Cryo-EM structures of tau filaments from Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07

AUTHORS

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres

ABSTRACT

Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filaments with different morphologies characterize other neurodegenerative diseases. No high-resolution structures of tau filaments are available. Here we present cryo-electron microscopy (cryo-EM) maps at 3.4-3.5 Å resolution and corresponding atomic models of paired helical and straight filaments from the brain of an individual with Alzheimer's disease. Filament cores are made of two identical protofilaments comprising residues 306-378 of tau protein, which adopt a combined cross-β/β-helix structure and define the seed for tau aggregation. Paired helical and straight filaments differ in their inter-protofilament packing, showing that they are ultrastructural polymorphs. These findings demonstrate that cryo-EM allows atomic characterization of amyloid filaments from patient-derived material, and pave the way for investigation of a range of neurodegenerative diseases. More... »

PAGES

185

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature23002

DOI

http://dx.doi.org/10.1038/nature23002

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090348371

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28678775


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cryoelectron Microscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Aggregation, Pathological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fitzpatrick", 
        "givenName": "Anthony W. P.", 
        "id": "sg:person.0577360004.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577360004.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcon", 
        "givenName": "Benjamin", 
        "id": "sg:person.01006444610.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006444610.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Shaoda", 
        "id": "sg:person.015052253665.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015052253665.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murzin", 
        "givenName": "Alexey G.", 
        "id": "sg:person.01137354422.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137354422.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murshudov", 
        "givenName": "Garib", 
        "id": "sg:person.01157620501.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157620501.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garringer", 
        "givenName": "Holly J.", 
        "id": "sg:person.0657240737.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657240737.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crowther", 
        "givenName": "R. Anthony", 
        "id": "sg:person.01031103714.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031103714.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghetti", 
        "givenName": "Bernardino", 
        "id": "sg:person.01332444654.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332444654.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goedert", 
        "givenName": "Michel", 
        "id": "sg:person.01266104015.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266104015.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheres", 
        "givenName": "Sjors H. W.", 
        "id": "sg:person.015537361467.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537361467.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444910007493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000235100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ultramic.2013.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000304364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/176780a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001173270", 
          "https://doi.org/10.1038/176780a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001760713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.51.32789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002057838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nan.12213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003446527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nan.12213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003446527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20160833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003787614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1607215114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005444647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1607215114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005444647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-015-1503-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008581766", 
          "https://doi.org/10.1007/s00401-015-1503-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-015-1503-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008581766", 
          "https://doi.org/10.1007/s00401-015-1503-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008757821", 
          "https://doi.org/10.1038/nature05695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1997.1348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008860580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cb900112v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009623070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.10.5129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010163892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(92)90117-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010264953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4547(19970415)48:2<128::aid-jnr5>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011494813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(89)90210-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013144390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016142352", 
          "https://doi.org/10.1038/nsmb.3194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016322528", 
