Targeting metastasis-initiating cells through the fatty acid receptor CD36 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Gloria Pascual, Alexandra Avgustinova, Stefania Mejetta, Mercè Martín, Andrés Castellanos, Camille Stephan-Otto Attolini, Antoni Berenguer, Neus Prats, Agustí Toll, Juan Antonio Hueto, Coro Bescós, Luciano Di Croce, Salvador Aznar Benitah

ABSTRACT

The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis. More... »

PAGES

41

References to SciGraph publications

  • 2014-08. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis in NATURE CELL BIOLOGY
  • 2004-08. Lipid metabolic enzymes: emerging drug targets for the treatment of obesity in NATURE REVIEWS DRUG DISCOVERY
  • 2014-09. Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S in NATURE CELL BIOLOGY
  • 2005-12. Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration in NATURE MEDICINE
  • 2012-06. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET in NATURE MEDICINE
  • 2014-03. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells in NATURE
  • 2009. Isolation and Culture of Epithelial Stem Cells in STEM CELLS IN REGENERATIVE MEDICINE
  • 2006-05. Fibroblasts in cancer in NATURE REVIEWS CANCER
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
  • 2013-12. VEGF targets the tumour cell in NATURE REVIEWS CANCER
  • 2015-11. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer in NATURE
  • 2015-12-09. Neutrophils support lung colonization of metastasis-initiating breast cancer cells in NATURE
  • 2015-04. Therapy-induced tumour secretomes promote resistance and tumour progression in NATURE
  • 2011-07. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs in NATURE MEDICINE
  • 2015-12. Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma in SCIENTIFIC REPORTS
  • 2011-11. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth in NATURE MEDICINE
  • 2016-05. Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers in SCIENTIFIC REPORTS
  • 2015-11. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance in NATURE
  • 2015-09. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells in NATURE
  • 2004-09. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature20791

