HER kinase inhibition in patients with HER2- and HER3-mutant cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-31

AUTHORS

David M. Hyman, Sarina A. Piha-Paul, Helen Won, Jordi Rodon, Cristina Saura, Geoffrey I. Shapiro, Dejan Juric, David I. Quinn, Victor Moreno, Bernard Doger, Ingrid A. Mayer, Valentina Boni, Emiliano Calvo, Sherene Loi, Albert C. Lockhart, Joseph P. Erinjeri, Maurizio Scaltriti, Gary A. Ulaner, Juber Patel, Jiabin Tang, Hannah Beer, S. Duygu Selcuklu, Aphrothiti J. Hanrahan, Nancy Bouvier, Myra Melcer, Rajmohan Murali, Alison M. Schram, Lillian M. Smyth, Komal Jhaveri, Bob T. Li, Alexander Drilon, James J. Harding, Gopa Iyer, Barry S. Taylor, Michael F. Berger, Richard E. Cutler Jr, Feng Xu, Anna Butturini, Lisa D. Eli, Grace Mann, Cynthia Farrell, Alshad S. Lalani, Richard P. Bryce, Carlos L. Arteaga, Funda Meric-Bernstam, José Baselga, David B. Solit

ABSTRACT

Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here we define the biological and therapeutic importance of known oncogenic HER2 and HER3 mutations and variants of unknown biological importance by conducting a multi-histology, genomically selected, ‘basket’ trial using the pan-HER kinase inhibitor neratinib (SUMMIT; clinicaltrials.gov identifier NCT01953926). Efficacy in HER2-mutant cancers varied as a function of both tumour type and mutant allele to a degree not predicted by preclinical models, with the greatest activity seen in breast, cervical and biliary cancers and with tumours that contain kinase domain missense mutations. This study demonstrates how a molecularly driven clinical trial can be used to refine our biological understanding of both characterized and new genomic alterations with potential broad applicability for advancing the paradigm of genome-driven oncology. More... »

