m6A modulates neuronal functions and sex determination in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-11-30

AUTHORS

Tina Lence, Junaid Akhtar, Marc Bayer, Katharina Schmid, Laura Spindler, Cheuk Hei Ho, Nastasja Kreim, Miguel A. Andrade-Navarro, Burkhard Poeck, Mark Helm, Jean-Yves Roignant

ABSTRACT

N6-methyladenosine RNA (m6A) is a prevalent messenger RNA modification in vertebrates. Although its functions in the regulation of post-transcriptional gene expression are beginning to be unveiled, the precise roles of m6A during development of complex organisms remain unclear. Here we carry out a comprehensive molecular and physiological characterization of the individual components of the methyltransferase complex, as well as of the YTH domain-containing nuclear reader protein in Drosophila melanogaster. We identify the member of the split ends protein family, Spenito, as a novel bona fide subunit of the methyltransferase complex. We further demonstrate important roles of this complex in neuronal functions and sex determination, and implicate the nuclear YT521-B protein as a main m6A effector in these processes. Altogether, our work substantially extends our knowledge of m6A biology, demonstrating the crucial functions of this modification in fundamental processes within the context of the whole animal. More... »

PAGES

242

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature20568

DOI

http://dx.doi.org/10.1038/nature20568

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052617207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27919077


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