd41afda
    445 rdf:rest N5be75ee83eb74dcfafc04f486c4f4067
    446 N5b66999607f14f1b92a4c1e97a2763b6 rdf:first sg:person.01104716566.89
    447 rdf:rest N8875efefb9c3455d800b7ac95bbcde9e
    448 N5bc588bc1bdc42449307108d666869ed rdf:first Ne930138450314166adf788c3c2df958d
    449 rdf:rest N10ac9adc02f24d49816c7c79433cf3b8
    450 N5be75ee83eb74dcfafc04f486c4f4067 rdf:first N5f63a234cded4c3cb0db367468696501
    451 rdf:rest N37d94ff11a5f46a9a7441c9123d3d9be
    452 N5bf0c347c7a24e889154aeedcf83a431 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
    453 schema:familyName Eggert
    454 schema:givenName Angelika
    455 rdf:type schema:Person
    456 N5c9556b4cac8470d8d03fa90d60f91a1 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
    457 schema:familyName Vassal
    458 schema:givenName Gilles
    459 rdf:type schema:Person
    460 N5e3278fc82664a088295d93807a1ba4a rdf:first N75d02a8ac4d349e98cf509e3ec5b719a
    461 rdf:rest N82d6ca862c6a4c91a8cd6a09921ad46a
    462 N5e7e74d55f364f4e809820ac5777a2e3 rdf:first sg:person.01236575653.42
    463 rdf:rest N43bd79bdc48a478daed969d9710cd0d4
    464 N5eb561e2a17b403099ade99d798cd700 schema:affiliation https://www.grid.ac/institutes/grid.8379.5
    465 schema:familyName Wegert
    466 schema:givenName Jenny
    467 rdf:type schema:Person
    468 N5f63a234cded4c3cb0db367468696501 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    469 schema:familyName Radlwimmer
    470 schema:givenName Bernhard
    471 rdf:type schema:Person
    472 N60cb04b51ff240f0bc62535388341c90 rdf:first Nfa7e0dba9e20420ca022e6ad19fa166e
    473 rdf:rest Nfcf0a5442e5244bd94f5d616b988b5dc
    474 N610bda4f961c4f5381418418edaf03f0 rdf:first Nda42da1790ed4b7f93f457f9ebc5f1a0
    475 rdf:rest N9713526955854ebb8134c81b8377b6f3
    476 N61852b97949142269f447989add8d058 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    477 schema:familyName Westermann
    478 schema:givenName Frank
    479 rdf:type schema:Person
    480 N62980013977a4ae1af833eda6c3748b6 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    481 schema:familyName Richter
    482 schema:givenName Günther H.
    483 rdf:type schema:Person
    484 N63f0958fb9994439a7c83f3d47dafa65 schema:affiliation Nd053ce2e4b584611849eb8ba75eb4b45
    485 schema:familyName Haas
    486 schema:givenName Siegfried
    487 rdf:type schema:Person
    488 N6447d9b896d04afe92da91e02e8cd115 rdf:first Ne98cfc7d1869402791e69ed9a42fe3a5
    489 rdf:rest Ne78a1864acb34cf591e6ca15fc065275
    490 N65832b4368204f87a12c35d955b7041b schema:affiliation https://www.grid.ac/institutes/grid.419801.5
    491 schema:familyName Frühwald
    492 schema:givenName Michael
    493 rdf:type schema:Person
    494 N6587fd767806458588c109ebfd639508 rdf:first Nac7a8d690bd34013a0ca2290f489955e
    495 rdf:rest N6b5c2039f26248848db1a0f8d6f16e5f
    496 N65980cd24bdf43c29d5d77409802c69e schema:name Hospital of Internal Medicine II, Hematology and Oncology, St-Georg Hospital Leipzig, Leipzig, Germany
    497 ICGC MMML-Seq Project
    498 rdf:type schema:Organization
    499 N6651dd26acda4f7189a20079e7e8495a rdf:first N47a01d51d26f4d66a4ee0ac71c3b3f6d
    500 rdf:rest N511776c5510043f0b00e555780bf4a1a
    501 N66ebcefb996f492ea702380a126384a3 rdf:first N5c9556b4cac8470d8d03fa90d60f91a1
