In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-11-16

AUTHORS

Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernandez-Benitez, Jun Wu, Jie Zhu, Euiseok J. Kim, Fumiyuki Hatanaka, Mako Yamamoto, Toshikazu Araoka, Zhe Li, Masakazu Kurita, Tomoaki Hishida, Mo Li, Emi Aizawa, Shicheng Guo, Song Chen, April Goebl, Rupa Devi Soligalla, Jing Qu, Tingshuai Jiang, Xin Fu, Maryam Jafari, Concepcion Rodriguez Esteban, W. Travis Berggren, Jeronimo Lajara, Estrella Nuñez-Delicado, Pedro Guillen, Josep M. Campistol, Fumio Matsuzaki, Guang-Hui Liu, Pierre Magistretti, Kun Zhang, Edward M. Callaway, Kang Zhang, Juan Carlos Izpisua Belmonte

ABSTRACT

A method for CRISPR-based genome editing that harnesses cellular non-homologous end joining activity to achieve targeted DNA knock-in in non-dividing tissues.

PAGES

144-149

References to SciGraph publications

  • 2011-08-21. Site-specific integration and tailoring of cassette design for sustainable gene transfer in NATURE METHODS
  • 2011-02-23. Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome in NATURE
  • 2014-02-01. Small Fragment Homologous Replacement (SFHR): Sequence-Specific Modification of Genomic DNA in Eukaryotic Cells by Small DNA Fragments in GENE CORRECTION
  • 2014-11-20. Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9 in NATURE COMMUNICATIONS
  • 2009-03-19. Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors in NATURE PROTOCOLS
  • 2013-07-21. DNA targeting specificity of RNA-guided Cas9 nucleases in NATURE BIOTECHNOLOGY
  • 2009-12-20. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain in NATURE NEUROSCIENCE
  • 2015-02-05. Therapeutic genome editing: prospects and challenges in NATURE MEDICINE
  • 2011-10-07. Isolation of Muscle Stem Cells by Fluorescence Activated Cell Sorting Cytometry in MYOGENESIS
  • 2015-12-09. A mechanism for the suppression of homologous recombination in G1 cells in NATURE
  • 2012-01-05. A transcription activator-like effector toolbox for genome engineering in NATURE PROTOCOLS
  • 2014-07-07. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs in NATURE COMMUNICATIONS
  • 2005-08-14. Millisecond-timescale, genetically targeted optical control of neural activity in NATURE NEUROSCIENCE
  • 2015-10-14. Gene therapy returns to centre stage in NATURE
  • 2014-05-28. Targeted genome editing in human repopulating haematopoietic stem cells in NATURE
  • 2015-05-06. An alternative pluripotent state confers interspecies chimaeric competency in NATURE
  • 2010-11-21. A robust system for production of minicircle DNA vectors in NATURE BIOTECHNOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7631

    VOLUME

    540

    Author Affiliations

  • Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, 92037, La Jolla, California, USA
  • Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, 650-0047, Chuo-ku, Kobe, Japan
  • 4700 King Abdullah University of Science and Technology (KAUST), 23955-6900, Thuwal, Saudi Arabia
  • Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe, 30107, Murcia, Spain
  • Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, 92023, La JollaCalifornia, USA
  • Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., 92037, La JollaCalifornia, USA
  • Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC041292093-0412, La Jolla, California, USA
  • University of Chinese Academy of Sciences, 100049, Beijing, China
  • Guangzhou EliteHealth Biological Pharmaceutical Technology Company Ltd, 510005, Guangzhou, China
  • Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, 92037, La Jolla, California, USA
  • Fundación Dr. Pedro Guillen, Investigación Biomedica de Clinica CEMTRO, Avenida Ventisquero de la Condesa, 42, 28035Madrid, Spain
  • Hospital Clinic, University of Barcelona, IDIBAPS, 08036, Barcelona, Spain
  • Beijing Institute for Brain Disorders, 100069, Beijing, China
  • Veterans Administration Healthcare System, 92093, San Diego, California, USA
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature20565

    DOI

    http://dx.doi.org/10.1038/nature20565

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039320813

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27851729


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    424 schema:name 4700 King Abdullah University of Science and Technology (KAUST), 23955-6900, Thuwal, Saudi Arabia
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