The coming of age of de novo protein design View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09

AUTHORS

Po-Ssu Huang, Scott E. Boyken, David Baker

ABSTRACT

There are 20(200) possible amino-acid sequences for a 200-residue protein, of which the natural evolutionary process has sampled only an infinitesimal subset. De novo protein design explores the full sequence space, guided by the physical principles that underlie protein folding. Computational methodology has advanced to the point that a wide range of structures can be designed from scratch with atomic-level accuracy. Almost all protein engineering so far has involved the modification of naturally occurring proteins; it should now be possible to design new functional proteins from the ground up to tackle current challenges in biomedicine and nanotechnology. More... »

PAGES

320

References to SciGraph publications

  • 2001-05. The myosin swinging cross-bridge model in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2016-09. Installing hydrolytic activity into a completely de novo protein framework in NATURE CHEMISTRY
  • 2013-08. Evolution of a designed retro-aldolase leads to complete active site remodeling in NATURE CHEMICAL BIOLOGY
  • 2011-12. A de novo peptide hexamer with a mutable channel in NATURE CHEMICAL BIOLOGY
  • 2001-04. Functional proteins from a random-sequence library in NATURE
  • 2009-04-16. Design of protein-interaction specificity gives selective bZIP-binding peptides in NATURE
  • 2003-01. DNA in a material world in NATURE
  • 2012-11. Principles for designing ideal protein structures in NATURE
  • 2014-02-05. Proof of principle for epitope-focused vaccine design in NATURE
  • 2013-09. Computational design of ligand-binding proteins with high affinity and selectivity in NATURE
  • 2015-12. Exploring the repeat protein universe through computational protein design in NATURE
  • 2016-07. Design of a hyperstable 60-subunit protein icosahedron in NATURE
  • 2016-10. Accurate de novo design of hyperstable constrained peptides in NATURE
  • 2013-06. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments in NATURE CHEMICAL BIOLOGY
  • 2014-07. Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring in NATURE CHEMICAL BIOLOGY
  • 2016-01. De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy in NATURE CHEMICAL BIOLOGY
  • 2001-09. How the olfactory system makes sense of scents in NATURE
  • 2015-12. Rational design of α-helical tandem repeat proteins with closed architectures in NATURE
  • 2001-09. ATP synthase — a marvellous rotary engine of the cell in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-06. Accurate design of co-assembling multi-component protein nanomaterials in NATURE
  • 2009-05. The structure and function of G-protein-coupled receptors in NATURE
  • 2015-02. Control of repeat-protein curvature by computational protein design in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature19946