    502 rdf:rest Na2091b4c429041ada16b5a357311e21d
    503 N67e14ceaa78f4427979851708e11b1bd rdf:first N97dc5773eb914009916ecedabe5ccf19
    504 rdf:rest rdf:nil
    505 N68ea53286985416892cd24bff289d3f6 rdf:first Nc24f3a56499d4adcb812eb7777ee91be
    506 rdf:rest N60cb04b51ff240f0bc62535388341c90
    507 N69ad036593e74871b6c891d0e0a45c5d rdf:first N281e0fe6566742b29116cf74d1ada02d
    508 rdf:rest N56f65d3d695b48368e7c08b9ecc0d592
    509 N6b5c2039f26248848db1a0f8d6f16e5f rdf:first N8f531dc0e2e04e569024c9feb5c6c359
    510 rdf:rest Ndbf7fac4c0094f3fa70e681510f11d83
    511 N6ba3b80ce9f34200889b73155f0fa5a7 schema:name Springer Nature - SN SciGraph project
    512 rdf:type schema:Organization
    513 N6c12ec32c1cc446e9fe960a61b2dbc44 schema:affiliation Nec34612e00ed463d805fbb9a33312bdb
    514 schema:familyName Schmidt
    515 schema:givenName Manfred
    516 rdf:type schema:Person
    517 N6d7e6a4b0c1e4f529eb779b380f80b85 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    518 schema:familyName Lawerenz
    519 schema:givenName Christian
    520 rdf:type schema:Person
    521 N6ebabfaa84ce4c86b5e53fbf74b40e24 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    522 schema:familyName Vater
    523 schema:givenName Inga
    524 rdf:type schema:Person
    525 N6ec76173e3744ed7953a584f70a5374b rdf:first N2747f710e59041da8eecfdde1f36a370
    526 rdf:rest N4ec6655a9e474d20952fcbdc5e1a61dc
    527 N70378a6d2dc347aab03c0a0f5a57e18d schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    528 schema:familyName Haake
    529 schema:givenName Andrea
    530 rdf:type schema:Person
    531 N706cd47f22d54170b2fa06a0c5f5d910 schema:name GeneWerk GmbH, Heidelberg, Germany
    532 ICGC PedBrain-Seq Project
    533 rdf:type schema:Organization
    534 N70db57727cb74498aa9413b6596b761f rdf:first N19fda505d02542238fb82da1f12fc34c
    535 rdf:rest Nbc298e8e9c8a4f1c9f2fc74cf20cefce
    536 N71d284caf2e844978b6670acccfc76bf schema:name ICGC MMML-Seq Project
    537 Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Duisburg-Essen, Medical School, Essen, Germany
    538 rdf:type schema:Organization
    539 N71f9f4bed9194235b207d8da22b0dc02 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    540 schema:familyName Kleinheinz
    541 schema:givenName Kortine
    542 rdf:type schema:Person
    543 N735738691a3d47179aa9512eb6a0b4c6 schema:affiliation https://www.grid.ac/institutes/grid.7450.6
    544 schema:familyName Trümper
    545 schema:givenName Lorenz
    546 rdf:type schema:Person
    547 N73f3fe9d962643a69010d9e01300675e rdf:first Nd2b5f66e88e648f9a6c0992d4c0162b7
    548 rdf:rest N9a0b588ba553405b9f5ffc82010922da
    549 N743d0f82a5c34f56b4db26fa498fe457 schema:name dimensions_id
    550 schema:value pub.1101264345
    551 rdf:type schema:PropertyValue
    552 N744c1006bd8943e7b4913897de7208af schema:affiliation https://www.grid.ac/institutes/grid.13648.38
    553 schema:familyName Rutkowski
    554 schema:givenName Stefan
    555 rdf:type schema:Person
    556 N74889b24205a4206b3bcc1500c330966 rdf:first sg:person.012641745337.62
    557 rdf:rest N38f3ebe40bc3439fb5717a44f7680bca
    558 N74d1504e3f7844668ff30af8c3d25731 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    559 schema:familyName Schilhabel
    560 schema:givenName Markus
    561 rdf:type schema:Person