    DOI

    http://dx.doi.org/10.1038/nature20791

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038744247

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27974793


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Neutralizing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD36 Antigens", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Fat", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hyaluronan Receptors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipid Metabolism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mouth Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplastic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Palmitic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Penetrance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pascual", 
            "givenName": "Gloria", 
            "id": "sg:person.01100327144.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100327144.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Avgustinova", 
            "givenName": "Alexandra", 
            "id": "sg:person.01272722721.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272722721.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Genomic Regulation", 
              "id": "https://www.grid.ac/institutes/grid.11478.3b", 
              "name": [
                "Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mejetta", 
            "givenName": "Stefania", 
            "id": "sg:person.0663266606.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663266606.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mart\u00edn", 
            "givenName": "Merc\u00e8", 
            "id": "sg:person.014340474165.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014340474165.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castellanos", 
            "givenName": "Andr\u00e9s", 
            "id": "sg:person.015136054565.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015136054565.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Attolini", 
            "givenName": "Camille Stephan-Otto", 
            "id": "sg:person.01326675511.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326675511.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berenguer", 
            "givenName": "Antoni", 
            "id": "sg:person.0660606757.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660606757.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Research in Biomedicine", 
              "id": "https://www.grid.ac/institutes/grid.7722.0", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prats", 
            "givenName": "Neus", 
            "id": "sg:person.01147621564.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147621564.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Del Mar", 
              "id": "https://www.grid.ac/institutes/grid.411142.3", 
              "name": [
                "IMIM, Department of Dermatology, Hospital del Mar, 08003 Barcelona"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toll", 
            "givenName": "Agust\u00ed", 
            "id": "sg:person.01124215277.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124215277.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Vall D\u00b4Hebron Hospital, Barcelona, Department of Oral and Maxillofacial Surgery, Universitat Aut\u00f2noma de Barcelona, Barcelona 08035 Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hueto", 
            "givenName": "Juan Antonio", 
            "id": "sg:person.011420705365.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011420705365.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitari Vall d'Hebron", 
              "id": "https://www.grid.ac/institutes/grid.411083.f", 
              "name": [
                "Vall D\u00b4Hebron Hospital, Barcelona, Department of Oral and Maxillofacial Surgery, Universitat Aut\u00f2noma de Barcelona, Barcelona 08035 Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Besc\u00f3s", 
            "givenName": "Coro", 
            "id": "sg:person.01214401165.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214401165.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pompeu Fabra University", 
              "id": "https://www.grid.ac/institutes/grid.5612.0", 
              "name": [
                "Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain", 
                "Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain", 
                "Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Di Croce", 
            "givenName": "Luciano", 
            "id": "sg:person.01134151165.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134151165.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats", 
              "id": "https://www.grid.ac/institutes/grid.425902.8", 
              "name": [
                "Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain", 
                "Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benitah", 
            "givenName": "Salvador Aznar", 
            "id": "sg:person.0706366706.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706366706.20"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/cyto.a.22434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000033410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.08.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000675028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.08.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000675028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jeb.047050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002483946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1771409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005293613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.38.26761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007064883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007708594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2014.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007977070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0029974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008043071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0029974", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008043071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-060-7_14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009387416", 
              "https://doi.org/10.1007/978-1-59745-060-7_14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-59745-060-7_14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009387416", 
              "https://doi.org/10.1007/978-1-59745-060-7_14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/biom2030389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010910684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011267322", 
              "https://doi.org/10.1038/nrc3627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011388399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0095", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011831914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012670260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013664882", 
              "https://doi.org/10.1038/nm.2492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016583334", 
              "https://doi.org/10.1038/nm.2753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017815588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018457673", 
              "https://doi.org/10.1186/gb-2004-5-10-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018771504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1167/iovs.05-1656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019037788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(06)11019-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019893733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2010.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020531681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021370605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00003.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021613349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.01.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021648733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024601516", 
              "https://doi.org/10.1038/nrd1469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024601516", 
              "https://doi.org/10.1038/nrd1469"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024942368", 
              "https://doi.org/10.1038/nature11412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.11.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024981859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2011/598358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025573856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025946880", 
              "https://doi.org/10.1038/nature14897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.04.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025956150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1203543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027317432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djv256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028344387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028965943", 
              "https://doi.org/10.1038/nature16064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.113.301523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029133404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.113.301523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029133404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci59218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031381862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.d500037-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031764332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jim.2009.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032716417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2004088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033807182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034420089", 
              "https://doi.org/10.1038/nm1336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034420089", 
              "https://doi.org/10.1038/nm1336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m003826200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036166338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036672274", 
              "https://doi.org/10.1038/nrc1877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036672274", 
              "https://doi.org/10.1038/nrc1877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep18669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036810713", 
              "https://doi.org/10.1038/srep18669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-1059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037007489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037543114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.01.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041022453", 
              "https://doi.org/10.1038/ncb3015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-nutr-071812-161220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042853682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0610117104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044178395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0014418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044306517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044677141", 
              "https://doi.org/10.1038/nature14336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.08.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044875310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045603885", 
              "https://doi.org/10.1038/nature15748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045846495", 
              "https://doi.org/10.1038/nature16140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047391109", 
              "https://doi.org/10.1038/ncb3011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047605946", 
              "https://doi.org/10.1038/nm.2379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.07.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048661024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0714.2007.00617.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049738716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0714.2007.00617.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049738716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2012.03.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051219389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btg363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051276435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051340125", 
              "https://doi.org/10.1038/nature12998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.1716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051634991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep14752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053379220", 
              "https://doi.org/10.1038/srep14752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/met.2011.0003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059298719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.00145.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063191797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074984093", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-01", 
        "datePublishedReg": "2017-01-01", 
        "description": "The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature20791", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3784783", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5148386", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7635", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "541"
          }
        ], 
        "name": "Targeting metastasis-initiating cells through the fatty acid receptor CD36", 
        "pagination": "41", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b88f97f271d01406ef9740dcfea786e7c6019b3e2afa2a2a24767b6b0eb81bd7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27974793"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature20791"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038744247"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature20791", 
          "https://app.dimensions.ai/details/publication/pub.1038744247"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature20791"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature20791'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature20791'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature20791'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature20791'


     

    This table displays all metadata directly associated to this object as RDF triples.

