MC4R-dependent suppression of appetite by bone-derived lipocalin 2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Ioanna Mosialou, Steven Shikhel, Jian-Min Liu, Antonio Maurizi, Na Luo, Zhenyan He, Yiru Huang, Haihong Zong, Richard A. Friedman, Jonathan Barasch, Patricia Lanzano, Liyong Deng, Rudolph L. Leibel, Mishaela Rubin, Thomas Nickolas, Wendy Chung, Lori M. Zeltser, Kevin W. Williams, Jeffrey E. Pessin, Stavroula Kousteni

ABSTRACT

Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here we identify, through molecular and genetic analyses in mice, lipocalin 2 (LCN2) as an osteoblast-enriched, secreted protein. Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity. In addition, osteoblast-derived LCN2 inhibits food intake. LCN2 crosses the blood-brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular and ventromedial neurons of the hypothalamus and activates an MC4R-dependent anorexigenic (appetite-suppressing) pathway. These results identify LCN2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone. More... »

PAGES

385

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature21697

DOI

http://dx.doi.org/10.1038/nature21697

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084128588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28273060


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Appetite Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood-Brain Barrier", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone and Bones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Secretion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipocalin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paraventricular Hypothalamic Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Melanocortin, Type 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thinness", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mosialou", 
        "givenName": "Ioanna", 
        "id": "sg:person.0745513777.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745513777.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shikhel", 
        "givenName": "Steven", 
        "id": "sg:person.014305171067.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305171067.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jian-Min", 
        "id": "sg:person.01270171762.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270171762.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maurizi", 
        "givenName": "Antonio", 
        "id": "sg:person.0743563314.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743563314.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Na", 
        "id": "sg:person.01364360215.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364360215.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China", 
            "Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9077, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Zhenyan", 
        "id": "sg:person.010640625325.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640625325.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China", 
            "Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9077, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Yiru", 
        "id": "sg:person.010043244725.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010043244725.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Medicine and Molecular Pharmacology, The Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zong", 
        "givenName": "Haihong", 
        "id": "sg:person.01321316116.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321316116.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Biomedical Informatics Shared Resource, Department of Biomedical Informatics, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Friedman", 
        "givenName": "Richard A.", 
        "id": "sg:person.01070164536.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070164536.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barasch", 
        "givenName": "Jonathan", 
        "id": "sg:person.0634104106.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634104106.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lanzano", 
        "givenName": "Patricia", 
        "id": "sg:person.01166363311.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166363311.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Liyong", 
        "id": "sg:person.0606035033.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606035033.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leibel", 
        "givenName": "Rudolph L.", 
        "id": "sg:person.011210063717.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011210063717.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Metabolic Bone Disease Unit, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rubin", 
        "givenName": "Mishaela", 
        "id": "sg:person.01321773732.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321773732.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Medicine Nephrology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nickolas", 
        "givenName": "Thomas", 