    562 N75d02a8ac4d349e98cf509e3ec5b719a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    563 schema:familyName Kuhlen
    564 schema:givenName Michaela
    565 rdf:type schema:Person
    566 N76ae8d350b4e4bf481f288cfae6c11e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    567 schema:name Tumor Suppressor Protein p53
    568 rdf:type schema:DefinedTerm
    569 N76d4c75e08804012afa2777b45fb88fe rdf:first N3752374982c941c9a8e2eca76570e274
    570 rdf:rest Ncef27419d98d4ca9b19f7dd9c5f0441e
    571 N77561ad18a334a3db89f1d100ea78556 rdf:first N1570ba9c0ebc4b40ae33f215ebfe71d8
    572 rdf:rest N172795eace054e1aa875b71218d101c5
    573 N77daf6b92cef4a71bfc8fba4dd2246d9 schema:affiliation https://www.grid.ac/institutes/grid.7450.6
    574 schema:familyName Kube
    575 schema:givenName Dieter
    576 rdf:type schema:Person
    577 N79fdfbb1353e46a688a0bf9890a367ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    578 schema:name Germ-Line Mutation
    579 rdf:type schema:DefinedTerm
    580 N7a895d9688f947f4b9a7ecc8c9b3d6f1 rdf:first Nb411f707f8e14a6dbaa267ada50cc4aa
    581 rdf:rest Nf5f83acf9dc0428a9b48e63c2aaf3d69
    582 N7aedead4b32b4dd188b7205955a65e3c schema:affiliation https://www.grid.ac/institutes/grid.416008.b
    583 schema:familyName Ott
    584 schema:givenName German
    585 rdf:type schema:Person
    586 N7b4a3e1103ff41dfa8d03b45492b9a03 schema:affiliation https://www.grid.ac/institutes/grid.459687.1
    587 schema:familyName Bielack
    588 schema:givenName Stefan
    589 rdf:type schema:Person
    590 N7b84bfe1689d44849b96d337960da552 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    591 schema:familyName Nagel
    592 schema:givenName Inga
    593 rdf:type schema:Person
    594 N7d1bb648683045e0995e4247ecb0f8c5 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
    595 schema:familyName Taylor
    596 schema:givenName Michael
    597 rdf:type schema:Person
    598 N7d40b85b847c4e71968c44dedb093a75 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    599 schema:familyName Eils
    600 schema:givenName Jürgen
    601 rdf:type schema:Person
    602 N7d42d1579db940968fec5d145c4bf2c3 schema:affiliation N55d82c475e614365b70cb529d539d33f
    603 schema:familyName Frickhofen
    604 schema:givenName Norbert
    605 rdf:type schema:Person
    606 N7e29d58dab7c404ea01d954859aa4273 schema:name ICGC MMML-Seq Project
    607 University Hospital Würzburg, Department of Medicine and Poliklinik II, University of Würzburg, Würzburg
    608 rdf:type schema:Organization
    609 N7e40b2dca7ac45199cfe2a15378d0aa9 rdf:first N499318193b7d4d42b15197b1fd310bc3
    610 rdf:rest Nc88aa3108c4d44a98bd7c1b3ecfcbaa0
    611 N8048ea08da88431b986d97a61c69417e rdf:first N10772ea11955483e9e09ff9d1cfac316
    612 rdf:rest N43a993ce8463448f88b706f9af21d175
    613 N8181ec29166a4a3cb4297bd30916c5a9 rdf:first N7b84bfe1689d44849b96d337960da552
    614 rdf:rest Nabcc8f790b374c11b770affba1f71b82
    615 N82b0ac12cca54704beaca150509de55e rdf:first N2774f8d42de0459eb354732607b3985d
    616 rdf:rest Na49e5a57c82c4562b7ae7a2f9f2c2797
    617 N82cd78e5103f4b22b71642e1dd062a94 schema:affiliation N706cd47f22d54170b2fa06a0c5f5d910
    618 schema:familyName Bartholomä
    619 schema:givenName Cynthia
    620 rdf:type schema:Person