    483 TRIPLES      21 PREDICATES      118 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature20791 schema:about N061ad2681c504cbfb2faa407f952bcee
    2 N1264c6edd4724d84a4a7d8ad27faf46a
    3 N2003c13812a846f8aa330668b1f71163
    4 N336792ead59a47f3bd4cc9db41e755a1
    5 N3e3031e8408c42b8bdc610c06d00b550
    6 N47990653d5274273a48f014e5aa6b47b
    7 N75c8ee9978764c1685cfef3f0e391702
    8 N7699e602d0814512b1a619a33a5546d9
    9 N7ec6d64a3b854a0cb6f49f025ce2de18
    10 N81d8fd91cd1b48e5ac27fb9b12819c35
    11 Na7f589ce0f7b43a380c1c20e3cc283de
    12 Nb355ccda16e14e0a9c6da8bd566a7d46
    13 Nb3f9036524f4489b812895730f7daf38
    14 Nb43a987cf0a9489baa2f68f2fcaed820
    15 Nbdc4f68d0b73425697c4ccdc27d42be8
    16 Ne278ae0ec56a468488dc6a87688141bf
    17 Ne84fdd2423f14cfa94ab30815ef705dd
    18 Ne8602b806df643d1a7fa90da34cdea38
    19 Nec53f5d645854ae5aa5bc891f3d37066
    20 Nf497c3bb16a14d28a5c68d571b322287
    21 Nf67119bc7e844d5e852b517f82ac45e3
    22 Nfc9c8332981c471a92c638d799f50152
    23 anzsrc-for:11
    24 anzsrc-for:1112
    25 schema:author N3b47f7e616cb46f4b25404b72f5bddfb
    26 schema:citation sg:pub.10.1007/978-1-59745-060-7_14
    27 sg:pub.10.1038/nature11412
    28 sg:pub.10.1038/nature12998
    29 sg:pub.10.1038/nature14336
    30 sg:pub.10.1038/nature14897
    31 sg:pub.10.1038/nature15748
    32 sg:pub.10.1038/nature16064
    33 sg:pub.10.1038/nature16140
    34 sg:pub.10.1038/ncb3011
    35 sg:pub.10.1038/ncb3015
    36 sg:pub.10.1038/nm.2379
    37 sg:pub.10.1038/nm.2492
    38 sg:pub.10.1038/nm.2753
    39 sg:pub.10.1038/nm1336
    40 sg:pub.10.1038/nrc1877
    41 sg:pub.10.1038/nrc3627
    42 sg:pub.10.1038/nrd1469
    43 sg:pub.10.1038/srep14752
    44 sg:pub.10.1038/srep18669
    45 sg:pub.10.1186/gb-2004-5-10-r80
    46 https://app.dimensions.ai/details/publication/pub.1074984093
    47 https://doi.org/10.1002/cyto.a.22434
    48 https://doi.org/10.1002/stem.1716
    49 https://doi.org/10.1016/j.ccr.2011.08.025
    50 https://doi.org/10.1016/j.ccr.2011.11.002
    51 https://doi.org/10.1016/j.ccr.2012.08.013
    52 https://doi.org/10.1016/j.ccr.2014.03.007
    53 https://doi.org/10.1016/j.cell.2009.12.007
    54 https://doi.org/10.1016/j.cell.2010.04.020
    55 https://doi.org/10.1016/j.cell.2013.07.036
    56 https://doi.org/10.1016/j.cell.2014.01.040
    57 https://doi.org/10.1016/j.cell.2015.01.043
    58 https://doi.org/10.1016/j.cell.2015.04.042
    59 https://doi.org/10.1016/j.celrep.2014.08.062
    60 https://doi.org/10.1016/j.celrep.2015.11.025
    61 https://doi.org/10.1016/j.cmet.2010.05.012
    62 https://doi.org/10.1016/j.jim.2009.06.008
    63 https://doi.org/10.1016/j.stem.2012.03.009
    64 https://doi.org/10.1016/j.stem.2014.02.002
    65 https://doi.org/10.1016/s0076-6879(06)11019-8
    66 https://doi.org/10.1073/pnas.0506580102
    67 https://doi.org/10.1073/pnas.0610117104
    68 https://doi.org/10.1074/jbc.274.38.26761
    69 https://doi.org/10.1074/jbc.m003826200
    70 https://doi.org/10.1089/met.2011.0003
    71 https://doi.org/10.1093/bioinformatics/btg363
    72 https://doi.org/10.1093/biostatistics/4.2.249
    73 https://doi.org/10.1093/jnci/djv256
    74 https://doi.org/10.1101/gad.1771409
    75 https://doi.org/10.1111/j.1600-0714.2007.00617.x
    76 https://doi.org/10.1126/science.1203543
    77 https://doi.org/10.1126/scisignal.2004088
    78 https://doi.org/10.1146/annurev-nutr-071812-161220
    79 https://doi.org/10.1152/ajpcell.00145.2015
    80 https://doi.org/10.1152/physrev.00003.2009
    81 https://doi.org/10.1155/2011/598358
    82 https://doi.org/10.1158/0008-5472.can-11-1059
    83 https://doi.org/10.1158/1078-0432.ccr-07-4615
    84 https://doi.org/10.1158/2159-8290.cd-12-0095
    85 https://doi.org/10.1161/atvbaha.113.301523
    86 https://doi.org/10.1167/iovs.05-1656
    87 https://doi.org/10.1172/jci59218
    88 https://doi.org/10.1194/jlr.d500037-jlr200
    89 https://doi.org/10.1242/jeb.047050
    90 https://doi.org/10.1371/journal.pone.0014418
    91 https://doi.org/10.1371/journal.pone.0029974
    92 https://doi.org/10.3390/biom2030389
    93 schema:datePublished 2017-01
    94 schema:datePublishedReg 2017-01-01
    95 schema:description The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44<sup>bright</sup> cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36<sup>+</sup> metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36<sup>+</sup> metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.
    96 schema:genre research_article
    97 schema:inLanguage en
    98 schema:isAccessibleForFree false
    99 schema:isPartOf N19b7d3c6f5df47a99a9f0a067a701d44
    100 N724d5c0229ef430890d6f7d26b48e24e
    101 sg:journal.1018957
    102 schema:name Targeting metastasis-initiating cells through the fatty acid receptor CD36
    103 schema:pagination 41
    104 schema:productId N59a18f4e07a14510b7070f70facd09b1
    105 N75c060b9e8a343a1836d25f45f0804bb
    106 N84d28bfc10344753b76e52a7d6f99662
    107 N9397decfbab54e3bae3d905e078de6b8
    108 Ne8fac9f1ed1b45599b45fa48dc76ff81
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038744247
    110 https://doi.org/10.1038/nature20791
    111 schema:sdDatePublished 2019-04-10T19:45