        "id": "sg:person.01026030225.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026030225.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chung", 
        "givenName": "Wendy", 
        "id": "sg:person.01334662250.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334662250.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Naomi Berrie Diabetes Center and Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeltser", 
        "givenName": "Lori M.", 
        "id": "sg:person.01241275353.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241275353.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9077, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "Kevin W.", 
        "id": "sg:person.013235203027.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235203027.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Albert Einstein College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.251993.5", 
          "name": [
            "Department of Medicine and Molecular Pharmacology, The Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pessin", 
        "givenName": "Jeffrey E.", 
        "id": "sg:person.0600160270.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600160270.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University", 
          "id": "https://www.grid.ac/institutes/grid.21729.3f", 
          "name": [
            "Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kousteni", 
        "givenName": "Stavroula", 
        "id": "sg:person.01261621423.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261621423.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2007.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003107469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2014.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003340383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.220409497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003453297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.05.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004362994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208265200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004436737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2011.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007414763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci64906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009402783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbmr.417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009904333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(02)00912-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010865332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s8756-3282(02)00912-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010865332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3249-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012155803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2006.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012753263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-1541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015086646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015586124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci39901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015586124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016531386", 
          "https://doi.org/10.1038/nature11705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-0007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017587613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018374665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2013.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2013.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018732341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.bjp.0707604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019900712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020693876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020693876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(90)90028-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021338506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021635244", 
          "https://doi.org/10.1038/nn.3737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.10100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022190578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024292763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmet.2016.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027378562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028318230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2012.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032271433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00429772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035963470", 
          "https://doi.org/10.1007/bf00429772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00429772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035963470", 
          "https://doi.org/10.1007/bf00429772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/75556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044135237", 