    621 N82d6ca862c6a4c91a8cd6a09921ad46a rdf:first N5bf0c347c7a24e889154aeedcf83a431
    622 rdf:rest Nf348d637aaac4c80bf7e9826a6ca56c3
    623 N83e3ff3f83e54aaaaa06a7af568d60d8 rdf:first N581d42db33a4450180459af92384ef64
    624 rdf:rest N69ad036593e74871b6c891d0e0a45c5d
    625 N846dfa248aca46c0b087392da6c42761 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    626 schema:familyName Reifenberger
    627 schema:givenName Guido
    628 rdf:type schema:Person
    629 N869b9aa7873146608c781d7cbbd504b0 rdf:first Ne3c6a7c191bf4162be9c9a2a7b2dddc4
    630 rdf:rest N582eead6d24d4e2ca0920c2015e69ae5
    631 N86b70442521743959edab89f2796c16c rdf:first Nd4ea19b565434eccb1c621728cd138be
    632 rdf:rest Ne8c08b1de6c54f7183fb3647a85abfc5
    633 N86bca0a35e97457da4fad9a5c861e752 rdf:first sg:person.01250404162.21
    634 rdf:rest N67e14ceaa78f4427979851708e11b1bd
    635 N8875efefb9c3455d800b7ac95bbcde9e rdf:first Na12ad2d372dc4d0bb40f3adbae82deae
    636 rdf:rest N24892c702366425e9e49bc128fdc5e0f
    637 N88ecb83b6d964e48b15488499824d18b rdf:first sg:person.01256454306.90
    638 rdf:rest N83e3ff3f83e54aaaaa06a7af568d60d8
    639 N8a182da25d014a61a94f6b4455e6ac6f schema:affiliation https://www.grid.ac/institutes/grid.7708.8
    640 schema:familyName Niemeyer
    641 schema:givenName Charlotte
    642 rdf:type schema:Person
    643 N8b86763656e04a59b9765c7f1e909842 rdf:first Nf7b1131f66e4460eb560e337a2e21bcf
    644 rdf:rest N081e05f427774c12ac44f8c452fa50f3
    645 N8c81879d14064e62ad6924867ef273fa rdf:first N354de258dc6d4772acdded8a6075689c
    646 rdf:rest Nd1184090ffde4d3289d6e8b562e7ff92
    647 N8e3fb681952e4a8c843517a32cb64c43 rdf:first Nc5c76328a6a245ec916a57cc832afb70
    648 rdf:rest Nc2e8c9849a284916988c5ec0b6a5de2a
    649 N8f531dc0e2e04e569024c9feb5c6c359 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    650 schema:familyName Hutter
    651 schema:givenName Barbara
    652 rdf:type schema:Person
    653 N8f5fd25bd29c485c92301b8543d97fe6 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    654 schema:familyName Rosenstiel
    655 schema:givenName Philip
    656 rdf:type schema:Person
    657 N8f6c116ef8804545a8db46d17e0593c0 rdf:first N1e77eefd100c4d0f882c1b89681ab027
    658 rdf:rest Nff1f066b64b64bc78959cbf6b2e07d12
    659 N90f1b9ca860c4e6bbc227f5bd810d6b7 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
    660 schema:familyName von Hoff
    661 schema:givenName Katja
    662 rdf:type schema:Person
    663 N93f2b5dc77474292be78359cd9671cf5 rdf:first Nc0313125e900468093eb02be8f4ab7cb
    664 rdf:rest N1ecd429cc22a4ea08c64c31780418f7b
    665 N94177d054fc9421e8ec4d20293cc8bad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    666 schema:name Cohort Studies
    667 rdf:type schema:DefinedTerm
    668 N943062a2c345498a8aa021d2dd41afda schema:affiliation https://www.grid.ac/institutes/grid.4709.a
    669 schema:familyName Rausch
    670 schema:givenName Tobias
    671 rdf:type schema:Person
    672 N943aaaff7ac64a69b0ec1037a1a3226c rdf:first N3c993c8137ee4ed1a5c800dafb9985ec
    673 rdf:rest Ndcc680cec46f4102bc065ee01c1685cb
    674 N9496624f00f247b8b53a4ba92fc35551 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    675 schema:familyName Schreiber
    676 schema:givenName Stefan
    677 rdf:type schema:Person