PAGES

189-194

Journal

TITLE

Nature

ISSUE

7691

VOLUME

554

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature25475

DOI

http://dx.doi.org/10.1038/nature25475

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100711838

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29420467


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Targeted Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation, Missense", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyman", 
        "givenName": "David M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Texas, MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "University of Texas, MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piha-Paul", 
        "givenName": "Sarina A.", 
        "id": "sg:person.01211050414.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211050414.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Won", 
        "givenName": "Helen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Oncology (VHIO), Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Oncology (VHIO), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodon", 
        "givenName": "Jordi", 
        "id": "sg:person.0640557257.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640557257.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Oncology (VHIO), Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Vall d\u2019Hebron University Hospital, Vall d\u2019Hebron Institute of Oncology (VHIO), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saura", 
        "givenName": "Cristina", 
        "id": "sg:person.0706672457.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706672457.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana-Faber Cancer Institute, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Dana-Faber Cancer Institute, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shapiro", 
        "givenName": "Geoffrey I.", 
        "id": "sg:person.0752005421.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752005421.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Hospital Cancer Center, BostonMassachusetts, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Massachusetts Hospital Cancer Center, BostonMassachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juric", 
        "givenName": "Dejan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "USC Norris Comprehensive Cancer Center, Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "USC Norris Comprehensive Cancer Center, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quinn", 
        "givenName": "David I.", 
        "id": "sg:person.01013134010.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013134010.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "START Madrid Fundaci\u00f3n J\u00edmenez D\u00edaz, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.419651.e", 
          "name": [
            "START Madrid Fundaci\u00f3n J\u00edmenez D\u00edaz, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "Victor", 
        "id": "sg:person.012262475710.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012262475710.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "START Madrid Fundaci\u00f3n J\u00edmenez D\u00edaz, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.419651.e", 
          "name": [
            "START Madrid Fundaci\u00f3n J\u00edmenez D\u00edaz, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Doger", 
        "givenName": "Bernard", 
        "id": "sg:person.011464242503.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464242503.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Ingrid A.", 
        "id": "sg:person.0743735512.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743735512.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "START Madrid, Centro Integral Oncol\u00f3gico Clara Campal (CIOCC), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428486.4", 
          "name": [
            "START Madrid, Centro Integral Oncol\u00f3gico Clara Campal (CIOCC), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boni", 
        "givenName": "Valentina", 
        "id": "sg:person.010026123150.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026123150.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "START Madrid, Centro Integral Oncol\u00f3gico Clara Campal (CIOCC), Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.428486.4", 
          "name": [
            "START Madrid, Centro Integral Oncol\u00f3gico Clara Campal (CIOCC), Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calvo", 
        "givenName": "Emiliano", 
        "id": "sg:person.01213300245.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213300245.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.1055.1", 
          "name": [
            "Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loi", 
        "givenName": "Sherene", 
        "id": "sg:person.0752311160.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752311160.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis School of Medicine, St Louis, Missouri, USA", 
          "id": "http://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Washington University in St. Louis School of Medicine, St Louis, Missouri, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lockhart", 
        "givenName": "Albert C.", 
        "id": "sg:person.01016673026.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016673026.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erinjeri", 
        "givenName": "Joseph P.", 
        "id": "sg:person.01365111477.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365111477.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scaltriti", 
        "givenName": "Maurizio", 
        "id": "sg:person.0773414311.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773414311.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ulaner", 
        "givenName": "Gary A.", 
        "id": "sg:person.0703053217.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703053217.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Juber", 
        "id": "sg:person.010720757537.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010720757537.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Jiabin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beer", 
        "givenName": "Hannah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Selcuklu", 
        "givenName": "S. Duygu", 
        "id": "sg:person.01157120373.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157120373.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanrahan", 
        "givenName": "Aphrothiti J.", 
        "id": "sg:person.0646633077.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646633077.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouvier", 
        "givenName": "Nancy", 
        "id": "sg:person.01040455641.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040455641.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melcer", 
        "givenName": "Myra", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murali", 
        "givenName": "Rajmohan", 
        "id": "sg:person.01333577301.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333577301.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schram", 
        "givenName": "Alison M.", 
        "id": "sg:person.016663733117.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016663733117.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smyth", 
        "givenName": "Lillian M.", 
        "id": "sg:person.012202131030.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202131030.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jhaveri", 
        "givenName": "Komal", 
        "id": "sg:person.01115006020.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115006020.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Bob T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drilon", 
        "givenName": "Alexander", 
        "id": "sg:person.01355654660.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355654660.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harding", 
        "givenName": "James J.", 
        "id": "sg:person.01154466504.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154466504.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iyer", 
        "givenName": "Gopa", 
        "id": "sg:person.014635271363.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014635271363.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Barry S.", 
        "id": "sg:person.01333376013.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333376013.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Michael F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cutler Jr", 
        "givenName": "Richard E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Feng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Butturini", 
        "givenName": "Anna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eli", 
        "givenName": "Lisa D.", 
        "id": "sg:person.010532626075.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010532626075.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "Grace", 
        "id": "sg:person.013310634466.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013310634466.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farrell", 
        "givenName": "Cynthia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalani", 
        "givenName": "Alshad S.", 
        "id": "sg:person.0773476167.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773476167.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Puma Biotechnology Inc., Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.476660.5", 
          "name": [
            "Puma Biotechnology Inc., Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bryce", 
        "givenName": "Richard P.", 
        "id": "sg:person.015635546561.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635546561.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arteaga", 
        "givenName": "Carlos L.", 
        "id": "sg:person.013436233237.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436233237.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Texas, MD Anderson Cancer Center, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "University of Texas, MD Anderson Cancer Center, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meric-Bernstam", 
        "givenName": "Funda", 
        "id": "sg:person.01065126442.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065126442.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baselga", 
        "givenName": "Jos\u00e9", 
        "id": "sg:person.01063677263.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063677263.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Memorial Sloan Kettering Cancer Center, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solit", 
        "givenName": "David B.", 
        "id": "sg:person.0656335277.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656335277.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.3466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003945434", 
          "https://doi.org/10.1038/ng.3466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.3391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004475958", 
          "https://doi.org/10.1038/nbt.3391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.4333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085214027", 
          "https://doi.org/10.1038/nm.4333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010515132", 
          "https://doi.org/10.1038/nbt.2203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050004918", 
          "https://doi.org/10.1038/nature12477"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01-31", 
    "datePublishedReg": "2018-01-31", 
    "description": "Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here we define the biological and therapeutic importance of known oncogenic HER2 and HER3 mutations and variants of unknown biological importance by conducting a multi-histology, genomically selected, \u2018basket\u2019 trial using the pan-HER kinase inhibitor neratinib (SUMMIT; clinicaltrials.gov identifier NCT01953926). Efficacy in HER2-mutant cancers varied as a function of both tumour type and mutant allele to a degree not predicted by preclinical models, with the greatest activity seen in breast, cervical and biliary cancers and with tumours that contain kinase domain missense mutations. This study demonstrates how a molecularly driven clinical trial can be used to refine our biological understanding of both characterized and new genomic alterations with potential broad applicability for advancing the paradigm of genome-driven oncology.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nature25475", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2474061", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440194", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2689300", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705229", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438805", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682501", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6617297", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2622404", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7691", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "554"
      }
    ], 
    "keywords": [
      "constitutive HER2 activation", 
      "HER2-mutant cancers", 
      "domain missense mutations", 
      "new genomic alterations", 
      "biliary cancer", 
      "clinical trials", 
      "preclinical models", 
      "tumor types", 
      "inhibitor neratinib", 
      "HER3 mutations", 
      "HER2 activation", 
      "cancer", 
      "preclinical modelling", 
      "oncogenic HER2", 
      "therapeutic importance", 
      "genomic alterations", 
      "kinase inhibition", 
      "somatic mutations", 
      "HER2", 
      "missense mutations", 
      "trials", 
      "potential broad applicability", 
      "greater activity", 
      "mutations", 
      "patients", 
      "neratinib", 
      "tumors", 
      "breast", 
      "oncology", 
      "efficacy", 
      "ErbB2", 
      "mutant alleles", 
      "biological understanding", 
      "ErbB3", 
      "inhibition", 
      "alterations", 
      "activation", 
      "subset", 
      "alleles", 
      "activity", 
      "variants", 
      "study", 
      "biological importance", 
      "importance", 
      "function", 
      "types", 
      "degree", 
      "basket", 
      "understanding", 
      "wide range", 
      "paradigm", 
      "broad applicability", 
      "model", 
      "range", 
      "pan", 
      "applicability", 
      "modelling"
    ], 
    "name": "HER kinase inhibition in patients with HER2- and HER3-mutant cancers", 
    "pagination": "189-194", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100711838"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature25475"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29420467"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature25475", 
      "https://app.dimensions.ai/details/publication/pub.1100711838"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_787.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nature25475"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature25475'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature25475'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature25475'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature25475'


 

This table displays all metadata directly associated to this object as RDF triples.

