Genomic evolution and chemoresistance in germ-cell tumours View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-30

AUTHORS

Amaro Taylor-Weiner, Travis Zack, Elizabeth O’Donnell, Jennifer L. Guerriero, Brandon Bernard, Anita Reddy, G. Celine Han, Saud AlDubayan, Ali Amin-Mansour, Steven E. Schumacher, Kevin Litchfield, Clare Turnbull, Stacey Gabriel, Rameen Beroukhim, Gad Getz, Scott L. Carter, Michelle S. Hirsch, Anthony Letai, Christopher Sweeney, Eliezer M Van Allen

ABSTRACT

Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

PAGES

114-118

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7631

    VOLUME

    540

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature20596

    DOI

    http://dx.doi.org/10.1038/nature20596

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047669560

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27905446


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