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher Nc8546b6b5e424b44a04b25da1e5033ec
    114 schema:url https://www.nature.com/articles/nature20791
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0112f82029a94b8f9ce40737f743076e rdf:first sg:person.01134151165.72
    119 rdf:rest N3ac47072773643dcad0a8b4ba5188d44
    120 N061ad2681c504cbfb2faa407f952bcee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Xenograft Model Antitumor Assays
    122 rdf:type schema:DefinedTerm
    123 N10fe6dfd22284691a7f0fb92f379b3c1 rdf:first sg:person.01326675511.38
    124 rdf:rest N42561ba51af24f84a2f97e4b8d68374d
    125 N1264c6edd4724d84a4a7d8ad27faf46a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Lipid Metabolism
    127 rdf:type schema:DefinedTerm
    128 N19b7d3c6f5df47a99a9f0a067a701d44 schema:volumeNumber 541
    129 rdf:type schema:PublicationVolume
    130 N1d22c35302bd4be28f37094923f0c0d2 rdf:first sg:person.01214401165.66
    131 rdf:rest N0112f82029a94b8f9ce40737f743076e
    132 N2003c13812a846f8aa330668b1f71163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Antibodies, Neutralizing
    134 rdf:type schema:DefinedTerm
    135 N336792ead59a47f3bd4cc9db41e755a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Animals
    137 rdf:type schema:DefinedTerm
    138 N3ac47072773643dcad0a8b4ba5188d44 rdf:first sg:person.0706366706.20
    139 rdf:rest rdf:nil
    140 N3b47f7e616cb46f4b25404b72f5bddfb rdf:first sg:person.01100327144.79
    141 rdf:rest N76c94286c466471f9a7cf41c7d13660c
    142 N3e3031e8408c42b8bdc610c06d00b550 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Palmitic Acid
    144 rdf:type schema:DefinedTerm
    145 N42561ba51af24f84a2f97e4b8d68374d rdf:first sg:person.0660606757.21
    146 rdf:rest N9e183f9f7cab48588fd4ef7fbf47b499
    147 N47990653d5274273a48f014e5aa6b47b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Humans
    149 rdf:type schema:DefinedTerm
    150 N59a18f4e07a14510b7070f70facd09b1 schema:name nlm_unique_id
    151 schema:value 0410462
    152 rdf:type schema:PropertyValue
    153 N61e199680f2f4ced8e57b3666d111e71 rdf:first sg:person.0663266606.24
    154 rdf:rest N86d8503355fa480a83c8e16df8c27d27
    155 N724d5c0229ef430890d6f7d26b48e24e schema:issueNumber 7635
    156 rdf:type schema:PublicationIssue
    157 N75c060b9e8a343a1836d25f45f0804bb schema:name dimensions_id
    158 schema:value pub.1038744247
    159 rdf:type schema:PropertyValue
    160 N75c8ee9978764c1685cfef3f0e391702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Transcriptome
    162 rdf:type schema:DefinedTerm
    163 N7699e602d0814512b1a619a33a5546d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Penetrance
    165 rdf:type schema:DefinedTerm
    166 N76c94286c466471f9a7cf41c7d13660c rdf:first sg:person.01272722721.25
    167 rdf:rest N61e199680f2f4ced8e57b3666d111e71
    168 N7ec6d64a3b854a0cb6f49f025ce2de18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Lymphatic Metastasis
    170 rdf:type schema:DefinedTerm
    171 N81d8fd91cd1b48e5ac27fb9b12819c35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Cell Proliferation
    173 rdf:type schema:DefinedTerm
    174 N81e802e3155b4e40bd3e45e0fa13722f rdf:first sg:person.01124215277.61
    175 rdf:rest Nc9de9a56ee854b5b9d3242fc60ec6727
    176 N84d28bfc10344753b76e52a7d6f99662 schema:name pubmed_id
    177 schema:value 27974793
    178 rdf:type schema:PropertyValue
    179 N86d8503355fa480a83c8e16df8c27d27 rdf:first sg:person.014340474165.88
    180 rdf:rest Nf824124fb42f400d941433cb187014dc
    181 N9397decfbab54e3bae3d905e078de6b8 schema:name doi
    182 schema:value 10.1038/nature20791
    183 rdf:type schema:PropertyValue
    184 N9e183f9f7cab48588fd4ef7fbf47b499 rdf:first sg:person.01147621564.03
    185 rdf:rest N81e802e3155b4e40bd3e45e0fa13722f
    186 Na7f589ce0f7b43a380c1c20e3cc283de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name CD36 Antigens
    188 rdf:type schema:DefinedTerm
    189 Nb355ccda16e14e0a9c6da8bd566a7d46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Mouth Neoplasms
    191 rdf:type schema:DefinedTerm
    192 Nb3f9036524f4489b812895730f7daf38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Neoplasm Metastasis
    194 rdf:type schema:DefinedTerm
    195 Nb43a987cf0a9489baa2f68f2fcaed820 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Female
    197 rdf:type schema:DefinedTerm
    198 Nbdc4f68d0b73425697c4ccdc27d42be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Mice
    200 rdf:type schema:DefinedTerm
    201 Nc8546b6b5e424b44a04b25da1e5033ec schema:name Springer Nature - SN SciGraph project
    202 rdf:type schema:Organization
    203 Nc9de9a56ee854b5b9d3242fc60ec6727 rdf:first sg:person.011420705365.39
    204 rdf:rest N1d22c35302bd4be28f37094923f0c0d2
    205 Ne278ae0ec56a468488dc6a87688141bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Gene Expression Regulation, Neoplastic
    207 rdf:type schema:DefinedTerm
    208 Ne84fdd2423f14cfa94ab30815ef705dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Neoplastic Stem Cells
    210 rdf:type schema:DefinedTerm
    211 Ne8602b806df643d1a7fa90da34cdea38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Disease Models, Animal