    DOI

    http://dx.doi.org/10.1038/nature19946

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023334970

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27629638


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biophysics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computational Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Design", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nanostructures", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Folding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Stability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.", 
                "Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Po-Ssu", 
            "id": "sg:person.01150346322.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150346322.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.", 
                "Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.", 
                "Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boyken", 
            "givenName": "Scott E.", 
            "id": "sg:person.01074446747.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074446747.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.", 
                "Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.", 
                "Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baker", 
            "givenName": "David", 
            "id": "sg:person.0714711062.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714711062.98"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.aad8865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000769076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001761618", 
              "https://doi.org/10.1038/nature07885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001761618", 
              "https://doi.org/10.1038/nature07885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002653202", 
              "https://doi.org/10.1038/nchembio.1276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.copbio.2013.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003038385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003276306", 
              "https://doi.org/10.1038/nchembio.1966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpa.2013.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003301173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35073086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003784089", 
              "https://doi.org/10.1038/35073086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35073086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003784089", 
              "https://doi.org/10.1038/35073086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004109776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006905519", 
              "https://doi.org/10.1038/nature13404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2012.03.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007208424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.11012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007525464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008349047", 
              "https://doi.org/10.1038/nchembio.1248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201204077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010495766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2010.08.058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010984163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011685737", 
              "https://doi.org/10.1038/nature08144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011685737", 
              "https://doi.org/10.1038/nature08144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011729333", 
              "https://doi.org/10.1038/35070613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011729333", 
              "https://doi.org/10.1038/35070613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1997.0959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011896927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.09248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013272350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013602023", 
              "https://doi.org/10.1038/35089509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013602023", 
              "https://doi.org/10.1038/35089509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.02030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014136006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1314045110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014807483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.22639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016118171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(87)90358-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016209422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-394292-0.00008-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018090246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1257452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018734545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1413638111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018877949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1261172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021653814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1509508112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021668581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340010105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022047016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340010105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022047016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-072611-101825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022324556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.692", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024836800", 
              "https://doi.org/10.1038/nchembio.692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024894486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature19791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026550462", 
              "https://doi.org/10.1038/nature19791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2013.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028881318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaa9897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028884052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/psc.1331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029054660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029123725", 
              "https://doi.org/10.1038/nature12443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0365110x53001964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029987264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0019230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030343862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2010.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031055257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031434303", 
              "https://doi.org/10.1038/nature12966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aaf8818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031690101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033838300", 
              "https://doi.org/10.1038/nchem.2555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1257481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033852059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033919453", 
              "https://doi.org/10.1038/nature01406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033919453", 
              "https://doi.org/10.1038/nature01406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jacs.6b00816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034187660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034778309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2015.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034778309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560050511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034905759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560050511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034905759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5335.82", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036753914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.10606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037124762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s003358351500013x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037663947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2013.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038909130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.22934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039386563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/sb300028q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041314400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja907617a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041415160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja907617a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041415160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041436848", 
              "https://doi.org/10.1038/nature16191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1505072112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042145385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.10.5486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042295133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1219364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042424531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043540416", 
              "https://doi.org/10.1038/nature11600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.1554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044044701", 
              "https://doi.org/10.1038/nchembio.1554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35093026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044886288", 
              "https://doi.org/10.1038/35093026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35093026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044886288", 
              "https://doi.org/10.1038/35093026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1233936", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045927994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-381270-4.00019-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046182923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.261563398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046512438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature18010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046561326", 
              "https://doi.org/10.1038/nature18010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046749580", 
              "https://doi.org/10.1038/nature16162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046975215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.2187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047345610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1089427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047464076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0024109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048040396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.ppat.1005409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048765515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.copbio.2009.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049816781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad8036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049866195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btu502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050222210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050791436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja505101a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051000906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2012.03.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051114210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.051454805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052197688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.051454805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052197688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052571306", 
              "https://doi.org/10.1038/nsmb.2938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.19.10383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052702234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.1963.028.01.060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060403551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5393.1462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3043666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062585338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/50476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071423802"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-09", 
        "datePublishedReg": "2016-09-01", 
        "description": "There are 20(200) possible amino-acid sequences for a 200-residue protein, of which the natural evolutionary process has sampled only an infinitesimal subset. De novo protein design explores the full sequence space, guided by the physical principles that underlie protein folding. Computational methodology has advanced to the point that a wide range of structures can be designed from scratch with atomic-level accuracy. Almost all protein engineering so far has involved the modification of naturally occurring proteins; it should now be possible to design new functional proteins from the ground up to tackle current challenges in biomedicine and nanotechnology. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature19946", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7620", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "537"
          }
        ], 
        "name": "The coming of age of de novo protein design", 
        "pagination": "320", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6f2cb3973fe039d64eb73ccebab202d36ea3e3a5d7cfba0cadd84e190b765b38"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27629638"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature19946"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023334970"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature19946", 
          "https://app.dimensions.ai/details/publication/pub.1023334970"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature19946"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature19946'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature19946'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature19946'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature19946'


     

    This table displays all metadata directly associated to this object as RDF triples.

