Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-23

AUTHORS

Kai Yang, Daniel Bastardo Blanco, Geoffrey Neale, Peter Vogel, Julian Avila, Clary B. Clish, Chuan Wu, Sharad Shrestha, Sherri Rankin, Lingyun Long, Anil KC, Hongbo Chi

ABSTRACT

The tumour suppressor liver kinase B1 (LKB1) regulates the metabolic and functional fitness of regulatory T cells in the control of immune tolerance and homeostasis.

PAGES

602-606

References to SciGraph publications

  • 2015-02-11. Potential effector and immunoregulatory functions of mast cells in mucosal immunity in MUCOSAL IMMUNOLOGY
  • 2014-01-31. Homeostatic control of regulatory T cell diversity in NATURE REVIEWS IMMUNOLOGY
  • 2013-06-30. mTORC1 couples immune signals and metabolic programming to establish Treg-cell function in NATURE
  • 2002-01-22. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance in NATURE IMMUNOLOGY
  • 2014-09-28. Continuous requirement for the TCR in regulatory T cell function in NATURE IMMUNOLOGY
  • 2014-03-16. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells in NATURE IMMUNOLOGY
  • 2013-11-15. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application in NATURE IMMUNOLOGY
  • 2005-09-04. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice in NATURE IMMUNOLOGY
  • 2011-01-07. ChIP-on-Chip for FoxP3 in REGULATORY T CELLS
  • 2013-12-25. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico in NATURE
  • 2009-08. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression in NATURE REVIEWS CANCER
  • 2015-03-26. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation in NATURE COMMUNICATIONS
  • 2015-01-19. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo in NATURE IMMUNOLOGY
  • 2010-09-19. The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells in NATURE IMMUNOLOGY
  • 2015-01-05. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses in NATURE IMMUNOLOGY
  • 2008-02-03. Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells in NATURE MEDICINE
  • 2012-12-16. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature23665

    DOI

    http://dx.doi.org/10.1038/nature23665

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091306733

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28847007


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