    678 N95a9c5857fa440d4a2aa4a792f7aaf4d rdf:first N44482cc9d35d407a8b0784a2fe45241c
    679 rdf:rest Na22dbebbf94d4bdc80277bbc8f189245
    680 N95f1bfc5f7e14cae97aca663ee0733eb rdf:first N62980013977a4ae1af833eda6c3748b6
    681 rdf:rest Nc57b27c4410641408dbb21730675be17
    682 N96fa143b9c5341bb91dc4386f2dc0a5f rdf:first N3f5202e17fe740cfad4d7303f4867f45
    683 rdf:rest Nf15a3be776f245cc8ec515223ad1a1aa
    684 N9713526955854ebb8134c81b8377b6f3 rdf:first N065a77bf83ae49539fba1619a3545cc8
    685 rdf:rest N1759b951d29e49448e89455e8cde8328
    686 N975bf8399d0a4f0e8e47b3b66c85047c rdf:first N9bb836c75d614c358b6ee6d0cb4beb13
    687 rdf:rest Na09d3fadfdc54a1c942bc5cb013f7976
    688 N97dc5773eb914009916ecedabe5ccf19 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    689 schema:familyName Pfister
    690 schema:givenName Stefan M.
    691 rdf:type schema:Person
    692 N9a0b588ba553405b9f5ffc82010922da rdf:first Nc6f8b207de4e46f5a20daec9f5bb970d
    693 rdf:rest N86b70442521743959edab89f2796c16c
    694 N9b55e1860ed842a1a78b006cc82afaa7 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    695 schema:familyName Felsberg
    696 schema:givenName Jörg
    697 rdf:type schema:Person
    698 N9bb836c75d614c358b6ee6d0cb4beb13 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    699 schema:familyName Siebert
    700 schema:givenName Reiner
    701 rdf:type schema:Person
    702 N9c1d89270db1486d936754d75ec941e2 rdf:first sg:person.01074160217.75
    703 rdf:rest N43757306199d40aa9e3e8ed9b7edf9a6
    704 N9c5fb72a0c154cd4a6e5abcb0ed1db1f rdf:first N74d1504e3f7844668ff30af8c3d25731
    705 rdf:rest N2317f469dff54156b1f8599fd9ccba5b
    706 N9f25490a85e443f9bd121680d1c67b66 rdf:first Nf9c96824d09d4d85bc5dec207e07feb0
    707 rdf:rest N70db57727cb74498aa9413b6596b761f
    708 Na07d73324e44482e9a38c5c306368648 rdf:first sg:person.01043665622.93
    709 rdf:rest N1187f20b2d6e482f8b0280cf40f0857d
    710 Na09d3fadfdc54a1c942bc5cb013f7976 rdf:first N61852b97949142269f447989add8d058
    711 rdf:rest Nc4fc8d410b47450384955059f622e8bb
    712 Na0ee9e25155c452a9adeb43d321c8612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    713 schema:name Diploidy
    714 rdf:type schema:DefinedTerm
    715 Na12ad2d372dc4d0bb40f3adbae82deae schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    716 schema:familyName Heinold
    717 schema:givenName Michael
    718 rdf:type schema:Person
    719 Na2091b4c429041ada16b5a357311e21d rdf:first Ne06cd74717424c4c81cf0b57d3863a72
    720 rdf:rest N77561ad18a334a3db89f1d100ea78556
    721 Na22dbebbf94d4bdc80277bbc8f189245 rdf:first N3c4a6cc3bcdb450fa54fbce8c620f2ce
    722 rdf:rest Ne4e42ed7dadb43e493f9833e8a719d08
    723 Na41bfd6bfae4490a882b0f5e0232841b schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    724 schema:familyName Klapper
    725 schema:givenName Wolfram
    726 rdf:type schema:Person
    727 Na49e5a57c82c4562b7ae7a2f9f2c2797 rdf:first Ne7ad130bc19e46ebad1dc1291f581a7d
    728 rdf:rest N8c81879d14064e62ad6924867ef273fa
    729 Na6d54e27c94b44cab67040a60bed3caf rdf:first sg:person.0650317071.46
    730 rdf:rest N8e3fb681952e4a8c843517a32cb64c43
    731 Na82701d82b744933933cb173ee98425a schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    732 schema:familyName Hoell
    733 schema:givenName Jessica I.