    390 TRIPLES      21 PREDICATES      121 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature19946 schema:about N056e9b24324a46cba0f21fc6f3fe103c
    2 N121c776718b44519a704a57f8c73e0b8
    3 N21dfd0e1cb94432092c48cf73c3a0c0a
    4 N27983fed738f449483ae884f15a49428
    5 N5ab35446a8294f7d830488d922f022ae
    6 Nb0ae63f8bd064608984a08429867e94f
    7 Nc44945b3241c49abbd360422d8939024
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author N318c2e6450634b5bbfdbfb5997f144e1
    11 schema:citation sg:pub.10.1038/35070613
    12 sg:pub.10.1038/35073086
    13 sg:pub.10.1038/35089509
    14 sg:pub.10.1038/35093026
    15 sg:pub.10.1038/nature01406
    16 sg:pub.10.1038/nature07885
    17 sg:pub.10.1038/nature08144
    18 sg:pub.10.1038/nature11600
    19 sg:pub.10.1038/nature12443
    20 sg:pub.10.1038/nature12966
    21 sg:pub.10.1038/nature13404
    22 sg:pub.10.1038/nature16162
    23 sg:pub.10.1038/nature16191
    24 sg:pub.10.1038/nature18010
    25 sg:pub.10.1038/nature19791
    26 sg:pub.10.1038/nchem.2555
    27 sg:pub.10.1038/nchembio.1248
    28 sg:pub.10.1038/nchembio.1276
    29 sg:pub.10.1038/nchembio.1554
    30 sg:pub.10.1038/nchembio.1966
    31 sg:pub.10.1038/nchembio.692
    32 sg:pub.10.1038/nsmb.2938
    33 https://doi.org/10.1002/anie.201204077
    34 https://doi.org/10.1002/bip.22639
    35 https://doi.org/10.1002/pro.2187
    36 https://doi.org/10.1002/pro.462
    37 https://doi.org/10.1002/pro.481
    38 https://doi.org/10.1002/pro.5560050511
    39 https://doi.org/10.1002/prot.22934
    40 https://doi.org/10.1002/prot.340010105
    41 https://doi.org/10.1002/psc.1331
    42 https://doi.org/10.1006/jmbi.1997.0959
    43 https://doi.org/10.1016/0022-2836(87)90358-5
    44 https://doi.org/10.1016/b978-0-12-381270-4.00019-6
    45 https://doi.org/10.1016/b978-0-12-394292-0.00008-4
    46 https://doi.org/10.1016/j.cbpa.2013.02.012
    47 https://doi.org/10.1016/j.copbio.2009.08.005
    48 https://doi.org/10.1016/j.copbio.2013.02.001
    49 https://doi.org/10.1016/j.jmb.2010.08.058
    50 https://doi.org/10.1016/j.jmb.2015.12.008
    51 https://doi.org/10.1016/j.jsb.2013.03.012
    52 https://doi.org/10.1016/j.sbi.2010.10.002
    53 https://doi.org/10.1016/j.sbi.2012.03.010
    54 https://doi.org/10.1016/j.str.2012.03.026
    55 https://doi.org/10.1016/j.tibtech.2013.10.008
    56 https://doi.org/10.1017/s003358351500013x
    57 https://doi.org/10.1021/ja505101a
    58 https://doi.org/10.1021/ja907617a
    59 https://doi.org/10.1021/jacs.6b00816
    60 https://doi.org/10.1021/sb300028q
    61 https://doi.org/10.1073/pnas.1314045110
    62 https://doi.org/10.1073/pnas.1413638111
    63 https://doi.org/10.1073/pnas.1505072112
    64 https://doi.org/10.1073/pnas.1509508112
    65 https://doi.org/10.1073/pnas.261563398
    66 https://doi.org/10.1073/pnas.96.10.5486
    67 https://doi.org/10.1073/pnas.97.19.10383
    68 https://doi.org/10.1093/bioinformatics/btu502
    69 https://doi.org/10.1101/sqb.1963.028.01.060
    70 https://doi.org/10.1107/s0365110x53001964
    71 https://doi.org/10.1110/ps.051454805
    72 https://doi.org/10.1126/science.1089427
    73 https://doi.org/10.1126/science.1198841
    74 https://doi.org/10.1126/science.1219364
    75 https://doi.org/10.1126/science.1233936
    76 https://doi.org/10.1126/science.1257452
    77 https://doi.org/10.1126/science.1257481
    78 https://doi.org/10.1126/science.1261172
    79 https://doi.org/10.1126/science.278.5335.82
    80 https://doi.org/10.1126/science.282.5393.1462
    81 https://doi.org/10.1126/science.3043666
    82 https://doi.org/10.1126/science.aaa9897
    83 https://doi.org/10.1126/science.aad8036
    84 https://doi.org/10.1126/science.aad8865
    85 https://doi.org/10.1126/science.aaf8818
    86 https://doi.org/10.1146/annurev-biochem-072611-101825
    87 https://doi.org/10.1371/journal.pone.0015364
    88 https://doi.org/10.1371/journal.pone.0019230
    89 https://doi.org/10.1371/journal.pone.0024109
    90 https://doi.org/10.1371/journal.ppat.1005409
    91 https://doi.org/10.3791/50476
    92 https://doi.org/10.7554/elife.02030
    93 https://doi.org/10.7554/elife.09248
    94 https://doi.org/10.7554/elife.10606
    95 https://doi.org/10.7554/elife.11012
    96 schema:datePublished 2016-09
    97 schema:datePublishedReg 2016-09-01
    98 schema:description There are 20(200) possible amino-acid sequences for a 200-residue protein, of which the natural evolutionary process has sampled only an infinitesimal subset. De novo protein design explores the full sequence space, guided by the physical principles that underlie protein folding. Computational methodology has advanced to the point that a wide range of structures can be designed from scratch with atomic-level accuracy. Almost all protein engineering so far has involved the modification of naturally occurring proteins; it should now be possible to design new functional proteins from the ground up to tackle current challenges in biomedicine and nanotechnology.
    99 schema:genre research_article
    100 schema:inLanguage en
    101 schema:isAccessibleForFree false
    102 schema:isPartOf Na25b7af3353d425585261dcce82d8f4d
    103 Ndfa8c595755e4bb5969fa9ca5e295239
    104 sg:journal.1018957
    105 schema:name The coming of age of de novo protein design
    106 schema:pagination 320
    107 schema:productId N1930fe9ff3444b15b62ac47affe281c0
    108 N26f837d5a09c4f1f98517c4d36025915
    109 N717cbdbfaa404461b1ab3192070fc563
    110 N9b8c4323377f4b62933831e73dbd3878
    111 Nd3eac1faf0074b028898d708ddfed7db
    112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023334970
    113 https://doi.org/10.1038/nature19946
    114 schema:sdDatePublished 2019-04-10T19:46
    115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    116 schema:sdPublisher N55721e9cfe1a44ddb9b5d939483d78d2
    117 schema:url https://www.nature.com/articles/nature19946
    118 sgo:license sg:explorer/license/
    119 sgo:sdDataset articles
    120 rdf:type schema:ScholarlyArticle
    121 N056e9b24324a46cba0f21fc6f3fe103c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Computational Biology
    123 rdf:type schema:DefinedTerm
    124 N121c776718b44519a704a57f8c73e0b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Biophysics
    126 rdf:type schema:DefinedTerm
    127 N13931f5e58374723b2cdf1b3dff671f5 rdf:first sg:person.01074446747.48
    128 rdf:rest N420553d0931b4df09f096d21a9531150
    129 N1930fe9ff3444b15b62ac47affe281c0 schema:name nlm_unique_id
    130 schema:value 0410462
    131 rdf:type schema:PropertyValue
    132 N21dfd0e1cb94432092c48cf73c3a0c0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Proteins
    134 rdf:type schema:DefinedTerm
    135 N26f837d5a09c4f1f98517c4d36025915 schema:name readcube_id
    136 schema:value 6f2cb3973fe039d64eb73ccebab202d36ea3e3a5d7cfba0cadd84e190b765b38
    137 rdf:type schema:PropertyValue
    138 N27983fed738f449483ae884f15a49428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Protein Folding
    140 rdf:type schema:DefinedTerm
    141 N318c2e6450634b5bbfdbfb5997f144e1 rdf:first sg:person.01150346322.46
    142 rdf:rest N13931f5e58374723b2cdf1b3dff671f5
    143 N420553d0931b4df09f096d21a9531150 rdf:first sg:person.0714711062.98
    144 rdf:rest rdf:nil
    145 N55721e9cfe1a44ddb9b5d939483d78d2 schema:name Springer Nature - SN SciGraph project