          "https://doi.org/10.1186/2051-5960-1-54"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.75.101304.123901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016481823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.12.4506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016689265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jacs.6b05129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018259669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444909042073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018458004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444996012255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020405374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201105493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023462552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023658774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1530287100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023923464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-3233(06)73003-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024655353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402254101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026040206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1301175110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028221411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.13.4884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029272999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature20416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030483760", 
          "https://doi.org/10.1038/nature20416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature20416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030483760", 
          "https://doi.org/10.1038/nature20416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1600749113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032221293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3542-15.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034264288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3542-15.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034264288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00687747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034444941", 
          "https://doi.org/10.1007/bf00687747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00687747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034444941", 
          "https://doi.org/10.1007/bf00687747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jsbi.2000.4270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035122599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.6.2288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038630988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/197192b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039641676", 
          "https://doi.org/10.1038/197192b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.589309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039947019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040916500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jnc.13228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041031717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201501714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041550222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042249205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.09.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042416233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aab1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045791662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1503455112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048238683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219476110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048276224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2015.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049504602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005072-196310000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049658494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(82)90155-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050124904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(82)90155-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050124904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi000204s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055157470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi000204s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055157470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00198a017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055164847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/aww230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059445231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a023630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a023721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060407131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1151839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1991.tb07820.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077836672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2017.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083743564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129286", 
          "https://doi.org/10.1038/nmeth.4193"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-07", 
    "datePublishedReg": "2017-07-01", 
    "description": "Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filaments with different morphologies characterize other neurodegenerative diseases. No high-resolution structures of tau filaments are available. Here we present cryo-electron microscopy (cryo-EM) maps at 3.4-3.5\u2009\u00c5 resolution and corresponding atomic models of paired helical and straight filaments from the brain of an individual with Alzheimer's disease. Filament cores are made of two identical protofilaments comprising residues 306-378 of tau protein, which adopt a combined cross-\u03b2/\u03b2-helix structure and define the seed for tau aggregation. Paired helical and straight filaments differ in their inter-protofilament packing, showing that they are ultrastructural polymorphs. These findings demonstrate that cryo-EM allows atomic characterization of amyloid filaments from patient-derived material, and pave the way for investigation of a range of neurodegenerative diseases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature23002", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2751546", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2755961", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4888169", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2761104", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438594", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2783908", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7662", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "547"
      }
    ], 
    "name": "Cryo-EM structures of tau filaments from Alzheimer\u2019s disease", 
    "pagination": "185", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "852ecea57a3908f2ea575ed89acec720606ba9bf4d0a48523b4a243a95217bc3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28678775"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature23002"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090348371"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature23002", 