    734 rdf:type schema:Person
    735 Na8a6821aeacb43299b923d466e10573a rdf:first N65832b4368204f87a12c35d955b7041b
    736 rdf:rest N48589e05161a465e986524dfd92caaea
    737 Na8a93177d4f74d9d999183e95a7e0923 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    738 schema:name Adult
    739 rdf:type schema:DefinedTerm
    740 Nab95c9fcf4b940b49cd00b24093d76de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    741 schema:name Genome, Human
    742 rdf:type schema:DefinedTerm
    743 Nabcc8f790b374c11b770affba1f71b82 rdf:first sg:person.015460151766.06
    744 rdf:rest N40f0b869d8f042a9b3fd43e9d71f9143
    745 Nac7a8d690bd34013a0ca2290f489955e schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    746 schema:familyName Bender
    747 schema:givenName Sebastian
    748 rdf:type schema:Person
    749 Nad17afcbaad74bfa9e5f20c9464748c0 schema:affiliation https://www.grid.ac/institutes/grid.487647.e
    750 schema:familyName Molenaar
    751 schema:givenName Jan J.
    752 rdf:type schema:Person
    753 Nad29694477324b2eb927c4be835125ff schema:name Department of Internal Medicine II: Hematology and Oncology, University Medical Centre, Campus Kiel, Kiel, Germany
    754 ICGC MMML-Seq Project
    755 rdf:type schema:Organization
    756 Nadc027a183d4494197ef2ee1101baebb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    757 schema:name Genetic Predisposition to Disease
    758 rdf:type schema:DefinedTerm
    759 Nae948456381047de80df86e5338a6b6c schema:affiliation https://www.grid.ac/institutes/grid.419538.2
    760 schema:familyName Warnatz
    761 schema:givenName Hans-Jörg
    762 rdf:type schema:Person
    763 Naf2d901702ec46f58ce0d0f4ace1ece9 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    764 schema:familyName López
    765 schema:givenName Cristina
    766 rdf:type schema:Person
    767 Nb19330e758cd444e9d816d0098b659d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    768 schema:name Neoplasms
    769 rdf:type schema:DefinedTerm
    770 Nb2434a2a7ca443678c192b8f5e71c348 rdf:first Ne50c9e91e3d44861a310414e7d52f4ed
    771 rdf:rest N5b66999607f14f1b92a4c1e97a2763b6
    772 Nb2a32f10f1494662811935089134164e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    773 schema:name Mutation Rate
    774 rdf:type schema:DefinedTerm
    775 Nb3d546ec4193408fbdd2437c346fa060 rdf:first sg:person.01306511165.45
    776 rdf:rest N35fa61c1ae45476b93929c396c0e4dd3
    777 Nb3e4f4af886e4b6a8ced110ef02f0d34 schema:name doi
    778 schema:value 10.1038/nature25480
    779 rdf:type schema:PropertyValue
    780 Nb411f707f8e14a6dbaa267ada50cc4aa schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    781 schema:familyName Kool
    782 schema:givenName Marcel
    783 rdf:type schema:Person
    784 Nb495ee7b07a3413795ab8a4d0799686f schema:affiliation https://www.grid.ac/institutes/grid.459687.1
    785 schema:familyName Koscielniak
    786 schema:givenName Ewa
    787 rdf:type schema:Person
    788 Nb4a94c30c0534fe988a25b36a747f33a schema:name readcube_id
    789 schema:value ae636187540c4acf147e78912ff09ac1f175e4fa3cbd6412ef2fbe855dd99cb6
    790 rdf:type schema:PropertyValue
    791 Nb50ea85fcb1946a6b03568daf5a56bbc schema:affiliation N7e29d58dab7c404ea01d954859aa4273
    792 schema:familyName Einsele
    793 schema:givenName Hermann
    794 rdf:type schema:Person