    146 rdf:type schema:Organization
    147 N5ab35446a8294f7d830488d922f022ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Drug Design
    149 rdf:type schema:DefinedTerm
    150 N717cbdbfaa404461b1ab3192070fc563 schema:name doi
    151 schema:value 10.1038/nature19946
    152 rdf:type schema:PropertyValue
    153 N9b8c4323377f4b62933831e73dbd3878 schema:name pubmed_id
    154 schema:value 27629638
    155 rdf:type schema:PropertyValue
    156 Na25b7af3353d425585261dcce82d8f4d schema:volumeNumber 537
    157 rdf:type schema:PublicationVolume
    158 Nb0ae63f8bd064608984a08429867e94f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Protein Stability
    160 rdf:type schema:DefinedTerm
    161 Nc44945b3241c49abbd360422d8939024 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Nanostructures
    163 rdf:type schema:DefinedTerm
    164 Nd3eac1faf0074b028898d708ddfed7db schema:name dimensions_id
    165 schema:value pub.1023334970
    166 rdf:type schema:PropertyValue
    167 Ndfa8c595755e4bb5969fa9ca5e295239 schema:issueNumber 7620
    168 rdf:type schema:PublicationIssue
    169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Biological Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Biochemistry and Cell Biology
    174 rdf:type schema:DefinedTerm
    175 sg:journal.1018957 schema:issn 0090-0028
    176 1476-4687
    177 schema:name Nature
    178 rdf:type schema:Periodical
    179 sg:person.01074446747.48 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    180 schema:familyName Boyken
    181 schema:givenName Scott E.
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074446747.48
    183 rdf:type schema:Person
    184 sg:person.01150346322.46 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    185 schema:familyName Huang
    186 schema:givenName Po-Ssu
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150346322.46
    188 rdf:type schema:Person
    189 sg:person.0714711062.98 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    190 schema:familyName Baker
    191 schema:givenName David
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714711062.98
    193 rdf:type schema:Person
    194 sg:pub.10.1038/35070613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011729333
    195 https://doi.org/10.1038/35070613
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/35073086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003784089
    198 https://doi.org/10.1038/35073086
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/35089509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013602023
    201 https://doi.org/10.1038/35089509
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/35093026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044886288
    204 https://doi.org/10.1038/35093026
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/nature01406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033919453
    207 https://doi.org/10.1038/nature01406
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/nature07885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001761618
    210 https://doi.org/10.1038/nature07885
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nature08144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011685737
    213 https://doi.org/10.1038/nature08144
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nature11600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043540416
    216 https://doi.org/10.1038/nature11600
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nature12443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029123725
    219 https://doi.org/10.1038/nature12443
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nature12966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031434303
    222 https://doi.org/10.1038/nature12966
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature13404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006905519
    225 https://doi.org/10.1038/nature13404
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature16162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046749580
    228 https://doi.org/10.1038/nature16162
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature16191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041436848
    231 https://doi.org/10.1038/nature16191
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature18010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046561326
    234 https://doi.org/10.1038/nature18010
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature19791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026550462
    237 https://doi.org/10.1038/nature19791
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nchem.2555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033838300
    240 https://doi.org/10.1038/nchem.2555
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nchembio.1248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008349047
    243 https://doi.org/10.1038/nchembio.1248
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nchembio.1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002653202
    246 https://doi.org/10.1038/nchembio.1276
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nchembio.1554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044044701
    249 https://doi.org/10.1038/nchembio.1554
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nchembio.1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003276306
    252 https://doi.org/10.1038/nchembio.1966
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nchembio.692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024836800
    255 https://doi.org/10.1038/nchembio.692
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/nsmb.2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052571306
    258 https://doi.org/10.1038/nsmb.2938
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1002/anie.201204077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010495766
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1002/bip.22639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016118171
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1002/pro.2187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047345610
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1002/pro.462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004109776
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1002/pro.481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024894486
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1002/pro.5560050511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034905759
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1002/prot.22934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039386563
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1002/prot.340010105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022047016
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1002/psc.1331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029054660
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1006/jmbi.1997.0959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011896927
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/0022-2836(87)90358-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016209422