577 TRIPLES      21 PREDICATES      106 URIs      93 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature25475 schema:about N09b253140b434a639d76887ad844dc95
2 N1504c7cdb83546e2a9432fad59169e0f
3 N16e6ffdb3bd64549bceec920ce14972d
4 N2b35bb78808a4b5db16f04fb72c4304a
5 N3a1d41cb3f944c95b5aa51a8362e46c4
6 N4f9f9d2e6bb54e1e9c2af17e92250bcd
7 N53560812a98e499fa9dc309c9db2ebc7
8 N59084c2ddc9a436fb1734088b9a000ee
9 N6176ebea2ba949209db1dbf4e8541007
10 N78fb5e4bcccc4623b35e3fca94878712
11 N9c54df88cbc64d36ba65e809391345dc
12 Na0b7390a74aa405287f19e052b654d81
13 Na75551262e724f7c99477334803d4607
14 Nbb75e8ed3696432585db0bdabc912616
15 Nc14ae1feb2e144f68ac859cd5682eec2
16 Nd6ba4688150945e08795e39458938f44
17 Ndcbc9277350641629197af920b4679e5
18 Nf86f756f5dbf4147bb34deb3a2b13c03
19 Nff2b0f127ade42b68e817e18143be570
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N96039b99ffbf4d05ac5029021a48ccc9
23 schema:citation sg:pub.10.1038/nature12477
24 sg:pub.10.1038/nbt.2203
25 sg:pub.10.1038/nbt.3391
26 sg:pub.10.1038/ng.3466
27 sg:pub.10.1038/nm.4333
28 schema:datePublished 2018-01-31
29 schema:datePublishedReg 2018-01-31
30 schema:description Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically uncharacterized. Here we define the biological and therapeutic importance of known oncogenic HER2 and HER3 mutations and variants of unknown biological importance by conducting a multi-histology, genomically selected, ‘basket’ trial using the pan-HER kinase inhibitor neratinib (SUMMIT; clinicaltrials.gov identifier NCT01953926). Efficacy in HER2-mutant cancers varied as a function of both tumour type and mutant allele to a degree not predicted by preclinical models, with the greatest activity seen in breast, cervical and biliary cancers and with tumours that contain kinase domain missense mutations. This study demonstrates how a molecularly driven clinical trial can be used to refine our biological understanding of both characterized and new genomic alterations with potential broad applicability for advancing the paradigm of genome-driven oncology.
31 schema:genre article
32 schema:isAccessibleForFree true
33 schema:isPartOf N8cae7582fde34484920fa71b533eb151
34 Nd461bafe0ae145518118dc3468c119b0
35 sg:journal.1018957
36 schema:keywords ErbB2
37 ErbB3
38 HER2
39 HER2 activation
40 HER2-mutant cancers
41 HER3 mutations
42 activation
43 activity
44 alleles
45 alterations
46 applicability
47 basket
48 biliary cancer
49 biological importance
50 biological understanding
51 breast
52 broad applicability
53 cancer
54 clinical trials
55 constitutive HER2 activation
56 degree
57 domain missense mutations
58 efficacy
59 function
60 genomic alterations
61 greater activity
62 importance
63 inhibition
64 inhibitor neratinib
65 kinase inhibition
66 missense mutations
67 model
68 modelling
69 mutant alleles
70 mutations
71 neratinib
72 new genomic alterations
73 oncogenic HER2
74 oncology
75 pan
76 paradigm
77 patients
78 potential broad applicability
79 preclinical modelling
80 preclinical models
81 range
82 somatic mutations
83 study
84 subset
85 therapeutic importance
86 trials
87 tumor types
88 tumors
89 types
90 understanding
91 variants
92 wide range
93 schema:name HER kinase inhibition in patients with HER2- and HER3-mutant cancers
94 schema:pagination 189-194
95 schema:productId N1f8c38027ee7472ba1aea69fd7b4a487
96 Na50557d2b0954cb8a1ec05f922406313
97 Ne5b30fc9bc254771960ce60f625249a9
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100711838
99 https://doi.org/10.1038/nature25475
100 schema:sdDatePublished 2022-09-02T16:02
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N973485e788484e88983393db2b1f9687
103 schema:url https://doi.org/10.1038/nature25475
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N0290dd20664443a2b8ad1b621bdcdd21 rdf:first sg:person.01365111477.00
108 rdf:rest N6854461ef2d44b92a09eaff7e8059859
109 N05a377d13c954348b2eb7557608b1df9 rdf:first sg:person.0703053217.10
110 rdf:rest Nbe53aee68a3c4ac7a55e51648645a7f4
111 N09b253140b434a639d76887ad844dc95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N0a05e91e2df1455a96c36d6de84f98db rdf:first sg:person.01013134010.15
115 rdf:rest Nf3781654f73d485591c98db9a5935563
116 N12ee8d16370d426eb42e0c7f25287899 rdf:first N6ab9163282b44caba75bb50b5d563ab4
117 rdf:rest N8b559a80695d49e2bf37bd6b8d0d1027
118 N1504c7cdb83546e2a9432fad59169e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antineoplastic Agents
120 rdf:type schema:DefinedTerm
121 N15945ad287fc499ebbbd47b562e8fcdc rdf:first sg:person.0706672457.25
122 rdf:rest Nae583d83b40746f1b2ab226e0f85e605
123 N16e6ffdb3bd64549bceec920ce14972d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Adult