    213 rdf:type schema:DefinedTerm
    214 Ne8fac9f1ed1b45599b45fa48dc76ff81 schema:name readcube_id
    215 schema:value b88f97f271d01406ef9740dcfea786e7c6019b3e2afa2a2a24767b6b0eb81bd7
    216 rdf:type schema:PropertyValue
    217 Nec53f5d645854ae5aa5bc891f3d37066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Prognosis
    219 rdf:type schema:DefinedTerm
    220 Nf497c3bb16a14d28a5c68d571b322287 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Hyaluronan Receptors
    222 rdf:type schema:DefinedTerm
    223 Nf67119bc7e844d5e852b517f82ac45e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Male
    225 rdf:type schema:DefinedTerm
    226 Nf824124fb42f400d941433cb187014dc rdf:first sg:person.015136054565.78
    227 rdf:rest N10fe6dfd22284691a7f0fb92f379b3c1
    228 Nfc9c8332981c471a92c638d799f50152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Diet, High-Fat
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Medical and Health Sciences
    233 rdf:type schema:DefinedTerm
    234 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    235 schema:name Oncology and Carcinogenesis
    236 rdf:type schema:DefinedTerm
    237 sg:grant.3784783 http://pending.schema.org/fundedItem sg:pub.10.1038/nature20791
    238 rdf:type schema:MonetaryGrant
    239 sg:grant.5148386 http://pending.schema.org/fundedItem sg:pub.10.1038/nature20791
    240 rdf:type schema:MonetaryGrant
    241 sg:journal.1018957 schema:issn 0090-0028
    242 1476-4687
    243 schema:name Nature
    244 rdf:type schema:Periodical
    245 sg:person.01100327144.79 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    246 schema:familyName Pascual
    247 schema:givenName Gloria
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100327144.79
    249 rdf:type schema:Person
    250 sg:person.01124215277.61 schema:affiliation https://www.grid.ac/institutes/grid.411142.3
    251 schema:familyName Toll
    252 schema:givenName Agustí
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124215277.61
    254 rdf:type schema:Person
    255 sg:person.01134151165.72 schema:affiliation https://www.grid.ac/institutes/grid.5612.0
    256 schema:familyName Di Croce
    257 schema:givenName Luciano
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134151165.72
    259 rdf:type schema:Person
    260 sg:person.011420705365.39 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    261 schema:familyName Hueto
    262 schema:givenName Juan Antonio
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011420705365.39
    264 rdf:type schema:Person
    265 sg:person.01147621564.03 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    266 schema:familyName Prats
    267 schema:givenName Neus
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147621564.03
    269 rdf:type schema:Person
    270 sg:person.01214401165.66 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
    271 schema:familyName Bescós
    272 schema:givenName Coro
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214401165.66
    274 rdf:type schema:Person
    275 sg:person.01272722721.25 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    276 schema:familyName Avgustinova
    277 schema:givenName Alexandra
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272722721.25
    279 rdf:type schema:Person
    280 sg:person.01326675511.38 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    281 schema:familyName Attolini
    282 schema:givenName Camille Stephan-Otto
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326675511.38
    284 rdf:type schema:Person
    285 sg:person.014340474165.88 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    286 schema:familyName Martín
    287 schema:givenName Mercè
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014340474165.88
    289 rdf:type schema:Person
    290 sg:person.015136054565.78 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    291 schema:familyName Castellanos
    292 schema:givenName Andrés
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015136054565.78
    294 rdf:type schema:Person
    295 sg:person.0660606757.21 schema:affiliation https://www.grid.ac/institutes/grid.7722.0
    296 schema:familyName Berenguer
    297 schema:givenName Antoni
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660606757.21
    299 rdf:type schema:Person
    300 sg:person.0663266606.24 schema:affiliation https://www.grid.ac/institutes/grid.11478.3b
    301 schema:familyName Mejetta
    302 schema:givenName Stefania
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663266606.24
    304 rdf:type schema:Person
    305 sg:person.0706366706.20 schema:affiliation https://www.grid.ac/institutes/grid.425902.8
    306 schema:familyName Benitah
    307 schema:givenName Salvador Aznar
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706366706.20
    309 rdf:type schema:Person
    310 sg:pub.10.1007/978-1-59745-060-7_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009387416
    311 https://doi.org/10.1007/978-1-59745-060-7_14
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
    314 https://doi.org/10.1038/nature11412
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature12998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051340125