          "https://doi.org/10.1038/75556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81865-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044272952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.4011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044642330", 
          "https://doi.org/10.1038/nn.4011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2006.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047354547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048314480", 
          "https://doi.org/10.1038/27376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048314480", 
          "https://doi.org/10.1038/27376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107101200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048689163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049311228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050202015", 
          "https://doi.org/10.1038/nm.2290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2016.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050438049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.27.070203.144206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050469196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-1735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050645149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1054/npep.2002.0890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050934640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051124792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052352207", 
          "https://doi.org/10.1038/nn1455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052352207", 
          "https://doi.org/10.1038/nn1455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053410928", 
          "https://doi.org/10.1038/nature06098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.289.5487.2122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-2056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2005-0483", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074630049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-18-07143.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075328341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1979.237.3.e214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079974987"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-03", 
    "datePublishedReg": "2017-03-01", 
    "description": "Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here we identify, through molecular and genetic analyses in mice, lipocalin 2 (LCN2) as an osteoblast-enriched, secreted protein. Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity. In addition, osteoblast-derived LCN2 inhibits food intake. LCN2 crosses the blood-brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular and ventromedial neurons of the hypothalamus and activates an MC4R-dependent anorexigenic (appetite-suppressing) pathway. These results identify LCN2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature21697", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2495878", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4054766", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439029", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2464978", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441231", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438976", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2434813", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2464836", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3801460", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683177", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7645", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "543"
      }
    ], 
    "name": "MC4R-dependent suppression of appetite by bone-derived lipocalin 2", 
    "pagination": "385", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fcb9bbbba648f9531bb0652e347f5411b1cb49ff3357e442cf64caeb6455fae6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28273060"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature21697"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084128588"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature21697", 
      "https://app.dimensions.ai/details/publication/pub.1084128588"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118309_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature21697"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature21697'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature21697'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature21697'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature21697'


 

This table displays all metadata directly associated to this object as RDF triples.

478 TRIPLES      21 PREDICATES      100 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature21697 schema:about N05df39a2572f440ab5da29a9804e3112
2 N06aa314f30d54368a0dfaed26e8ad3ad
3 N165a030c37104459a283fc7580d9fc81
4 N39f5d62944a24661adaa8b3befda75a3
5 N3b15975e9c3c40b5a57262a035cfba81
6 N3d4d7e56f31c41478e5dd9cb7bbb12bb
7 N67a16469dfab4a909e468a86e42c4928
8 N6efaa8be3e954b03896f99d27874e47e
9 N732f107dca3749d5920d26544ca12cf7