125 rdf:type schema:DefinedTerm
126 N1bf0c5a7f1db4475a2fb8fda2bf77c02 rdf:first sg:person.014635271363.05
127 rdf:rest Ncc3f6746f0414215942963264d2d84a2
128 N1f8c38027ee7472ba1aea69fd7b4a487 schema:name doi
129 schema:value 10.1038/nature25475
130 rdf:type schema:PropertyValue
131 N2213065840954f1db8e0ae1fbfe57fbb rdf:first Nabda24ee2d4f48a8be39072249db4573
132 rdf:rest Naf8cf52209d547168ff4a1bd6e7de285
133 N250aa7aae56644679325c1404ddd99ed rdf:first Neebe83c126774e4493ccad8ed7f60125
134 rdf:rest N5a40e17fe1e64497be0e7d3b47b26e20
135 N2b35bb78808a4b5db16f04fb72c4304a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mutation, Missense
137 rdf:type schema:DefinedTerm
138 N33a2d28a59e2498ebb9ba3246281357b schema:affiliation grid-institutes:grid.51462.34
139 schema:familyName Beer
140 schema:givenName Hannah
141 rdf:type schema:Person
142 N3a1d41cb3f944c95b5aa51a8362e46c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 N3d001c86dedc4ae9b3c0b5dad21a8aa2 rdf:first Nd56ffdb847474abeb974582fb503726b
146 rdf:rest Necc1270ac71d4478a748aa7b533c2612
147 N44a9637d5aae43ad83247abe0ee7789b rdf:first sg:person.01213300245.49
148 rdf:rest Nca5a056a66024756aa68f712d7c86863
149 N44d2821fcc10482497003584aa94c6cf schema:affiliation grid-institutes:grid.51462.34
150 schema:familyName Won
151 schema:givenName Helen
152 rdf:type schema:Person
153 N45579df62a21499e9ba2ebdf6e5f992b rdf:first sg:person.01115006020.77
154 rdf:rest N55581c7f8be64a47bb35429edc7bacb9
155 N47d190d74e654fe4ad4622eb75f3f836 schema:affiliation grid-institutes:grid.51462.34
156 schema:familyName Tang
157 schema:givenName Jiabin
158 rdf:type schema:Person
159 N4f390409a1b445108369068963977cda rdf:first N33a2d28a59e2498ebb9ba3246281357b
160 rdf:rest N6bbb01a085954241803fb2099c1bc14f
161 N4f9f9d2e6bb54e1e9c2af17e92250bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cohort Studies
163 rdf:type schema:DefinedTerm
164 N53560812a98e499fa9dc309c9db2ebc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Middle Aged
166 rdf:type schema:DefinedTerm
167 N55581c7f8be64a47bb35429edc7bacb9 rdf:first N74c9c5f0acc44844a217dda85d391a32
168 rdf:rest Nf19e47e0651b403489f2262b41d08ca2
169 N58e34914bae54e408e491da88729d42f rdf:first sg:person.0640557257.82
170 rdf:rest N15945ad287fc499ebbbd47b562e8fcdc
171 N59084c2ddc9a436fb1734088b9a000ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Female
173 rdf:type schema:DefinedTerm
174 N5a40e17fe1e64497be0e7d3b47b26e20 rdf:first sg:person.01333577301.55
175 rdf:rest N79b5f3615c9142eb99153f3275878633
176 N5b331e81a2a44b62915fd66240f3fda9 rdf:first sg:person.013310634466.64
177 rdf:rest N12ee8d16370d426eb42e0c7f25287899
178 N5e833d97cd3a43619b41de79e778ab44 schema:affiliation grid-institutes:grid.476660.5
179 schema:familyName Xu
180 schema:givenName Feng
181 rdf:type schema:Person
182 N6176ebea2ba949209db1dbf4e8541007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mutation
184 rdf:type schema:DefinedTerm
185 N6854461ef2d44b92a09eaff7e8059859 rdf:first sg:person.0773414311.69
186 rdf:rest N05a377d13c954348b2eb7557608b1df9
187 N6ab9163282b44caba75bb50b5d563ab4 schema:affiliation grid-institutes:grid.476660.5
188 schema:familyName Farrell
189 schema:givenName Cynthia
190 rdf:type schema:Person
191 N6bbb01a085954241803fb2099c1bc14f rdf:first sg:person.01157120373.08
192 rdf:rest Ncd047adc22dd41cb873898d136992f3c
193 N728d35eb617a4c0f82fc24a8d87cc3a5 rdf:first sg:person.01040455641.38
194 rdf:rest N250aa7aae56644679325c1404ddd99ed
195 N737de150dd7a47808075418c5f8c771f rdf:first N44d2821fcc10482497003584aa94c6cf
196 rdf:rest N58e34914bae54e408e491da88729d42f
197 N74c9c5f0acc44844a217dda85d391a32 schema:affiliation grid-institutes:grid.51462.34
198 schema:familyName Li
199 schema:givenName Bob T.
200 rdf:type schema:Person
201 N78fb5e4bcccc4623b35e3fca94878712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Receptor, ErbB-3
203 rdf:type schema:DefinedTerm
204 N79b5f3615c9142eb99153f3275878633 rdf:first sg:person.016663733117.00
205 rdf:rest Nacac81ea1220447b8b01652ac2b6f08f
206 N7a64aa34ff7445bf9fe2c9c4437c72e1 schema:affiliation grid-institutes:None
207 schema:familyName Juric
208 schema:givenName Dejan
209 rdf:type schema:Person
210 N8345b17efa754678831e0264bb061dbb rdf:first sg:person.015635546561.24
211 rdf:rest Nf53d0649fb1a4c228303536c2f40b594
212 N844e998951c54eabaa67e1d5600e8eb5 schema:affiliation grid-institutes:grid.51462.34
213 schema:familyName Hyman
214 schema:givenName David M.
215 rdf:type schema:Person
216 N8588503a97964c6d86004eb064e30cec rdf:first N47d190d74e654fe4ad4622eb75f3f836
217 rdf:rest N4f390409a1b445108369068963977cda