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/b978-0-12-381270-4.00019-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046182923
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/b978-0-12-394292-0.00008-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018090246
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.cbpa.2013.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003301173
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.copbio.2009.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049816781
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.copbio.2013.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003038385
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/j.jmb.2010.08.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010984163
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/j.jmb.2015.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034778309
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/j.jsb.2013.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038909130
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/j.sbi.2010.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031055257
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/j.sbi.2012.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007208424
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/j.str.2012.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051114210
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/j.tibtech.2013.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028881318
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1017/s003358351500013x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037663947
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1021/ja505101a schema:sameAs https://app.dimensions.ai/details/publication/pub.1051000906
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1021/ja907617a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041415160
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1021/jacs.6b00816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034187660
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1021/sb300028q schema:sameAs https://app.dimensions.ai/details/publication/pub.1041314400
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1073/pnas.1314045110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014807483
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1073/pnas.1413638111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018877949
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1073/pnas.1505072112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042145385
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1073/pnas.1509508112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021668581
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1073/pnas.261563398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046512438
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1073/pnas.96.10.5486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042295133
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1073/pnas.97.19.10383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052702234
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1093/bioinformatics/btu502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050222210
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1101/sqb.1963.028.01.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060403551
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1107/s0365110x53001964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029987264
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1110/ps.051454805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052197688
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1126/science.1089427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047464076
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1126/science.1198841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046975215
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1126/science.1219364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042424531
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1126/science.1233936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045927994
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1126/science.1257452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018734545
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1257481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033852059
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.1261172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021653814
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1126/science.278.5335.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036753914
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1126/science.282.5393.1462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563274
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1126/science.3043666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062585338
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1126/science.aaa9897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028884052
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1126/science.aad8036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049866195
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1126/science.aad8865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000769076
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1126/science.aaf8818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031690101
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1146/annurev-biochem-072611-101825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022324556
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1371/journal.pone.0015364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050791436
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1371/journal.pone.0019230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343862
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1371/journal.pone.0024109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048040396
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1371/journal.ppat.1005409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048765515
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.3791/50476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071423802
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.7554/elife.02030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014136006
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.7554/elife.09248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013272350
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.7554/elife.10606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037124762
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.7554/elife.11012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007525464
    385 rdf:type schema:CreativeWork
    386 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    387 schema:name Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
    388 Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA.
    389 Institute for Protein Design, University of Washington, Seattle, Washington 98195, USA.
    390 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...