10 N7bcf18d8a9bc423abedf0cdb076f3f0d
11 N7f595d27118e4133bede7965a25fbfa3
12 Na86bc4f4f69748efb910857b52bba4cc
13 Na8788744a70f4941bfd58b7ebfe82394
14 Na983f2a385e94bef9fcc99d68c62b49b
15 Nb12f7de200d345388595ff141b11d8db
16 Nbaad3e76d29743189d44a1133cd4f1b5
17 Nbf2268f4fae04b83a6416da3a37d502f
18 Nd37937b0c74849bc8df592587907f2ce
19 Nd688dd88a91f443b899d76d260fc38d1
20 Nf0a7ba647cb1450a81d7f04852b65d88
21 Nf1d643971049423cb21e9582deae6c45
22 Nf34127a363d449488e1b3064d17aad56
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N5c7de8aae14944cfbc66918c8d86fbbb
26 schema:citation sg:pub.10.1007/bf00429772
27 sg:pub.10.1038/27376
28 sg:pub.10.1038/75556
29 sg:pub.10.1038/nature06098
30 sg:pub.10.1038/nature11705
31 sg:pub.10.1038/nm.2290
32 sg:pub.10.1038/nn.3737
33 sg:pub.10.1038/nn.4011
34 sg:pub.10.1038/nn1455
35 https://app.dimensions.ai/details/publication/pub.1074630049
36 https://doi.org/10.1002/dvdy.10100
37 https://doi.org/10.1002/jbmr.417
38 https://doi.org/10.1016/0896-6273(90)90028-e
39 https://doi.org/10.1016/j.cell.2005.08.035
40 https://doi.org/10.1016/j.cell.2007.04.001
41 https://doi.org/10.1016/j.cell.2007.05.047
42 https://doi.org/10.1016/j.cell.2010.06.002
43 https://doi.org/10.1016/j.cell.2010.06.003
44 https://doi.org/10.1016/j.chembiol.2013.04.015
45 https://doi.org/10.1016/j.cmet.2006.01.004
46 https://doi.org/10.1016/j.cmet.2006.08.001
47 https://doi.org/10.1016/j.cmet.2011.02.005
48 https://doi.org/10.1016/j.cmet.2014.06.002
49 https://doi.org/10.1016/j.molmet.2016.05.005
50 https://doi.org/10.1016/j.neuron.2011.06.012
51 https://doi.org/10.1016/j.tem.2012.07.002
52 https://doi.org/10.1016/j.tem.2016.03.016
53 https://doi.org/10.1016/s0092-8674(00)81865-6
54 https://doi.org/10.1016/s8756-3282(02)00912-2
55 https://doi.org/10.1038/sj.bjp.0707604
56 https://doi.org/10.1054/npep.2002.0890
57 https://doi.org/10.1073/pnas.220409497
58 https://doi.org/10.1074/jbc.m107101200
59 https://doi.org/10.1074/jbc.m208265200
60 https://doi.org/10.1126/science.289.5487.2122
61 https://doi.org/10.1146/annurev.neuro.27.070203.144206
62 https://doi.org/10.1152/ajpendo.1979.237.3.e214
63 https://doi.org/10.1172/jci24445
64 https://doi.org/10.1172/jci39901
65 https://doi.org/10.1172/jci64906
66 https://doi.org/10.1210/jc.2004-0428
67 https://doi.org/10.1210/jc.2004-0497
68 https://doi.org/10.1210/jc.2005-2056
69 https://doi.org/10.1210/me.2005-0483
70 https://doi.org/10.1523/jneurosci.23-18-07143.2003
71 https://doi.org/10.1523/jneurosci.3249-08.2009
72 https://doi.org/10.2337/db07-0007
73 https://doi.org/10.2337/db09-1541
74 https://doi.org/10.2337/db09-1735
75 schema:datePublished 2017-03
76 schema:datePublishedReg 2017-03-01
77 schema:description Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here we identify, through molecular and genetic analyses in mice, lipocalin 2 (LCN2) as an osteoblast-enriched, secreted protein. Loss- and gain-of-function experiments in mice demonstrate that osteoblast-derived LCN2 maintains glucose homeostasis by inducing insulin secretion and improves glucose tolerance and insulin sensitivity. In addition, osteoblast-derived LCN2 inhibits food intake. LCN2 crosses the blood-brain barrier, binds to the melanocortin 4 receptor (MC4R) in the paraventricular and ventromedial neurons of the hypothalamus and activates an MC4R-dependent anorexigenic (appetite-suppressing) pathway. These results identify LCN2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R-dependent manner, and show that the control of appetite is an endocrine function of bone.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree false
81 schema:isPartOf N61630c14dc8f4cc6bee21c1033c63c7d
82 Nf72ed3d605304a5681a29f8e98d8d208
83 sg:journal.1018957
84 schema:name MC4R-dependent suppression of appetite by bone-derived lipocalin 2
85 schema:pagination 385
86 schema:productId N056d7f3557ae4fb591be9d70630cdf14
87 N9c4cef36dc4d4c629e1011163fb215d3
88 Na713fd30f8854dbaa85ea5f1183e046e
89 Nb9739443b904469aa832c7b886a62d1a
90 Nf7e446e9bfad44c6b30df9e177a2df4a
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084128588
92 https://doi.org/10.1038/nature21697
93 schema:sdDatePublished 2019-04-11T12:04
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Ndabcb4d87d814ce7a64a6fbd79c76fb9
96 schema:url https://www.nature.com/articles/nature21697
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N056d7f3557ae4fb591be9d70630cdf14 schema:name readcube_id
101 schema:value fcb9bbbba648f9531bb0652e347f5411b1cb49ff3357e442cf64caeb6455fae6
102 rdf:type schema:PropertyValue
103 N05df39a2572f440ab5da29a9804e3112 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Osteoblasts
105 rdf:type schema:DefinedTerm
106 N06aa314f30d54368a0dfaed26e8ad3ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Thinness
108 rdf:type schema:DefinedTerm
109 N165a030c37104459a283fc7580d9fc81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Insulin
111 rdf:type schema:DefinedTerm
112 N193e3eff97d94168bce3852151f8e185 rdf:first sg:person.0600160270.15
113 rdf:rest Ncf16b933a9204b2da7f9a32fe4dadf1e
114 N216998cc86604e27a2b56c1befb55338 rdf:first sg:person.010043244725.33
115 rdf:rest N32ff31574fd4476fafeed39c9f228ea4
116 N32ff31574fd4476fafeed39c9f228ea4 rdf:first sg:person.01321316116.14