    317 https://doi.org/10.1038/nature12998
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nature14336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044677141
    320 https://doi.org/10.1038/nature14336
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nature14897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025946880
    323 https://doi.org/10.1038/nature14897
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nature15748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045603885
    326 https://doi.org/10.1038/nature15748
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nature16064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028965943
    329 https://doi.org/10.1038/nature16064
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nature16140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045846495
    332 https://doi.org/10.1038/nature16140
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ncb3011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047391109
    335 https://doi.org/10.1038/ncb3011
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/ncb3015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041022453
    338 https://doi.org/10.1038/ncb3015
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nm.2379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047605946
    341 https://doi.org/10.1038/nm.2379
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nm.2492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013664882
    344 https://doi.org/10.1038/nm.2492
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nm.2753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016583334
    347 https://doi.org/10.1038/nm.2753
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nm1336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034420089
    350 https://doi.org/10.1038/nm1336
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/nrc1877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036672274
    353 https://doi.org/10.1038/nrc1877
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/nrc3627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011267322
    356 https://doi.org/10.1038/nrc3627
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nrd1469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024601516
    359 https://doi.org/10.1038/nrd1469
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/srep14752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053379220
    362 https://doi.org/10.1038/srep14752
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/srep18669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036810713
    365 https://doi.org/10.1038/srep18669
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
    368 https://doi.org/10.1186/gb-2004-5-10-r80
    369 rdf:type schema:CreativeWork
    370 https://app.dimensions.ai/details/publication/pub.1074984093 schema:CreativeWork
    371 https://doi.org/10.1002/cyto.a.22434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000033410
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1002/stem.1716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051634991
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.ccr.2011.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044875310
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.ccr.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021370605
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/j.ccr.2012.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017815588
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.ccr.2014.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007977070
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/j.cell.2009.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018771504
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.cell.2010.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012670260
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/j.cell.2013.07.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048661024
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.cell.2014.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240985
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.cell.2015.01.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021648733
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/j.cell.2015.04.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025956150
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/j.celrep.2014.08.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000675028
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/j.celrep.2015.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024981859
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/j.cmet.2010.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020531681
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/j.jim.2009.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032716417
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/j.stem.2012.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051219389
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/j.stem.2014.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011388399
