Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-04-05

AUTHORS

Moritz Mall, Michael S. Kareta, Soham Chanda, Henrik Ahlenius, Nicholas Perotti, Bo Zhou, Sarah D. Grieder, Xuecai Ge, Sienna Drake, Cheen Euong Ang, Brandon M. Walker, Thomas Vierbuchen, Daniel R. Fuentes, Philip Brennecke, Kazuhiro R. Nitta, Arttu Jolma, Lars M. Steinmetz, Jussi Taipale, Thomas C. Südhof, Marius Wernig

ABSTRACT

Normal differentiation and induced reprogramming require the activation of target cell programs and silencing of donor cell programs. In reprogramming, the same factors are often used to reprogram many different donor cell types. As most developmental repressors, such as RE1-silencing transcription factor (REST) and Groucho (also known as TLE), are considered lineage-specific repressors, it remains unclear how identical combinations of transcription factors can silence so many different donor programs. Distinct lineage repressors would have to be induced in different donor cell types. Here, by studying the reprogramming of mouse fibroblasts to neurons, we found that the pan neuron-specific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different somatic lineage programs except the neuronal program. The repressive function of Myt1l is mediated via recruitment of a complex containing Sin3b by binding to a previously uncharacterized N-terminal domain. In agreement with its repressive function, the genomic binding sites of Myt1l are similar in neurons and fibroblasts and are preferentially in an open chromatin configuration. The Notch signalling pathway is repressed by Myt1l through silencing of several members, including Hes1. Acute knockdown of Myt1l in the developing mouse brain mimicked a Notch gain-of-function phenotype, suggesting that Myt1l allows newborn neurons to escape Notch activation during normal development. Depletion of Myt1l in primary postmitotic neurons de-repressed non-neuronal programs and impaired neuronal gene expression and function, indicating that many somatic lineage programs are actively and persistently repressed by Myt1l to maintain neuronal identity. It is now tempting to speculate that similar 'many-but-one' lineage repressors exist for other cell fates; such repressors, in combination with lineage-specific activators, would be prime candidates for use in reprogramming additional cell types. More... »

PAGES

245

References to SciGraph publications

  • 2000-12-01. The Mad1–Sin3B interaction involves a novel helical fold in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-08. Large-scale gene function analysis with the PANTHER classification system in NATURE PROTOCOLS
  • 2008-11. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2008-11. Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition in NATURE NEUROSCIENCE
  • 2012-11. Genome-wide nucleosome positioning during embryonic stem cell development in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-05. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation in NATURE BIOTECHNOLOGY
  • 2013-04. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2008-12. Design and analysis of ChIP-seq experiments for DNA-binding proteins in NATURE BIOTECHNOLOGY
  • 2015-12. A novel ATAC-seq approach reveals lineage-specific reinforcement of the open chromatin landscape via cooperation between BAF and p63 in GENOME BIOLOGY
  • 2010-02. Direct conversion of fibroblasts to functional neurons by defined factors in NATURE
  • 1990-03. Effect of cell history on response to helix–loop–helix family of myogenic regulators in NATURE
  • 2015-06. Refinement of the critical 2p25.3 deletion region: the role of MYT1L in intellectual disability and obesity in GENETICS IN MEDICINE
  • 2014-11. Synaptic, transcriptional and chromatin genes disrupted in autism in NATURE
  • 2003-07. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes in NATURE GENETICS
  • 2012-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • 2012-01. Differential oestrogen receptor binding is associated with clinical outcome in breast cancer in NATURE
  • 2009-03. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2010-09. Comprehensive comparative analysis of strand-specific RNA sequencing methods in NATURE METHODS
  • 2013-01. Differential analysis of gene regulation at transcript resolution with RNA-seq in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature21722

    DOI

    http://dx.doi.org/10.1038/nature21722

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084537611

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28379941


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