117 rdf:rest N550f9b39fe9b4fc68541f110f2157e79
118 N34bc7c8cc68d4d1187233ce9a1d4ea0f rdf:first sg:person.014305171067.37
119 rdf:rest N7599273d924a47e08113349a17a156d2
120 N35130e69991d48838f80afe4594a3834 rdf:first sg:person.0606035033.61
121 rdf:rest Ncc23cbba88b540ad8f35a48a7a5fc6ce
122 N39f5d62944a24661adaa8b3befda75a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Paraventricular Hypothalamic Nucleus
124 rdf:type schema:DefinedTerm
125 N3b15975e9c3c40b5a57262a035cfba81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 N3d4d7e56f31c41478e5dd9cb7bbb12bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N492d07b705fc4942a61853c424d25122 rdf:first sg:person.013235203027.23
132 rdf:rest N193e3eff97d94168bce3852151f8e185
133 N550f9b39fe9b4fc68541f110f2157e79 rdf:first sg:person.01070164536.06
134 rdf:rest N8854fd2b3b46426ba5d4a6f1053adbf7
135 N5c7de8aae14944cfbc66918c8d86fbbb rdf:first sg:person.0745513777.32
136 rdf:rest N34bc7c8cc68d4d1187233ce9a1d4ea0f
137 N61630c14dc8f4cc6bee21c1033c63c7d schema:volumeNumber 543
138 rdf:type schema:PublicationVolume
139 N67a16469dfab4a909e468a86e42c4928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Bone and Bones
141 rdf:type schema:DefinedTerm
142 N6efaa8be3e954b03896f99d27874e47e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Animals
144 rdf:type schema:DefinedTerm
145 N732f107dca3749d5920d26544ca12cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Eating
147 rdf:type schema:DefinedTerm
148 N7599273d924a47e08113349a17a156d2 rdf:first sg:person.01270171762.15
149 rdf:rest Nfdb9722bbb61410cb246bc6bd4009c8c
150 N7bcf18d8a9bc423abedf0cdb076f3f0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Obesity
152 rdf:type schema:DefinedTerm
153 N7f595d27118e4133bede7965a25fbfa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Insulin Secretion
155 rdf:type schema:DefinedTerm
156 N8854fd2b3b46426ba5d4a6f1053adbf7 rdf:first sg:person.0634104106.31
157 rdf:rest Ncbaf9999724b47e6968975175e2e2be2
158 N93ba1e239ae348149ed9ffce649258d2 rdf:first sg:person.01321773732.19
159 rdf:rest N9847100d381643e28fea0b1cdf186084
160 N9847100d381643e28fea0b1cdf186084 rdf:first sg:person.01026030225.99
161 rdf:rest Nd7af4d4e92834c4a97d845f8cc80e26f
162 N9c4cef36dc4d4c629e1011163fb215d3 schema:name nlm_unique_id
163 schema:value 0410462
164 rdf:type schema:PropertyValue
165 Na713fd30f8854dbaa85ea5f1183e046e schema:name pubmed_id
166 schema:value 28273060
167 rdf:type schema:PropertyValue
168 Na86bc4f4f69748efb910857b52bba4cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cyclic AMP
170 rdf:type schema:DefinedTerm
171 Na8788744a70f4941bfd58b7ebfe82394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Insulin Resistance
173 rdf:type schema:DefinedTerm
174 Na983f2a385e94bef9fcc99d68c62b49b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Neurons
176 rdf:type schema:DefinedTerm
177 Na9a39be7a79f47e0b9034aad46b1daf7 rdf:first sg:person.01241275353.35
178 rdf:rest N492d07b705fc4942a61853c424d25122
179 Nb12f7de200d345388595ff141b11d8db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Male
181 rdf:type schema:DefinedTerm
182 Nb9739443b904469aa832c7b886a62d1a schema:name dimensions_id
183 schema:value pub.1084128588
184 rdf:type schema:PropertyValue
185 Nbaad3e76d29743189d44a1133cd4f1b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Homeostasis
187 rdf:type schema:DefinedTerm
188 Nbf2268f4fae04b83a6416da3a37d502f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Appetite Regulation
190 rdf:type schema:DefinedTerm
191 Ncbaf9999724b47e6968975175e2e2be2 rdf:first sg:person.01166363311.71
192 rdf:rest N35130e69991d48838f80afe4594a3834
193 Ncc23cbba88b540ad8f35a48a7a5fc6ce rdf:first sg:person.011210063717.15
194 rdf:rest N93ba1e239ae348149ed9ffce649258d2
195 Ncf16b933a9204b2da7f9a32fe4dadf1e rdf:first sg:person.01261621423.86
196 rdf:rest rdf:nil
197 Nd37937b0c74849bc8df592587907f2ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Lipocalin-2
199 rdf:type schema:DefinedTerm
200 Nd688dd88a91f443b899d76d260fc38d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Receptor, Melanocortin, Type 4
202 rdf:type schema:DefinedTerm
203 Nd7af4d4e92834c4a97d845f8cc80e26f rdf:first sg:person.01334662250.43
204 rdf:rest Na9a39be7a79f47e0b9034aad46b1daf7
205 Ndabcb4d87d814ce7a64a6fbd79c76fb9 schema:name Springer Nature - SN SciGraph project
206 rdf:type schema:Organization
207 Ne9f35bc7db574378a855e6d513c41c13 rdf:first sg:person.010640625325.92
208 rdf:rest N216998cc86604e27a2b56c1befb55338
209 Nf0a7ba647cb1450a81d7f04852b65d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Hypothalamus
211 rdf:type schema:DefinedTerm
212 Nf1d643971049423cb21e9582deae6c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Blood-Brain Barrier
214 rdf:type schema:DefinedTerm
215 Nf34127a363d449488e1b3064d17aad56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Glucose
217 rdf:type schema:DefinedTerm
218 Nf72ed3d605304a5681a29f8e98d8d208 schema:issueNumber 7645
219 rdf:type schema:PublicationIssue
220 Nf7e446e9bfad44c6b30df9e177a2df4a schema:name doi
221 schema:value 10.1038/nature21697
222 rdf:type schema:PropertyValue
223 Nfdb9722bbb61410cb246bc6bd4009c8c rdf:first sg:person.0743563314.23
224 rdf:rest Nfe5af1dc6e044e9d93db4b097eb6fc2a
