The 4D nucleome project View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09

AUTHORS

Job Dekker, Andrew S. Belmont, Mitchell Guttman, Victor O. Leshyk, John T. Lis, Stavros Lomvardas, Leonid A. Mirny, Clodagh C. O’Shea, Peter J. Park, Bing Ren, Joan C. Ritland Politz, Jay Shendure, Sheng Zhong, D Nucleome Network

ABSTRACT

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells. More... »

PAGES

219

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature23884

    DOI

    http://dx.doi.org/10.1038/nature23884

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091600986

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28905911


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