218 N89e22bef9406438996e3973b875e79b3 rdf:first N7a64aa34ff7445bf9fe2c9c4437c72e1
219 rdf:rest N0a05e91e2df1455a96c36d6de84f98db
220 N8b559a80695d49e2bf37bd6b8d0d1027 rdf:first sg:person.0773476167.89
221 rdf:rest N8345b17efa754678831e0264bb061dbb
222 N8cae7582fde34484920fa71b533eb151 schema:volumeNumber 554
223 rdf:type schema:PublicationVolume
224 N8f3113ccdbdd4411a358b23d249218d1 rdf:first sg:person.01016673026.04
225 rdf:rest N0290dd20664443a2b8ad1b621bdcdd21
226 N96039b99ffbf4d05ac5029021a48ccc9 rdf:first N844e998951c54eabaa67e1d5600e8eb5
227 rdf:rest N969b14010e324ad99b9411c0eccca252
228 N969b14010e324ad99b9411c0eccca252 rdf:first sg:person.01211050414.50
229 rdf:rest N737de150dd7a47808075418c5f8c771f
230 N973485e788484e88983393db2b1f9687 schema:name Springer Nature - SN SciGraph project
231 rdf:type schema:Organization
232 N975af23da89f42f99596815a00bdba45 rdf:first sg:person.0656335277.50
233 rdf:rest rdf:nil
234 N9c54df88cbc64d36ba65e809391345dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
235 schema:name Treatment Outcome
236 rdf:type schema:DefinedTerm
237 Na0b7390a74aa405287f19e052b654d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Receptor, ErbB-2
239 rdf:type schema:DefinedTerm
240 Na50557d2b0954cb8a1ec05f922406313 schema:name dimensions_id
241 schema:value pub.1100711838
242 rdf:type schema:PropertyValue
243 Na75551262e724f7c99477334803d4607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name Aged, 80 and over
245 rdf:type schema:DefinedTerm
246 Nabda24ee2d4f48a8be39072249db4573 schema:affiliation grid-institutes:grid.51462.34
247 schema:familyName Berger
248 schema:givenName Michael F.
249 rdf:type schema:Person
250 Nac4afb5e18354bfcb6f0bb53d2af8ccd rdf:first sg:person.010026123150.72
251 rdf:rest N44a9637d5aae43ad83247abe0ee7789b
252 Nacac81ea1220447b8b01652ac2b6f08f rdf:first sg:person.012202131030.61
253 rdf:rest N45579df62a21499e9ba2ebdf6e5f992b
254 Nacb905ec046f450f9d58913838ceeca4 rdf:first sg:person.01065126442.79
255 rdf:rest Ne23d7d36ed8e40f39b5e1209a996884a
256 Nae583d83b40746f1b2ab226e0f85e605 rdf:first sg:person.0752005421.01
257 rdf:rest N89e22bef9406438996e3973b875e79b3
258 Naf8cf52209d547168ff4a1bd6e7de285 rdf:first Nb5c6cbf2cb1a4d49bed7f51e4d84212d
259 rdf:rest Nc446ea1d00f74b32bcf25560b10ddd46
260 Nb5c6cbf2cb1a4d49bed7f51e4d84212d schema:affiliation grid-institutes:grid.476660.5
261 schema:familyName Cutler Jr
262 schema:givenName Richard E.
263 rdf:type schema:Person
264 Nbb75e8ed3696432585db0bdabc912616 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
265 schema:name Humans
266 rdf:type schema:DefinedTerm
267 Nbe53aee68a3c4ac7a55e51648645a7f4 rdf:first sg:person.010720757537.65
268 rdf:rest N8588503a97964c6d86004eb064e30cec
269 Nc14ae1feb2e144f68ac859cd5682eec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
270 schema:name Alleles
271 rdf:type schema:DefinedTerm
272 Nc446ea1d00f74b32bcf25560b10ddd46 rdf:first N5e833d97cd3a43619b41de79e778ab44
273 rdf:rest N3d001c86dedc4ae9b3c0b5dad21a8aa2
274 Nca5a056a66024756aa68f712d7c86863 rdf:first sg:person.0752311160.93
275 rdf:rest N8f3113ccdbdd4411a358b23d249218d1
276 Nca7a8f32750041d7a9a00da67e627736 rdf:first sg:person.011464242503.81
277 rdf:rest Nff65eb80d5c3464ba782101613c7ef00
278 Ncc3f6746f0414215942963264d2d84a2 rdf:first sg:person.01333376013.47
279 rdf:rest N2213065840954f1db8e0ae1fbfe57fbb
280 Ncd047adc22dd41cb873898d136992f3c rdf:first sg:person.0646633077.45
281 rdf:rest N728d35eb617a4c0f82fc24a8d87cc3a5
282 Nd461bafe0ae145518118dc3468c119b0 schema:issueNumber 7691
283 rdf:type schema:PublicationIssue
284 Nd56ffdb847474abeb974582fb503726b schema:affiliation grid-institutes:grid.476660.5
285 schema:familyName Butturini
286 schema:givenName Anna
287 rdf:type schema:Person
288 Nd6ba4688150945e08795e39458938f44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
289 schema:name Molecular Targeted Therapy
290 rdf:type schema:DefinedTerm
291 Ndcbc9277350641629197af920b4679e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
292 schema:name Neoplasms
293 rdf:type schema:DefinedTerm
294 Ne23d7d36ed8e40f39b5e1209a996884a rdf:first sg:person.01063677263.55
295 rdf:rest N975af23da89f42f99596815a00bdba45
296 Ne5b30fc9bc254771960ce60f625249a9 schema:name pubmed_id
297 schema:value 29420467
298 rdf:type schema:PropertyValue
299 Necc1270ac71d4478a748aa7b533c2612 rdf:first sg:person.010532626075.49
300 rdf:rest N5b331e81a2a44b62915fd66240f3fda9
301 Neebe83c126774e4493ccad8ed7f60125 schema:affiliation grid-institutes:grid.51462.34
302 schema:familyName Melcer
303 schema:givenName Myra
304 rdf:type schema:Person
305 Nf19e47e0651b403489f2262b41d08ca2 rdf:first sg:person.01355654660.61