225 Nfe5af1dc6e044e9d93db4b097eb6fc2a rdf:first sg:person.01364360215.71
226 rdf:rest Ne9f35bc7db574378a855e6d513c41c13
227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medical and Health Sciences
229 rdf:type schema:DefinedTerm
230 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
231 schema:name Clinical Sciences
232 rdf:type schema:DefinedTerm
233 sg:grant.2434813 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
234 rdf:type schema:MonetaryGrant
235 sg:grant.2438976 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
236 rdf:type schema:MonetaryGrant
237 sg:grant.2439029 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
238 rdf:type schema:MonetaryGrant
239 sg:grant.2441231 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
240 rdf:type schema:MonetaryGrant
241 sg:grant.2464836 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
242 rdf:type schema:MonetaryGrant
243 sg:grant.2464978 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
244 rdf:type schema:MonetaryGrant
245 sg:grant.2495878 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
246 rdf:type schema:MonetaryGrant
247 sg:grant.2683177 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
248 rdf:type schema:MonetaryGrant
249 sg:grant.3801460 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
250 rdf:type schema:MonetaryGrant
251 sg:grant.4054766 http://pending.schema.org/fundedItem sg:pub.10.1038/nature21697
252 rdf:type schema:MonetaryGrant
253 sg:journal.1018957 schema:issn 0090-0028
254 1476-4687
255 schema:name Nature
256 rdf:type schema:Periodical
257 sg:person.010043244725.33 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
258 schema:familyName Huang
259 schema:givenName Yiru
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010043244725.33
261 rdf:type schema:Person
262 sg:person.01026030225.99 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
263 schema:familyName Nickolas
264 schema:givenName Thomas
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026030225.99
266 rdf:type schema:Person
267 sg:person.010640625325.92 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
268 schema:familyName He
269 schema:givenName Zhenyan
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640625325.92
271 rdf:type schema:Person
272 sg:person.01070164536.06 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
273 schema:familyName Friedman
274 schema:givenName Richard A.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070164536.06
276 rdf:type schema:Person
277 sg:person.011210063717.15 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
278 schema:familyName Leibel
279 schema:givenName Rudolph L.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011210063717.15
281 rdf:type schema:Person
282 sg:person.01166363311.71 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
283 schema:familyName Lanzano
284 schema:givenName Patricia
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166363311.71
286 rdf:type schema:Person
287 sg:person.01241275353.35 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
288 schema:familyName Zeltser
289 schema:givenName Lori M.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241275353.35
291 rdf:type schema:Person
292 sg:person.01261621423.86 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
293 schema:familyName Kousteni
294 schema:givenName Stavroula
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261621423.86
296 rdf:type schema:Person
297 sg:person.01270171762.15 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
298 schema:familyName Liu
299 schema:givenName Jian-Min
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270171762.15
301 rdf:type schema:Person
302 sg:person.01321316116.14 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
303 schema:familyName Zong
304 schema:givenName Haihong
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321316116.14
306 rdf:type schema:Person
307 sg:person.01321773732.19 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
308 schema:familyName Rubin
309 schema:givenName Mishaela
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321773732.19
311 rdf:type schema:Person
312 sg:person.013235203027.23 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
313 schema:familyName Williams
314 schema:givenName Kevin W.
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013235203027.23
316 rdf:type schema:Person
317 sg:person.01334662250.43 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
318 schema:familyName Chung
319 schema:givenName Wendy
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334662250.43
321 rdf:type schema:Person
322 sg:person.01364360215.71 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
323 schema:familyName Luo
324 schema:givenName Na
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364360215.71
326 rdf:type schema:Person
327 sg:person.014305171067.37 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
328 schema:familyName Shikhel
329 schema:givenName Steven
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305171067.37
331 rdf:type schema:Person
332 sg:person.0600160270.15 schema:affiliation https://www.grid.ac/institutes/grid.251993.5
333 schema:familyName Pessin
334 schema:givenName Jeffrey E.