    795 Nb62fdd6f676545649d8d122e49bc656a rdf:first Nf1949901d1534479a57d894c1a08965b
    796 rdf:rest N869b9aa7873146608c781d7cbbd504b0
    797 Nb6fe4def6929491d9f56876bdd873d24 schema:affiliation https://www.grid.ac/institutes/grid.411067.5
    798 schema:familyName Burkhardt
    799 schema:givenName Birgit
    800 rdf:type schema:Person
    801 Nb7f85f5a201d4fdcbb0e3b07fed9611a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    802 schema:familyName Lawerenz
    803 schema:givenName Chris
    804 rdf:type schema:Person
    805 Nb857b1802c3444a8b9deb2c6dadb6d09 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    806 schema:familyName Eils
    807 schema:givenName Roland
    808 rdf:type schema:Person
    809 Nb8a51893ae1e4c5fbf93e672ac166c6c schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    810 schema:familyName Weber
    811 schema:givenName Ursula
    812 rdf:type schema:Person
    813 Nb90f266678ba46faa02af7de171fc872 rdf:first N4b9fe81cc1014e44a929112a6e4d517c
    814 rdf:rest N12636f1865784c2ea12af8109f90305e
    815 Nba45180799934af8994587f3ea290056 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    816 schema:familyName Buchhalter
    817 schema:givenName Ivo
    818 rdf:type schema:Person
    819 Nbb4cb1a900b54a9498444832d34847af rdf:first Nd20c5a9426eb4a3db9ca6dc683d46bc6
    820 rdf:rest N4681753345d74de4bf124ddb4a7a3793
    821 Nbc298e8e9c8a4f1c9f2fc74cf20cefce rdf:first N129ac3c7fb0745a397bb140413aed249
    822 rdf:rest Nd10eca7aef8e4c528f65e7da2796c7cb
    823 Nbd68b6af07904bcbba362ed4551414dd rdf:first N31849b264e124730ab179714ae92ac0f
    824 rdf:rest Nfa93fb42d3b5459aa617d481d07c13ea
    825 Nbdf6197244c7498c8d243beaaca1e507 rdf:first sg:person.01254025021.16
    826 rdf:rest Nb62fdd6f676545649d8d122e49bc656a
    827 Nbe071083b3654288afaa45b686b952d0 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    828 schema:familyName Szczepanowski
    829 schema:givenName Monika
    830 rdf:type schema:Person
    831 Nbe51d438e4ac42139a096f4990d74f7d rdf:first sg:person.01254175041.58
    832 rdf:rest N0a3b3a08d03841108de5b7b57e022899
    833 Nbebc7c8a9a204ac18f8453e958e89989 rdf:first Na82701d82b744933933cb173ee98425a
    834 rdf:rest N6447d9b896d04afe92da91e02e8cd115
    835 Nbec8546ad5994159ad6408a285035df6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    836 schema:name DNA Copy Number Variations
    837 rdf:type schema:DefinedTerm
    838 Nbedee74d2d2647ebae4fbd686d680fce rdf:first N54cb1bd798cc4be79f53fa0851d917e3
    839 rdf:rest N8f6c116ef8804545a8db46d17e0593c0
    840 Nbf74ffc3edb74c4db0f83a85926cc452 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    841 schema:familyName Jaeger-Schmidt
    842 schema:givenName Christina
    843 rdf:type schema:Person
    844 Nc0313125e900468093eb02be8f4ab7cb schema:affiliation https://www.grid.ac/institutes/grid.6363.0
    845 schema:familyName Hummel
    846 schema:givenName Michael
    847 rdf:type schema:Person
    848 Nc163b8da14eb4081b289357505058cf8 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    849 schema:familyName Hansmann
    850 schema:givenName Martin-Leo
    851 rdf:type schema:Person
    852 Nc24f3a56499d4adcb812eb7777ee91be schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    853 schema:familyName Bergmann
    854 schema:givenName Anke K.
