Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-17

AUTHORS

Yang Liu, Jianying Liu, Senyan Du, Chao Shan, Kaixiao Nie, Rudian Zhang, Xiao-Feng Li, Renli Zhang, Tao Wang, Cheng-Feng Qin, Penghua Wang, Pei-Yong Shi, Gong Cheng

ABSTRACT

Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the underlying mechanisms through which ZIKV rapidly and explosively spread from Asia to the Americas are unclear. Non-structural protein 1 (NS1) facilitates flavivirus acquisition by mosquitoes from an infected mammalian host and subsequently enhances viral prevalence in mosquitoes. Here we show that NS1 antigenaemia determines ZIKV infectivity in its mosquito vector Aedes aegypti, which acquires ZIKV via a blood meal. Clinical isolates from the most recent outbreak in the Americas were much more infectious in mosquitoes than the FSS13025 strain, which was isolated in Cambodia in 2010. Further analyses showed that these epidemic strains have higher NS1 antigenaemia than the FSS13025 strain because of an alanine-to-valine amino acid substitution at residue 188 in NS1. ZIKV infectivity was enhanced by this amino acid substitution in the ZIKV FSS13025 strain in mosquitoes that acquired ZIKV from a viraemic C57BL/6 mouse deficient in type I and II interferon (IFN) receptors (AG6 mouse). Our results reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 protein, resulting in increased NS1 antigenaemia. Enhancement of NS1 antigenaemia in infected hosts promotes ZIKV infectivity and prevalence in mosquitoes, which could have facilitated transmission during recent ZIKV epidemics. More... »

PAGES

482-486

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature22365

DOI

http://dx.doi.org/10.1038/nature22365

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085422188

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28514450


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29 schema:description Zika virus (ZIKV) remained obscure until the recent explosive outbreaks in French Polynesia (2013-2014) and South America (2015-2016). Phylogenetic studies have shown that ZIKV has evolved into African and Asian lineages. The Asian lineage of ZIKV was responsible for the recent epidemics in the Americas. However, the underlying mechanisms through which ZIKV rapidly and explosively spread from Asia to the Americas are unclear. Non-structural protein 1 (NS1) facilitates flavivirus acquisition by mosquitoes from an infected mammalian host and subsequently enhances viral prevalence in mosquitoes. Here we show that NS1 antigenaemia determines ZIKV infectivity in its mosquito vector Aedes aegypti, which acquires ZIKV via a blood meal. Clinical isolates from the most recent outbreak in the Americas were much more infectious in mosquitoes than the FSS13025 strain, which was isolated in Cambodia in 2010. Further analyses showed that these epidemic strains have higher NS1 antigenaemia than the FSS13025 strain because of an alanine-to-valine amino acid substitution at residue 188 in NS1. ZIKV infectivity was enhanced by this amino acid substitution in the ZIKV FSS13025 strain in mosquitoes that acquired ZIKV from a viraemic C57BL/6 mouse deficient in type I and II interferon (IFN) receptors (AG6 mouse). Our results reveal that ZIKV evolved to acquire a spontaneous mutation in its NS1 protein, resulting in increased NS1 antigenaemia. Enhancement of NS1 antigenaemia in infected hosts promotes ZIKV infectivity and prevalence in mosquitoes, which could have facilitated transmission during recent ZIKV epidemics.
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37 Aedes aegypti mosquitoes
38 America
39 Asia
40 Asian lineage
41 C57BL/6 mice
42 Cambodia
43 FSS13025 strain
44 French Polynesia
45 Further analysis
46 NS1 antigenaemia
47 NS1 protein
48 Polynesia
49 South America
50 ZIKV FSS13025 strain
51 ZIKV epidemic
52 ZIKV infectivity
53 Zika virus
54 Zika virus infectivity
55 acid substitutions
56 acquisition
57 aegypti
58 aegypti mosquitoes
59 alanine
60 amino acid substitutions
61 analysis
62 antigenaemia
63 blood meal
64 enhancement
65 epidemic
66 epidemic strains
67 evolutionary enhancements
68 explosive outbreaks
69 flavivirus acquisition
70 higher NS1 antigenaemia
71 host
72 infected host
73 infected mammalian hosts
74 infectivity
75 interferon receptor
76 lineages
77 mammalian hosts
78 meal
79 mechanism
80 mice
81 mosquito vector Aedes aegypti
82 mosquitoes
83 mutations
84 non-structural protein 1
85 outbreak
86 phylogenetic studies
87 prevalence
88 protein
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95 residue 188
96 results
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