306 rdf:rest Nf3e23751fa46485783aabc95f0a9d4d2
307 Nf3781654f73d485591c98db9a5935563 rdf:first sg:person.012262475710.78
308 rdf:rest Nca7a8f32750041d7a9a00da67e627736
309 Nf3e23751fa46485783aabc95f0a9d4d2 rdf:first sg:person.01154466504.00
310 rdf:rest N1bf0c5a7f1db4475a2fb8fda2bf77c02
311 Nf53d0649fb1a4c228303536c2f40b594 rdf:first sg:person.013436233237.01
312 rdf:rest Nacb905ec046f450f9d58913838ceeca4
313 Nf86f756f5dbf4147bb34deb3a2b13c03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
314 schema:name Protein Kinase Inhibitors
315 rdf:type schema:DefinedTerm
316 Nff2b0f127ade42b68e817e18143be570 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
317 schema:name Quinolines
318 rdf:type schema:DefinedTerm
319 Nff65eb80d5c3464ba782101613c7ef00 rdf:first sg:person.0743735512.24
320 rdf:rest Nac4afb5e18354bfcb6f0bb53d2af8ccd
321 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
322 schema:name Medical and Health Sciences
323 rdf:type schema:DefinedTerm
324 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
325 schema:name Oncology and Carcinogenesis
326 rdf:type schema:DefinedTerm
327 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
328 rdf:type schema:MonetaryGrant
329 sg:grant.2438805 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
330 rdf:type schema:MonetaryGrant
331 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
332 rdf:type schema:MonetaryGrant
333 sg:grant.2440194 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
334 rdf:type schema:MonetaryGrant
335 sg:grant.2474061 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
336 rdf:type schema:MonetaryGrant
337 sg:grant.2622404 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
338 rdf:type schema:MonetaryGrant
339 sg:grant.2682501 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
340 rdf:type schema:MonetaryGrant
341 sg:grant.2689300 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
342 rdf:type schema:MonetaryGrant
343 sg:grant.2705229 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
344 rdf:type schema:MonetaryGrant
345 sg:grant.6617297 http://pending.schema.org/fundedItem sg:pub.10.1038/nature25475
346 rdf:type schema:MonetaryGrant
347 sg:journal.1018957 schema:issn 0028-0836
348 1476-4687
349 schema:name Nature
350 schema:publisher Springer Nature
351 rdf:type schema:Periodical
352 sg:person.010026123150.72 schema:affiliation grid-institutes:grid.428486.4
353 schema:familyName Boni
354 schema:givenName Valentina
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010026123150.72
356 rdf:type schema:Person
357 sg:person.01013134010.15 schema:affiliation grid-institutes:grid.42505.36
358 schema:familyName Quinn
359 schema:givenName David I.
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013134010.15
361 rdf:type schema:Person
362 sg:person.01016673026.04 schema:affiliation grid-institutes:grid.4367.6
363 schema:familyName Lockhart
364 schema:givenName Albert C.
365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016673026.04
366 rdf:type schema:Person
367 sg:person.01040455641.38 schema:affiliation grid-institutes:grid.51462.34
368 schema:familyName Bouvier
369 schema:givenName Nancy
370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040455641.38
371 rdf:type schema:Person
372 sg:person.010532626075.49 schema:affiliation grid-institutes:grid.476660.5
373 schema:familyName Eli
374 schema:givenName Lisa D.
375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010532626075.49
376 rdf:type schema:Person
377 sg:person.01063677263.55 schema:affiliation grid-institutes:grid.51462.34
378 schema:familyName Baselga
379 schema:givenName José
380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063677263.55
381 rdf:type schema:Person
382 sg:person.01065126442.79 schema:affiliation grid-institutes:grid.240145.6
383 schema:familyName Meric-Bernstam
384 schema:givenName Funda
385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065126442.79
386 rdf:type schema:Person
387 sg:person.010720757537.65 schema:affiliation grid-institutes:grid.51462.34
388 schema:familyName Patel
389 schema:givenName Juber
390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010720757537.65
391 rdf:type schema:Person
392 sg:person.01115006020.77 schema:affiliation grid-institutes:grid.51462.34
393 schema:familyName Jhaveri
394 schema:givenName Komal
395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115006020.77
396 rdf:type schema:Person
397 sg:person.011464242503.81 schema:affiliation grid-institutes:grid.419651.e
398 schema:familyName Doger
399 schema:givenName Bernard
400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011464242503.81
401 rdf:type schema:Person