    855 rdf:type schema:Person
    856 Nc2e8c9849a284916988c5ec0b6a5de2a rdf:first Nd4b1cd985f884301b8ceeddc1141d239
    857 rdf:rest Nb90f266678ba46faa02af7de171fc872
    858 Nc3afcf7c6ff84183a7466126ac20a8b7 rdf:first N0b94993403ca4272b779b3a08d79341c
    859 rdf:rest N93f2b5dc77474292be78359cd9671cf5
    860 Nc49729b4be3e4aeb9996a71dc8bd058d schema:affiliation https://www.grid.ac/institutes/grid.9647.c
    861 schema:familyName Binder
    862 schema:givenName Hans
    863 rdf:type schema:Person
    864 Nc4fc8d410b47450384955059f622e8bb rdf:first Nad17afcbaad74bfa9e5f20c9464748c0
    865 rdf:rest N66ebcefb996f492ea702380a126384a3
    866 Nc503cff29cdb46c1b61f2d4a023d7c33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    867 schema:name Young Adult
    868 rdf:type schema:DefinedTerm
    869 Nc57b27c4410641408dbb21730675be17 rdf:first N5aa89ec07cdb40b19f797eea270c313c
    870 rdf:rest N975bf8399d0a4f0e8e47b3b66c85047c
    871 Nc5c76328a6a245ec916a57cc832afb70 schema:affiliation https://www.grid.ac/institutes/grid.9647.c
    872 schema:familyName Hoffmann
    873 schema:givenName Steve
    874 rdf:type schema:Person
    875 Nc6f8b207de4e46f5a20daec9f5bb970d schema:affiliation https://www.grid.ac/institutes/grid.459927.4
    876 schema:familyName Staib
    877 schema:givenName Peter
    878 rdf:type schema:Person
    879 Nc88aa3108c4d44a98bd7c1b3ecfcbaa0 rdf:first N70378a6d2dc347aab03c0a0f5a57e18d
    880 rdf:rest N5bc588bc1bdc42449307108d666869ed
    881 Nca295c690a8848ca828cc3455509e525 rdf:first N0be5c5b879e74e468d3b3a4c1bbbdc38
    882 rdf:rest N3cc01abb35b94934b446a247aeb0c1de
    883 Nca7a0d9e2cfa4ac798634c854deec55d rdf:first Nf3f1e7fbdbd34f14a6281b44d02d5162
    884 rdf:rest Nbebc7c8a9a204ac18f8453e958e89989
    885 Ncafe697f179847bba371ed8afc7a5713 schema:affiliation https://www.grid.ac/institutes/grid.459687.1
    886 schema:familyName Blattmann
    887 schema:givenName Claudia
    888 rdf:type schema:Person
    889 Ncb55e7493bd147c79b190c40a7cd2387 rdf:first sg:person.0667127770.76
    890 rdf:rest Nbd68b6af07904bcbba362ed4551414dd
    891 Ncdc58b1d18d74c22a7283ee2f7f911d6 rdf:first sg:person.0635065571.25
    892 rdf:rest Nca7a0d9e2cfa4ac798634c854deec55d
    893 Ncef27419d98d4ca9b19f7dd9c5f0441e rdf:first Ne6879c06b818400db976216f05141871
    894 rdf:rest N610bda4f961c4f5381418418edaf03f0
    895 Ncfe300d1503245b4bbd7888833c82bc3 rdf:first sg:person.01350775415.50
    896 rdf:rest N0d468d68cf4e4b5883eed4d09e118b51
    897 Nd01a000a23d44950a2ad21dc1dfc01d8 rdf:first Nfe719ef6daf9485ba4f3a337e316132a
    898 rdf:rest N96fa143b9c5341bb91dc4386f2dc0a5f
    899 Nd021f89690884bb5a41f7f3b4053c2c2 rdf:first sg:person.013413514417.54
    900 rdf:rest N464365017cad48f2a5863e964e27fa3b
    901 Nd053ce2e4b584611849eb8ba75eb4b45 schema:name Department of Internal Medicine/Hematology, Friedrich-Ebert-Hospital, Neumünster, Germany
    902 ICGC MMML-Seq Project
    903 rdf:type schema:Organization
    904 Nd10eca7aef8e4c528f65e7da2796c7cb rdf:first sg:person.01042507125.08
    905 rdf:rest Neab20c350d154923a2f18c7e44d0b097
    906 Nd1184090ffde4d3289d6e8b562e7ff92