      "https://app.dimensions.ai/details/publication/pub.1090348371"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature23002"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature23002'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature23002'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature23002'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature23002'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      97 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature23002 schema:about N2c7a2303114e4a55b4950f3eb0f7e78b
2 N2efd8fc9263743459e3ad48b28961592
3 N4682a61357a6410095a7749edc7b4861
4 N50d0329bd4604a5da829eb2493a50bcc
5 N8212e9eddd234a05ad52e20e32374683
6 Nb8d64f3b550143498c62fce6383bc1fd
7 Ncb07e34da3074787a77dab129a3f9fac
8 Nd70384dd24634887b4b8ebc91e1b1825
9 Ne2c35971a1874569903d25d8b13da64e
10 Nf030dff40ab642e3aa3eab0b98d66c10
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author Nf0295adec3a348b88586413757849b57
14 schema:citation sg:pub.10.1007/bf00687747
15 sg:pub.10.1007/s00401-015-1503-3
16 sg:pub.10.1038/176780a0
17 sg:pub.10.1038/197192b0
18 sg:pub.10.1038/nature05695
19 sg:pub.10.1038/nature20416
20 sg:pub.10.1038/nmeth.4193
21 sg:pub.10.1038/nsmb.3194
22 sg:pub.10.1186/2051-5960-1-54
23 https://doi.org/10.1002/(sici)1097-4547(19970415)48:2<128::aid-jnr5>3.0.co;2-e
24 https://doi.org/10.1002/ana.10163
25 https://doi.org/10.1002/ana.10340
26 https://doi.org/10.1002/anie.201105493
27 https://doi.org/10.1002/anie.201501714
28 https://doi.org/10.1002/j.1460-2075.1991.tb07820.x
29 https://doi.org/10.1006/jmbi.1997.1348
30 https://doi.org/10.1006/jsbi.2000.4270
31 https://doi.org/10.1016/0022-510x(82)90155-1
32 https://doi.org/10.1016/0896-6273(89)90210-9
33 https://doi.org/10.1016/0896-6273(92)90117-v
34 https://doi.org/10.1016/j.cell.2013.08.035
35 https://doi.org/10.1016/j.jsb.2015.11.003
36 https://doi.org/10.1016/j.jsb.2017.02.003
37 https://doi.org/10.1016/j.neuron.2016.09.055
38 https://doi.org/10.1016/j.ultramic.2013.06.004
39 https://doi.org/10.1016/s0065-3233(06)73003-0
40 https://doi.org/10.1021/bi000204s
41 https://doi.org/10.1021/bi00198a017
42 https://doi.org/10.1021/cb900112v
43 https://doi.org/10.1021/jacs.6b05129
44 https://doi.org/10.1073/pnas.0402254101
45 https://doi.org/10.1073/pnas.1219476110
46 https://doi.org/10.1073/pnas.1301175110
47 https://doi.org/10.1073/pnas.1503455112
48 https://doi.org/10.1073/pnas.1530287100
49 https://doi.org/10.1073/pnas.1600749113
50 https://doi.org/10.1073/pnas.1607215114
51 https://doi.org/10.1073/pnas.85.12.4506
52 https://doi.org/10.1073/pnas.85.13.4884
53 https://doi.org/10.1073/pnas.88.6.2288
54 https://doi.org/10.1073/pnas.97.10.5129
55 https://doi.org/10.1074/jbc.271.51.32789
56 https://doi.org/10.1074/jbc.m114.589309
57 https://doi.org/10.1084/jem.20160833
58 https://doi.org/10.1093/brain/awm280
59 https://doi.org/10.1093/brain/aww230
60 https://doi.org/10.1097/00005072-196310000-00005
61 https://doi.org/10.1101/cshperspect.a023630
62 https://doi.org/10.1101/cshperspect.a023721
63 https://doi.org/10.1107/s0907444909042073
64 https://doi.org/10.1107/s0907444910007493
65 https://doi.org/10.1107/s0907444996012255
66 https://doi.org/10.1111/jnc.13228
67 https://doi.org/10.1111/nan.12213
68 https://doi.org/10.1126/science.1151839
69 https://doi.org/10.1126/scitranslmed.aab1923
70 https://doi.org/10.1146/annurev.biochem.75.101304.123901
71 https://doi.org/10.1523/jneurosci.3542-15.2016
72 schema:datePublished 2017-07
73 schema:datePublishedReg 2017-07-01
74 schema:description Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau filaments with different morphologies characterize other neurodegenerative diseases. No high-resolution structures of tau filaments are available. Here we present cryo-electron microscopy (cryo-EM) maps at 3.4-3.5 Å resolution and corresponding atomic models of paired helical and straight filaments from the brain of an individual with Alzheimer's disease. Filament cores are made of two identical protofilaments comprising residues 306-378 of tau protein, which adopt a combined cross-β/β-helix structure and define the seed for tau aggregation. Paired helical and straight filaments differ in their inter-protofilament packing, showing that they are ultrastructural polymorphs. These findings demonstrate that cryo-EM allows atomic characterization of amyloid filaments from patient-derived material, and pave the way for investigation of a range of neurodegenerative diseases.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N45eb8d187bdc40d88ddb1294d3de47b1
79 Ne2bf707a7e5646dc8b6e4540d5610853
80 sg:journal.1018957
81 schema:name Cryo-EM structures of tau filaments from Alzheimer’s disease
82 schema:pagination 185
83 schema:productId N27f0b61b0fc444348e1eaf0922455636
84 N2e19e5ff4662419d8e06a6769b6deed8
85 N8af56e553ff9418385d8975ee67b54ed
86 Na9abae3aa6a54d14904e28b52bcad074
87 Nf9163287037841328ead5c83011920b9
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090348371
89 https://doi.org/10.1038/nature23002
90 schema:sdDatePublished 2019-04-11T12:24
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N9deb640c707642a1b96ff16cdd381242
93 schema:url https://www.nature.com/articles/nature23002
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N27f0b61b0fc444348e1eaf0922455636 schema:name readcube_id
98 schema:value 852ecea57a3908f2ea575ed89acec720606ba9bf4d0a48523b4a243a95217bc3
99 rdf:type schema:PropertyValue
100 N2c7a2303114e4a55b4950f3eb0f7e78b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Amyloid
102 rdf:type schema:DefinedTerm
103 N2e19e5ff4662419d8e06a6769b6deed8 schema:name dimensions_id
104 schema:value pub.1090348371
105 rdf:type schema:PropertyValue
106 N2efd8fc9263743459e3ad48b28961592 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cryoelectron Microscopy
108 rdf:type schema:DefinedTerm
109 N45eb8d187bdc40d88ddb1294d3de47b1 schema:volumeNumber 547
110 rdf:type schema:PublicationVolume
111 N4682a61357a6410095a7749edc7b4861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Protein Aggregation, Pathological
113 rdf:type schema:DefinedTerm
114 N50d0329bd4604a5da829eb2493a50bcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Amino Acid Sequence
116 rdf:type schema:DefinedTerm
117 N78a0ba11b21a49d68851e2206ed02a21 rdf:first sg:person.0657240737.49
118 rdf:rest Ne616840678dc4167b5b33fdf99017319
119 N8212e9eddd234a05ad52e20e32374683 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Brain
121 rdf:type schema:DefinedTerm
122 N82c4bb2b84b14023a3dc862c281c8460 rdf:first sg:person.01157620501.20
123 rdf:rest N78a0ba11b21a49d68851e2206ed02a21
124 N8af56e553ff9418385d8975ee67b54ed schema:name pubmed_id