402 sg:person.01154466504.00 schema:affiliation grid-institutes:grid.51462.34
403 schema:familyName Harding
404 schema:givenName James J.
405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154466504.00
406 rdf:type schema:Person
407 sg:person.01157120373.08 schema:affiliation grid-institutes:grid.51462.34
408 schema:familyName Selcuklu
409 schema:givenName S. Duygu
410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157120373.08
411 rdf:type schema:Person
412 sg:person.01211050414.50 schema:affiliation grid-institutes:grid.240145.6
413 schema:familyName Piha-Paul
414 schema:givenName Sarina A.
415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211050414.50
416 rdf:type schema:Person
417 sg:person.01213300245.49 schema:affiliation grid-institutes:grid.428486.4
418 schema:familyName Calvo
419 schema:givenName Emiliano
420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213300245.49
421 rdf:type schema:Person
422 sg:person.012202131030.61 schema:affiliation grid-institutes:grid.51462.34
423 schema:familyName Smyth
424 schema:givenName Lillian M.
425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012202131030.61
426 rdf:type schema:Person
427 sg:person.012262475710.78 schema:affiliation grid-institutes:grid.419651.e
428 schema:familyName Moreno
429 schema:givenName Victor
430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012262475710.78
431 rdf:type schema:Person
432 sg:person.013310634466.64 schema:affiliation grid-institutes:grid.476660.5
433 schema:familyName Mann
434 schema:givenName Grace
435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013310634466.64
436 rdf:type schema:Person
437 sg:person.01333376013.47 schema:affiliation grid-institutes:grid.51462.34
438 schema:familyName Taylor
439 schema:givenName Barry S.
440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333376013.47
441 rdf:type schema:Person
442 sg:person.01333577301.55 schema:affiliation grid-institutes:grid.51462.34
443 schema:familyName Murali
444 schema:givenName Rajmohan
445 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333577301.55
446 rdf:type schema:Person
447 sg:person.013436233237.01 schema:affiliation grid-institutes:grid.412807.8
448 schema:familyName Arteaga
449 schema:givenName Carlos L.
450 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013436233237.01
451 rdf:type schema:Person
452 sg:person.01355654660.61 schema:affiliation grid-institutes:grid.51462.34
453 schema:familyName Drilon
454 schema:givenName Alexander
455 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355654660.61
456 rdf:type schema:Person
457 sg:person.01365111477.00 schema:affiliation grid-institutes:grid.51462.34
458 schema:familyName Erinjeri
459 schema:givenName Joseph P.
460 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365111477.00
461 rdf:type schema:Person
462 sg:person.014635271363.05 schema:affiliation grid-institutes:grid.51462.34
463 schema:familyName Iyer
464 schema:givenName Gopa
465 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014635271363.05
466 rdf:type schema:Person
467 sg:person.015635546561.24 schema:affiliation grid-institutes:grid.476660.5
468 schema:familyName Bryce
469 schema:givenName Richard P.
470 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015635546561.24
471 rdf:type schema:Person
472 sg:person.016663733117.00 schema:affiliation grid-institutes:grid.51462.34
473 schema:familyName Schram
474 schema:givenName Alison M.
475 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016663733117.00
476 rdf:type schema:Person
477 sg:person.0640557257.82 schema:affiliation grid-institutes:grid.411083.f
478 schema:familyName Rodon
479 schema:givenName Jordi
480 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640557257.82
481 rdf:type schema:Person
482 sg:person.0646633077.45 schema:affiliation grid-institutes:grid.51462.34
483 schema:familyName Hanrahan
484 schema:givenName Aphrothiti J.
485 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646633077.45
486 rdf:type schema:Person
487 sg:person.0656335277.50 schema:affiliation grid-institutes:grid.51462.34
488 schema:familyName Solit
489 schema:givenName David B.
490 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656335277.50
491 rdf:type schema:Person
492 sg:person.0703053217.10 schema:affiliation grid-institutes:grid.51462.34
493 schema:familyName Ulaner
494 schema:givenName Gary A.
495 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703053217.10
496 rdf:type schema:Person
497 sg:person.0706672457.25 schema:affiliation grid-institutes:grid.411083.f
498 schema:familyName Saura
499 schema:givenName Cristina
500 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706672457.25