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/s0076-6879(06)11019-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019893733
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1073/pnas.0610117104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044178395
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1074/jbc.274.38.26761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007064883
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1074/jbc.m003826200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036166338
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1089/met.2011.0003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059298719
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1093/bioinformatics/btg363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051276435
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1093/jnci/djv256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028344387
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1101/gad.1771409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005293613
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1111/j.1600-0714.2007.00617.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049738716
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1126/science.1203543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027317432
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1126/scisignal.2004088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033807182
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1146/annurev-nutr-071812-161220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042853682
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1152/ajpcell.00145.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063191797
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1152/physrev.00003.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021613349
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1155/2011/598358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573856
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1158/0008-5472.can-11-1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037007489
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1158/1078-0432.ccr-07-4615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007708594
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1158/2159-8290.cd-12-0095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011831914
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1161/atvbaha.113.301523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029133404
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1167/iovs.05-1656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019037788
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1172/jci59218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031381862
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1194/jlr.d500037-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031764332
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1242/jeb.047050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002483946
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1371/journal.pone.0014418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044306517
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1371/journal.pone.0029974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008043071
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.3390/biom2030389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010910684
    462 rdf:type schema:CreativeWork
    463 https://www.grid.ac/institutes/grid.11478.3b schema:alternateName Centre for Genomic Regulation
    464 schema:name Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
    465 rdf:type schema:Organization
    466 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
    467 schema:name Vall D´Hebron Hospital, Barcelona, Department of Oral and Maxillofacial Surgery, Universitat Autònoma de Barcelona, Barcelona 08035 Spain
    468 rdf:type schema:Organization
    469 https://www.grid.ac/institutes/grid.411142.3 schema:alternateName Hospital Del Mar
    470 schema:name IMIM, Department of Dermatology, Hospital del Mar, 08003 Barcelona
    471 rdf:type schema:Organization
    472 https://www.grid.ac/institutes/grid.425902.8 schema:alternateName Institució Catalana de Recerca i Estudis Avançats
    473 schema:name Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
    474 Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
    475 rdf:type schema:Organization
    476 https://www.grid.ac/institutes/grid.5612.0 schema:alternateName Pompeu Fabra University
    477 schema:name Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain
    478 Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain
    479 Universitat Pompeu Fabra (UPF), Barcelona 08002, Spain
    480 rdf:type schema:Organization
    481 https://www.grid.ac/institutes/grid.7722.0 schema:alternateName Institute for Research in Biomedicine
    482 schema:name Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
    483 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...