125 schema:value 28678775
126 rdf:type schema:PropertyValue
127 N8b665215f9014bab951b5f5047842d3a rdf:first sg:person.01332444654.75
128 rdf:rest Nc222c3717e49496383f00b0c26ad72a7
129 N9deb640c707642a1b96ff16cdd381242 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Na9abae3aa6a54d14904e28b52bcad074 schema:name nlm_unique_id
132 schema:value 0410462
133 rdf:type schema:PropertyValue
134 Nb8d64f3b550143498c62fce6383bc1fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Nbd9320f39e824b59b593e4ff4f1ef6be rdf:first sg:person.01137354422.66
138 rdf:rest N82c4bb2b84b14023a3dc862c281c8460
139 Nc222c3717e49496383f00b0c26ad72a7 rdf:first sg:person.01266104015.37
140 rdf:rest Nd0bd43059bf548b4ac07a1ae3a9d14c7
141 Nc3d94f9ecd3c44ee8cd1633dd6b1dbb4 rdf:first sg:person.01006444610.60
142 rdf:rest Ndfea96ea31a64fbaaa4d4624f3fdbf33
143 Ncb07e34da3074787a77dab129a3f9fac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Aged
145 rdf:type schema:DefinedTerm
146 Nd0bd43059bf548b4ac07a1ae3a9d14c7 rdf:first sg:person.015537361467.29
147 rdf:rest rdf:nil
148 Nd70384dd24634887b4b8ebc91e1b1825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 Ndfea96ea31a64fbaaa4d4624f3fdbf33 rdf:first sg:person.015052253665.87
152 rdf:rest Nbd9320f39e824b59b593e4ff4f1ef6be
153 Ne2bf707a7e5646dc8b6e4540d5610853 schema:issueNumber 7662
154 rdf:type schema:PublicationIssue
155 Ne2c35971a1874569903d25d8b13da64e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Alzheimer Disease
157 rdf:type schema:DefinedTerm
158 Ne616840678dc4167b5b33fdf99017319 rdf:first sg:person.01031103714.70
159 rdf:rest N8b665215f9014bab951b5f5047842d3a
160 Nf0295adec3a348b88586413757849b57 rdf:first sg:person.0577360004.26
161 rdf:rest Nc3d94f9ecd3c44ee8cd1633dd6b1dbb4
162 Nf030dff40ab642e3aa3eab0b98d66c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name tau Proteins
164 rdf:type schema:DefinedTerm
165 Nf9163287037841328ead5c83011920b9 schema:name doi
166 schema:value 10.1038/nature23002
167 rdf:type schema:PropertyValue
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
172 schema:name Biochemistry and Cell Biology
173 rdf:type schema:DefinedTerm
174 sg:grant.2438594 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
175 rdf:type schema:MonetaryGrant
176 sg:grant.2751546 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
177 rdf:type schema:MonetaryGrant
178 sg:grant.2755961 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
179 rdf:type schema:MonetaryGrant
180 sg:grant.2761104 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
181 rdf:type schema:MonetaryGrant
182 sg:grant.2783908 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
183 rdf:type schema:MonetaryGrant
184 sg:grant.4888169 http://pending.schema.org/fundedItem sg:pub.10.1038/nature23002
185 rdf:type schema:MonetaryGrant
186 sg:journal.1018957 schema:issn 0090-0028
187 1476-4687
188 schema:name Nature
189 rdf:type schema:Periodical
190 sg:person.01006444610.60 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
191 schema:familyName Falcon
192 schema:givenName Benjamin
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006444610.60
194 rdf:type schema:Person
195 sg:person.01031103714.70 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
196 schema:familyName Crowther
197 schema:givenName R. Anthony
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031103714.70
199 rdf:type schema:Person
200 sg:person.01137354422.66 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
201 schema:familyName Murzin
202 schema:givenName Alexey G.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137354422.66
204 rdf:type schema:Person
205 sg:person.01157620501.20 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
206 schema:familyName Murshudov
207 schema:givenName Garib
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157620501.20
209 rdf:type schema:Person
210 sg:person.01266104015.37 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
211 schema:familyName Goedert
212 schema:givenName Michel
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266104015.37
214 rdf:type schema:Person
215 sg:person.01332444654.75 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
216 schema:familyName Ghetti
217 schema:givenName Bernardino
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332444654.75
219 rdf:type schema:Person
220 sg:person.015052253665.87 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
221 schema:familyName He
222 schema:givenName Shaoda
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015052253665.87
224 rdf:type schema:Person
225 sg:person.015537361467.29 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
226 schema:familyName Scheres
227 schema:givenName Sjors H. W.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015537361467.29
229 rdf:type schema:Person
230 sg:person.0577360004.26 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
231 schema:familyName Fitzpatrick
232 schema:givenName Anthony W. P.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577360004.26
234 rdf:type schema:Person
235 sg:person.0657240737.49 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
236 schema:familyName Garringer
237 schema:givenName Holly J.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657240737.49
239 rdf:type schema:Person
240 sg:pub.10.1007/bf00687747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034444941
241 https://doi.org/10.1007/bf00687747
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s00401-015-1503-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008581766
244 https://doi.org/10.1007/s00401-015-1503-3
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/176780a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001173270
247 https://doi.org/10.1038/176780a0
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/197192b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039641676
250 https://doi.org/10.1038/197192b0
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature05695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008757821
253 https://doi.org/10.1038/nature05695
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature20416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030483760
256 https://doi.org/10.1038/nature20416
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nmeth.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129286
259 https://doi.org/10.1038/nmeth.4193
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nsmb.3194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016142352
262 https://doi.org/10.1038/nsmb.3194
263 rdf:type schema:CreativeWork
264 sg:pub.10.1186/2051-5960-1-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016322528
265 https://doi.org/10.1186/2051-5960-1-54