501 rdf:type schema:Person
502 sg:person.0743735512.24 schema:affiliation grid-institutes:grid.412807.8
503 schema:familyName Mayer
504 schema:givenName Ingrid A.
505 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743735512.24
506 rdf:type schema:Person
507 sg:person.0752005421.01 schema:affiliation grid-institutes:grid.65499.37
508 schema:familyName Shapiro
509 schema:givenName Geoffrey I.
510 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752005421.01
511 rdf:type schema:Person
512 sg:person.0752311160.93 schema:affiliation grid-institutes:grid.1055.1
513 schema:familyName Loi
514 schema:givenName Sherene
515 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752311160.93
516 rdf:type schema:Person
517 sg:person.0773414311.69 schema:affiliation grid-institutes:grid.51462.34
518 schema:familyName Scaltriti
519 schema:givenName Maurizio
520 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773414311.69
521 rdf:type schema:Person
522 sg:person.0773476167.89 schema:affiliation grid-institutes:grid.476660.5
523 schema:familyName Lalani
524 schema:givenName Alshad S.
525 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773476167.89
526 rdf:type schema:Person
527 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
528 https://doi.org/10.1038/nature12477
529 rdf:type schema:CreativeWork
530 sg:pub.10.1038/nbt.2203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010515132
531 https://doi.org/10.1038/nbt.2203
532 rdf:type schema:CreativeWork
533 sg:pub.10.1038/nbt.3391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004475958
534 https://doi.org/10.1038/nbt.3391
535 rdf:type schema:CreativeWork
536 sg:pub.10.1038/ng.3466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003945434
537 https://doi.org/10.1038/ng.3466
538 rdf:type schema:CreativeWork
539 sg:pub.10.1038/nm.4333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085214027
540 https://doi.org/10.1038/nm.4333
541 rdf:type schema:CreativeWork
542 grid-institutes:None schema:alternateName Massachusetts Hospital Cancer Center, BostonMassachusetts, USA
543 schema:name Massachusetts Hospital Cancer Center, BostonMassachusetts, USA
544 rdf:type schema:Organization
545 grid-institutes:grid.1055.1 schema:alternateName Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
546 schema:name Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
547 rdf:type schema:Organization
548 grid-institutes:grid.240145.6 schema:alternateName University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
549 schema:name University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
550 rdf:type schema:Organization
551 grid-institutes:grid.411083.f schema:alternateName Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
552 schema:name Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
553 rdf:type schema:Organization
554 grid-institutes:grid.412807.8 schema:alternateName Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA
555 schema:name Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA
556 rdf:type schema:Organization
557 grid-institutes:grid.419651.e schema:alternateName START Madrid Fundación Jímenez Díaz, Madrid, Spain
558 schema:name START Madrid Fundación Jímenez Díaz, Madrid, Spain
559 rdf:type schema:Organization
560 grid-institutes:grid.42505.36 schema:alternateName USC Norris Comprehensive Cancer Center, Los Angeles, California, USA
561 schema:name USC Norris Comprehensive Cancer Center, Los Angeles, California, USA
562 rdf:type schema:Organization
563 grid-institutes:grid.428486.4 schema:alternateName START Madrid, Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain
564 schema:name START Madrid, Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain
565 rdf:type schema:Organization
566 grid-institutes:grid.4367.6 schema:alternateName Washington University in St. Louis School of Medicine, St Louis, Missouri, USA
567 schema:name Washington University in St. Louis School of Medicine, St Louis, Missouri, USA
568 rdf:type schema:Organization
569 grid-institutes:grid.476660.5 schema:alternateName Puma Biotechnology Inc., Los Angeles, California, USA
570 schema:name Puma Biotechnology Inc., Los Angeles, California, USA
571 rdf:type schema:Organization
572 grid-institutes:grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center, New York, New York, USA
573 schema:name Memorial Sloan Kettering Cancer Center, New York, New York, USA
574 rdf:type schema:Organization
575 grid-institutes:grid.65499.37 schema:alternateName Dana-Faber Cancer Institute, Boston, Massachusetts, USA
576 schema:name Dana-Faber Cancer Institute, Boston, Massachusetts, USA
577 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...