Balancing selection shapes density-dependent foraging behaviour View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-31

AUTHORS

Joshua S. Greene, Maximillian Brown, May Dobosiewicz, Itzel G. Ishida, Evan Z. Macosko, Xinxing Zhang, Rebecca A. Butcher, Devin J. Cline, Patrick T. McGrath, Cornelia I. Bargmann

ABSTRACT

The optimal foraging strategy in a given environment depends on the number of competing individuals and their behavioural strategies. Little is known about the genes and neural circuits that integrate social information into foraging decisions. Here we show that ascaroside pheromones, small glycolipids that signal population density, suppress exploratory foraging in Caenorhabditis elegans, and that heritable variation in this behaviour generates alternative foraging strategies. We find that natural C. elegans isolates differ in their sensitivity to the potent ascaroside icas#9 (IC-asc-C5). A quantitative trait locus (QTL) regulating icas#9 sensitivity includes srx-43, a G-protein-coupled icas#9 receptor that acts in the ASI class of sensory neurons to suppress exploration. Two ancient haplotypes associated with this QTL confer competitive growth advantages that depend on ascaroside secretion, its detection by srx-43 and the distribution of food. These results suggest that balancing selection at the srx-43 locus generates alternative density-dependent behaviours, fulfilling a prediction of foraging game theory. More... »

PAGES

254

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature19848

DOI

http://dx.doi.org/10.1038/nature19848

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027244565

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27799655


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature19848'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature19848'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature19848'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature19848'


 

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323 schema:name School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
324 rdf:type schema:Organization
 




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