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/(sici)1097-4547(19970415)48:2<128::aid-jnr5>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1011494813
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/ana.10163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023658774
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/ana.10340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001760713
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/anie.201105493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023462552
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/anie.201501714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041550222
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/j.1460-2075.1991.tb07820.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077836672
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1006/jmbi.1997.1348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008860580
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1006/jsbi.2000.4270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035122599
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0022-510x(82)90155-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050124904
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0896-6273(89)90210-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013144390
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0896-6273(92)90117-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1010264953
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.cell.2013.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040916500
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.jsb.2015.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049504602
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.jsb.2017.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083743564
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.neuron.2016.09.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042416233
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.ultramic.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000304364
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s0065-3233(06)73003-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024655353
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1021/bi000204s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055157470
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1021/bi00198a017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055164847
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1021/cb900112v schema:sameAs https://app.dimensions.ai/details/publication/pub.1009623070
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1021/jacs.6b05129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018259669
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1073/pnas.0402254101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026040206
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1073/pnas.1219476110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048276224
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1073/pnas.1301175110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028221411
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1073/pnas.1503455112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048238683
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1073/pnas.1530287100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023923464
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1073/pnas.1600749113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032221293
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.1607215114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005444647
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.85.12.4506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016689265
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.85.13.4884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029272999
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.88.6.2288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038630988
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.97.10.5129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010163892
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1074/jbc.271.51.32789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002057838
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1074/jbc.m114.589309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039947019
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1084/jem.20160833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003787614
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/brain/awm280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042249205
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/brain/aww230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059445231
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1097/00005072-196310000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049658494
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/cshperspect.a023630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407127
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1101/cshperspect.a023721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060407131
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1107/s0907444909042073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018458004
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1107/s0907444910007493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000235100
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1107/s0907444996012255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405374
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1111/jnc.13228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041031717
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1111/nan.12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003446527
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1126/science.1151839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457243
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1126/scitranslmed.aab1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045791662
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1146/annurev.biochem.75.101304.123901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016481823
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1523/jneurosci.3542-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034264288
364 rdf:type schema:CreativeWork
365 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
366 schema:name Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
367 rdf:type schema:Organization
368 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
369 schema:name MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...