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600160270.15
336 rdf:type schema:Person
337 sg:person.0606035033.61 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
338 schema:familyName Deng
339 schema:givenName Liyong
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606035033.61
341 rdf:type schema:Person
342 sg:person.0634104106.31 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
343 schema:familyName Barasch
344 schema:givenName Jonathan
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634104106.31
346 rdf:type schema:Person
347 sg:person.0743563314.23 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
348 schema:familyName Maurizi
349 schema:givenName Antonio
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743563314.23
351 rdf:type schema:Person
352 sg:person.0745513777.32 schema:affiliation https://www.grid.ac/institutes/grid.21729.3f
353 schema:familyName Mosialou
354 schema:givenName Ioanna
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745513777.32
356 rdf:type schema:Person
357 sg:pub.10.1007/bf00429772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035963470
358 https://doi.org/10.1007/bf00429772
359 rdf:type schema:CreativeWork
360 sg:pub.10.1038/27376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048314480
361 https://doi.org/10.1038/27376
362 rdf:type schema:CreativeWork
363 sg:pub.10.1038/75556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044135237
364 https://doi.org/10.1038/75556
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/nature06098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053410928
367 https://doi.org/10.1038/nature06098
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/nature11705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016531386
370 https://doi.org/10.1038/nature11705
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/nm.2290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050202015
373 https://doi.org/10.1038/nm.2290
374 rdf:type schema:CreativeWork
375 sg:pub.10.1038/nn.3737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021635244
376 https://doi.org/10.1038/nn.3737
377 rdf:type schema:CreativeWork
378 sg:pub.10.1038/nn.4011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044642330
379 https://doi.org/10.1038/nn.4011
380 rdf:type schema:CreativeWork
381 sg:pub.10.1038/nn1455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052352207
382 https://doi.org/10.1038/nn1455
383 rdf:type schema:CreativeWork
384 https://app.dimensions.ai/details/publication/pub.1074630049 schema:CreativeWork
385 https://doi.org/10.1002/dvdy.10100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022190578
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1002/jbmr.417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009904333
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/0896-6273(90)90028-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1021338506
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1016/j.cell.2005.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020693876
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/j.cell.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003107469
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/j.cell.2007.05.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004362994
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/j.cell.2010.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028318230
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/j.cell.2010.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051124792
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1016/j.chembiol.2013.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018732341
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/j.cmet.2006.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047354547
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/j.cmet.2006.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012753263
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/j.cmet.2011.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007414763
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/j.cmet.2014.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003340383
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1016/j.molmet.2016.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027378562
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/j.neuron.2011.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024292763
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1016/j.tem.2012.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032271433
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1016/j.tem.2016.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050438049
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1016/s0092-8674(00)81865-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044272952
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1016/s8756-3282(02)00912-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010865332
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1038/sj.bjp.0707604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019900712
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1054/npep.2002.0890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050934640
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1073/pnas.220409497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003453297
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1074/jbc.m107101200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689163
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1074/jbc.m208265200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004436737
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1126/science.289.5487.2122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571004
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1146/annurev.neuro.27.070203.144206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050469196
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1152/ajpendo.1979.237.3.e214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079974987
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1172/jci24445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049311228
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1172/jci39901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015586124
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1172/jci64906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009402783
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1210/jc.2004-0428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287773
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1210/jc.2004-0497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018374665
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1210/jc.2005-2056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288821
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1210/me.2005-0483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327643
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1523/jneurosci.23-18-07143.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075328341
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1523/jneurosci.3249-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012155803
456 rdf:type schema:CreativeWork
457 https://doi.org/10.2337/db07-0007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017587613
458 rdf:type schema:CreativeWork
459 https://doi.org/10.2337/db09-1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015086646
460 rdf:type schema:CreativeWork
461 https://doi.org/10.2337/db09-1735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050645149
462 rdf:type schema:CreativeWork
463 https://www.grid.ac/institutes/grid.21729.3f schema:alternateName Columbia University
464 schema:name Biomedical Informatics Shared Resource, Department of Biomedical Informatics, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
465 Department of Medicine Nephrology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
466 Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
467 Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
468 Metabolic Bone Disease Unit, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
469 Naomi Berrie Diabetes Center and Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
470 Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
471 rdf:type schema:Organization
472 https://www.grid.ac/institutes/grid.251993.5 schema:alternateName Albert Einstein College of Medicine
473 schema:name Department of Medicine and Molecular Pharmacology, The Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
474 rdf:type schema:Organization
475 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
476 schema:name Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China
477 Division of Hypothalamic Research, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9077, USA
478 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...